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Compile Data Set for Download or QSAR

Found 484 hits of ph data with Target = 'Phosphatidylinositol 3-kinase regulatory subunit alpha'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178372
PNG
(US9120812, 157)
Show SMILES CC1(C)CN(C2CCOCC2)C(=O)c2c(O1)nc(nc2-c1ccc(NC(=O)Nc2ccon2)cc1)N1CC2CCC(C1)O2
Show InChI InChI=1S/C30H35N7O6/c1-30(2)17-37(20-9-12-40-13-10-20)27(38)24-25(18-3-5-19(6-4-18)31-29(39)32-23-11-14-41-35-23)33-28(34-26(24)43-30)36-15-21-7-8-22(16-36)42-21/h3-6,11,14,20-22H,7-10,12-13,15-17H2,1-2H3,(H2,31,32,35,39)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178373
PNG
(US9120812, 158)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccccn4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C29H32FN7O4/c1-4-36-16-29(2,3)41-25-23(26(36)38)24(34-27(35-25)37-14-18-9-10-19(15-37)40-18)17-8-11-21(20(30)13-17)32-28(39)33-22-7-5-6-12-31-22/h5-8,11-13,18-19H,4,9-10,14-16H2,1-3H3,(H2,31,32,33,39)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178374
PNG
(US9120812, 159)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C26H30FN7O5/c1-5-33-14-26(3,4)39-22-20(23(33)35)21(30-24(31-22)34-9-11-37-13-15(34)2)16-6-7-18(17(27)12-16)28-25(36)29-19-8-10-38-32-19/h6-8,10,12,15H,5,9,11,13-14H2,1-4H3,(H2,28,29,32,36)/t15-/m0/s1
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n/an/a 561n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178375
PNG
(US9120812, 160)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cnccn4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C27H31FN8O4/c1-5-35-15-27(3,4)40-23-21(24(35)37)22(33-25(34-23)36-10-11-39-14-16(36)2)17-6-7-19(18(28)12-17)31-26(38)32-20-13-29-8-9-30-20/h6-9,12-13,16H,5,10-11,14-15H2,1-4H3,(H2,30,31,32,38)/t16-/m0/s1
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n/an/a 4.90E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178376
PNG
(US9120812, 161)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)nc4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C29H34FN7O4/c1-6-36-16-29(4,5)41-25-23(26(36)38)24(34-27(35-25)37-11-12-40-15-18(37)3)19-8-10-22(21(30)13-19)33-28(39)32-20-9-7-17(2)31-14-20/h7-10,13-14,18H,6,11-12,15-16H2,1-5H3,(H2,32,33,39)/t18-/m0/s1
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n/an/a 321n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178377
PNG
(US9120812, 162)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C31H34F2N6O5/c1-31(2)17-38(12-13-42-3)28(40)25-26(36-29(37-27(25)44-31)39-15-21-9-10-22(16-39)43-21)18-4-7-20(8-5-18)34-30(41)35-24-11-6-19(32)14-23(24)33/h4-8,11,14,21-22H,9-10,12-13,15-17H2,1-3H3,(H2,34,35,41)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178378
PNG
(US9120812, 163)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(OC)cn4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C29H34FN7O5/c1-6-36-16-29(3,4)42-25-23(26(36)38)24(34-27(35-25)37-11-12-41-15-17(37)2)18-7-9-21(20(30)13-18)32-28(39)33-22-10-8-19(40-5)14-31-22/h7-10,13-14,17H,6,11-12,15-16H2,1-5H3,(H2,31,32,33,39)/t17-/m0/s1
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n/an/a 3.87E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178379
PNG
(US9120812, 164)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)cn4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C29H34FN7O4/c1-6-36-16-29(4,5)41-25-23(26(36)38)24(34-27(35-25)37-11-12-40-15-18(37)3)19-8-9-21(20(30)13-19)32-28(39)33-22-10-7-17(2)14-31-22/h7-10,13-14,18H,6,11-12,15-16H2,1-5H3,(H2,31,32,33,39)/t18-/m0/s1
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n/an/a 3.80E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178380
PNG
(US9120812, 165)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)c(C)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C28H33N7O5/c1-5-34-15-28(3,4)40-24-22(25(34)36)23(31-26(32-24)35-13-18-7-8-19(14-35)39-18)17-6-9-20(16(2)12-17)29-27(37)30-21-10-11-38-33-21/h6,9-12,18-19H,5,7-8,13-15H2,1-4H3,(H2,29,30,33,37)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178381
PNG
(US9120812, 166)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccn(C)n4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C27H33FN8O4/c1-6-35-15-27(3,4)40-23-21(24(35)37)22(31-25(32-23)36-11-12-39-14-16(36)2)17-7-8-19(18(28)13-17)29-26(38)30-20-9-10-34(5)33-20/h7-10,13,16H,6,11-12,14-15H2,1-5H3,(H2,29,30,33,38)/t16-/m0/s1
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n/an/a 2.30E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178382
PNG
(US9120812, 167)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cnc(C)cn4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C28H33FN8O4/c1-6-36-15-28(4,5)41-24-22(25(36)38)23(34-26(35-24)37-9-10-40-14-17(37)3)18-7-8-20(19(29)11-18)32-27(39)33-21-13-30-16(2)12-31-21/h7-8,11-13,17H,6,9-10,14-15H2,1-5H3,(H2,31,32,33,39)/t17-/m0/s1
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n/an/a 3.52E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178383
PNG
(US9120812, 168 | US9120812, 169)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)cn4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C29H35N7O4/c1-6-35-17-29(4,5)40-25-23(26(35)37)24(33-27(34-25)36-13-14-39-16-19(36)3)20-8-10-21(11-9-20)31-28(38)32-22-12-7-18(2)15-30-22/h7-12,15,19H,6,13-14,16-17H2,1-5H3,(H2,30,31,32,38)/t19-/m0/s1
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n/an/a 1.39E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178383
PNG
(US9120812, 168 | US9120812, 169)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)cn4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C29H35N7O4/c1-6-35-17-29(4,5)40-25-23(26(35)37)24(33-27(34-25)36-13-14-39-16-19(36)3)20-8-10-21(11-9-20)31-28(38)32-22-12-7-18(2)15-30-22/h7-12,15,19H,6,13-14,16-17H2,1-5H3,(H2,30,31,32,38)/t19-/m0/s1
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n/an/a 1.45E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178385
PNG
(US9120812, 170)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4nnc(C)o4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C26H31FN8O5/c1-6-34-13-26(4,5)40-21-19(22(34)36)20(29-23(30-21)35-9-10-38-12-14(35)2)16-7-8-18(17(27)11-16)28-24(37)31-25-33-32-15(3)39-25/h7-8,11,14H,6,9-10,12-13H2,1-5H3,(H2,28,31,33,37)/t14-/m0/s1
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n/an/a 824n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178386
PNG
(US9120812, 171)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4CCN(C)CC4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C33H42FN9O4/c1-6-41-20-33(3,4)47-29-27(30(41)44)28(38-31(39-29)43-15-16-46-19-21(43)2)22-7-9-25(24(34)17-22)37-32(45)36-23-8-10-26(35-18-23)42-13-11-40(5)12-14-42/h7-10,17-18,21H,6,11-16,19-20H2,1-5H3,(H2,36,37,45)/t21-/m0/s1
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n/an/a 308n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178387
PNG
(US9120812, 172)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C28H33N7O6/c1-28(2)16-34(11-13-38-3)25(36)22-23(17-4-6-18(7-5-17)29-27(37)30-21-10-12-39-33-21)31-26(32-24(22)41-28)35-14-19-8-9-20(15-35)40-19/h4-7,10,12,19-20H,8-9,11,13-16H2,1-3H3,(H2,29,30,33,37)
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n/an/a<1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178388
PNG
(US9120812, 173)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(OC)cn4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C29H35N7O5/c1-6-35-17-29(3,4)41-25-23(26(35)37)24(33-27(34-25)36-13-14-40-16-18(36)2)19-7-9-20(10-8-19)31-28(38)32-22-12-11-21(39-5)15-30-22/h7-12,15,18H,6,13-14,16-17H2,1-5H3,(H2,30,31,32,38)/t18-/m0/s1
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n/an/a 1.60E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178389
PNG
(US9120812, 174)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4CCN(C)CC4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C33H43N9O4/c1-6-40-21-33(3,4)46-29-27(30(40)43)28(37-31(38-29)42-17-18-45-20-22(42)2)23-7-9-24(10-8-23)35-32(44)36-25-11-12-26(34-19-25)41-15-13-39(5)14-16-41/h7-12,19,22H,6,13-18,20-21H2,1-5H3,(H2,35,36,44)/t22-/m0/s1
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n/an/a 326n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178390
PNG
(US9120812, 175)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(OC)nc4)c(C)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C31H37N7O5/c1-6-37-17-31(3,4)43-27-25(28(37)39)26(35-29(36-27)38-15-21-9-10-22(16-38)42-21)19-7-11-23(18(2)13-19)34-30(40)33-20-8-12-24(41-5)32-14-20/h7-8,11-14,21-22H,6,9-10,15-17H2,1-5H3,(H2,33,34,40)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178391
PNG
(US9120812, 176)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4)C(=O)N(C)CCN(C)C)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C36H46N8O5/c1-7-43-22-36(2,3)49-31-29(33(43)46)30(39-34(40-31)44-20-27-16-17-28(21-44)48-27)23-8-12-25(13-9-23)37-35(47)38-26-14-10-24(11-15-26)32(45)42(6)19-18-41(4)5/h8-15,27-28H,7,16-22H2,1-6H3,(H2,37,38,47)
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n/an/a 100n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178392
PNG
(US9120812, 177)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4)C(=O)N4CCC(CC4)N(C)C)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C38H48N8O5/c1-6-44-23-38(2,3)51-33-31(35(44)48)32(41-36(42-33)46-21-29-15-16-30(22-46)50-29)24-7-11-26(12-8-24)39-37(49)40-27-13-9-25(10-14-27)34(47)45-19-17-28(18-20-45)43(4)5/h7-14,28-30H,6,15-23H2,1-5H3,(H2,39,40,49)
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n/an/a 87n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178393
PNG
(US9120812, 178)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(OC)nc4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C31H36FN7O6/c1-31(2)17-38(11-12-42-3)28(40)25-26(36-29(37-27(25)45-31)39-15-20-7-8-21(16-39)44-20)18-5-9-23(22(32)13-18)35-30(41)34-19-6-10-24(43-4)33-14-19/h5-6,9-10,13-14,20-21H,7-8,11-12,15-17H2,1-4H3,(H2,34,35,41)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178394
PNG
(US9120812, 179)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C28H32FN7O6/c1-28(2)15-35(9-11-39-3)25(37)22-23(32-26(33-24(22)42-28)36-13-17-5-6-18(14-36)41-17)16-4-7-20(19(29)12-16)30-27(38)31-21-8-10-40-34-21/h4,7-8,10,12,17-18H,5-6,9,11,13-15H2,1-3H3,(H2,30,31,34,38)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178395
PNG
(US9120812, 180)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccon4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C27H33N7O6/c1-17-15-38-14-11-34(17)25-30-22(18-5-7-19(8-6-18)28-26(36)29-20-9-12-39-32-20)21-23(31-25)40-27(2,3)16-33(24(21)35)10-13-37-4/h5-9,12,17H,10-11,13-16H2,1-4H3,(H2,28,29,32,36)/t17-/m0/s1
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n/an/a 604n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178396
PNG
(US9120812, 181)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cc(OC)ccn4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C29H34FN7O5/c1-6-36-16-29(3,4)42-25-23(26(36)38)24(34-27(35-25)37-11-12-41-15-17(37)2)18-7-8-21(20(30)13-18)32-28(39)33-22-14-19(40-5)9-10-31-22/h7-10,13-14,17H,6,11-12,15-16H2,1-5H3,(H2,31,32,33,39)/t17-/m0/s1
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n/an/a 7.65E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178397
PNG
(US9120812, 182)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cn(C)cn4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C27H33FN8O4/c1-6-35-14-27(3,4)40-23-21(24(35)37)22(32-25(33-23)36-9-10-39-13-16(36)2)17-7-8-19(18(28)11-17)30-26(38)31-20-12-34(5)15-29-20/h7-8,11-12,15-16H,6,9-10,13-14H2,1-5H3,(H2,30,31,38)/t16-/m0/s1
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n/an/a 159n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178398
PNG
(US9120812, 183)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(Nc4nnc([nH]4)-c4ccc(OC)nc4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C31H34FN9O4/c1-5-40-16-31(2,3)45-27-24(28(40)42)25(35-30(37-27)41-14-19-8-9-20(15-41)44-19)17-6-10-22(21(32)12-17)34-29-36-26(38-39-29)18-7-11-23(43-4)33-13-18/h6-7,10-13,19-20H,5,8-9,14-16H2,1-4H3,(H2,34,36,38,39)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178399
PNG
(US9120812, 184)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cc(OC)ccn4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C29H35N7O5/c1-6-35-17-29(3,4)41-25-23(26(35)37)24(33-27(34-25)36-13-14-40-16-18(36)2)19-7-9-20(10-8-19)31-28(38)32-22-15-21(39-5)11-12-30-22/h7-12,15,18H,6,13-14,16-17H2,1-5H3,(H2,30,31,32,38)/t18-/m0/s1
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n/an/a 1.30E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178400
PNG
(US9120812, 185)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(C)nc4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C30H34FN7O4/c1-5-37-16-30(3,4)42-26-24(27(37)39)25(35-28(36-26)38-14-20-9-10-21(15-38)41-20)18-7-11-23(22(31)12-18)34-29(40)33-19-8-6-17(2)32-13-19/h6-8,11-13,20-21H,5,9-10,14-16H2,1-4H3,(H2,33,34,40)
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n/an/a 5.68E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178401
PNG
(US9120812, 186)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)OCCO)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C25H33N5O6/c1-5-29-15-25(3,4)36-21-19(22(29)32)20(27-23(28-21)30-10-12-34-14-16(30)2)17-6-8-18(9-7-17)26-24(33)35-13-11-31/h6-9,16,31H,5,10-15H2,1-4H3,(H,26,33)/t16-/m0/s1
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n/an/a 3.94E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178402
PNG
(US9120812, 187)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4CCOCC4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C32H39FN8O5/c1-5-39-19-32(3,4)46-28-26(29(39)42)27(37-30(38-28)41-12-15-45-18-20(41)2)21-6-8-24(23(33)16-21)36-31(43)35-22-7-9-25(34-17-22)40-10-13-44-14-11-40/h6-9,16-17,20H,5,10-15,18-19H2,1-4H3,(H2,35,36,43)/t20-/m0/s1
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n/an/a 472n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178403
PNG
(US9120812, 188)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C30H34F2N6O5/c1-18-16-42-14-12-38(18)28-35-25(24-26(36-28)43-30(2,3)17-37(27(24)39)11-13-41-4)19-5-8-21(9-6-19)33-29(40)34-23-10-7-20(31)15-22(23)32/h5-10,15,18H,11-14,16-17H2,1-4H3,(H2,33,34,40)/t18-/m0/s1
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n/an/a 2.33E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178404
PNG
(US9120812, 189)
Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2F)-c2nc(nc3OC(C)(C)CN(C4CCOCC4)C(=O)c23)N2CCOC[C@@H]2C)cn1
Show InChI InChI=1S/C32H38FN7O6/c1-19-17-45-14-11-39(19)30-37-27(26-28(38-30)46-32(2,3)18-40(29(26)41)22-9-12-44-13-10-22)20-5-7-24(23(33)15-20)36-31(42)35-21-6-8-25(43-4)34-16-21/h5-8,15-16,19,22H,9-14,17-18H2,1-4H3,(H2,35,36,42)/t19-/m0/s1
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n/an/a 1.89E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178405
PNG
(US9120812, 190)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4)C(=O)NCC(C)(C)O)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C35H43N7O6/c1-6-41-20-35(4,5)48-30-27(31(41)44)28(39-32(40-30)42-17-25-15-16-26(18-42)47-25)21-7-11-23(12-8-21)37-33(45)38-24-13-9-22(10-14-24)29(43)36-19-34(2,3)46/h7-14,25-26,46H,6,15-20H2,1-5H3,(H,36,43)(H2,37,38,45)
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n/an/a 927n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178406
PNG
(US9120812, 191)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C29H32F2N6O4/c1-5-36-16-29(3,4)41-25-23(26(36)38)24(34-27(35-25)37-12-13-40-15-17(37)2)18-6-9-20(10-7-18)32-28(39)33-22-11-8-19(30)14-21(22)31/h6-11,14,17H,5,12-13,15-16H2,1-4H3,(H2,32,33,39)/t17-/m0/s1
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n/an/a 570n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178407
PNG
(US9120812, 192)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccccn4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C28H32FN7O4/c1-5-35-16-28(3,4)40-24-22(25(35)37)23(33-26(34-24)36-12-13-39-15-17(36)2)18-9-10-20(19(29)14-18)31-27(38)32-21-8-6-7-11-30-21/h6-11,14,17H,5,12-13,15-16H2,1-4H3,(H2,30,31,32,38)/t17-/m0/s1
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n/an/a 1.31E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178408
PNG
(US9120812, 193)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Oc4cccc(OC)c4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C30H35N5O6/c1-6-34-18-30(3,4)41-26-24(27(34)36)25(32-28(33-26)35-14-15-39-17-19(35)2)20-10-12-21(13-11-20)31-29(37)40-23-9-7-8-22(16-23)38-5/h7-13,16,19H,6,14-15,17-18H2,1-5H3,(H,31,37)/t19-/m0/s1
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n/an/a 9.44E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178409
PNG
(US9120812, 194)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cn(C)cn4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C28H33FN8O4/c1-5-36-14-28(2,3)41-24-22(25(36)38)23(33-26(34-24)37-11-17-7-8-18(12-37)40-17)16-6-9-20(19(29)10-16)31-27(39)32-21-13-35(4)15-30-21/h6,9-10,13,15,17-18H,5,7-8,11-12,14H2,1-4H3,(H2,31,32,39)
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n/an/a 1.23E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178410
PNG
(US9120812, 195)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4CCN(C)CC4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C34H42FN9O4/c1-5-42-20-34(2,3)48-30-28(31(42)45)29(39-32(40-30)44-18-23-8-9-24(19-44)47-23)21-6-10-26(25(35)16-21)38-33(46)37-22-7-11-27(36-17-22)43-14-12-41(4)13-15-43/h6-7,10-11,16-17,23-24H,5,8-9,12-15,18-20H2,1-4H3,(H2,37,38,46)
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n/an/a 6.80E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178411
PNG
(US9120812, 196)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(OC)nc4)c(C)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C30H37N7O5/c1-7-36-17-30(4,5)42-26-24(27(36)38)25(34-28(35-26)37-12-13-41-16-19(37)3)20-8-10-22(18(2)14-20)33-29(39)32-21-9-11-23(40-6)31-15-21/h8-11,14-15,19H,7,12-13,16-17H2,1-6H3,(H2,32,33,39)/t19-/m0/s1
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n/an/a 7.47E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178412
PNG
(US9120812, 197)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(OC)nc4)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C31H37N7O6/c1-31(2)18-37(13-14-41-3)28(39)25-26(35-29(36-27(25)44-31)38-16-22-10-11-23(17-38)43-22)19-5-7-20(8-6-19)33-30(40)34-21-9-12-24(42-4)32-15-21/h5-9,12,15,22-23H,10-11,13-14,16-18H2,1-4H3,(H2,33,34,40)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178413
PNG
(US9120812, 198)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cnc(OC)cn4)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C29H34N8O5/c1-5-36-16-29(2,3)42-25-23(26(36)38)24(34-27(35-25)37-14-19-10-11-20(15-37)41-19)17-6-8-18(9-7-17)32-28(39)33-21-12-31-22(40-4)13-30-21/h6-9,12-13,19-20H,5,10-11,14-16H2,1-4H3,(H2,30,32,33,39)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178414
PNG
(US9120812, 199)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccnc(C)c4)c(F)c3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C29H34FN7O4/c1-6-36-16-29(4,5)41-25-23(26(36)38)24(34-27(35-25)37-11-12-40-15-18(37)3)19-7-8-22(21(30)14-19)33-28(39)32-20-9-10-31-17(2)13-20/h7-10,13-14,18H,6,11-12,15-16H2,1-5H3,(H2,31,32,33,39)/t18-/m0/s1
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n/an/a 174n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178369
PNG
(US9120812, 154)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(cc4F)C(F)(F)F)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C31H32F4N6O4/c1-4-40-16-30(2,3)45-26-24(27(40)42)25(38-28(39-26)41-14-20-10-11-21(15-41)44-20)17-5-8-19(9-6-17)36-29(43)37-23-12-7-18(13-22(23)32)31(33,34)35/h5-9,12-13,20-21H,4,10-11,14-16H2,1-3H3,(H2,36,37,43)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178370
PNG
(US9120812, 155)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cc(OC)c(F)cc4F)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C31H34F2N6O5/c1-5-38-16-31(2,3)44-27-25(28(38)40)26(36-29(37-27)39-14-19-10-11-20(15-39)43-19)17-6-8-18(9-7-17)34-30(41)35-23-13-24(42-4)22(33)12-21(23)32/h6-9,12-13,19-20H,5,10-11,14-16H2,1-4H3,(H2,34,35,41)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178371
PNG
(US9120812, 156)
Show SMILES C[C@H]1COCCN1c1nc2OC(C)(C)CN(C3CCOCC3)C(=O)c2c(n1)-c1ccc(NC(=O)Nc2ccon2)c(F)c1
Show InChI InChI=1S/C29H34FN7O6/c1-17-15-41-13-9-36(17)27-33-24(18-4-5-21(20(30)14-18)31-28(39)32-22-8-12-42-35-22)23-25(34-27)43-29(2,3)16-37(26(23)38)19-6-10-40-11-7-19/h4-5,8,12,14,17,19H,6-7,9-11,13,15-16H2,1-3H3,(H2,31,32,35,39)/t17-/m0/s1
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n/an/a 1.14E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178415
PNG
(US9120812, 200)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(nc4)N4CCOCC4)c(F)c3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C33H39FN8O5/c1-4-40-19-33(2,3)47-29-27(30(40)43)28(38-31(39-29)42-17-22-7-8-23(18-42)46-22)20-5-9-25(24(34)15-20)37-32(44)36-21-6-10-26(35-16-21)41-11-13-45-14-12-41/h5-6,9-10,15-16,22-23H,4,7-8,11-14,17-19H2,1-3H3,(H2,36,37,44)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178416
PNG
(US9120812, 201)
Show SMILES COCCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4cnn(C)c4)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C28H36N8O5/c1-18-16-40-13-11-36(18)26-32-23(22-24(33-26)41-28(2,3)17-35(25(22)37)10-12-39-5)19-6-8-20(9-7-19)30-27(38)31-21-14-29-34(4)15-21/h6-9,14-15,18H,10-13,16-17H2,1-5H3,(H2,30,31,38)/t18-/m0/s1
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n/an/a 813n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178417
PNG
(US9120812, 202)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c2C1=O)N1CCOC[C@@H]1C
Show InChI InChI=1S/C29H33FN6O4/c1-5-35-17-29(3,4)40-25-23(26(35)37)24(33-27(34-25)36-14-15-39-16-18(36)2)19-10-12-20(13-11-19)31-28(38)32-22-9-7-6-8-21(22)30/h6-13,18H,5,14-17H2,1-4H3,(H2,31,32,38)/t18-/m0/s1
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n/an/a 213n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha


(Homo sapiens (Human))
BDBM178418
PNG
(US9120812, 203)
Show SMILES CCN1CC(C)(C)Oc2nc(nc(-c3ccc(NC(=O)Nc4ccc(CN5CCCCC5)cc4)cc3)c2C1=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C36H45N7O4/c1-4-42-23-36(2,3)47-32-30(33(42)44)31(39-34(40-32)43-21-28-16-17-29(22-43)46-28)25-10-14-27(15-11-25)38-35(45)37-26-12-8-24(9-13-26)20-41-18-6-5-7-19-41/h8-15,28-29H,4-7,16-23H2,1-3H3,(H2,37,38,45)
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n/an/a 9.61E+3n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The test uses a lucifeurerin/luciferase system to measure the concentration of ATP and its consumption during the enzymatic reaction. The test is per...


US Patent US9120812 (2015)


BindingDB Entry DOI: 10.7270/Q2KH0M2D
More data for this
Ligand-Target Pair
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