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Compile Data Set for Download or QSAR

Found 136 hits of ph data with Target = 'Phosphatidylinositol 3-kinase regulatory subunit beta'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288866
PNG
(US10092563, Compound 1)
Show SMILES CN1CCN(CC1)n1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1
Show InChI InChI=1S/C22H25ClN10O/c1-31-7-9-32(10-8-31)33-20(27-15-4-2-3-14(23)16(15)21(33)34)17(12-5-6-12)28-19-13(11-24)18(25)29-22(26)30-19/h2-4,12,17H,5-10H2,1H3,(H5,25,26,28,29,30)/t17-/m0/s1
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n/an/a 3.00E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288867
PNG
(US10092563, Compound 2)
Show SMILES CN1CCN(CC1)n1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1Cl)C1CC1
Show InChI InChI=1S/C21H25Cl2N9O/c1-30-7-9-31(10-8-30)32-19(26-13-4-2-3-12(22)14(13)20(32)33)16(11-5-6-11)27-18-15(23)17(24)28-21(25)29-18/h2-4,11,16H,5-10H2,1H3,(H5,24,25,27,28,29)/t16-/m0/s1
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n/an/a 9.50E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288868
PNG
(US10092563, Compound 3)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C26H27ClN10O/c1-16(31-23-18(14-28)22(29)33-26(30)34-23)24-32-20-9-5-8-19(27)21(20)25(38)37(24)36-12-10-35(11-13-36)15-17-6-3-2-4-7-17/h2-9,16H,10-13,15H2,1H3,(H5,29,30,31,33,34)/t16-/m0/s1
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n/an/a 8.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288869
PNG
(US10092563, Compound 4)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1C[C@@H]2CC[C@H](C1)N2C
Show InChI InChI=1S/C23H26ClN9O/c1-11(28-20-15(10-25)19(26)30-23(27)31-20)21-29-17-5-3-4-16(24)18(17)22(34)33(21)14-8-12-6-7-13(9-14)32(12)2/h3-5,11-14H,6-9H2,1-2H3,(H5,26,27,28,30,31)/t11-,12-,13+,14?/m0/s1
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n/an/a 2.90E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288870
PNG
(US10092563, Compound 5)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCN(C)CC1
Show InChI InChI=1S/C20H22ClN9O/c1-12(26-18-13(10-22)17(23)24-11-25-18)19-27-15-5-3-4-14(21)16(15)20(31)30(19)29-8-6-28(2)7-9-29/h3-5,11-12H,6-9H2,1-2H3,(H3,23,24,25,26)/t12-/m0/s1
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n/an/a 1.90E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288871
PNG
(US10092563, Compound 6)
Show SMILES C[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCN(C)CC1
Show InChI InChI=1S/C21H23ClN8O/c1-12(27-19-14(10-23)18(24)25-11-26-19)20-28-16-5-3-4-15(22)17(16)21(31)30(20)13-6-8-29(2)9-7-13/h3-5,11-13H,6-9H2,1-2H3,(H3,24,25,26,27)/t12-/m0/s1
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n/an/a 4.60E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288872
PNG
(US10092563, Compound 7)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNC2(CC2)C1
Show InChI InChI=1S/C21H23ClN10O/c1-11(27-17-12(9-23)16(24)29-20(25)30-17)18-28-14-4-2-3-13(22)15(14)19(33)32(18)31-8-7-26-21(10-31)5-6-21/h2-4,11,26H,5-8,10H2,1H3,(H5,24,25,27,29,30)/t11-/m0/s1
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n/an/a 2.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288873
PNG
(US10092563, Compound 8)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@H]1CCCNCC1
Show InChI InChI=1S/C21H24ClN9O/c1-11(27-18-13(10-23)17(24)29-21(25)30-18)19-28-15-6-2-5-14(22)16(15)20(32)31(19)12-4-3-8-26-9-7-12/h2,5-6,11-12,26H,3-4,7-9H2,1H3,(H5,24,25,27,29,30)/t11-,12-/m0/s1
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n/an/a 6.20E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288874
PNG
(US10092563, Compound 9)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1CCCNCC1
Show InChI InChI=1S/C21H24ClN9O/c1-11(27-18-13(10-23)17(24)29-21(25)30-18)19-28-15-6-2-5-14(22)16(15)20(32)31(19)12-4-3-8-26-9-7-12/h2,5-6,11-12,26H,3-4,7-9H2,1H3,(H5,24,25,27,29,30)/t11-,12+/m0/s1
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n/an/a 9.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288875
PNG
(US10092563, Compound 10)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@H]1CCCNCC1
Show InChI InChI=1S/C22H25ClN8O/c1-12-15(11-24)19(30-22(25)28-12)27-13(2)20-29-17-7-3-6-16(23)18(17)21(32)31(20)14-5-4-9-26-10-8-14/h3,6-7,13-14,26H,4-5,8-10H2,1-2H3,(H3,25,27,28,30)/t13-,14-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288876
PNG
(US10092563, Compound 11)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1CCCNCC1
Show InChI InChI=1S/C22H25ClN8O/c1-12-15(11-24)19(30-22(25)28-12)27-13(2)20-29-17-7-3-6-16(23)18(17)21(32)31(20)14-5-4-9-26-10-8-14/h3,6-7,13-14,26H,4-5,8-10H2,1-2H3,(H3,25,27,28,30)/t13-,14+/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288877
PNG
(US10092563, Compound 12)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1[C@H]1CCCNCC1
Show InChI InChI=1S/C20H24Cl2N8O/c1-10(26-17-15(22)16(23)28-20(24)29-17)18-27-13-6-2-5-12(21)14(13)19(31)30(18)11-4-3-8-25-9-7-11/h2,5-6,10-11,25H,3-4,7-9H2,1H3,(H5,23,24,26,28,29)/t10-,11-/m0/s1
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n/an/a 6.60E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288878
PNG
(US10092563, Compound 13)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1CCCNCC1
Show InChI InChI=1S/C20H24Cl2N8O/c1-10(26-17-15(22)16(23)28-20(24)29-17)18-27-13-6-2-5-12(21)14(13)19(31)30(18)11-4-3-8-25-9-7-11/h2,5-6,10-11,25H,3-4,7-9H2,1H3,(H5,23,24,26,28,29)/t10-,11+/m0/s1
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n/an/a 1.80E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288879
PNG
(US10092563, Compound 14)
Show SMILES Cc1nc(N)nc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2[C@@H]2[C@H]3CNC[C@@H]23)c1C#N
Show InChI InChI=1S/C23H23ClN8O/c1-10-12(7-25)20(31-23(26)28-10)30-18(11-5-6-11)21-29-16-4-2-3-15(24)17(16)22(33)32(21)19-13-8-27-9-14(13)19/h2-4,11,13-14,18-19,27H,5-6,8-9H2,1H3,(H3,26,28,30,31)/t13-,14+,18-,19+/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288880
PNG
(US10092563, Compound 15)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2[C@@H]2[C@H]3CNC[C@@H]23)n1
Show InChI InChI=1S/C22H22ClN9O/c23-13-2-1-3-14-15(13)21(33)32(17-11-7-27-8-12(11)17)20(28-14)16(9-4-5-9)29-19-10(6-24)18(25)30-22(26)31-19/h1-3,9,11-12,16-17,27H,4-5,7-8H2,(H5,25,26,29,30,31)/t11-,12+,16-,17+/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288881
PNG
(US10092563, Compound 16)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1C1C2CNCC12
Show InChI InChI=1S/C21H20ClFN8O/c1-8-10(5-24)18(30-21(25)28-8)27-9(2)19-29-16-14(23)4-3-13(22)15(16)20(32)31(19)17-11-6-26-7-12(11)17/h3-4,9,11-12,17,26H,6-7H2,1-2H3,(H3,25,27,28,30)/t9-,11?,12?,17?/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288882
PNG
(US10092563, Compound 17)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1C1C2CNCC12
Show InChI InChI=1S/C20H19ClFN9O/c1-7(27-17-8(4-23)16(24)29-20(25)30-17)18-28-14-12(22)3-2-11(21)13(14)19(32)31(18)15-9-5-26-6-10(9)15/h2-3,7,9-10,15,26H,5-6H2,1H3,(H5,24,25,27,29,30)/t7-,9?,10?,15?/m0/s1
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n/an/a 3.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288883
PNG
(US10092563, Compound 18)
Show SMILES C[C@H](Nc1ncnc2scnc12)c1nc2cccc(Cl)c2c(=O)n1C1CCNCC1
Show InChI InChI=1S/C20H20ClN7OS/c1-11(26-17-16-19(24-9-23-17)30-10-25-16)18-27-14-4-2-3-13(21)15(14)20(29)28(18)12-5-7-22-8-6-12/h2-4,9-12,22H,5-8H2,1H3,(H,23,24,26)/t11-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288884
PNG
(US10092563, Compound 19)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1[C@H]2CNC[C@@H]12
Show InChI InChI=1S/C20H20ClN9O/c1-8(26-17-9(5-22)16(23)28-20(24)29-17)18-27-13-4-2-3-12(21)14(13)19(31)30(18)15-10-6-25-7-11(10)15/h2-4,8,10-11,15,25H,6-7H2,1H3,(H5,23,24,26,28,29)/t8-,10-,11+,15+/m0/s1
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n/an/a 3.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288885
PNG
(US10092563, Compound 20)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2c(F)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C18H20Cl2FN9O/c1-8(25-15-12(20)14(22)27-18(23)28-15)16-26-13-10(21)3-2-9(19)11(13)17(31)30(16)29-6-4-24-5-7-29/h2-3,8,24H,4-7H2,1H3,(H5,22,23,25,27,28)/t8-/m0/s1
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n/an/a 4.00E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288886
PNG
(US10092563, Compound 21)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2c(F)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C20H21ClFN9O/c1-10-12(9-23)17(29-20(24)27-10)26-11(2)18-28-16-14(22)4-3-13(21)15(16)19(32)31(18)30-7-5-25-6-8-30/h3-4,11,25H,5-8H2,1-2H3,(H3,24,26,27,29)/t11-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288887
PNG
(US10092563, Compound 22)
Show SMILES CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCNCC1
Show InChI InChI=1S/C21H24ClN9O/c1-2-14(27-18-12(10-23)17(24)29-21(25)30-18)19-28-15-5-3-4-13(22)16(15)20(32)31(19)11-6-8-26-9-7-11/h3-5,11,14,26H,2,6-9H2,1H3,(H5,24,25,27,29,30)/t14-/m0/s1
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n/an/a 1.50E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288888
PNG
(US10092563, Compound 23)
Show SMILES CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCNCC1
Show InChI InChI=1S/C22H25ClN8O/c1-3-16(28-19-14(11-24)12(2)27-22(25)30-19)20-29-17-6-4-5-15(23)18(17)21(32)31(20)13-7-9-26-10-8-13/h4-6,13,16,26H,3,7-10H2,1-2H3,(H3,25,27,28,30)/t16-/m0/s1
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n/an/a 3.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288889
PNG
(US10092563, Compound 24)
Show SMILES C[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCNCC1
Show InChI InChI=1S/C21H23ClN8O/c1-11-14(10-23)18(29-21(24)27-11)26-12(2)19-28-16-5-3-4-15(22)17(16)20(31)30(19)13-6-8-25-9-7-13/h3-5,12-13,25H,6-9H2,1-2H3,(H3,24,26,27,29)/t12-/m0/s1
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n/an/a 2.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288890
PNG
(US10092563, Compound 25)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1C1CCNCC1
Show InChI InChI=1S/C19H22Cl2N8O/c1-9(25-16-14(21)15(22)27-19(23)28-16)17-26-12-4-2-3-11(20)13(12)18(30)29(17)10-5-7-24-8-6-10/h2-4,9-10,24H,5-8H2,1H3,(H5,22,23,25,27,28)/t9-/m0/s1
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n/an/a 1.00E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288891
PNG
(US10092563, Compound 26)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCNCC1
Show InChI InChI=1S/C20H22ClN9O/c1-10(26-17-12(9-22)16(23)28-20(24)29-17)18-27-14-4-2-3-13(21)15(14)19(31)30(18)11-5-7-25-8-6-11/h2-4,10-11,25H,5-8H2,1H3,(H5,23,24,26,28,29)/t10-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288892
PNG
(US10092563, Compound 27)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCCNC1
Show InChI InChI=1S/C20H22ClN9O/c1-10(26-17-12(8-22)16(23)28-20(24)29-17)18-27-14-6-2-5-13(21)15(14)19(31)30(18)11-4-3-7-25-9-11/h2,5-6,10-11,25H,3-4,7,9H2,1H3,(H5,23,24,26,28,29)/t10-,11?/m0/s1
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n/an/a 5.60E+6n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288893
PNG
(US10092563, Compound 28)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@H]1CCCNC1
Show InChI InChI=1S/C20H22ClN9O/c1-10(26-17-12(8-22)16(23)28-20(24)29-17)18-27-14-6-2-5-13(21)15(14)19(31)30(18)11-4-3-7-25-9-11/h2,5-6,10-11,25H,3-4,7,9H2,1H3,(H5,23,24,26,28,29)/t10-,11-/m0/s1
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n/an/a 1.70E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288894
PNG
(US10092563, Compound 29)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CNC1
Show InChI InChI=1S/C18H18ClN9O/c1-8(24-15-10(5-20)14(21)26-18(22)27-15)16-25-12-4-2-3-11(19)13(12)17(29)28(16)9-6-23-7-9/h2-4,8-9,23H,6-7H2,1H3,(H5,21,22,24,26,27)/t8-/m0/s1
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n/an/a 9.10E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288895
PNG
(US10092563, Compound 30)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@H]1CCNC1
Show InChI InChI=1S/C19H20ClN9O/c1-9(25-16-11(7-21)15(22)27-19(23)28-16)17-26-13-4-2-3-12(20)14(13)18(30)29(17)10-5-6-24-8-10/h2-4,9-10,24H,5-6,8H2,1H3,(H5,22,23,25,27,28)/t9-,10-/m0/s1
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n/an/a 3.50E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288896
PNG
(US10092563, Compound 31)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1CCNC1
Show InChI InChI=1S/C19H20ClN9O/c1-9(25-16-11(7-21)15(22)27-19(23)28-16)17-26-13-4-2-3-12(20)14(13)18(30)29(17)10-5-6-24-8-10/h2-4,9-10,24H,5-6,8H2,1H3,(H5,22,23,25,27,28)/t9-,10+/m0/s1
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n/an/a 7.80E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288897
PNG
(US10092563, Compound 32)
Show SMILES C[C@H](NC(=O)c1nc(Cl)cnc1N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H20Cl2N8O2/c1-10(25-18(30)15-16(22)24-9-13(21)27-15)17-26-12-4-2-3-11(20)14(12)19(31)29(17)28-7-5-23-6-8-28/h2-4,9-10,23H,5-8H2,1H3,(H2,22,24)(H,25,30)/t10-/m0/s1
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n/an/a 3.20E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288898
PNG
(US10092563, Compound 33)
Show SMILES C[C@H](NC(=O)c1nc(Cl)c(N)nc1N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H21Cl2N9O2/c1-9(25-18(31)13-15(22)28-16(23)14(21)27-13)17-26-11-4-2-3-10(20)12(11)19(32)30(17)29-7-5-24-6-8-29/h2-4,9,24H,5-8H2,1H3,(H,25,31)(H4,22,23,28)/t9-/m0/s1
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n/an/a 4.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288899
PNG
(US10092563, Compound 34)
Show SMILES C[C@H](Nc1ncnc2ccoc12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C20H20ClN7O2/c1-12(25-18-17-15(5-10-30-17)23-11-24-18)19-26-14-4-2-3-13(21)16(14)20(29)28(19)27-8-6-22-7-9-27/h2-5,10-12,22H,6-9H2,1H3,(H,23,24,25)/t12-/m0/s1
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n/an/a 8.30E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288900
PNG
(US10092563, Compound 35)
Show SMILES C[C@H](Nc1ncnc2scc(Cl)c12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C20H19Cl2N7OS/c1-11(26-17-16-13(22)9-31-19(16)25-10-24-17)18-27-14-4-2-3-12(21)15(14)20(30)29(18)28-7-5-23-6-8-28/h2-4,9-11,23H,5-8H2,1H3,(H,24,25,26)/t11-/m0/s1
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n/an/a 5.70E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288901
PNG
(US10092563, Compound 36)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C21H22ClN9O2/c1-12(26-20(32)16-17(23)28-30-9-3-6-25-19(16)30)18-27-14-5-2-4-13(22)15(14)21(33)31(18)29-10-7-24-8-11-29/h2-6,9,12,24H,7-8,10-11H2,1H3,(H2,23,28)(H,26,32)/t12-/m0/s1
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n/an/a 6.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288902
PNG
(US10092563, Compound 37)
Show SMILES C[C@H](Nc1ncnc(N)c1Cl)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C18H20Cl2N8O/c1-10(25-16-14(20)15(21)23-9-24-16)17-26-12-4-2-3-11(19)13(12)18(29)28(17)27-7-5-22-6-8-27/h2-4,9-10,22H,5-8H2,1H3,(H3,21,23,24,25)/t10-/m0/s1
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n/an/a 3.90E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288903
PNG
(US10092563, Compound 38)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1C1CCNCC1(F)F
Show InChI InChI=1S/C20H20ClF2N9O/c1-9(28-16-10(7-24)15(25)30-19(26)31-16)17-29-12-4-2-3-11(21)14(12)18(33)32(17)13-5-6-27-8-20(13,22)23/h2-4,9,13,27H,5-6,8H2,1H3,(H5,25,26,28,30,31)/t9-,13?/m0/s1
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n/an/a 2.20E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288904
PNG
(US10092563, Compound 39)
Show SMILES C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2c(F)ccc(F)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H20F2N10O/c1-9(26-16-10(8-22)15(23)28-19(24)29-16)17-27-14-12(21)3-2-11(20)13(14)18(32)31(17)30-6-4-25-5-7-30/h2-3,9,25H,4-7H2,1H3,(H5,23,24,26,28,29)/t9-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288905
PNG
(US10092563, Compound 40)
Show SMILES C[C@H](Nc1ncnn2ccnc12)c1nc2c(F)ccc(F)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H19F2N9O/c1-11(26-16-18-23-6-9-29(18)25-10-24-16)17-27-15-13(21)3-2-12(20)14(15)19(31)30(17)28-7-4-22-5-8-28/h2-3,6,9-11,22H,4-5,7-8H2,1H3,(H,24,25,26)/t11-/m0/s1
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Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288906
PNG
(US10092563, Compound 41)
Show SMILES Fc1ccc(F)c2c1nc([C@@H](Nc1ncnn3ccnc13)C1CC1)n(N1CCNCC1)c2=O
Show InChI InChI=1S/C21H21F2N9O/c22-13-3-4-14(23)17-15(13)21(33)32(30-8-5-24-6-9-30)19(29-17)16(12-1-2-12)28-18-20-25-7-10-31(20)27-11-26-18/h3-4,7,10-12,16,24H,1-2,5-6,8-9H2,(H,26,27,28)/t16-/m0/s1
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n/an/a 2.10E+5n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288907
PNG
(US10092563, Compound 42)
Show SMILES CC[C@H](Nc1ncnn2ccnc12)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C20H22ClN9O/c1-2-14(26-17-19-23-8-11-29(19)25-12-24-17)18-27-15-5-3-4-13(21)16(15)20(31)30(18)28-9-6-22-7-10-28/h3-5,8,11-12,14,22H,2,6-7,9-10H2,1H3,(H,24,25,26)/t14-/m0/s1
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n/an/a 4.50E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288908
PNG
(US10092563, Compound 43)
Show SMILES Clc1cccc2nc([C@@H](Nc3ncnn4ccnc34)C3CC3)n(N3CCNCC3)c(=O)c12
Show InChI InChI=1S/C21H22ClN9O/c22-14-2-1-3-15-16(14)21(32)31(29-9-6-23-7-10-29)19(27-15)17(13-4-5-13)28-18-20-24-8-11-30(20)26-12-25-18/h1-3,8,11-13,17,23H,4-7,9-10H2,(H,25,26,28)/t17-/m0/s1
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n/an/a 3.00E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288909
PNG
(US10092563, Compound 44)
Show SMILES CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C21H24ClN9O/c1-3-15(27-18-13(11-23)12(2)26-21(24)29-18)19-28-16-6-4-5-14(22)17(16)20(32)31(19)30-9-7-25-8-10-30/h4-6,15,25H,3,7-10H2,1-2H3,(H3,24,26,27,29)/t15-/m0/s1
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n/an/a 2.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288910
PNG
(US10092563, Compound 46)
Show SMILES Cc1nc(N)nc(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2N2CCNCC2)c1C#N
Show InChI InChI=1S/C22H24ClN9O/c1-12-14(11-24)19(30-22(25)27-12)29-18(13-5-6-13)20-28-16-4-2-3-15(23)17(16)21(33)32(20)31-9-7-26-8-10-31/h2-4,13,18,26H,5-10H2,1H3,(H3,25,27,29,30)/t18-/m0/s1
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n/an/a 2.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288911
PNG
(US10092563, Compound 47)
Show SMILES Fc1ccc(Cl)c2c1nc([C@@H](Nc1ncnn3ccnc13)C1CC1)n(N1CCNCC1)c2=O
Show InChI InChI=1S/C21H21ClFN9O/c22-13-3-4-14(23)17-15(13)21(33)32(30-8-5-24-6-9-30)19(29-17)16(12-1-2-12)28-18-20-25-7-10-31(20)27-11-26-18/h3-4,7,10-12,16,24H,1-2,5-6,8-9H2,(H,26,27,28)/t16-/m0/s1
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n/an/a 4.80E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288912
PNG
(US10092563, Compound 48)
Show SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3c(F)ccc(Cl)c3c(=O)n2N2CCNCC2)n1
Show InChI InChI=1S/C21H22ClFN10O/c22-12-3-4-13(23)16-14(12)20(34)33(32-7-5-27-6-8-32)19(29-16)15(10-1-2-10)28-18-11(9-24)17(25)30-21(26)31-18/h3-4,10,15,27H,1-2,5-8H2,(H5,25,26,28,30,31)/t15-/m0/s1
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n/an/a 3.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288913
PNG
(US10092563, Compound 49)
Show SMILES C[C@H](Nc1ncnc2scnc12)c1nc2c(Cl)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H18Cl2N8OS/c1-10(26-16-15-18(24-8-23-16)31-9-25-15)17-27-14-12(21)3-2-11(20)13(14)19(30)29(17)28-6-4-22-5-7-28/h2-3,8-10,22H,4-7H2,1H3,(H,23,24,26)/t10-/m0/s1
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n/an/a 1.90E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288914
PNG
(US10092563, Compound 50)
Show SMILES C[C@H](Nc1ncnc2scnc12)c1nc2c(F)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C19H18ClFN8OS/c1-10(26-16-15-18(24-8-23-16)31-9-25-15)17-27-14-12(21)3-2-11(20)13(14)19(30)29(17)28-6-4-22-5-7-28/h2-3,8-10,22H,4-7H2,1H3,(H,23,24,26)/t10-/m0/s1
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n/an/a 1.50E+4n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta


(Homo sapiens (human))
BDBM288915
PNG
(US10092563, Compound 52)
Show SMILES C[C@H](Nc1ncnc2ccc(Cl)nc12)c1nc2c(Cl)ccc(Cl)c2c(=O)n1N1CCNCC1
Show InChI InChI=1S/C21H19Cl3N8O/c1-11(28-19-18-14(26-10-27-19)4-5-15(24)29-18)20-30-17-13(23)3-2-12(22)16(17)21(33)32(20)31-8-6-25-7-9-31/h2-5,10-11,25H,6-9H2,1H3,(H,26,27,28)/t11-/m0/s1
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n/an/a 8.00E+3n/an/an/an/a7.4n/a



Gilead Sciences, Inc.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...


US Patent US10092563 (2018)

More data for this
Ligand-Target Pair
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