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Compile Data Set for Download or QSAR

Found 1435 hits of ph data with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261320
PNG
(US10092570, Example 323 | US9707233, 323 (3rd peak...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261320
PNG
(US10092570, Example 323 | US9707233, 323 (3rd peak...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261320
PNG
(US10092570, Example 323 | US9707233, 323 (3rd peak...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261320
PNG
(US10092570, Example 323 | US9707233, 323 (3rd peak...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289341
PNG
(US10092570, Example 324)
Show SMILES COc1c(cc(Cl)c(C)c1C1CNC(=O)CO1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H23ClN6O3/c1-9-13(21)5-12(18(29-4)16(9)14-6-23-15(28)7-30-14)11(3)27-20-17(10(2)26-27)19(22)24-8-25-20/h5,8,11,14H,6-7H2,1-4H3,(H,23,28)(H2,22,24,25)
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n/an/a 125n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289341
PNG
(US10092570, Example 324)
Show SMILES COc1c(cc(Cl)c(C)c1C1CNC(=O)CO1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H23ClN6O3/c1-9-13(21)5-12(18(29-4)16(9)14-6-23-15(28)7-30-14)11(3)27-20-17(10(2)26-27)19(22)24-8-25-20/h5,8,11,14H,6-7H2,1-4H3,(H,23,28)(H2,22,24,25)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261324
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H21ClN6O3/c1-8-12(20)5-11(16(28-4)14(8)13-6-22-19(27)29-13)10(3)26-18-15(9(2)25-26)17(21)23-7-24-18/h5,7,10,13H,6H2,1-4H3,(H,22,27)(H2,21,23,24)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM272571
PNG
(US10065963, Compound 32a)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11+/m1/s1
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n/an/a 125n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM272573
PNG
(US10065963, 32c)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11-/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM272572
PNG
(US10065963, Compound 32b)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@H]1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11-/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM272574
PNG
(US10065963, Compound 32d)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11+/m0/s1
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n/an/a 125n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289347
PNG
(US10092570, Example 349)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1[C@@H]1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O2/c1-4-31-19-13(6-15(22)14(7-23)18(19)12-5-16(30)25-8-12)11(3)29-21-17(10(2)28-29)20(24)26-9-27-21/h6,9,11-12H,4-5,8H2,1-3H3,(H,25,30)(H2,24,26,27)/t11-,12+/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289348
PNG
(US10092570, Example 350)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1[C@@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O2/c1-4-31-19-13(6-15(22)14(7-23)18(19)12-5-16(30)25-8-12)11(3)29-21-17(10(2)28-29)20(24)26-9-27-21/h6,9,11-12H,4-5,8H2,1-3H3,(H,25,30)(H2,24,26,27)/t11-,12-/m0/s1
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n/an/a>500n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261329
PNG
(US10092570, Example 351 | US9707233, 349 | US97072...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O2/c1-4-31-19-13(6-15(22)14(7-23)18(19)12-5-16(30)25-8-12)11(3)29-21-17(10(2)28-29)20(24)26-9-27-21/h6,9,11-12H,4-5,8H2,1-3H3,(H,25,30)(H2,24,26,27)/t11-,12?/m1/s1
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n/an/a 125n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261330
PNG
(US10092570, Example 352 | US9707233, 350)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O2/c1-4-31-19-13(6-15(22)14(7-23)18(19)12-5-16(30)25-8-12)11(3)29-21-17(10(2)28-29)20(24)26-9-27-21/h6,9,11-12H,4-5,8H2,1-3H3,(H,25,30)(H2,24,26,27)/t11-,12?/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289351
PNG
(US10092570, Example 353)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@H]1COC(=O)N1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-30-19(28)25-12)9(3)27-18-13(8(2)26-27)17(22)23-7-24-18/h5,7,9,12H,4,6H2,1-3H3,(H,25,28)(H2,22,23,24)/t9?,12-/m1/s1
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n/an/a>500n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289352
PNG
(US10092570, Example 354)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@@H]1COC(=O)N1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-30-19(28)25-12)9(3)27-18-13(8(2)26-27)17(22)23-7-24-18/h5,7,9,12H,4,6H2,1-3H3,(H,25,28)(H2,22,23,24)/t9?,12-/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261335
PNG
(R-5-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyri...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CNC(=O)O1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-23-19(28)30-12)9(3)27-18-13(8(2)26-27)17(22)24-7-25-18/h5,7,9,12H,4,6H2,1-3H3,(H,23,28)(H2,22,24,25)/t9-,12?/m1/s1
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n/an/a 125n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289354
PNG
(US10092570, Example 356)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@H]1CNC(=O)O1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-23-19(28)30-12)9(3)27-18-13(8(2)26-27)17(22)24-7-25-18/h5,7,9,12H,4,6H2,1-3H3,(H,23,28)(H2,22,24,25)/t9-,12+/m0/s1
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n/an/a 125n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261335
PNG
(R-5-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyri...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CNC(=O)O1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-23-19(28)30-12)9(3)27-18-13(8(2)26-27)17(22)24-7-25-18/h5,7,9,12H,4,6H2,1-3H3,(H,23,28)(H2,22,24,25)/t9-,12?/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261336
PNG
(S-5-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyri...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CNC(=O)O1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-23-19(28)30-12)9(3)27-18-13(8(2)26-27)17(22)24-7-25-18/h5,7,9,12H,4,6H2,1-3H3,(H,23,28)(H2,22,24,25)/t9-,12?/m0/s1
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n/an/a>500n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261339
PNG
(5-(3-{1-[4-Amino-5-oxo-6-(1H-pyrazol-4-yl)pyrid [2...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1cc(-c2cn[nH]c2)c(=O)c2c(N)ncnc12
Show InChI InChI=1S/C28H27ClN8O3/c1-14-20(29)8-18(25(40-5)22(14)16-6-7-21(31-9-16)28(39)36(3)4)15(2)37-12-19(17-10-34-35-11-17)24(38)23-26(30)32-13-33-27(23)37/h6-13,15H,1-5H3,(H,34,35)(H2,30,32,33)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261340
PNG
(5-{3-[1-(4-Amino-6-methyl-5-oxopyrido[2,3-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1cc(C)c(=O)c2c(N)ncnc12
Show InChI InChI=1S/C26H27ClN6O3/c1-13-11-33(25-21(22(13)34)24(28)30-12-31-25)15(3)17-9-18(27)14(2)20(23(17)36-6)16-7-8-19(29-10-16)26(35)32(4)5/h7-12,15H,1-6H3,(H2,28,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261247
PNG
(US10092570, Example 363 | US9707233, 270)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-11(31)7-29-8-14(9-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261246
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-11(31)7-29-8-14(9-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/m0/s1
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n/an/a>500n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phophoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α, ...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261247
PNG
(US10092570, Example 363 | US9707233, 270)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-11(31)7-29-8-14(9-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/m1/s1
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n/an/a 125n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phophoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α, ...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261254
PNG
(US10092570, Example 277 | US9707233, 277)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C1CCOCC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H28ClN7O2/c1-13-20-23(27)28-12-29-24(20)32(30-13)14(2)17-8-19(25)18(9-26)21(22(17)33-3)15-10-31(11-15)16-4-6-34-7-5-16/h8,12,14-16H,4-7,10-11H2,1-3H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289277
PNG
(4-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C[C@@H]2CCOC2)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H28ClN7O2/c1-13-20-23(27)28-12-29-24(20)32(30-13)14(2)17-6-19(25)18(7-26)21(22(17)33-3)16-9-31(10-16)8-15-4-5-34-11-15/h6,12,14-16H,4-5,8-11H2,1-3H3,(H2,27,28,29)/t14?,15-/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289278
PNG
(4-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C[C@H]2CCOC2)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H28ClN7O2/c1-13-20-23(27)28-12-29-24(20)32(30-13)14(2)17-6-19(25)18(7-26)21(22(17)33-3)16-9-31(10-16)8-15-4-5-34-11-15/h6,12,14-16H,4-5,8-11H2,1-3H3,(H2,27,28,29)/t14?,15-/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261257
PNG
(US10092570, Example 280 | US9707233, 280)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(CC2CCOCC2)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H30ClN7O2/c1-14-21-24(28)29-13-30-25(21)33(31-14)15(2)18-8-20(26)19(9-27)22(23(18)34-3)17-11-32(12-17)10-16-4-6-35-7-5-16/h8,13,15-17H,4-7,10-12H2,1-3H3,(H2,28,29,30)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289280
PNG
(US10092570, Example 281)
Show SMILES COc1c(cc(Cl)c([N+]#[C-])c1C1CN(C1)C(C)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O2/c1-10-16-20(23)25-9-26-21(16)29(27-10)11(2)14-6-15(22)18(24-4)17(19(14)31-5)13-7-28(8-13)12(3)30/h6,9,11,13H,7-8H2,1-3,5H3,(H2,23,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261259
PNG
(US10092570, Example 282 | US9707233, 282)
Show SMILES CCC(=O)N1CC(C1)c1c(OC)c(cc(Cl)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H24ClN7O2/c1-5-17(31)29-8-13(9-29)19-15(7-24)16(23)6-14(20(19)32-4)12(3)30-22-18(11(2)28-30)21(25)26-10-27-22/h6,10,12-13H,5,8-9H2,1-4H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261260
PNG
(US10092570, Example 283 | US9707233, 283)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H26ClN7O2/c1-11(2)23(32)30-8-14(9-30)19-16(7-25)17(24)6-15(20(19)33-5)13(4)31-22-18(12(3)29-31)21(26)27-10-28-22/h6,10-11,13-14H,8-9H2,1-5H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261260
PNG
(US10092570, Example 283 | US9707233, 283)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H26ClN7O2/c1-11(2)23(32)30-8-14(9-30)19-16(7-25)17(24)6-15(20(19)33-5)13(4)31-22-18(12(3)29-31)21(26)27-10-28-22/h6,10-11,13-14H,8-9H2,1-5H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289284
PNG
(US10092570, Example 285)
Show SMILES COc1c(cc(Cl)c([N+]#[C-])c1C1CN(C1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClN7O3S/c1-10-15-19(22)24-9-25-20(15)28(26-10)11(2)13-6-14(21)17(23-3)16(18(13)31-4)12-7-27(8-12)32(5,29)30/h6,9,11-12H,7-8H2,1-2,4-5H3,(H2,22,24,25)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261263
PNG
(US10092570, Example 286 | US9707233, 286)
Show SMILES CCS(=O)(=O)N1CC(C1)c1c(OC)c(cc(Cl)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O3S/c1-5-33(30,31)28-8-13(9-28)18-15(7-23)16(22)6-14(19(18)32-4)12(3)29-21-17(11(2)27-29)20(24)25-10-26-21/h6,10,12-13H,5,8-9H2,1-4H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261264
PNG
(US10092570, Example 287 | US9707233, 287)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)S(=O)(=O)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O3S/c1-11(2)34(31,32)29-8-14(9-29)19-16(7-24)17(23)6-15(20(19)33-5)13(4)30-22-18(12(3)28-30)21(25)26-10-27-22/h6,10-11,13-14H,8-9H2,1-5H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261265
PNG
(US10092570, Example 288 | US9707233, 288)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)S(=O)(=O)C1CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H24ClN7O3S/c1-11-18-21(25)26-10-27-22(18)30(28-11)12(2)15-6-17(23)16(7-24)19(20(15)33-3)13-8-29(9-13)34(31,32)14-4-5-14/h6,10,12-14H,4-5,8-9H2,1-3H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289288
PNG
(US10092570, Example 289)
Show SMILES COC(=O)N1CC(C1)c1c(OC)c(cc(Cl)c1[N+]#[C-])C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O3/c1-10-15-19(23)25-9-26-20(15)29(27-10)11(2)13-6-14(22)17(24-3)16(18(13)31-4)12-7-28(8-12)21(30)32-5/h6,9,11-12H,7-8H2,1-2,4-5H3,(H2,23,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261267
PNG
(US10092570, Example 290 | US9707233, 290)
Show SMILES CCOC(=O)N1CC(C1)c1c(OC)c(cc(Cl)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H24ClN7O3/c1-5-33-22(31)29-8-13(9-29)18-15(7-24)16(23)6-14(19(18)32-4)12(3)30-21-17(11(2)28-30)20(25)26-10-27-21/h6,10,12-13H,5,8-9H2,1-4H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261268
PNG
(US10092570, Example 291 | US9707233, 291)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)OC(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H26ClN7O3/c1-11(2)34-23(32)30-8-14(9-30)19-16(7-25)17(24)6-15(20(19)33-5)13(4)31-22-18(12(3)29-31)21(26)27-10-28-22/h6,10-11,13-14H,8-9H2,1-5H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289291
PNG
(US10092570, Example 292)
Show SMILES COc1c(cc(Cl)c([N+]#[C-])c1C1CN(C1)C(=O)NC(C)(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H29ClN8O2/c1-12-17-21(26)28-11-29-22(17)33(31-12)13(2)15-8-16(25)19(27-6)18(20(15)35-7)14-9-32(10-14)23(34)30-24(3,4)5/h8,11,13-14H,9-10H2,1-5,7H3,(H,30,34)(H2,26,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289292
PNG
(US10092570, Example 293)
Show SMILES COc1c(cc(Cl)c([N+]#[C-])c1C1CN(C1)C(N)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H21ClN8O2/c1-9-14-18(22)25-8-26-19(14)29(27-9)10(2)12-5-13(21)16(24-3)15(17(12)31-4)11-6-28(7-11)20(23)30/h5,8,10-11H,6-7H2,1-2,4H3,(H2,23,30)(H2,22,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261271
PNG
(US10092570, Example 294 | US9707233, 294)
Show SMILES CNC(=O)N1CC(C1)c1c(OC)c(cc(Cl)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H23ClN8O2/c1-10-16-19(24)26-9-27-20(16)30(28-10)11(2)13-5-15(22)14(6-23)17(18(13)32-4)12-7-29(8-12)21(31)25-3/h5,9,11-12H,7-8H2,1-4H3,(H,25,31)(H2,24,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261272
PNG
(US10092570, Example 295 | US9707233, 295)
Show SMILES CCNC(=O)N1CC(C1)c1c(OC)c(cc(Cl)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H25ClN8O2/c1-5-26-22(32)30-8-13(9-30)18-15(7-24)16(23)6-14(19(18)33-4)12(3)31-21-17(11(2)29-31)20(25)27-10-28-21/h6,10,12-13H,5,8-9H2,1-4H3,(H,26,32)(H2,25,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289295
PNG
(US10092570, Example 296)
Show SMILES COc1c(cc(Cl)c([N+]#[C-])c1C1CN(C1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H25ClN8O2/c1-11-16-20(24)26-10-27-21(16)31(28-11)12(2)14-7-15(23)18(25-3)17(19(14)33-6)13-8-30(9-13)22(32)29(4)5/h7,10,12-13H,8-9H2,1-2,4-6H3,(H2,24,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261245
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-11-17-20(24)25-10-26-21(17)29(27-11)12(2)14-6-16(22)15(7-23)18(19(14)31-3)13-8-28(9-13)4-5-30/h6,10,12-13,30H,4-5,8-9H2,1-3H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM289297
PNG
(US10092570, Example 298)
Show SMILES CCN1CC(C1)c1c(Cl)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C20H24Cl2N6O/c1-5-27-7-12(8-27)16-17(22)14(21)6-13(18(16)29-4)11(3)28-20-15(10(2)26-28)19(23)24-9-25-20/h6,9,11-12H,5,7-8H2,1-4H3,(H2,23,24,25)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261241
PNG
(US10092570, Example 299 | US9707233, 264)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O/c1-11(2)29-8-14(9-29)19-16(7-24)17(23)6-15(20(19)31-5)13(4)30-22-18(12(3)28-30)21(25)26-10-27-22/h6,10-11,13-14H,8-9H2,1-5H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (human))
BDBM261245
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-11-17-20(24)25-10-26-21(17)29(27-11)12(2)14-6-16(22)15(7-23)18(19(14)31-3)13-8-28(9-13)4-5-30/h6,10,12-13,30H,4-5,8-9H2,1-3H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)

More data for this
Ligand-Target Pair
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