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Compile Data Set for Download or QSAR

Found 1733 hits of ph data with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261340
PNG
(5-{3-[1-(4-Amino-6-methyl-5-oxopyrido[2,3-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1cc(C)c(=O)c2c(N)ncnc12
Show InChI InChI=1S/C26H27ClN6O3/c1-13-11-33(25-21(22(13)34)24(28)30-12-31-25)15(3)17-9-18(27)14(2)20(23(17)36-6)16-7-8-19(29-10-16)26(35)32(4)5/h7-12,15H,1-6H3,(H2,28,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261247
PNG
(US10092570, Example 363 | US10376513, Example 270 ...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-11(31)7-29-8-14(9-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261246
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-11(31)7-29-8-14(9-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/m0/s1
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n/an/a>500n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
Lipid kinase substrate, phophoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α, ...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261247
PNG
(US10092570, Example 363 | US10376513, Example 270 ...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-11(31)7-29-8-14(9-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/m1/s1
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n/an/a 125n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
Lipid kinase substrate, phophoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α, ...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261241
PNG
(US10092570, Example 299 | US10376513, Example 307 ...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O/c1-11(2)29-8-14(9-29)19-16(7-24)17(23)6-15(20(19)31-5)13(4)30-22-18(12(3)28-30)21(25)26-10-27-22/h6,10-11,13-14H,8-9H2,1-5H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261245
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-11-17-20(24)25-10-26-21(17)29(27-11)12(2)14-6-16(22)15(7-23)18(19(14)31-3)13-8-28(9-13)4-5-30/h6,10,12-13,30H,4-5,8-9H2,1-3H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289300
PNG
((2S)-1-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES COc1c(cc(Cl)c(Cl)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26Cl2N6O2/c1-10(30)6-28-7-13(8-28)17-18(23)15(22)5-14(19(17)31-4)12(3)29-21-16(11(2)27-29)20(24)25-9-26-21/h5,9-10,12-13,30H,6-8H2,1-4H3,(H2,24,25,26)/t10-,12?/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289301
PNG
((2R)-1-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES COc1c(cc(Cl)c(Cl)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26Cl2N6O2/c1-10(30)6-28-7-13(8-28)17-18(23)15(22)5-14(19(17)31-4)12(3)29-21-16(11(2)27-29)20(24)25-9-26-21/h5,9-10,12-13,30H,6-8H2,1-4H3,(H2,24,25,26)/t10-,12?/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261248
PNG
(US10092570, Example 303 | US10376513, Example 271 ...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O2/c1-12-18-21(26)27-11-28-22(18)31(29-12)13(2)15-6-17(24)16(7-25)19(20(15)33-5)14-8-30(9-14)10-23(3,4)32/h6,11,13-14,32H,8-10H2,1-5H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289303
PNG
(1-{1-[4,5-Dichloro-2-methoxy-3- (1-oxetan-3-ylazet...)
Show SMILES COc1c(cc(Cl)c(Cl)c1C1CN(C1)C1COC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24Cl2N6O2/c1-10-16-20(24)25-9-26-21(16)29(27-10)11(2)14-4-15(22)18(23)17(19(14)30-3)12-5-28(6-12)13-7-31-8-13/h4,9,11-13H,5-8H2,1-3H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289304
PNG
((3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyri...)
Show SMILES COc1c(cc(Cl)c(Cl)c1C1CN(CC#N)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H21Cl2N7O/c1-10-15-19(24)25-9-26-20(15)29(27-10)11(2)13-6-14(21)17(22)16(18(13)30-3)12-7-28(8-12)5-4-23/h6,9,11-12H,5,7-8H2,1-3H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289305
PNG
(US10092570, Example 306 | US10376513, Example 306 ...)
Show SMILES COc1c(cc(Cl)c(Cl)c1C1CN(C1)C(C)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22Cl2N6O2/c1-9-15-19(23)24-8-25-20(15)28(26-9)10(2)13-5-14(21)17(22)16(18(13)30-4)12-6-27(7-12)11(3)29/h5,8,10,12H,6-7H2,1-4H3,(H2,23,24,25)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289306
PNG
(US10092570, Example 307)
Show SMILES CCOc1c(cc(Cl)c([N+]#[C-])c1C1CN(C1)C(C)C)C(C)n1cc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H29ClN6O/c1-7-32-22-17(15(5)31-9-14(4)19-23(26)28-12-29-24(19)31)8-18(25)21(27-6)20(22)16-10-30(11-16)13(2)3/h8-9,12-13,15-16H,7,10-11H2,1-5H3,(H2,26,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289307
PNG
(4-[1-(4-Amino-5-methyl-7H- pyrrolo[2,3-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(Cl)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H24Cl2N6O2/c1-10-15-19(23)24-9-25-20(15)28(26-10)11(2)13-6-14(21)17(22)16(18(13)30-3)12-7-27(8-12)4-5-29/h6,9,11-12,29H,4-5,7-8H2,1-3H3,(H2,23,24,25)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289300
PNG
((2S)-1-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES COc1c(cc(Cl)c(Cl)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H26Cl2N6O2/c1-10(30)6-28-7-13(8-28)17-18(23)15(22)5-14(19(17)31-4)12(3)29-21-16(11(2)27-29)20(24)25-9-26-21/h5,9-10,12-13,30H,6-8H2,1-4H3,(H2,24,25,26)/t10-,12?/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289309
PNG
(US10092570, Example 313 | US10376513, Example 313 ...)
Show SMILES COc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H23ClN8O2/c1-12-19-22(27)29-11-30-23(19)33(31-12)13(2)15-8-17(25)16(9-26)20(21(15)35-5)14-6-7-18(28-10-14)24(34)32(3)4/h6-8,10-11,13H,1-5H3,(H2,27,29,30)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM246893
PNG
(5-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Show SMILES CCOc1c(cc(C)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H28N8O2/c1-7-36-23-18(16(4)34-25-21(15(3)32-34)24(28)30-13-31-25)10-14(2)19(11-27)22(23)17-8-9-20(29-12-17)26(35)33(5)6/h8-10,12-13,16H,7H2,1-6H3,(H2,28,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261289
PNG
(4-[-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidi...)
Show SMILES COc1c(cc(C)c(C#N)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H29N7O2/c1-12-6-17(15(4)30-23-19(14(3)28-30)22(25)26-11-27-23)21(32-5)20(18(12)7-24)16-9-29(10-16)8-13(2)31/h6,11,13,15-16,31H,8-10H2,1-5H3,(H2,25,26,27)/t13-,15?/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261290
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(C)(C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClN7O2/c1-6-35-22-16(14(3)33-24-20(13(2)32-33)23(28)30-12-31-24)9-18(26)17(10-27)21(22)15-7-8-19(29-11-15)25(4,5)34/h7-9,11-12,14,34H,6H2,1-5H3,(H2,28,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261291
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(C)c(C#N)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H23N7O3S/c1-12-6-17(14(3)30-23-19(13(2)29-30)22(25)27-11-28-23)21(33-4)20(18(12)8-24)15-7-16(10-26-9-15)34(5,31)32/h6-7,9-11,14H,1-5H3,(H2,25,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261292
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1N1CCCC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O/c1-4-30-19-14(9-16(22)15(10-23)18(19)28-7-5-6-8-28)13(3)29-21-17(12(2)27-29)20(24)25-11-26-21/h9,11,13H,4-8H2,1-3H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261293
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1N1CC(C1)OC)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-5-31-19-14(6-16(22)15(7-23)18(19)28-8-13(9-28)30-4)12(3)29-21-17(11(2)27-29)20(24)25-10-26-21/h6,10,12-13H,5,8-9H2,1-4H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261294
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H31N7O/c1-7-32-22-18(16(6)31-24-20(15(5)29-31)23(26)27-12-28-24)8-14(4)19(9-25)21(22)17-10-30(11-17)13(2)3/h8,12-13,16-17H,7,10-11H2,1-6H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261299
PNG
(US10092570, Example 321 | US10376513, Example 328 ...)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H33N7O2/c1-7-34-22-18(16(4)32-24-20(15(3)30-32)23(27)28-13-29-24)8-14(2)19(9-26)21(22)17-10-31(11-17)12-25(5,6)33/h8,13,16-17,33H,7,10-12H2,1-6H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289318
PNG
(US10092570, Example 322 | US10376513, Example 322 ...)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(C1)C(=O)C(C)(C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H31N7O3/c1-7-35-21-17(15(4)32-23-19(14(3)30-32)22(27)28-12-29-23)8-13(2)18(9-26)20(21)16-10-31(11-16)24(33)25(5,6)34/h8,12,15-16,34H,7,10-11H2,1-6H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261297
PNG
(US10092570, Example 326 | US9707233, 326)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H31N7O2/c1-6-33-22-18(16(5)31-24-20(15(4)29-31)23(26)27-12-28-24)7-13(2)19(8-25)21(22)17-10-30(11-17)9-14(3)32/h7,12,14,16-17,32H,6,9-11H2,1-5H3,(H2,26,27,28)/t14-,16?/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261298
PNG
(US10092570, Example 327 | US10376513, Example 327 ...)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H29N7O2/c1-5-32-21-17(15(4)30-23-19(14(3)28-30)22(25)26-12-27-23)8-13(2)18(9-24)20(21)16-10-29(11-16)6-7-31/h8,12,15-16,31H,5-7,10-11H2,1-4H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289321
PNG
(US10092570, Example 328 | US9730939, Example 328)
Show SMILES COc1c(cc(C)c(C#N)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H31N7O2/c1-13-7-17(15(3)31-23-19(14(2)29-31)22(26)27-12-28-23)21(33-6)20(18(13)8-25)16-9-30(10-16)11-24(4,5)32/h7,12,15-16,32H,9-11H2,1-6H3,(H2,26,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289322
PNG
(4-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)c1cncnc1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H24ClN9O/c1-4-35-22-17(14(3)34-24-20(13(2)32-34)23(27)30-12-31-24)5-19(25)18(6-26)21(22)15-9-33(10-15)16-7-28-11-29-8-16/h5,7-8,11-12,14-15H,4,9-10H2,1-3H3,(H2,27,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261301
PNG
(US10092570, Example 330 | US10376513, Example 330 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1cncc(c1)C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H19ClN8O/c1-4-33-21-16(13(3)32-23-19(12(2)31-32)22(27)29-11-30-23)6-18(24)17(8-26)20(21)15-5-14(7-25)9-28-10-15/h5-6,9-11,13H,4H2,1-3H3,(H2,27,29,30)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261302
PNG
(US10092570, Example 334 | US10376513, Example 331 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1cncc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H25ClN8O2/c1-6-36-22-17(14(3)34-24-20(13(2)32-34)23(28)30-12-31-24)8-19(26)18(9-27)21(22)15-7-16(11-29-10-15)25(35)33(4)5/h7-8,10-12,14H,6H2,1-5H3,(H2,28,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261303
PNG
(US10092570, Example 332 | US10376513, Example 332 ...)
Show SMILES COc1c(cc(Cl)c(C#N)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H20ClN7O3S/c1-11-18-21(25)27-10-28-22(18)30(29-11)12(2)15-6-17(23)16(7-24)19(20(15)33-3)13-5-14(9-26-8-13)34(4,31)32/h5-6,8-10,12H,1-4H3,(H2,25,27,28)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261304
PNG
(US10092570, Example 333 | US9707233, 333)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1cncc(c1)C(=O)NC)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H23ClN8O2/c1-5-35-21-16(13(3)33-23-19(12(2)32-33)22(27)30-11-31-23)7-18(25)17(8-26)20(21)14-6-15(10-29-9-14)24(34)28-4/h6-7,9-11,13H,5H2,1-4H3,(H,28,34)(H2,27,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261302
PNG
(US10092570, Example 334 | US10376513, Example 331 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1cncc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H25ClN8O2/c1-6-36-22-17(14(3)34-24-20(13(2)32-34)23(28)30-12-31-24)8-19(26)18(9-27)21(22)15-7-16(11-29-10-15)25(35)33(4)5/h7-8,10-12,14H,6H2,1-5H3,(H2,28,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255834
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H22ClN7O3S/c1-5-34-21-16(13(3)31-23-19(12(2)30-31)22(26)28-11-29-23)7-18(24)17(8-25)20(21)14-6-15(10-27-9-14)35(4,32)33/h6-7,9-11,13H,5H2,1-4H3,(H2,26,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261307
PNG
(US10092570, Example 336 | US10376513, Example 336 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)-c1nnn(C)n1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H22ClN11O/c1-5-37-21-15(13(3)36-24-19(12(2)32-36)22(27)29-11-30-24)8-17(25)16(9-26)20(21)14-6-7-18(28-10-14)23-31-34-35(4)33-23/h6-8,10-11,13H,5H2,1-4H3,(H2,27,29,30)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261308
PNG
(US10092570, Example 337 | US10376513, Example 337 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)-c1cnn(C)n1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H23ClN10O/c1-5-37-23-16(14(3)36-25-21(13(2)33-36)24(28)30-12-31-25)8-18(26)17(9-27)22(23)15-6-7-19(29-10-15)20-11-32-35(4)34-20/h6-8,10-12,14H,5H2,1-4H3,(H2,28,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261309
PNG
(US10092570, Example 338 | US10376513, Example 338 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)-c1nnc(C)o1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H22ClN9O2/c1-5-36-22-16(13(3)35-24-20(12(2)34-35)23(28)30-11-31-24)8-18(26)17(9-27)21(22)15-6-7-19(29-10-15)25-33-32-14(4)37-25/h6-8,10-11,13H,5H2,1-4H3,(H2,28,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261310
PNG
(US10092570, Example 339 | US10376513, Example 339 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1cncc(c1)-c1ncco1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H21ClN8O2/c1-4-35-22-17(14(3)34-24-20(13(2)33-34)23(28)31-12-32-24)8-19(26)18(9-27)21(22)15-7-16(11-29-10-15)25-30-5-6-36-25/h5-8,10-12,14H,4H2,1-3H3,(H2,28,31,32)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261305
PNG
(US10092570, Example 340 | US10376513, Example 334 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccnc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H25ClN8O2/c1-6-36-22-16(14(3)34-24-20(13(2)32-34)23(28)30-12-31-24)10-18(26)17(11-27)21(22)15-7-8-29-19(9-15)25(35)33(4)5/h7-10,12,14H,6H2,1-5H3,(H2,28,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261312
PNG
(US10092570, Example 341 | US10376513, Example 341 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1N1CC(COC)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-5-32-20-15(13(3)30-22-18(12(2)28-30)21(25)26-11-27-22)6-17(23)16(7-24)19(20)29-8-14(9-29)10-31-4/h6,11,13-14H,5,8-10H2,1-4H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261313
PNG
(US10092570, Example 342 | US10376513, Example 342 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1N1CC(C1)C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H21ClN8O/c1-4-31-19-14(5-16(22)15(7-24)18(19)29-8-13(6-23)9-29)12(3)30-21-17(11(2)28-30)20(25)26-10-27-21/h5,10,12-13H,4,8-9H2,1-3H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289336
PNG
(4-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Show SMILES CCOc1c(cc(C)c(C#N)c1-c1ccnn1C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H24N8O/c1-6-31-20-15(9-12(2)16(10-23)19(20)17-7-8-27-29(17)5)14(4)30-22-18(13(3)28-30)21(24)25-11-26-22/h7-9,11,14H,6H2,1-5H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM255835
PNG
(5-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H25ClN8O2/c1-6-36-22-16(14(3)34-24-20(13(2)32-34)23(28)30-12-31-24)9-18(26)17(10-27)21(22)15-7-8-19(29-11-15)25(35)33(4)5/h7-9,11-12,14H,6H2,1-5H3,(H2,28,30,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289338
PNG
(US10092570, Example 310)
Show SMILES CCOc1c(cc(Cl)c(C)c1[C@@H]1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H23ClN6O3/c1-5-29-17-12(6-13(21)9(2)15(17)14-7-23-20(28)30-14)11(4)27-19-16(10(3)26-27)18(22)24-8-25-19/h6,8,11,14H,5,7H2,1-4H3,(H,23,28)(H2,22,24,25)/t11?,14-/m0/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM289339
PNG
(US10092570, Example 311)
Show SMILES CCOc1c(cc(Cl)c(C)c1[C@H]1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H23ClN6O3/c1-5-29-17-12(6-13(21)9(2)15(17)14-7-23-20(28)30-14)11(4)27-19-16(10(3)26-27)18(22)24-8-25-19/h6,8,11,14H,5,7H2,1-4H3,(H,23,28)(H2,22,24,25)/t11?,14-/m1/s1
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261320
PNG
(US10092570, Example 323 | US10646492, Example 323 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261320
PNG
(US10092570, Example 323 | US10646492, Example 323 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261320
PNG
(US10092570, Example 323 | US10646492, Example 323 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM261320
PNG
(US10092570, Example 323 | US10646492, Example 323 ...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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Incyte Holdings Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...


US Patent US10092570 (2018)


BindingDB Entry DOI: 10.7270/Q2PZ5BW5
More data for this
Ligand-Target Pair
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