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Compile Data Set for Download or QSAR

Found 429 hits of ph data with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM50004547
PNG
(CHEMBL2216863 | US10065963, Compound 28 | US970833...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)/t11-/m0/s1
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Patents


Similars

US Patent
n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM246891
PNG
(4-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES COc1c(cc(Cl)c([N+]#[C-])c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-11(31)7-29-8-14(9-29)18-19(25-4)16(23)6-15(20(18)32-5)13(3)30-22-17(12(2)28-30)21(24)26-10-27-22/h6,10-11,13-14,31H,7-9H2,1-3,5H3,(H2,24,26,27)/t11-,13?/m0/s1
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM246892
PNG
(4-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimid...)
Show SMILES COc1c(cc(Cl)c([N+]#[C-])c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-11-16-20(23)25-10-26-21(16)29(27-11)12(2)14-7-15(22)18(24-3)17(19(14)31-4)13-8-28(9-13)5-6-30/h7,10,12-13,30H,5-6,8-9H2,1-2,4H3,(H2,23,25,26)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM246893
PNG
(5-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Show SMILES CCOc1c(cc(C)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H28N8O2/c1-7-36-23-18(16(4)34-25-21(15(3)32-34)24(28)30-13-31-25)10-14(2)19(11-27)22(23)17-8-9-20(29-12-17)26(35)33(5)6/h8-10,12-13,16H,7H2,1-6H3,(H2,28,30,31)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272571
PNG
(US10065963, Compound 32a)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11+/m1/s1
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n/an/a 32n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272572
PNG
(US10065963, Compound 32b)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@H]1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11-/m1/s1
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n/an/a 32n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272573
PNG
(US10065963, 32c)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11-/m0/s1
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n/an/a 32n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272574
PNG
(US10065963, Compound 32d)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11+/m0/s1
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n/an/a 32n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM50004539
PNG
(CHEMBL2216867 | US10065963, Compound 33 | US970833...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1cc(Cl)c2ccnnc2c1-c1cccc(F)c1
Show InChI InChI=1S/C21H15ClFN7/c1-11(29-21-19-20(25-9-24-19)26-10-27-21)15-8-16(22)14-5-6-28-30-18(14)17(15)12-3-2-4-13(23)7-12/h2-11H,1H3,(H2,24,25,26,27,29)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM246896
PNG
(4-chloro-3'-fluoro-3- methyl-6-[1-(9H-purin-6-...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1cc(Cl)c(C)c(C#N)c1-c1cccc(F)c1
Show InChI InChI=1S/C21H16ClFN6/c1-11-16(8-24)18(13-4-3-5-14(23)6-13)15(7-17(11)22)12(2)29-21-19-20(26-9-25-19)27-10-28-21/h3-7,9-10,12H,1-2H3,(H2,25,26,27,28,29)
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n/an/a<2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272577
PNG
(US10065963, Example 1)
Show SMILES CCOc1c(cc(Cl)c2cn(C)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C19H20ClN7O2/c1-4-29-16-11(8-13(20)12-9-26(3)24-15(12)16)10(2)23-19(28)14-17(21)25-27-7-5-6-22-18(14)27/h5-10H,4H2,1-3H3,(H2,21,25)(H,23,28)
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n/an/a<500n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272577
PNG
(US10065963, Example 1)
Show SMILES CCOc1c(cc(Cl)c2cn(C)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C19H20ClN7O2/c1-4-29-16-11(8-13(20)12-9-26(3)24-15(12)16)10(2)23-19(28)14-17(21)25-27-7-5-6-22-18(14)27/h5-10H,4H2,1-3H3,(H2,21,25)(H,23,28)
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n/an/a<500n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272578
PNG
(US10065963, Example 2)
Show SMILES CCOc1c(cc(Cl)c2cn(CC)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C20H22ClN7O2/c1-4-27-10-13-14(21)9-12(17(30-5-2)16(13)25-27)11(3)24-20(29)15-18(22)26-28-8-6-7-23-19(15)28/h6-11H,4-5H2,1-3H3,(H2,22,26)(H,24,29)
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n/an/a<500n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272578
PNG
(US10065963, Example 2)
Show SMILES CCOc1c(cc(Cl)c2cn(CC)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C20H22ClN7O2/c1-4-27-10-13-14(21)9-12(17(30-5-2)16(13)25-27)11(3)24-20(29)15-18(22)26-28-8-6-7-23-19(15)28/h6-11H,4-5H2,1-3H3,(H2,22,26)(H,24,29)
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n/an/a<2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272579
PNG
(2-amino-N-[1-(4-chloro-7-ethoxy-1H-indazol-6-yl)et...)
Show SMILES CCOc1c(cc(Cl)c2cn[nH]c12)[C@@H](C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C18H18ClN7O2/c1-3-28-15-10(7-12(19)11-8-22-24-14(11)15)9(2)23-18(27)13-16(20)25-26-6-4-5-21-17(13)26/h4-9H,3H2,1-2H3,(H2,20,25)(H,22,24)(H,23,27)/t9-/m1/s1
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272579
PNG
(2-amino-N-[1-(4-chloro-7-ethoxy-1H-indazol-6-yl)et...)
Show SMILES CCOc1c(cc(Cl)c2cn[nH]c12)[C@@H](C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C18H18ClN7O2/c1-3-28-15-10(7-12(19)11-8-22-24-14(11)15)9(2)23-18(27)13-16(20)25-26-6-4-5-21-17(13)26/h4-9H,3H2,1-2H3,(H2,20,25)(H,22,24)(H,23,27)/t9-/m1/s1
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272580
PNG
(2-amino-N-[1-(4-chloro-7-ethoxy-1H-indazol-6-yl)et...)
Show SMILES CCOc1c(cc(Cl)c2cn[nH]c12)[C@H](C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C18H18ClN7O2/c1-3-28-15-10(7-12(19)11-8-22-24-14(11)15)9(2)23-18(27)13-16(20)25-26-6-4-5-21-17(13)26/h4-9H,3H2,1-2H3,(H2,20,25)(H,22,24)(H,23,27)/t9-/m0/s1
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n/an/a>2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272580
PNG
(2-amino-N-[1-(4-chloro-7-ethoxy-1H-indazol-6-yl)et...)
Show SMILES CCOc1c(cc(Cl)c2cn[nH]c12)[C@H](C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C18H18ClN7O2/c1-3-28-15-10(7-12(19)11-8-22-24-14(11)15)9(2)23-18(27)13-16(20)25-26-6-4-5-21-17(13)26/h4-9H,3H2,1-2H3,(H2,20,25)(H,22,24)(H,23,27)/t9-/m0/s1
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n/an/a>2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272581
PNG
(US10065963, Example 4)
Show SMILES CCOc1c(cc(Cl)c2cnn(C)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C19H20ClN7O2/c1-4-29-16-11(8-13(20)12-9-23-26(3)15(12)16)10(2)24-19(28)14-17(21)25-27-7-5-6-22-18(14)27/h5-10H,4H2,1-3H3,(H2,21,25)(H,24,28)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272581
PNG
(US10065963, Example 4)
Show SMILES CCOc1c(cc(Cl)c2cnn(C)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C19H20ClN7O2/c1-4-29-16-11(8-13(20)12-9-23-26(3)15(12)16)10(2)24-19(28)14-17(21)25-27-7-5-6-22-18(14)27/h5-10H,4H2,1-3H3,(H2,21,25)(H,24,28)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272582
PNG
(2-amino-N-{1-[4-chloro- 7-ethoxy-1-(2- methoxyethy...)
Show SMILES CCOc1c(cc(Cl)c2cnn(CCOC)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C21H24ClN7O3/c1-4-32-18-13(10-15(22)14-11-25-28(17(14)18)8-9-31-3)12(2)26-21(30)16-19(23)27-29-7-5-6-24-20(16)29/h5-7,10-12H,4,8-9H2,1-3H3,(H2,23,27)(H,26,30)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272582
PNG
(2-amino-N-{1-[4-chloro- 7-ethoxy-1-(2- methoxyethy...)
Show SMILES CCOc1c(cc(Cl)c2cnn(CCOC)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C21H24ClN7O3/c1-4-32-18-13(10-15(22)14-11-25-28(17(14)18)8-9-31-3)12(2)26-21(30)16-19(23)27-29-7-5-6-24-20(16)29/h5-7,10-12H,4,8-9H2,1-3H3,(H2,23,27)(H,26,30)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272583
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-1-(2- hydroxyethy...)
Show SMILES CCOc1c(cc(Cl)c2cnn(CCO)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C20H22ClN7O3/c1-3-31-17-12(9-14(21)13-10-24-27(7-8-29)16(13)17)11(2)25-20(30)15-18(22)26-28-6-4-5-23-19(15)28/h4-6,9-11,29H,3,7-8H2,1-2H3,(H2,22,26)(H,25,30)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272583
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-1-(2- hydroxyethy...)
Show SMILES CCOc1c(cc(Cl)c2cnn(CCO)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C20H22ClN7O3/c1-3-31-17-12(9-14(21)13-10-24-27(7-8-29)16(13)17)11(2)25-20(30)15-18(22)26-28-6-4-5-23-19(15)28/h4-6,9-11,29H,3,7-8H2,1-2H3,(H2,22,26)(H,25,30)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272584
PNG
(2-amino-N-(1-(4-chloro- 1-(cyanomethyl)-7- ethoxy-...)
Show SMILES CCOc1c(cc(Cl)c2cnn(CC#N)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C20H19ClN8O2/c1-3-31-17-12(9-14(21)13-10-25-28(8-5-22)16(13)17)11(2)26-20(30)15-18(23)27-29-7-4-6-24-19(15)29/h4,6-7,9-11H,3,8H2,1-2H3,(H2,23,27)(H,26,30)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272584
PNG
(2-amino-N-(1-(4-chloro- 1-(cyanomethyl)-7- ethoxy-...)
Show SMILES CCOc1c(cc(Cl)c2cnn(CC#N)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C20H19ClN8O2/c1-3-31-17-12(9-14(21)13-10-25-28(8-5-22)16(13)17)11(2)26-20(30)15-18(23)27-29-7-4-6-24-19(15)29/h4,6-7,9-11H,3,8H2,1-2H3,(H2,23,27)(H,26,30)
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n/an/a<100n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272585
PNG
(2-amino-N-(1-(1-benzyl- 4-chloro-7-ethoxy-1H- inda...)
Show SMILES CCOc1c(cc(Cl)c2cnn(Cc3ccccc3)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C25H24ClN7O2/c1-3-35-22-17(15(2)30-25(34)20-23(27)31-32-11-7-10-28-24(20)32)12-19(26)18-13-29-33(21(18)22)14-16-8-5-4-6-9-16/h4-13,15H,3,14H2,1-2H3,(H2,27,31)(H,30,34)
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n/an/a<2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272585
PNG
(2-amino-N-(1-(1-benzyl- 4-chloro-7-ethoxy-1H- inda...)
Show SMILES CCOc1c(cc(Cl)c2cnn(Cc3ccccc3)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C25H24ClN7O2/c1-3-35-22-17(15(2)30-25(34)20-23(27)31-32-11-7-10-28-24(20)32)12-19(26)18-13-29-33(21(18)22)14-16-8-5-4-6-9-16/h4-13,15H,3,14H2,1-2H3,(H2,27,31)(H,30,34)
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n/an/a<2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272586
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-1-isobutyl-1H- in...)
Show SMILES CCOc1c(cc(Cl)c2cnn(CC(C)C)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-5-32-19-14(9-16(23)15-10-26-30(18(15)19)11-12(2)3)13(4)27-22(31)17-20(24)28-29-8-6-7-25-21(17)29/h6-10,12-13H,5,11H2,1-4H3,(H2,24,28)(H,27,31)
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n/an/a<500n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272586
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-1-isobutyl-1H- in...)
Show SMILES CCOc1c(cc(Cl)c2cnn(CC(C)C)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-5-32-19-14(9-16(23)15-10-26-30(18(15)19)11-12(2)3)13(4)27-22(31)17-20(24)28-29-8-6-7-25-21(17)29/h6-10,12-13H,5,11H2,1-4H3,(H2,24,28)(H,27,31)
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n/an/a<500n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272587
PNG
(2-amino-N-(1-(4-chloro- 1-cyclobutyl-7-ethoxy- 1H-...)
Show SMILES CCOc1c(cc(Cl)c2cnn(C3CCC3)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C22H24ClN7O2/c1-3-32-19-14(10-16(23)15-11-26-30(18(15)19)13-6-4-7-13)12(2)27-22(31)17-20(24)28-29-9-5-8-25-21(17)29/h5,8-13H,3-4,6-7H2,1-2H3,(H2,24,28)(H,27,31)
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n/an/a<500n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272587
PNG
(2-amino-N-(1-(4-chloro- 1-cyclobutyl-7-ethoxy- 1H-...)
Show SMILES CCOc1c(cc(Cl)c2cnn(C3CCC3)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C22H24ClN7O2/c1-3-32-19-14(10-16(23)15-11-26-30(18(15)19)13-6-4-7-13)12(2)27-22(31)17-20(24)28-29-9-5-8-25-21(17)29/h5,8-13H,3-4,6-7H2,1-2H3,(H2,24,28)(H,27,31)
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n/an/a<2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272588
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-1-isopropyl- 1H-i...)
Show SMILES CCOc1c(cc(Cl)c2cnn(C(C)C)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-5-31-18-13(9-15(22)14-10-25-29(11(2)3)17(14)18)12(4)26-21(30)16-19(23)27-28-8-6-7-24-20(16)28/h6-12H,5H2,1-4H3,(H2,23,27)(H,26,30)
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n/an/a<500n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272588
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-1-isopropyl- 1H-i...)
Show SMILES CCOc1c(cc(Cl)c2cnn(C(C)C)c12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-5-31-18-13(9-15(22)14-10-25-29(11(2)3)17(14)18)12(4)26-21(30)16-19(23)27-28-8-6-7-24-20(16)28/h6-12H,5H2,1-4H3,(H2,23,27)(H,26,30)
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n/an/a<500n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272589
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-2-(2- methoxyethy...)
Show SMILES CCOc1c(cc(Cl)c2cn(CCOC)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C21H24ClN7O3/c1-4-32-18-13(10-15(22)14-11-28(8-9-31-3)26-17(14)18)12(2)25-21(30)16-19(23)27-29-7-5-6-24-20(16)29/h5-7,10-12H,4,8-9H2,1-3H3,(H2,23,27)(H,25,30)
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n/an/a<2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272589
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-2-(2- methoxyethy...)
Show SMILES CCOc1c(cc(Cl)c2cn(CCOC)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C21H24ClN7O3/c1-4-32-18-13(10-15(22)14-11-28(8-9-31-3)26-17(14)18)12(2)25-21(30)16-19(23)27-29-7-5-6-24-20(16)29/h5-7,10-12H,4,8-9H2,1-3H3,(H2,23,27)(H,25,30)
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n/an/a<2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272590
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-2-(2- hydroxyethy...)
Show SMILES CCOc1c(cc(Cl)c2cn(CCO)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C20H22ClN7O3/c1-3-31-17-12(9-14(21)13-10-27(7-8-29)25-16(13)17)11(2)24-20(30)15-18(22)26-28-6-4-5-23-19(15)28/h4-6,9-11,29H,3,7-8H2,1-2H3,(H2,22,26)(H,24,30)
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n/an/a<2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272590
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-2-(2- hydroxyethy...)
Show SMILES CCOc1c(cc(Cl)c2cn(CCO)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C20H22ClN7O3/c1-3-31-17-12(9-14(21)13-10-27(7-8-29)25-16(13)17)11(2)24-20(30)15-18(22)26-28-6-4-5-23-19(15)28/h4-6,9-11,29H,3,7-8H2,1-2H3,(H2,22,26)(H,24,30)
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n/an/a<2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272591
PNG
(2-amino-N-(1-(4-chloro- 2-(cyanomethyl)-7- ethoxy-...)
Show SMILES CCOc1c(cc(Cl)c2cn(CC#N)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C20H19ClN8O2/c1-3-31-17-12(9-14(21)13-10-28(8-5-22)26-16(13)17)11(2)25-20(30)15-18(23)27-29-7-4-6-24-19(15)29/h4,6-7,9-11H,3,8H2,1-2H3,(H2,23,27)(H,25,30)
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n/an/a>2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272591
PNG
(2-amino-N-(1-(4-chloro- 2-(cyanomethyl)-7- ethoxy-...)
Show SMILES CCOc1c(cc(Cl)c2cn(CC#N)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C20H19ClN8O2/c1-3-31-17-12(9-14(21)13-10-28(8-5-22)26-16(13)17)11(2)25-20(30)15-18(23)27-29-7-4-6-24-19(15)29/h4,6-7,9-11H,3,8H2,1-2H3,(H2,23,27)(H,25,30)
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n/an/a>2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272592
PNG
(2-amino-N-(1-(2- benzyl-4-chloro-7- ethoxy-2H-inda...)
Show SMILES CCOc1c(cc(Cl)c2cn(Cc3ccccc3)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C25H24ClN7O2/c1-3-35-22-17(15(2)29-25(34)20-23(27)31-33-11-7-10-28-24(20)33)12-19(26)18-14-32(30-21(18)22)13-16-8-5-4-6-9-16/h4-12,14-15H,3,13H2,1-2H3,(H2,27,31)(H,29,34)
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n/an/a<2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272592
PNG
(2-amino-N-(1-(2- benzyl-4-chloro-7- ethoxy-2H-inda...)
Show SMILES CCOc1c(cc(Cl)c2cn(Cc3ccccc3)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C25H24ClN7O2/c1-3-35-22-17(15(2)29-25(34)20-23(27)31-33-11-7-10-28-24(20)33)12-19(26)18-14-32(30-21(18)22)13-16-8-5-4-6-9-16/h4-12,14-15H,3,13H2,1-2H3,(H2,27,31)(H,29,34)
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n/an/a>2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272593
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-2-isobutyl-2H- in...)
Show SMILES CCOc1c(cc(Cl)c2cn(CC(C)C)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-5-32-19-14(9-16(23)15-11-29(10-12(2)3)27-18(15)19)13(4)26-22(31)17-20(24)28-30-8-6-7-25-21(17)30/h6-9,11-13H,5,10H2,1-4H3,(H2,24,28)(H,26,31)
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n/an/a<2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272593
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-2-isobutyl-2H- in...)
Show SMILES CCOc1c(cc(Cl)c2cn(CC(C)C)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-5-32-19-14(9-16(23)15-11-29(10-12(2)3)27-18(15)19)13(4)26-22(31)17-20(24)28-30-8-6-7-25-21(17)30/h6-9,11-13H,5,10H2,1-4H3,(H2,24,28)(H,26,31)
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n/an/a>2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272594
PNG
(2-amino-N-(1-(4-chloro- 2-cyclobutyl-7-ethoxy- 2H-...)
Show SMILES CCOc1c(cc(Cl)c2cn(nc12)C1CCC1)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C22H24ClN7O2/c1-3-32-19-14(10-16(23)15-11-30(27-18(15)19)13-6-4-7-13)12(2)26-22(31)17-20(24)28-29-9-5-8-25-21(17)29/h5,8-13H,3-4,6-7H2,1-2H3,(H2,24,28)(H,26,31)
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n/an/a<2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272594
PNG
(2-amino-N-(1-(4-chloro- 2-cyclobutyl-7-ethoxy- 2H-...)
Show SMILES CCOc1c(cc(Cl)c2cn(nc12)C1CCC1)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C22H24ClN7O2/c1-3-32-19-14(10-16(23)15-11-30(27-18(15)19)13-6-4-7-13)12(2)26-22(31)17-20(24)28-29-9-5-8-25-21(17)29/h5,8-13H,3-4,6-7H2,1-2H3,(H2,24,28)(H,26,31)
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n/an/a>2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272595
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-2-isopropyl- 2H-i...)
Show SMILES CCOc1c(cc(Cl)c2cn(nc12)C(C)C)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-5-31-18-13(9-15(22)14-10-29(11(2)3)26-17(14)18)12(4)25-21(30)16-19(23)27-28-8-6-7-24-20(16)28/h6-12H,5H2,1-4H3,(H2,23,27)(H,25,30)
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n/an/a<2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272595
PNG
(2-amino-N-(1-(4-chloro- 7-ethoxy-2-isopropyl- 2H-i...)
Show SMILES CCOc1c(cc(Cl)c2cn(nc12)C(C)C)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C21H24ClN7O2/c1-5-31-18-13(9-15(22)14-10-29(11(2)3)26-17(14)18)12(4)25-21(30)16-19(23)27-28-8-6-7-24-20(16)28/h6-12H,5H2,1-4H3,(H2,23,27)(H,25,30)
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n/an/a>2.00E+3n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (human))
BDBM272596
PNG
(2-amino-N-(1-(2-(2- amino-2-oxoethyl)-4- chloro-7-...)
Show SMILES CCOc1c(cc(Cl)c2cn(CC(N)=O)nc12)C(C)NC(=O)c1c(N)nn2cccnc12
Show InChI InChI=1S/C20H21ClN8O3/c1-3-32-17-11(7-13(21)12-8-28(9-14(22)30)26-16(12)17)10(2)25-20(31)15-18(23)27-29-6-4-5-24-19(15)29/h4-8,10H,3,9H2,1-2H3,(H2,22,30)(H2,23,27)(H,25,31)
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n/an/a<500n/an/an/an/a6.725



Incyte Corporation

US Patent


Assay Description
[γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...


US Patent US10065963 (2018)

More data for this
Ligand-Target Pair
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