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Compile Data Set for Download or QSAR

Found 202 hits of ph data with Target = 'Phosphodiesterase, PDE1/PDE5'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278971
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2nnc(C)o2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24)
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n/an/a 1.60n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278972
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ncc(C)s2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26)
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n/an/a 0.0710n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278973
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cc(C)on2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)30-27-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25)
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n/an/a 0.110n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278974
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnc(C)o2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26)
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n/an/a 0.860n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278975
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-24-28(5)27-15)20-19(25-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25)
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n/an/a 1.80n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278976
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cn(C)nn2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C21H26N8O/c1-6-30-21-16(8-7-9-22-21)17-10-18(23-11-15-12-28(5)27-25-15)20-19(24-17)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,24)
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n/an/a 0.220n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278977
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cn[nH]c2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-25-12-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-9,11-13H,5,10H2,1-4H3,(H,23,26)(H,24,25)
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n/an/a 1.10n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278978
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C20H25N9O/c1-6-30-20-14(8-7-9-21-20)15-10-16(22-11-17-24-27-28(5)26-17)19-18(23-15)13(4)25-29(19)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,22,23)
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n/an/a 0.340n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278979
PNG
(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(24-11-16-12-25-28(5)13-16)21-20(26-18)15(4)27-29(21)14(2)3/h7-10,12-14H,6,11H2,1-5H3,(H,24,26)
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n/an/a 0.490n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278980
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)27-30-16)21-20(25-18)15(5)26-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25)
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n/an/a 0.470n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278981
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2csc(C)n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26)
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n/an/a 0.720n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278982
PNG
(1-cyclopropyl-5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1CC1
Show InChI InChI=1S/C22H25N7O/c1-4-30-22-17(6-5-9-23-22)18-10-19(24-11-15-12-25-28(3)13-15)21-20(26-18)14(2)27-29(21)16-7-8-16/h5-6,9-10,12-13,16H,4,7-8,11H2,1-3H3,(H,24,26)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278983
PNG
(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Show SMILES CCCn1ncc2nc(cc(NCc3cnn(C)c3)c12)-c1cccnc1OCC
Show InChI InChI=1S/C21H25N7O/c1-4-9-28-20-18(23-11-15-12-24-27(3)14-15)10-17(26-19(20)13-25-28)16-7-6-8-22-21(16)29-5-2/h6-8,10,12-14H,4-5,9,11H2,1-3H3,(H,23,26)
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n/an/a 15n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278984
PNG
(5-(2-ethoxypyridin-3-yl)-N-((1-methyl-1H-pyrazol-4...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C1COC1
Show InChI InChI=1S/C21H23N7O2/c1-3-30-21-16(5-4-6-22-21)17-7-18(23-8-14-9-24-27(2)11-14)20-19(26-17)10-25-28(20)15-12-29-13-15/h4-7,9-11,15H,3,8,12-13H2,1-2H3,(H,23,26)
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n/an/a 38n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278985
PNG
(5-(2-ethoxypyridin-3-yl)-1-methyl-N-(1-(1-methyl-1...)
Show SMILES CCOc1ncccc1-c1cc(NC(C)c2cnn(C)c2)c2n(C)ncc2n1
Show InChI InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(19-18(25-16)11-23-27(19)4)24-13(2)14-10-22-26(3)12-14/h6-13H,5H2,1-4H3,(H,24,25)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278986
PNG
(5-(2-ethoxypyridin-3-yl)-1-methyl-N-((1-methyl-1H-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)ncc2n1
Show InChI InChI=1S/C19H21N7O/c1-4-27-19-14(6-5-7-20-19)15-8-16(18-17(24-15)11-23-26(18)3)21-9-13-10-22-25(2)12-13/h5-8,10-12H,4,9H2,1-3H3,(H,21,24)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278987
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Show SMILES CCOc1ncccc1-c1cc(NCc2nccn2C)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C21H25N7O/c1-5-29-21-15(7-6-8-23-21)16-11-17(24-13-19-22-9-10-27(19)4)20-18(26-16)12-25-28(20)14(2)3/h6-12,14H,5,13H2,1-4H3,(H,24,26)
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n/an/a 54n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278988
PNG
(5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccnn2C)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-27(15)4)20-19(26-17)13-25-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,26)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278989
PNG
(5-(2-ethoxypyridin-3-yl)-1-isopropyl-N-((1-methyl-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccn(C)n2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-27(4)26-15)20-19(25-17)13-24-28(20)14(2)3/h6-11,13-14H,5,12H2,1-4H3,(H,23,25)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278990
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(thiazol-2-yl...)
Show SMILES CCOc1ncccc1-c1cc(NCc2nccs2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C20H22N6OS/c1-4-27-20-14(6-5-7-22-20)15-10-16(23-12-18-21-8-9-28-18)19-17(25-15)11-24-26(19)13(2)3/h5-11,13H,4,12H2,1-3H3,(H,23,25)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278991
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylimi...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cn(C)cn2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-12-27(4)13-24-15)20-19(26-17)11-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26)
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n/an/a 0.440n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278992
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(4-pyridylmet...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccncc2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C22H24N6O/c1-4-29-22-17(6-5-9-24-22)18-12-19(25-13-16-7-10-23-11-8-16)21-20(27-18)14-26-28(21)15(2)3/h5-12,14-15H,4,13H2,1-3H3,(H,25,27)
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n/an/a 50n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278993
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(m-tolylmethy...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cccc(C)c2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C24H27N5O/c1-5-30-24-19(10-7-11-25-24)20-13-21(26-14-18-9-6-8-17(4)12-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28)
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n/an/a 38n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278994
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-(p-tolylmethy...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccc(C)cc2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C24H27N5O/c1-5-30-24-19(7-6-12-25-24)20-13-21(26-14-18-10-8-17(4)9-11-18)23-22(28-20)15-27-29(23)16(2)3/h6-13,15-16H,5,14H2,1-4H3,(H,26,28)
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n/an/a 160n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278995
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(1-methylpyr...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-22-21)17-9-18(23-10-15-11-24-27(4)13-15)20-19(26-17)12-25-28(20)14(2)3/h6-9,11-14H,5,10H2,1-4H3,(H,23,26)
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n/an/a 4.60n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278996
PNG
(5-(2-ethoxy-3-pyridyl)-1-ethyl-N-[(1-methylpyrazol...)
Show SMILES CCOc1ccncc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1
Show InChI InChI=1S/C20H23N7O/c1-4-27-20-17(22-9-14-10-23-26(3)13-14)8-16(25-18(20)12-24-27)15-11-21-7-6-19(15)28-5-2/h6-8,10-13H,4-5,9H2,1-3H3,(H,22,25)
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n/an/a 22n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278997
PNG
(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylpyrazo...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C1COC1
Show InChI InChI=1S/C22H25N7O2/c1-4-31-22-17(6-5-7-23-22)18-8-19(24-9-15-10-25-28(3)11-15)21-20(26-18)14(2)27-29(21)16-12-30-13-16/h5-8,10-11,16H,4,9,12-13H2,1-3H3,(H,24,26)
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n/an/a 6.60n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278998
PNG
(5-(2-ethoxy-3-pyridyl)-1,3-dimethyl-N-[(1-methylpy...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(C)nc(C)c2n1
Show InChI InChI=1S/C20H23N7O/c1-5-28-20-15(7-6-8-21-20)16-9-17(22-10-14-11-23-26(3)12-14)19-18(24-16)13(2)25-27(19)4/h6-9,11-12H,5,10H2,1-4H3,(H,22,24)
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n/an/a 85n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM278999
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2nc(C)cs2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C22H26N6OS/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279000
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(3-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2nc(C)no2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C21H25N7O2/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-24-14(5)27-30-18)20-19(25-16)13(4)26-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,25)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279001
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(1-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ncn(C)n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C21H26N8O/c1-6-30-21-15(8-7-9-22-21)16-10-17(23-11-18-24-12-28(5)27-18)20-19(25-16)14(4)26-29(20)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,23,25)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279002
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnc(C)s2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C22H26N6OS/c1-6-29-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)30-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,25,26)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279003
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2nnc(C)s2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C21H25N7OS/c1-6-29-21-15(8-7-9-22-21)16-10-17(23-11-18-26-25-14(5)30-18)20-19(24-16)13(4)27-28(20)12(2)3/h7-10,12H,6,11H2,1-5H3,(H,23,24)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279004
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2csc(C)c2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)30-13-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279005
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cc(C)cs2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-9-24-23)19-11-20(25-12-17-10-15(4)13-30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,25,26)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279006
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccc(C)s2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C23H27N5OS/c1-6-29-23-18(8-7-11-24-23)19-12-20(25-13-17-10-9-15(4)30-17)22-21(26-19)16(5)27-28(22)14(2)3/h7-12,14H,6,13H2,1-5H3,(H,25,26)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279007
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2coc(C)n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C22H26N6O2/c1-6-29-22-17(8-7-9-23-22)18-10-19(24-11-16-12-30-15(5)25-16)21-20(26-18)14(4)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279008
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ncc(C)o2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-12-19-25-11-14(4)30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279009
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-(1H-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cc[nH]n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-9-22-21)17-11-18(23-12-15-8-10-24-26-15)20-19(25-17)14(4)27-28(20)13(2)3/h6-11,13H,5,12H2,1-4H3,(H,23,25)(H,24,26)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279010
PNG
(5-(2-ethoxy-3-pyridyl)-N-(1H-imidazol-4-ylmethyl)-...)
Show SMILES CCOc1ncccc1-c1cc(NCc2c[nH]cn2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C21H25N7O/c1-5-29-21-16(7-6-8-23-21)17-9-18(24-11-15-10-22-12-25-15)20-19(26-17)14(4)27-28(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,22,25)(H,24,26)
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H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279011
PNG
(N-benzyl-5-(2-ethoxy-3-pyridyl)-1-isopropyl-pyrazo...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccccc2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C23H25N5O/c1-4-29-23-18(11-8-12-24-23)19-13-20(25-14-17-9-6-5-7-10-17)22-21(27-19)15-26-28(22)16(2)3/h5-13,15-16H,4,14H2,1-3H3,(H,25,27)
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n/an/a 45n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279012
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(3-methyliso...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cc(C)no2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C21H24N6O2/c1-5-28-21-16(7-6-8-22-21)17-10-18(23-11-15-9-14(4)26-29-15)20-19(25-17)12-24-27(20)13(2)3/h6-10,12-13H,5,11H2,1-4H3,(H,23,25)
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n/an/a 5.80n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279013
PNG
(5-(2-ethoxy-3-pyridyl)-1-isopropyl-N-[(5-methyl-1,...)
Show SMILES CCOc1ncccc1-c1cc(NCc2noc(C)n2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C20H23N7O2/c1-5-28-20-14(7-6-8-21-20)15-9-16(22-11-18-24-13(4)29-26-18)19-17(25-15)10-23-27(19)12(2)3/h6-10,12H,5,11H2,1-4H3,(H,22,25)
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n/an/a 2.40n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279014
PNG
(N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cc(C)n(C)n2)c2n(ncc2n1)C(C)C
Show InChI InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-15(4)28(5)27-16)21-20(26-18)13-25-29(21)14(2)3/h7-11,13-14H,6,12H2,1-5H3,(H,24,26)
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n/an/a 1.40n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279015
PNG
(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Show SMILES CCOc1ncccc1-c1cc(NCc2ccc(=O)n(C)c2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C24H28N6O2/c1-6-32-24-18(8-7-11-25-24)19-12-20(26-13-17-9-10-21(31)29(5)14-17)23-22(27-19)16(4)28-30(23)15(2)3/h7-12,14-15H,6,13H2,1-5H3,(H,26,27)
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n/an/a 0.620n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279016
PNG
(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Show SMILES CCOc1ncccc1-c1cc(NCc2c[nH]c(C)n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-10-19(25-12-16-11-24-15(5)26-16)21-20(27-18)14(4)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,26)(H,25,27)
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n/an/a 0.420n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279017
PNG
(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cc(C)[nH]n2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C22H27N7O/c1-6-30-22-17(8-7-9-23-22)18-11-19(24-12-16-10-14(4)26-27-16)21-20(25-18)15(5)28-29(21)13(2)3/h7-11,13H,6,12H2,1-5H3,(H,24,25)(H,26,27)
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n/an/a 0.0690n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279018
PNG
(5-(2-ethoxypyridin-3-yl)-1-ethyl-3-methyl-N-((1-me...)
Show SMILES CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)nc(C)c2n1
Show InChI InChI=1S/C21H25N7O/c1-5-28-20-18(23-11-15-12-24-27(4)13-15)10-17(25-19(20)14(3)26-28)16-8-7-9-22-21(16)29-6-2/h7-10,12-13H,5-6,11H2,1-4H3,(H,23,25)
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n/an/a 6.30n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279019
PNG
(3-(1-isopropyl-3-methyl-7-(((1-methyl-1H-pyrazol-4...)
Show SMILES CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1cccn(C)c1=O
Show InChI InChI=1S/C21H25N7O/c1-13(2)28-20-18(22-10-15-11-23-27(5)12-15)9-17(24-19(20)14(3)25-28)16-7-6-8-26(4)21(16)29/h6-9,11-13H,10H2,1-5H3,(H,22,24)
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n/an/a 20n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
Phosphodiesterase, PDE1/PDE5


(Homo sapiens (human))
BDBM279020
PNG
(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Show SMILES CCOc1ncccc1-c1cc(NCc2nc(C)co2)c2n(nc(C)c2n1)C(C)C
Show InChI InChI=1S/C22H26N6O2/c1-6-29-22-16(8-7-9-23-22)17-10-18(24-11-19-25-14(4)12-30-19)21-20(26-17)15(5)27-28(21)13(2)3/h7-10,12-13H,6,11H2,1-5H3,(H,24,26)
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n/an/a 0.5n/an/an/an/a7.625



H. Lundbeck A/S

US Patent


Assay Description
PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...


US Patent US10034861 (2018)

More data for this
Ligand-Target Pair
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