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Compile Data Set for Download or QSAR

Found 17 hits of ph data with Target = 'Phosphodiesterase 11A (PDE11A)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM123687
PNG
(US8741907, 3 | US9067945, 2)
Show SMILES CCC(CC)n1ncc2c1nc(CC1CCCCC1)[nH]c2=O
Show InChI InChI=1S/C17H26N4O/c1-3-13(4-2)21-16-14(11-18-21)17(22)20-15(19-16)10-12-8-6-5-7-9-12/h11-13H,3-10H2,1-2H3,(H,19,20,22)
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Similars

US Patent
n/an/a>4.00E+3n/an/an/an/a7.5n/a



Boehringer Ingehleim International GmbH

US Patent


Assay Description
The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20...


US Patent US9067945 (2015)


BindingDB Entry DOI: 10.7270/Q2708052
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM253042
PNG
(US9493447, 1001)
Show SMILES CCOC(C(=O)c1ccc(o1)-c1cc(OC)c(Cl)c(OC)c1)c1ccc(cc1)-c1nnc(C)s1
Show InChI InChI=1S/C25H23ClN2O5S/c1-5-32-24(15-6-8-16(9-7-15)25-28-27-14(2)34-25)23(29)19-11-10-18(33-19)17-12-20(30-3)22(26)21(13-17)31-4/h6-13,24H,5H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/a7.530



Omeros Corporation

US Patent


Assay Description
The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...


US Patent US9493447 (2016)


BindingDB Entry DOI: 10.7270/Q2SB44PB
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235734
PNG
(US9359371, 2)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccn2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H25ClN6O2/c1-33-21-6-5-15(8-20(21)25)10-27-22-19(23(32)28-11-18-4-2-3-7-26-18)12-29-24(30-22)31-13-16-9-17(16)14-31/h2-8,12,16-17H,9-11,13-14H2,1H3,(H,28,32)(H,27,29,30)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235736
PNG
(US9359371, 4)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2cnc(C)cn2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H26ClN7O2/c1-14-7-27-18(9-26-14)10-29-23(33)19-11-30-24(32-12-16-6-17(16)13-32)31-22(19)28-8-15-3-4-21(34-2)20(25)5-15/h3-5,7,9,11,16-17H,6,8,10,12-13H2,1-2H3,(H,29,33)(H,28,30,31)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235737
PNG
(US9359371, 5)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccc(F)cc2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C25H25ClFN5O2/c1-34-22-7-4-16(8-21(22)26)11-28-23-20(24(33)29-10-15-2-5-19(27)6-3-15)12-30-25(31-23)32-13-17-9-18(17)14-32/h2-8,12,17-18H,9-11,13-14H2,1H3,(H,29,33)(H,28,30,31)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235738
PNG
(US9359371, 6)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCOCC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H31ClN6O3/c1-33-21-3-2-16(10-20(21)25)12-27-22-19(23(32)26-4-5-30-6-8-34-9-7-30)13-28-24(29-22)31-14-17-11-18(17)15-31/h2-3,10,13,17-18H,4-9,11-12,14-15H2,1H3,(H,26,32)(H,27,28,29)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235739
PNG
(US9359371, 7)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCC2CCNCC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H31ClN6O2/c1-33-21-3-2-16(8-20(21)25)11-27-22-19(23(32)28-10-15-4-6-26-7-5-15)12-29-24(30-22)31-13-17-9-18(17)14-31/h2-3,8,12,15,17-18,26H,4-7,9-11,13-14H2,1H3,(H,28,32)(H,27,29,30)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235740
PNG
(US9359371, 8)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CCCCNC2=O)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H29ClN6O3/c1-34-20-6-5-14(8-18(20)25)10-27-21-17(22(32)29-19-4-2-3-7-26-23(19)33)11-28-24(30-21)31-12-15-9-16(15)13-31/h5-6,8,11,15-16,19H,2-4,7,9-10,12-13H2,1H3,(H,26,33)(H,29,32)(H,27,28,30)/t15?,16?,19-/m0/s1
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235741
PNG
(US9359371, 9)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NC2CCCCCC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C25H32ClN5O2/c1-33-22-9-8-16(10-21(22)26)12-27-23-20(24(32)29-19-6-4-2-3-5-7-19)13-28-25(30-23)31-14-17-11-18(17)15-31/h8-10,13,17-19H,2-7,11-12,14-15H2,1H3,(H,29,32)(H,27,28,30)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235742
PNG
(US9359371, 11)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H30ClN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18-
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235743
PNG
(US9359371, 14)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CCC3(CCC3)CC2)cc1Cl
Show InChI InChI=1S/C26H30ClN7O2/c1-36-21-5-4-18(14-20(21)27)15-30-23-19(24(35)31-17-22-28-10-3-11-29-22)16-32-25(33-23)34-12-8-26(9-13-34)6-2-7-26/h3-5,10-11,14,16H,2,6-9,12-13,15,17H2,1H3,(H,31,35)(H,30,32,33)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235745
PNG
(US9359371, 18)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CCC3(CCN(C)C3)C2)cc1Cl
Show InChI InChI=1S/C26H31ClN8O2/c1-34-10-6-26(16-34)7-11-35(17-26)25-32-14-19(24(36)31-15-22-28-8-3-9-29-22)23(33-25)30-13-18-4-5-21(37-2)20(27)12-18/h3-5,8-9,12,14H,6-7,10-11,13,15-17H2,1-2H3,(H,31,36)(H,30,32,33)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235759
PNG
(US9359371, 42)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCNCC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C25H34ClN7O2/c1-35-21-3-2-18(14-20(21)26)15-29-22-19(23(34)28-9-13-32-11-7-27-8-12-32)16-30-24(31-22)33-10-6-25(17-33)4-5-25/h2-3,14,16,27H,4-13,15,17H2,1H3,(H,28,34)(H,29,30,31)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235761
PNG
(US9359371, 44)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](N)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C25H33ClN6O2/c1-34-21-7-2-16(12-20(21)26)13-28-22-19(23(33)30-18-5-3-17(27)4-6-18)14-29-24(31-22)32-11-10-25(15-32)8-9-25/h2,7,12,14,17-18H,3-6,8-11,13,15,27H2,1H3,(H,30,33)(H,28,29,31)/t17-,18-
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235762
PNG
(US9359371, 46)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCN(C)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C26H36ClN7O2/c1-32-11-13-33(14-12-32)10-8-28-24(35)20-17-30-25(34-9-7-26(18-34)5-6-26)31-23(20)29-16-19-3-4-22(36-2)21(27)15-19/h3-4,15,17H,5-14,16,18H2,1-2H3,(H,28,35)(H,29,30,31)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235763
PNG
(US9359371, 47)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCC2CCC(O)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C26H34ClN5O3/c1-35-22-7-4-18(12-21(22)27)14-28-23-20(24(34)29-13-17-2-5-19(33)6-3-17)15-30-25(31-23)32-11-10-26(16-32)8-9-26/h4,7,12,15,17,19,33H,2-3,5-6,8-11,13-14,16H2,1H3,(H,29,34)(H,28,30,31)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 11A (PDE11A)


(Homo sapiens (Human))
BDBM235733
PNG
(US9359371, 1)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ncccn2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C23H24ClN7O2/c1-33-19-4-3-14(7-18(19)24)9-27-21-17(22(32)28-11-20-25-5-2-6-26-20)10-29-23(30-21)31-12-15-8-16(15)13-31/h2-7,10,15-16H,8-9,11-13H2,1H3,(H,28,32)(H,27,29,30)
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n/an/a>1.00E+4n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair