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Compile Data Set for Download or QSAR

Found 7 hits of ph data with Target = 'Phosphodiesterase 6'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235735
PNG
(US9359371, 3)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccc2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C25H26ClN5O2/c1-33-22-8-7-17(9-21(22)26)12-27-23-20(24(32)28-11-16-5-3-2-4-6-16)13-29-25(30-23)31-14-18-10-19(18)15-31/h2-9,13,18-19H,10-12,14-15H2,1H3,(H,28,32)(H,27,29,30)
PDB

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UniChem
US Patent
n/an/a 8.89n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235742
PNG
(US9359371, 11)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H30ClN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18-
PDB

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PC sid
UniChem
US Patent
n/an/a 61n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235755
PNG
(US9359371, 38)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C25H32ClN5O3/c1-34-21-7-2-16(12-20(21)26)13-27-22-19(23(33)29-17-3-5-18(32)6-4-17)14-28-24(30-22)31-11-10-25(15-31)8-9-25/h2,7,12,14,17-18,32H,3-6,8-11,13,15H2,1H3,(H,29,33)(H,27,28,30)/t17-,18-
PDB

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PC sid
UniChem
US Patent
n/an/a 58n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM253042
PNG
(US9493447, 1001)
Show SMILES CCOC(C(=O)c1ccc(o1)-c1cc(OC)c(Cl)c(OC)c1)c1ccc(cc1)-c1nnc(C)s1
Show InChI InChI=1S/C25H23ClN2O5S/c1-5-32-24(15-6-8-16(9-7-15)25-28-27-14(2)34-25)23(29)19-11-10-18(33-19)17-12-20(30-3)22(26)21(13-17)31-4/h6-13,24H,5H2,1-4H3
PDB

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US Patent
n/an/a>3.00E+3n/an/an/an/a7.530



Omeros Corporation

US Patent


Assay Description
The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...


US Patent US9493447 (2016)


BindingDB Entry DOI: 10.7270/Q2SB44PB
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235764
PNG
(US9359371, 48)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1F
Show InChI InChI=1S/C24H30FN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18-
PDB

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UniChem
US Patent
n/an/a 1.11E+3n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235765
PNG
(US9359371, 50)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1C
Show InChI InChI=1S/C25H33N5O3/c1-15-9-16(3-8-22(15)33-2)11-26-23-21(24(32)28-19-4-6-20(31)7-5-19)12-27-25(29-23)30-13-17-10-18(17)14-30/h3,8-9,12,17-20,31H,4-7,10-11,13-14H2,1-2H3,(H,28,32)(H,26,27,29)/t17?,18?,19-,20-
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 660n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235762
PNG
(US9359371, 46)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCN(C)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C26H36ClN7O2/c1-32-11-13-33(14-12-32)10-8-28-24(35)20-17-30-25(34-9-7-26(18-34)5-6-26)31-23(20)29-16-19-3-4-22(36-2)21(27)15-19/h3-4,15,17H,5-14,16,18H2,1-2H3,(H,28,35)(H,29,30,31)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 310n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair