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Compile Data Set for Download or QSAR

Found 183 hits of ph data with Target = 'Phosphodiesterase 7'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM135578
PNG
(US8846654, 16)
Show SMILES COc1ccc(Cn2c(=O)n(C3CCN(CC3)C=O)c3ccc(OCC(F)F)cc3c2=O)cc1OC
Show InChI InChI=1S/C25H27F2N3O6/c1-34-21-6-3-16(11-22(21)35-2)13-29-24(32)19-12-18(36-14-23(26)27)4-5-20(19)30(25(29)33)17-7-9-28(15-31)10-8-17/h3-6,11-12,15,17,23H,7-10,13-14H2,1-2H3
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n/an/a 15n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...


US Patent US8846654 (2014)


BindingDB Entry DOI: 10.7270/Q21V5CPZ
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM135579
PNG
(US8846654, 72)
Show SMILES COc1ccc(Cn2c(=O)n(C3CCN(CC3)C=O)c3ccc(OCCO)cc3c2=O)cc1OC
Show InChI InChI=1S/C25H29N3O7/c1-33-22-6-3-17(13-23(22)34-2)15-27-24(31)20-14-19(35-12-11-29)4-5-21(20)28(25(27)32)18-7-9-26(16-30)10-8-18/h3-6,13-14,16,18,29H,7-12,15H2,1-2H3
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n/an/a 89n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...


US Patent US8846654 (2014)


BindingDB Entry DOI: 10.7270/Q21V5CPZ
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM135580
PNG
(US8846654, 77)
Show SMILES COc1ccc(Cn2c(=O)n(C3CCN(C3)C=O)c3ccc(CNC(C)=O)cc3c2=O)cc1OC
Show InChI InChI=1S/C25H28N4O6/c1-16(31)26-12-17-4-6-21-20(10-17)24(32)28(13-18-5-7-22(34-2)23(11-18)35-3)25(33)29(21)19-8-9-27(14-19)15-30/h4-7,10-11,15,19H,8-9,12-14H2,1-3H3,(H,26,31)
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n/an/a 820n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...


US Patent US8846654 (2014)


BindingDB Entry DOI: 10.7270/Q21V5CPZ
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM135581
PNG
(US8846654, 97)
Show SMILES COc1ccc(Cn2c(=O)n(C3CCN(CC3)C=O)c3cc(Cl)cc(Cl)c3c2=O)cc1OC
Show InChI InChI=1S/C23H23Cl2N3O5/c1-32-19-4-3-14(9-20(19)33-2)12-27-22(30)21-17(25)10-15(24)11-18(21)28(23(27)31)16-5-7-26(13-29)8-6-16/h3-4,9-11,13,16H,5-8,12H2,1-2H3
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n/an/a 61n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...


US Patent US8846654 (2014)


BindingDB Entry DOI: 10.7270/Q21V5CPZ
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM135582
PNG
(US8846654, 111)
Show SMILES COc1ccc(Cn2c(=O)n(C3CCN(CC3)C=O)c3ccc(OC(F)F)cc3c2=O)cc1OC
Show InChI InChI=1S/C24H25F2N3O6/c1-33-20-6-3-15(11-21(20)34-2)13-28-22(31)18-12-17(35-23(25)26)4-5-19(18)29(24(28)32)16-7-9-27(14-30)10-8-16/h3-6,11-12,14,16,23H,7-10,13H2,1-2H3
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n/an/a 6.70n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...


US Patent US8846654 (2014)


BindingDB Entry DOI: 10.7270/Q21V5CPZ
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM135577
PNG
(US8846654, 11)
Show SMILES COc1ccc(Cn2c(=O)n(C3CCN(CC3)C=O)c3ccc(OC(CF)CF)cc3c2=O)cc1OC
Show InChI InChI=1S/C26H29F2N3O6/c1-35-23-6-3-17(11-24(23)36-2)15-30-25(33)21-12-19(37-20(13-27)14-28)4-5-22(21)31(26(30)34)18-7-9-29(16-32)10-8-18/h3-6,11-12,16,18,20H,7-10,13-15H2,1-2H3
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n/an/a 39n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...


US Patent US8846654 (2014)


BindingDB Entry DOI: 10.7270/Q21V5CPZ
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM135583
PNG
(US8846654, 251)
Show SMILES COc1cc(Cn2c(=O)n(C3CCN(CC3)C=O)c3ccc(OC(CF)CF)cc3c2=O)ccc1OCC(=O)N1CCCCC1
Show InChI InChI=1S/C32H38F2N4O7/c1-43-29-15-22(5-8-28(29)44-20-30(40)36-11-3-2-4-12-36)19-37-31(41)26-16-24(45-25(17-33)18-34)6-7-27(26)38(32(37)42)23-9-13-35(21-39)14-10-23/h5-8,15-16,21,23,25H,2-4,9-14,17-20H2,1H3
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n/an/a 46n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...


US Patent US8846654 (2014)


BindingDB Entry DOI: 10.7270/Q21V5CPZ
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM135584
PNG
(US8846654, 294)
Show SMILES FCC(CF)Oc1ccc2n(C3CCN(CC3)C=O)c(=O)n(Cc3ccc(-c4ccccc4)c(c3)C#N)c(=O)c2c1
Show InChI InChI=1S/C31H28F2N4O4/c32-16-26(17-33)41-25-7-9-29-28(15-25)30(39)36(31(40)37(29)24-10-12-35(20-38)13-11-24)19-21-6-8-27(23(14-21)18-34)22-4-2-1-3-5-22/h1-9,14-15,20,24,26H,10-13,16-17,19H2
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n/an/a 37n/an/an/an/a7.5n/a



Sanofi

US Patent


Assay Description
The assay is carried out in 1.5 ml Eppendorf tubes comprising 40 mM of Tris-HCl (pH 7.5), 15 mM of MgCl2, 1 mM of EGTA, 0.5 mg/ml of bovine serum alb...


US Patent US8846654 (2014)


BindingDB Entry DOI: 10.7270/Q21V5CPZ
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140022
PNG
(US8901315, 10)
Show SMILES COc1cc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)ccc1NC(C)=O
Show InChI InChI=1S/C22H26N4O3S/c1-13-17-12-20(30-22(17)26(25-13)16-7-5-4-6-8-16)21(28)24-15-9-10-18(23-14(2)27)19(11-15)29-3/h9-12,16H,4-8H2,1-3H3,(H,23,27)(H,24,28)
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n/an/a 27n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140023
PNG
(US8901315, 11)
Show SMILES CC(=O)N1CCc2cc(NC(=O)c3cc4c(C)nn(C5CCCCC5)c4s3)ccc12
Show InChI InChI=1S/C23H26N4O2S/c1-14-19-13-21(30-23(19)27(25-14)18-6-4-3-5-7-18)22(29)24-17-8-9-20-16(12-17)10-11-26(20)15(2)28/h8-9,12-13,18H,3-7,10-11H2,1-2H3,(H,24,29)
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n/an/a 19n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140024
PNG
(US8901315, 12)
Show SMILES CCOC(=O)Nc1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C22H26N4O3S/c1-3-29-22(28)24-16-11-9-15(10-12-16)23-20(27)19-13-18-14(2)25-26(21(18)30-19)17-7-5-4-6-8-17/h9-13,17H,3-8H2,1-2H3,(H,23,27)(H,24,28)
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n/an/a 53n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140025
PNG
(US8901315, 14)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc2NCCc2c1
Show InChI InChI=1S/C21H24N4OS/c1-13-17-12-19(27-21(17)25(24-13)16-5-3-2-4-6-16)20(26)23-15-7-8-18-14(11-15)9-10-22-18/h7-8,11-12,16,22H,2-6,9-10H2,1H3,(H,23,26)
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n/an/a 88n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140026
PNG
(US8901315, 16)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C23H28N4O2S/c1-16-20-15-21(30-23(20)27(25-16)19-5-3-2-4-6-19)22(28)24-17-7-9-18(10-8-17)26-11-13-29-14-12-26/h7-10,15,19H,2-6,11-14H2,1H3,(H,24,28)
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n/an/a 34n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140027
PNG
(US8901315, 20)
Show SMILES CNC(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C21H24N4O2S/c1-13-17-12-18(28-21(17)25(24-13)16-6-4-3-5-7-16)20(27)23-15-10-8-14(9-11-15)19(26)22-2/h8-12,16H,3-7H2,1-2H3,(H,22,26)(H,23,27)
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n/an/a 33n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140028
PNG
(US8901315, 21)
Show SMILES CCC(=O)N1CCc2cc(NC(=O)c3cc4c(C)nn(C5CCCCC5)c4s3)ccc12
Show InChI InChI=1S/C24H28N4O2S/c1-3-22(29)27-12-11-16-13-17(9-10-20(16)27)25-23(30)21-14-19-15(2)26-28(24(19)31-21)18-7-5-4-6-8-18/h9-10,13-14,18H,3-8,11-12H2,1-2H3,(H,25,30)
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n/an/a 84n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140029
PNG
(US8901315, 23)
Show SMILES CC(C)C(=O)N1CCc2cc(NC(=O)c3cc4c(C)nn(C5CCCCC5)c4s3)ccc12
Show InChI InChI=1S/C25H30N4O2S/c1-15(2)24(31)28-12-11-17-13-18(9-10-21(17)28)26-23(30)22-14-20-16(3)27-29(25(20)32-22)19-7-5-4-6-8-19/h9-10,13-15,19H,4-8,11-12H2,1-3H3,(H,26,30)
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n/an/a 83n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140030
PNG
(US8901315, 25)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc2N(CCc2c1)C(=O)C(C)(C)C
Show InChI InChI=1S/C26H32N4O2S/c1-16-20-15-22(33-24(20)30(28-16)19-8-6-5-7-9-19)23(31)27-18-10-11-21-17(14-18)12-13-29(21)25(32)26(2,3)4/h10-11,14-15,19H,5-9,12-13H2,1-4H3,(H,27,31)
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n/an/a 98n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140031
PNG
(US8901315, 26)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C21H22N4O2S/c1-12-16-11-18(28-21(16)25(24-12)15-5-3-2-4-6-15)20(27)22-14-7-8-17-13(9-14)10-19(26)23-17/h7-9,11,15H,2-6,10H2,1H3,(H,22,27)(H,23,26)
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n/an/a 44n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140032
PNG
(US8901315, 28)
Show SMILES CCNC(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C22H26N4O2S/c1-3-23-20(27)15-9-11-16(12-10-15)24-21(28)19-13-18-14(2)25-26(22(18)29-19)17-7-5-4-6-8-17/h9-13,17H,3-8H2,1-2H3,(H,23,27)(H,24,28)
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n/an/a 50n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140033
PNG
(US8901315, 32)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C25H31N5O2S/c1-17-21-16-22(33-25(21)30(27-17)20-6-4-3-5-7-20)23(31)26-19-10-8-18(9-11-19)24(32)29-14-12-28(2)13-15-29/h8-11,16,20H,3-7,12-15H2,1-2H3,(H,26,31)
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n/an/a 95n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140034
PNG
(US8901315, 36)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C24H31N5O3S2/c1-17-21-16-22(33-24(21)29(26-17)19-6-4-3-5-7-19)23(30)25-18-8-10-20(11-9-18)34(31,32)28-14-12-27(2)13-15-28/h8-11,16,19H,3-7,12-15H2,1-2H3,(H,25,30)
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n/an/a 40n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140035
PNG
(US8901315, 37)
Show SMILES COCCNC(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C23H28N4O3S/c1-15-19-14-20(31-23(19)27(26-15)18-6-4-3-5-7-18)22(29)25-17-10-8-16(9-11-17)21(28)24-12-13-30-2/h8-11,14,18H,3-7,12-13H2,1-2H3,(H,24,28)(H,25,29)
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n/an/a 28n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140036
PNG
(US8901315, 38)
Show SMILES CC(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C21H23N3O2S/c1-13-18-12-19(20(26)22-16-10-8-15(9-11-16)14(2)25)27-21(18)24(23-13)17-6-4-3-5-7-17/h8-12,17H,3-7H2,1-2H3,(H,22,26)
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n/an/a 33n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140037
PNG
(US8901315, 39)
Show SMILES CN(C)C(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C22H26N4O2S/c1-14-18-13-19(29-22(18)26(24-14)17-7-5-4-6-8-17)20(27)23-16-11-9-15(10-12-16)21(28)25(2)3/h9-13,17H,4-8H2,1-3H3,(H,23,27)
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n/an/a 14n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140038
PNG
(US8901315, 40)
Show SMILES CCOC(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C22H25N3O3S/c1-3-28-22(27)15-9-11-16(12-10-15)23-20(26)19-13-18-14(2)24-25(21(18)29-19)17-7-5-4-6-8-17/h9-13,17H,3-8H2,1-2H3,(H,23,26)
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n/an/a 75n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140039
PNG
(US8901315, 41)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H21N3O3S/c1-12-16-11-17(18(24)21-14-9-7-13(8-10-14)20(25)26)27-19(16)23(22-12)15-5-3-2-4-6-15/h7-11,15H,2-6H2,1H3,(H,21,24)(H,25,26)
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n/an/a 50n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140040
PNG
(US8901315, 45)
Show SMILES CC(C)NC(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C23H28N4O2S/c1-14(2)24-21(28)16-9-11-17(12-10-16)25-22(29)20-13-19-15(3)26-27(23(19)30-20)18-7-5-4-6-8-18/h9-14,18H,4-8H2,1-3H3,(H,24,28)(H,25,29)
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n/an/a 50n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140041
PNG
(US8901315, 46)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(cc1)C(=O)NCCO
Show InChI InChI=1S/C22H26N4O3S/c1-14-18-13-19(30-22(18)26(25-14)17-5-3-2-4-6-17)21(29)24-16-9-7-15(8-10-16)20(28)23-11-12-27/h7-10,13,17,27H,2-6,11-12H2,1H3,(H,23,28)(H,24,29)
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n/an/a 30n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140042
PNG
(US8901315, 47)
Show SMILES CC(=O)Nc1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cn1
Show InChI InChI=1S/C20H23N5O2S/c1-12-16-10-17(28-20(16)25(24-12)15-6-4-3-5-7-15)19(27)23-14-8-9-18(21-11-14)22-13(2)26/h8-11,15H,3-7H2,1-2H3,(H,23,27)(H,21,22,26)
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n/an/a 32n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140043
PNG
(US8901315, 51)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(cc1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C24H30N4O2S/c1-15-19-14-20(31-23(19)28(27-15)18-8-6-5-7-9-18)22(30)25-17-12-10-16(11-13-17)21(29)26-24(2,3)4/h10-14,18H,5-9H2,1-4H3,(H,25,30)(H,26,29)
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n/an/a 75n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140044
PNG
(US8901315, 53)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(NC=O)cc1
Show InChI InChI=1S/C20H22N4O2S/c1-13-17-11-18(19(26)22-15-9-7-14(8-10-15)21-12-25)27-20(17)24(23-13)16-5-3-2-4-6-16/h7-12,16H,2-6H2,1H3,(H,21,25)(H,22,26)
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n/an/a 55n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140045
PNG
(US8901315, 58)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc2N(CCc2c1)C(=O)C1CC1
Show InChI InChI=1S/C25H28N4O2S/c1-15-20-14-22(32-25(20)29(27-15)19-5-3-2-4-6-19)23(30)26-18-9-10-21-17(13-18)11-12-28(21)24(31)16-7-8-16/h9-10,13-14,16,19H,2-8,11-12H2,1H3,(H,26,30)
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n/an/a 36n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140046
PNG
(US8901315, 59)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc2N(CCc2c1)S(C)(=O)=O
Show InChI InChI=1S/C22H26N4O3S2/c1-14-18-13-20(30-22(18)26(24-14)17-6-4-3-5-7-17)21(27)23-16-8-9-19-15(12-16)10-11-25(19)31(2,28)29/h8-9,12-13,17H,3-7,10-11H2,1-2H3,(H,23,27)
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n/an/a 80n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140047
PNG
(US8901315, 60)
Show SMILES CC(=O)n1ccc2cc(NC(=O)c3cc4c(C)nn(C5CCCCC5)c4s3)ccc12
Show InChI InChI=1S/C23H24N4O2S/c1-14-19-13-21(30-23(19)27(25-14)18-6-4-3-5-7-18)22(29)24-17-8-9-20-16(12-17)10-11-26(20)15(2)28/h8-13,18H,3-7H2,1-2H3,(H,24,29)
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n/an/a 65n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140048
PNG
(US8901315, 67)
Show SMILES CNC(=O)COc1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C22H26N4O3S/c1-14-18-12-19(30-22(18)26(25-14)16-6-4-3-5-7-16)21(28)24-15-8-10-17(11-9-15)29-13-20(27)23-2/h8-12,16H,3-7,13H2,1-2H3,(H,23,27)(H,24,28)
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n/an/a 23n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140049
PNG
(US8901315, 70)
Show SMILES CNC(=O)Cc1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C22H26N4O2S/c1-14-18-13-19(29-22(18)26(25-14)17-6-4-3-5-7-17)21(28)24-16-10-8-15(9-11-16)12-20(27)23-2/h8-11,13,17H,3-7,12H2,1-2H3,(H,23,27)(H,24,28)
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n/an/a 25n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140050
PNG
(US8901315, 72)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C23H29N5OS/c1-16-20-15-21(30-23(20)28(26-16)19-5-3-2-4-6-19)22(29)25-17-7-9-18(10-8-17)27-13-11-24-12-14-27/h7-10,15,19,24H,2-6,11-14H2,1H3,(H,25,29)
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n/an/a 10n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140051
PNG
(US8901315, 73)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C25H31N5O2S/c1-17-22-16-23(33-25(22)30(27-17)21-6-4-3-5-7-21)24(32)26-19-8-10-20(11-9-19)29-14-12-28(13-15-29)18(2)31/h8-11,16,21H,3-7,12-15H2,1-2H3,(H,26,32)
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n/an/a 12n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140052
PNG
(US8901315, 74)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C19H27N3O2S/c1-12-16-11-17(18(24)20-13-7-9-15(23)10-8-13)25-19(16)22(21-12)14-5-3-2-4-6-14/h11,13-15,23H,2-10H2,1H3,(H,20,24)/t13-,15-
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n/an/a 50n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140053
PNG
(US8901315, 76)
Show SMILES CN1CCN(CC1)C(=O)COc1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C26H33N5O3S/c1-18-22-16-23(35-26(22)31(28-18)20-6-4-3-5-7-20)25(33)27-19-8-10-21(11-9-19)34-17-24(32)30-14-12-29(2)13-15-30/h8-11,16,20H,3-7,12-15,17H2,1-2H3,(H,27,33)
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n/an/a 20n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140054
PNG
(US8901315, 77)
Show SMILES CN(C)C(=O)COc1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C23H28N4O3S/c1-15-19-13-20(31-23(19)27(25-15)17-7-5-4-6-8-17)22(29)24-16-9-11-18(12-10-16)30-14-21(28)26(2)3/h9-13,17H,4-8,14H2,1-3H3,(H,24,29)
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n/an/a 20n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140055
PNG
(US8901315, 79)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CCO)CC1
Show InChI InChI=1S/C25H33N5O4S2/c1-18-22-17-23(35-25(22)30(27-18)20-5-3-2-4-6-20)24(32)26-19-7-9-21(10-8-19)36(33,34)29-13-11-28(12-14-29)15-16-31/h7-10,17,20,31H,2-6,11-16H2,1H3,(H,26,32)
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n/an/a 60n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140056
PNG
(US8901315, 80)
Show SMILES CC(=O)N[C@H]1CC[C@@H](CC1)NC(=O)c1cc2c(C)nn(C3CCCCC3)c2s1
Show InChI InChI=1S/C21H30N4O2S/c1-13-18-12-19(28-21(18)25(24-13)17-6-4-3-5-7-17)20(27)23-16-10-8-15(9-11-16)22-14(2)26/h12,15-17H,3-11H2,1-2H3,(H,22,26)(H,23,27)/t15-,16-
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n/an/a 60n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140057
PNG
(US8901315, 94)
Show SMILES CC(=O)Nc1ccc(NC(=O)c2cc3c(C)nn(C4CCCCCC4)c3s2)cc1
Show InChI InChI=1S/C22H26N4O2S/c1-14-19-13-20(21(28)24-17-11-9-16(10-12-17)23-15(2)27)29-22(19)26(25-14)18-7-5-3-4-6-8-18/h9-13,18H,3-8H2,1-2H3,(H,23,27)(H,24,28)
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n/an/a 58n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140058
PNG
(US8901315, 99)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(N)cc1
Show InChI InChI=1S/C19H22N4OS/c1-12-16-11-17(18(24)21-14-9-7-13(20)8-10-14)25-19(16)23(22-12)15-5-3-2-4-6-15/h7-11,15H,2-6,20H2,1H3,(H,21,24)
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n/an/a 99n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140059
PNG
(US8901315, 100)
Show SMILES CC(=O)Nc1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C21H24N4O2S/c1-13-18-12-19(28-21(18)25(24-13)17-6-4-3-5-7-17)20(27)23-16-10-8-15(9-11-16)22-14(2)26/h8-12,17H,3-7H2,1-2H3,(H,22,26)(H,23,27)
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n/an/a 37n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140060
PNG
(US8901315, 101)
Show SMILES COCC(=O)Nc1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C22H26N4O3S/c1-14-18-12-19(30-22(18)26(25-14)17-6-4-3-5-7-17)21(28)24-16-10-8-15(9-11-16)23-20(27)13-29-2/h8-12,17H,3-7,13H2,1-2H3,(H,23,27)(H,24,28)
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n/an/a 30n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140061
PNG
(US8901315, 102)
Show SMILES COC(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cn1
Show InChI InChI=1S/C20H22N4O3S/c1-12-15-10-17(28-19(15)24(23-12)14-6-4-3-5-7-14)18(25)22-13-8-9-16(21-11-13)20(26)27-2/h8-11,14H,3-7H2,1-2H3,(H,22,25)
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n/an/a 85n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140062
PNG
(US8901315, 104)
Show SMILES CNC(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cn1
Show InChI InChI=1S/C20H23N5O2S/c1-12-15-10-17(28-20(15)25(24-12)14-6-4-3-5-7-14)19(27)23-13-8-9-16(22-11-13)18(26)21-2/h8-11,14H,3-7H2,1-2H3,(H,21,26)(H,23,27)
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n/an/a 58n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140063
PNG
(US8901315, 106 | US8901315, 107)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cc1
Show InChI InChI=1S/C24H31N5OS/c1-17-21-16-22(31-24(21)29(26-17)20-6-4-3-5-7-20)23(30)25-18-8-10-19(11-9-18)28-14-12-27(2)13-15-28/h8-11,16,20H,3-7,12-15H2,1-2H3,(H,25,30)
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n/an/a 9n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
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