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Compile Data Set for Download or QSAR

Found 18 hits of ph data with Target = 'Plasminogen'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasminogen


(Homo sapiens (human))
BDBM14350
PNG
(2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benz...)
Show SMILES C[C@H]1CCCC[C@@H]1Oc1cccc(-c2nc3cc(C(N)=[NH2+])c(F)cc3[nH]2)c1[O-]
Show InChI InChI=1S/C21H23FN4O2/c1-11-5-2-3-7-17(11)28-18-8-4-6-12(19(18)27)21-25-15-9-13(20(23)24)14(22)10-16(15)26-21/h4,6,8-11,17,27H,2-3,5,7H2,1H3,(H3,23,24)(H,25,26)/t11-,17-/m0/s1
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1.10E+3 -33.7n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


J Mol Biol 344: 527-47 (2004)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2V40SF3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM14481
PNG
(CA-23 | [amino({5-[(3,4-dihydroxynaphthalene-2-)am...)
Show SMILES NC(N)=[NH+]c1ccc(NC(=O)c2cc3ccccc3c(O)c2O)cn1
Show InChI InChI=1S/C17H15N5O3/c18-17(19)22-13-6-5-10(8-20-13)21-16(25)12-7-9-3-1-2-4-11(9)14(23)15(12)24/h1-8,23-24H,(H,21,25)(H4,18,19,20,22)/p+1
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4.00E+3 -30.5n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


J Mol Biol 344: 527-47 (2004)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2V40SF3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM14333
PNG
(2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benz...)
Show SMILES NC(=[NH2+])c1cc2nc([nH]c2cc1F)-c1cccc(-c2ccccc2)c1[O-]
Show InChI InChI=1S/C20H15FN4O/c21-15-10-17-16(9-14(15)19(22)23)24-20(25-17)13-8-4-7-12(18(13)26)11-5-2-1-3-6-11/h1-10,26H,(H3,22,23)(H,24,25)
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6.40E+3 -29.3n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


J Mol Biol 344: 527-47 (2004)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2V40SF3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM233005
PNG
(H-D-Ser-Ala-Arg-NH-(CH2)5-NH2 (4))
Show SMILES C[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCCCCN
Show InChI InChI=1S/C17H36N8O4/c1-11(24-15(28)12(19)10-26)14(27)25-13(6-5-9-23-17(20)21)16(29)22-8-4-2-3-7-18/h11-13,26H,2-10,18-19H2,1H3,(H,22,29)(H,24,28)(H,25,27)(H4,20,21,23)/t11-,12-,13-/m0/s1
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3.70E+4n/an/an/an/an/an/a7.4n/a



Medical University of Bialystok



Assay Description
Determination of amidolytic activity was performed as described previously [Okada et al., Chem. Pharm. Bull., 36:1289-1297]. Detailed description of ...


J Enzyme Inhib Med Chem 25: 139-42 (2010)


Article DOI: 10.3109/14756360903049042
BindingDB Entry DOI: 10.7270/Q23R0RR3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM14483
PNG
(2-amino-5-[(2-hydroxy-3-phenylbenzene)amido]-1H-1,...)
Show SMILES Nc1[nH]c2ccc(NC(=O)c3cccc(-c4ccccc4)c3O)cc2[nH+]1
Show InChI InChI=1S/C20H16N4O2/c21-20-23-16-10-9-13(11-17(16)24-20)22-19(26)15-8-4-7-14(18(15)25)12-5-2-1-3-6-12/h1-11,25H,(H,22,26)(H3,21,23,24)/p+1
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>7.50E+4>-23.3n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


J Mol Biol 344: 527-47 (2004)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2V40SF3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM14482
PNG
(2-amino-5-[(3-hydroxynaphthalene-2-)amido]-1H-1,3-...)
Show SMILES Nc1[nH]c2ccc(NC(=O)c3cc4ccccc4cc3O)cc2[nH+]1
Show InChI InChI=1S/C18H14N4O2/c19-18-21-14-6-5-12(9-15(14)22-18)20-17(24)13-7-10-3-1-2-4-11(10)8-16(13)23/h1-9,23H,(H,20,24)(H3,19,21,22)/p+1
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>7.50E+4>-23.3n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


J Mol Biol 344: 527-47 (2004)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2V40SF3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM233009
PNG
(H-D-Ser-Ala-Arg-NH-(CH2)9-NH2 (8))
Show SMILES C[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCCCCCCCCN
Show InChI InChI=1S/C21H44N8O4/c1-15(28-19(32)16(23)14-30)18(31)29-17(10-9-13-27-21(24)25)20(33)26-12-8-6-4-2-3-5-7-11-22/h15-17,30H,2-14,22-23H2,1H3,(H,26,33)(H,28,32)(H,29,31)(H4,24,25,27)/t15-,16-,17-/m0/s1
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9.00E+4n/an/an/an/an/an/a7.4n/a



Medical University of Bialystok



Assay Description
Determination of amidolytic activity was performed as described previously [Okada et al., Chem. Pharm. Bull., 36:1289-1297]. Detailed description of ...


J Enzyme Inhib Med Chem 25: 139-42 (2010)


Article DOI: 10.3109/14756360903049042
BindingDB Entry DOI: 10.7270/Q23R0RR3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM14480
PNG
(CA-22 | [amino({4-[(3-hydroxynaphthalene-2-)amido]...)
Show SMILES NC(N)=[NH+]c1ccc(NC(=O)c2cc3ccccc3cc2O)cc1
Show InChI InChI=1S/C18H16N4O2/c19-18(20)22-14-7-5-13(6-8-14)21-17(24)15-9-11-3-1-2-4-12(11)10-16(15)23/h1-10,23H,(H,21,24)(H4,19,20,22)/p+1
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1.30E+5 -22.0n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


J Mol Biol 344: 527-47 (2004)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2V40SF3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM14479
PNG
(CA-21 | [amino({5-[(3-hydroxynaphthalene-2-)amido]...)
Show SMILES NC(N)=[NH+]c1ccc(NC(=O)c2cc3ccccc3cc2O)cn1
Show InChI InChI=1S/C17H15N5O2/c18-17(19)22-15-6-5-12(9-20-15)21-16(24)13-7-10-3-1-2-4-11(10)8-14(13)23/h1-9,23H,(H,21,24)(H4,18,19,20,22)/p+1
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1.30E+5 -22.0n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


J Mol Biol 344: 527-47 (2004)


Article DOI: 10.1016/j.jmb.2004.09.032
BindingDB Entry DOI: 10.7270/Q2V40SF3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM233006
PNG
(H-D-Ser-Ala-Arg-NH-(CH2)6-NH2 (5))
Show SMILES C[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCCCCCN
Show InChI InChI=1S/C18H38N8O4/c1-12(25-16(29)13(20)11-27)15(28)26-14(7-6-10-24-18(21)22)17(30)23-9-5-3-2-4-8-19/h12-14,27H,2-11,19-20H2,1H3,(H,23,30)(H,25,29)(H,26,28)(H4,21,22,24)/t12-,13-,14-/m0/s1
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1.81E+5n/an/an/an/an/an/a7.4n/a



Medical University of Bialystok



Assay Description
Determination of amidolytic activity was performed as described previously [Okada et al., Chem. Pharm. Bull., 36:1289-1297]. Detailed description of ...


J Enzyme Inhib Med Chem 25: 139-42 (2010)


Article DOI: 10.3109/14756360903049042
BindingDB Entry DOI: 10.7270/Q23R0RR3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM233007
PNG
(H-D-Ser-Ala-Arg-NH-(CH2)7-NH2 (6))
Show SMILES C[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCCCCCCN
Show InChI InChI=1S/C19H40N8O4/c1-13(26-17(30)14(21)12-28)16(29)27-15(8-7-11-25-19(22)23)18(31)24-10-6-4-2-3-5-9-20/h13-15,28H,2-12,20-21H2,1H3,(H,24,31)(H,26,30)(H,27,29)(H4,22,23,25)/t13-,14-,15-/m0/s1
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3.64E+5n/an/an/an/an/an/a7.4n/a



Medical University of Bialystok



Assay Description
Determination of amidolytic activity was performed as described previously [Okada et al., Chem. Pharm. Bull., 36:1289-1297]. Detailed description of ...


J Enzyme Inhib Med Chem 25: 139-42 (2010)


Article DOI: 10.3109/14756360903049042
BindingDB Entry DOI: 10.7270/Q23R0RR3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM233012
PNG
(H-D-Ser-Ala-Arg-NH-(CH2)4-OH (11))
Show SMILES C[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCCCO
Show InChI InChI=1S/C16H33N7O5/c1-10(22-14(27)11(17)9-25)13(26)23-12(5-4-7-21-16(18)19)15(28)20-6-2-3-8-24/h10-12,24-25H,2-9,17H2,1H3,(H,20,28)(H,22,27)(H,23,26)(H4,18,19,21)/t10-,11-,12-/m0/s1
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5.45E+5n/an/an/an/an/an/a7.4n/a



Medical University of Bialystok



Assay Description
Determination of amidolytic activity was performed as described previously [Okada et al., Chem. Pharm. Bull., 36:1289-1297]. Detailed description of ...


J Enzyme Inhib Med Chem 25: 139-42 (2010)


Article DOI: 10.3109/14756360903049042
BindingDB Entry DOI: 10.7270/Q23R0RR3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM233010
PNG
(H-D-Ser-Ala-Arg-NH-(CH2)2-OH (9))
Show SMILES C[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCO
Show InChI InChI=1S/C14H29N7O5/c1-8(20-12(25)9(15)7-23)11(24)21-10(13(26)18-5-6-22)3-2-4-19-14(16)17/h8-10,22-23H,2-7,15H2,1H3,(H,18,26)(H,20,25)(H,21,24)(H4,16,17,19)/t8-,9-,10-/m0/s1
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7.27E+5n/an/an/an/an/an/a7.4n/a



Medical University of Bialystok



Assay Description
Determination of amidolytic activity was performed as described previously [Okada et al., Chem. Pharm. Bull., 36:1289-1297]. Detailed description of ...


J Enzyme Inhib Med Chem 25: 139-42 (2010)


Article DOI: 10.3109/14756360903049042
BindingDB Entry DOI: 10.7270/Q23R0RR3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM233011
PNG
(H-D-Ser-Ala-Arg-NH-(CH2)3-OH (10))
Show SMILES C[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCCO
Show InChI InChI=1S/C15H31N7O5/c1-9(21-13(26)10(16)8-24)12(25)22-11(4-2-5-20-15(17)18)14(27)19-6-3-7-23/h9-11,23-24H,2-8,16H2,1H3,(H,19,27)(H,21,26)(H,22,25)(H4,17,18,20)/t9-,10-,11-/m0/s1
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1.09E+6n/an/an/an/an/an/a7.4n/a



Medical University of Bialystok



Assay Description
Determination of amidolytic activity was performed as described previously [Okada et al., Chem. Pharm. Bull., 36:1289-1297]. Detailed description of ...


J Enzyme Inhib Med Chem 25: 139-42 (2010)


Article DOI: 10.3109/14756360903049042
BindingDB Entry DOI: 10.7270/Q23R0RR3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM14714
PNG
((2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimid...)
Show SMILES CCOc1cc(OCC)c(F)c(c1)[C@@H](Nc1ccc(C(N)=N)c(O)c1)C(=O)NS(=O)(=O)c1cccc(N)c1
Show InChI InChI=1S/C25H28FN5O6S/c1-3-36-16-12-19(22(26)21(13-16)37-4-2)23(30-15-8-9-18(24(28)29)20(32)11-15)25(33)31-38(34,35)17-7-5-6-14(27)10-17/h5-13,23,30,32H,3-4,27H2,1-2H3,(H3,28,29)(H,31,33)/t23-/m1/s1
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1.20E+3 -33.5n/an/an/an/an/a7.822



Genentech



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


J Biol Chem 280: 9160-9 (2005)


Article DOI: 10.1074/jbc.M409068200
BindingDB Entry DOI: 10.7270/Q2JM27W3
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM17295
PNG
(BIBT0871 | ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoyl...)
Show SMILES CCOC(=O)CO\N=C(\c1ccccn1)C1(CC1)c1ccc2n(C)c(CNc3ccc(cc3)C(N)=N)nc2c1
Show InChI InChI=1S/C29H31N7O3/c1-3-38-26(37)18-39-35-27(22-6-4-5-15-32-22)29(13-14-29)20-9-12-24-23(16-20)34-25(36(24)2)17-33-21-10-7-19(8-11-21)28(30)31/h4-12,15-16,33H,3,13-14,17-18H2,1-2H3,(H3,30,31)/b35-27-
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6.80E+3 -30.7n/an/an/an/an/a8.037



Boehringer Ingelheim Pharma KG



Assay Description
For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...


Structure 9: 29-37 (2001)


BindingDB Entry DOI: 10.7270/Q2028PTC
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM17297
PNG
(4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl...)
Show SMILES Cc1nc2ccccc2n1Cc1ccc2n(C)c(CNc3ccc(cc3)C(N)=N)nc2c1
Show InChI InChI=1S/C25H25N7/c1-16-29-20-5-3-4-6-23(20)32(16)15-17-7-12-22-21(13-17)30-24(31(22)2)14-28-19-10-8-18(9-11-19)25(26)27/h3-13,28H,14-15H2,1-2H3,(H3,26,27)
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9.20E+3 -29.9n/an/an/an/an/a8.037



Boehringer Ingelheim Pharma KG



Assay Description
For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...


Structure 9: 29-37 (2001)


BindingDB Entry DOI: 10.7270/Q2028PTC
More data for this
Ligand-Target Pair
Plasminogen


(Homo sapiens (human))
BDBM17298
PNG
(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Show SMILES Cn1c(CNc2ccc(cc2)C(N)=N)nc2cc(ccc12)C1(CC1)C(=O)N1CCCC1
Show InChI InChI=1S/C24H28N6O/c1-29-20-9-6-17(24(10-11-24)23(31)30-12-2-3-13-30)14-19(20)28-21(29)15-27-18-7-4-16(5-8-18)22(25)26/h4-9,14,27H,2-3,10-13,15H2,1H3,(H3,25,26)
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1.30E+4 -29.0n/an/an/an/an/a8.037



Boehringer Ingelheim Pharma KG



Assay Description
For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...


Structure 9: 29-37 (2001)


BindingDB Entry DOI: 10.7270/Q2028PTC
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Ligand-Target Pair