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Compile Data Set for Download or QSAR

Found 112 hits of ph data with Target = 'Platelet-derived growth factor receptor beta'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6619
PNG
(3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...)
Show SMILES O=C(Nc1ccccn1)Nc1cccc2C(=O)N3CCC[C@@H]3c12
Show InChI InChI=1S/C17H16N4O2/c22-16-11-5-3-6-12(15(11)13-7-4-10-21(13)16)19-17(23)20-14-8-1-2-9-18-14/h1-3,5-6,8-9,13H,4,7,10H2,(H2,18,19,20,23)/t13-/m1/s1
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Article
PubMed
n/an/a 5.00E+3n/an/an/an/a7.022



Banyu Tsukuba Research Institute



Assay Description
Src, Lck, Flt-1, ZAP, EGFR, FGFR1, and PFGFR-beta were assayed in the Merck research laboratory (Homogeneous proximity tyrosine kinase assays: scinti...


J Med Chem 44: 4628-40 (2001)


Article DOI: 10.1021/jm010326y
BindingDB Entry DOI: 10.7270/Q2BV7DS8
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4168
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7a | 7-Amino-3-(...)
Show SMILES Cn1c2cc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C15H11Cl2N3O/c1-20-12-6-13(18)19-7-8(12)5-9(15(20)21)14-10(16)3-2-4-11(14)17/h2-7H,1H3,(H2,18,19)
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PubMed
n/an/a 3.60E+3n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4169
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7b | 3-(2,6-Dich...)
Show SMILES CNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C16H13Cl2N3O/c1-19-14-7-13-9(8-20-14)6-10(16(22)21(13)2)15-11(17)4-3-5-12(15)18/h3-8H,1-2H3,(H,19,20)
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PubMed
n/an/a 8.00E+3n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4174
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7g | 3-(2,6-Dich...)
Show SMILES CCN(CC)CCCCCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H30Cl2N4O/c1-4-30(5-2)13-8-6-7-12-27-22-15-21-17(16-28-22)14-18(24(31)29(21)3)23-19(25)10-9-11-20(23)26/h9-11,14-16H,4-8,12-13H2,1-3H3,(H,27,28)
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PubMed
n/an/a 740n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4171
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7d | 3-(2,6-Dich...)
Show SMILES CCN(CC)CCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C21H24Cl2N4O/c1-4-27(5-2)10-9-24-19-12-18-14(13-25-19)11-15(21(28)26(18)3)20-16(22)7-6-8-17(20)23/h6-8,11-13H,4-5,9-10H2,1-3H3,(H,24,25)
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PubMed
n/an/a>5.00E+4n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4172
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7e | 3-(2,6-Dich...)
Show SMILES CCN(CC)CCCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C22H26Cl2N4O/c1-4-28(5-2)11-7-10-25-20-13-19-15(14-26-20)12-16(22(29)27(19)3)21-17(23)8-6-9-18(21)24/h6,8-9,12-14H,4-5,7,10-11H2,1-3H3,(H,25,26)
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PubMed
n/an/a 4.60E+3n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4173
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7f | 3-(2,6-Dich...)
Show SMILES CCN(CC)CCCCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H28Cl2N4O/c1-4-29(5-2)12-7-6-11-26-21-14-20-16(15-27-21)13-17(23(30)28(20)3)22-18(24)9-8-10-19(22)25/h8-10,13-15H,4-7,11-12H2,1-3H3,(H,26,27)
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PubMed
n/an/a 2.40E+3n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4170
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7c | 3-(2,6-Dich...)
Show SMILES CN(C)c1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C17H15Cl2N3O/c1-21(2)15-8-14-10(9-20-15)7-11(17(23)22(14)3)16-12(18)5-4-6-13(16)19/h4-9H,1-3H3
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PubMed
n/an/a>5.00E+4n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3050
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-...)
Show SMILES Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C14H10Cl2N4O/c1-20-12-7(6-18-14(17)19-12)5-8(13(20)21)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H2,17,18,19)
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PubMed
n/an/a 4.90E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3051
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 5 | N-[6-(...)
Show SMILES CC(=O)Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C16H12Cl2N4O2/c1-8(23)20-16-19-7-9-6-10(15(24)22(2)14(9)21-16)13-11(17)4-3-5-12(13)18/h3-7H,1-2H3,(H,19,20,21,23)
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PubMed
n/an/a 5.20E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3052
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 19 | 6-(2,...)
Show SMILES Cc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C15H11Cl2N3O/c1-8-18-7-9-6-10(15(21)20(2)14(9)19-8)13-11(16)4-3-5-12(13)17/h3-7H,1-2H3
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PubMed
n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3053
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 20 | 6-(2,...)
Show SMILES Cn1c2nc(=O)[nH]cc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C14H9Cl2N3O2/c1-19-12-7(6-17-14(21)18-12)5-8(13(19)20)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H,17,18,21)
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PubMed
n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3054
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 21 | 6-(2,...)
Show SMILES CNc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C15H12Cl2N4O/c1-18-15-19-7-8-6-9(14(22)21(2)13(8)20-15)12-10(16)4-3-5-11(12)17/h3-7H,1-2H3,(H,18,19,20)
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PubMed
n/an/a 6.20E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3055
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 22 | 6-(2,...)
Show SMILES CCNc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C16H14Cl2N4O/c1-3-19-16-20-8-9-7-10(15(23)22(2)14(9)21-16)13-11(17)5-4-6-12(13)18/h4-8H,3H2,1-2H3,(H,19,20,21)
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PubMed
n/an/a 4.00E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3787
PNG
(1-Phenylbenzimidazole deriv. 4 | 1-benzyl-1H-1,3-b...)
Show SMILES C(c1ccccc1)n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2/c1-2-6-12(7-3-1)10-16-11-15-13-8-4-5-9-14(13)16/h1-9,11H,10H2
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3788
PNG
(1-Phenylbenzimidazole deriv. 5 | 1-benzoyl-1H-1,3-...)
Show SMILES O=C(c1ccccc1)n1cnc2ccccc12
Show InChI InChI=1S/C14H10N2O/c17-14(11-6-2-1-3-7-11)16-10-15-12-8-4-5-9-13(12)16/h1-10H
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3789
PNG
(1-Phenylbenzimidazole Analog 6 | 2-phenyl-1H-1,3-b...)
Show SMILES c1ccc(cc1)-c1nc2ccccc2[nH]1
Show InChI InChI=1S/C13H10N2/c1-2-6-10(7-3-1)13-14-11-8-4-5-9-12(11)15-13/h1-9H,(H,14,15)
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3790
PNG
(1-Phenylbenzimidazole Analog 7 | 4-phenyl-2,3-dihy...)
Show SMILES C1CC(=Nc2ccccc2N1)c1ccccc1
Show InChI InChI=1S/C15H14N2/c1-2-6-12(7-3-1)13-10-11-16-14-8-4-5-9-15(14)17-13/h1-9,16H,10-11H2
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Article
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3791
PNG
(1-Phenylbenzimidazole deriv. 8 | 1-phenyl-1H-indol...)
Show SMILES c1cc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C14H11N/c1-2-7-13(8-3-1)15-11-10-12-6-4-5-9-14(12)15/h1-11H
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3792
PNG
(1-Phenylbenzimidazole deriv. 9 | 1-phenyl-1H-indaz...)
Show SMILES c1nn(-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C13H10N2/c1-2-7-12(8-3-1)15-13-9-5-4-6-11(13)10-14-15/h1-10H
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PubMed
n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3793
PNG
(1-Phenylbenzimidazole deriv. 10 | 1-phenyl-1H-1,2,...)
Show SMILES c1ccc(cc1)-n1nnc2ccccc12
Show InChI InChI=1S/C12H9N3/c1-2-6-10(7-3-1)15-12-9-5-4-8-11(12)13-14-15/h1-9H
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3794
PNG
(1-Phenylbenzimidazole 3 | 1-Phenylbenzimidazole de...)
Show SMILES c1nc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C13H10N2/c1-2-6-11(7-3-1)15-10-14-12-8-4-5-9-13(12)15/h1-10H
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PubMed
n/an/a 9.30E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3795
PNG
(1-(2-methylphenyl)-1H-1,3-benzodiazole | 1-Phenylb...)
Show SMILES Cc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2/c1-11-6-2-4-8-13(11)16-10-15-12-7-3-5-9-14(12)16/h2-10H,1H3
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PubMed
n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3796
PNG
(1-(2-Methoxyphenyl)benzimidazole Hydrochloride | 1...)
Show SMILES COc1ccccc1-n1cnc2ccccc12
Show InChI InChI=1S/C14H12N2O/c1-17-14-9-5-4-8-13(14)16-10-15-11-6-2-3-7-12(11)16/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 5457-65 (1998)


Article DOI: 10.1021/jm9804681
BindingDB Entry DOI: 10.7270/Q24T6GJC
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3794
PNG
(1-Phenylbenzimidazole 3 | 1-Phenylbenzimidazole de...)
Show SMILES c1nc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C13H10N2/c1-2-6-11(7-3-1)15-10-14-12-8-4-5-9-13(12)15/h1-10H
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n/an/a 9.30E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3839
PNG
(1-Phenylbenzimidazole 4 | 1-Phenylbenzimidazole de...)
Show SMILES Oc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-12-8-4-7-11-13(12)14-9-15(11)10-5-2-1-3-6-10/h1-9,16H
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n/an/a 1.40E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3848
PNG
(1-Phenylbenzimidazole deriv. 65 | 1-phenyl-1H-1,3-...)
Show SMILES Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-11-6-7-13-12(8-11)14-9-15(13)10-4-2-1-3-5-10/h1-9,16H
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n/an/a 440n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3847
PNG
(1-Phenylbenzimidazole deriv. 64 | 5-Substituted 1-...)
Show SMILES COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H12N2O/c1-17-12-7-8-14-13(9-12)15-10-16(14)11-5-3-2-4-6-11/h2-10H,1H3
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n/an/a 430n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3918
PNG
(5-Ethoxy-1-phenylbenzimidazole Hydrochloride | 5-S...)
Show SMILES CCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C15H14N2O/c1-2-18-13-8-9-15-14(10-13)16-11-17(15)12-6-4-3-5-7-12/h3-11H,2H2,1H3
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n/an/a 240n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3919
PNG
(1-Phenyl-5-propoxybenzimidazole Hydrochloride | 1-...)
Show SMILES CCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H16N2O/c1-2-10-19-14-8-9-16-15(11-14)17-12-18(16)13-6-4-3-5-7-13/h3-9,11-12H,2,10H2,1H3
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n/an/a 250n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3920
PNG
(1-phenyl-5-(propan-2-yloxy)-1H-1,3-benzodiazole | ...)
Show SMILES CC(C)Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H16N2O/c1-12(2)19-14-8-9-16-15(10-14)17-11-18(16)13-6-4-3-5-7-13/h3-12H,1-2H3
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n/an/a 3.10E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3921
PNG
(5-Butoxy-1-phenylbenzimidazole Hydrochloride | 5-S...)
Show SMILES CCCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C17H18N2O/c1-2-3-11-20-15-9-10-17-16(12-15)18-13-19(17)14-7-5-4-6-8-14/h4-10,12-13H,2-3,11H2,1H3
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n/an/a 1.30E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3922
PNG
(1-phenyl-5-(prop-2-en-1-yloxy)-1H-1,3-benzodiazole...)
Show SMILES C=CCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H14N2O/c1-2-10-19-14-8-9-16-15(11-14)17-12-18(16)13-6-4-3-5-7-13/h2-9,11-12H,1,10H2
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n/an/a 610n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3923
PNG
(4-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]butan-1-o...)
Show SMILES OCCCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C17H18N2O2/c20-10-4-5-11-21-15-8-9-17-16(12-15)18-13-19(17)14-6-2-1-3-7-14/h1-3,6-9,12-13,20H,4-5,10-11H2
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n/an/a 450n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3924
PNG
(5-(2,3-Epoxypropoxy)-1-phenylbenzimidazole | 5-(ox...)
Show SMILES C(Oc1ccc2n(cnc2c1)-c1ccccc1)C1CO1
Show InChI InChI=1S/C16H14N2O2/c1-2-4-12(5-3-1)18-11-17-15-8-13(6-7-16(15)18)19-9-14-10-20-14/h1-8,11,14H,9-10H2
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n/an/a 320n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3925
PNG
(3-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]propane-1...)
Show SMILES OCC(O)COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H16N2O3/c19-9-13(20)10-21-14-6-7-16-15(8-14)17-11-18(16)12-4-2-1-3-5-12/h1-8,11,13,19-20H,9-10H2
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n/an/a 310n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3926
PNG
(5-(2-Aminoethoxy)-1-phenylbenzimidazole Dihydrochl...)
Show SMILES NCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C15H15N3O/c16-8-9-19-13-6-7-15-14(10-13)17-11-18(15)12-4-2-1-3-5-12/h1-7,10-11H,8-9,16H2
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n/an/a 650n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3927
PNG
(5-Substituted 1-Phenylbenzimidazole 16 | 5-[2-(N,N...)
Show SMILES CN(C)CCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C17H19N3O/c1-19(2)10-11-21-15-8-9-17-16(12-15)18-13-20(17)14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3
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n/an/a 1.50E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3928
PNG
(5-Substituted 1-Phenylbenzimidazole 17 | 5-[3-(N,N...)
Show SMILES CN(C)CCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C18H21N3O/c1-20(2)11-6-12-22-16-9-10-18-17(13-16)19-14-21(18)15-7-4-3-5-8-15/h3-5,7-10,13-14H,6,11-12H2,1-2H3
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n/an/a 150n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3929
PNG
(5-Substituted 1-Phenylbenzimidazole 18 | 5-[4-(N,N...)
Show SMILES CN(C)CCCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C19H23N3O/c1-21(2)12-6-7-13-23-17-10-11-19-18(14-17)20-15-22(19)16-8-4-3-5-9-16/h3-5,8-11,14-15H,6-7,12-13H2,1-2H3
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n/an/a 160n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3930
PNG
(4-{2-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]ethyl}...)
Show SMILES C(CN1CCOCC1)Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C19H21N3O2/c1-2-4-16(5-3-1)22-15-20-18-14-17(6-7-19(18)22)24-13-10-21-8-11-23-12-9-21/h1-7,14-15H,8-13H2
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n/an/a 730n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3931
PNG
(4-{3-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]propyl...)
Show SMILES C(COc1ccc2n(cnc2c1)-c1ccccc1)CN1CCOCC1
Show InChI InChI=1S/C20H23N3O2/c1-2-5-17(6-3-1)23-16-21-19-15-18(7-8-20(19)23)25-12-4-9-22-10-13-24-14-11-22/h1-3,5-8,15-16H,4,9-14H2
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n/an/a 170n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3932
PNG
(4-{4-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]butyl}...)
Show SMILES C(CCN1CCOCC1)COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C21H25N3O2/c1-2-6-18(7-3-1)24-17-22-20-16-19(8-9-21(20)24)26-13-5-4-10-23-11-14-25-15-12-23/h1-3,6-9,16-17H,4-5,10-15H2
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n/an/a 270n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3933
PNG
(1-(4-Aminophenyl)-5-methoxybenzimidazole Dihydroch...)
Show SMILES COc1ccc2n(cnc2c1)-c1ccc(N)cc1
Show InChI InChI=1S/C14H13N3O/c1-18-12-6-7-14-13(8-12)16-9-17(14)11-4-2-10(15)3-5-11/h2-9H,15H2,1H3
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n/an/a 280n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3934
PNG
(1-phenyl-1H-1,3-benzodiazole-5-thiol | 5-Mercapto-...)
Show SMILES Sc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H10N2S/c16-11-6-7-13-12(8-11)14-9-15(13)10-4-2-1-3-5-10/h1-9,16H
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n/an/a 3.30E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
BindingDB Entry DOI: 10.7270/Q2W957B2
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3428
PNG
(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C18H18Cl2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 1.20E+3n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3429
PNG
(6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-...)
Show SMILES Nc1ncc2cc(c(N)nc2n1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C13H9Cl2N5/c14-8-2-1-3-9(15)10(8)7-4-6-5-18-13(17)20-12(6)19-11(7)16/h1-5H,(H4,16,17,18,19,20)
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n/an/a 1.60E+4n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3430
PNG
(6-(2,6-dichlorophenyl)-2-N-[3-(diethylamino)propyl...)
Show SMILES CCN(CC)CCCNc1ncc2cc(c(N)nc2n1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C20H24Cl2N6/c1-3-28(4-2)10-6-9-24-20-25-12-13-11-14(18(23)26-19(13)27-20)17-15(21)7-5-8-16(17)22/h5,7-8,11-12H,3-4,6,9-10H2,1-2H3,(H3,23,24,25,26,27)
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n/an/a 4.60E+4n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3431
PNG
(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[3-(diet...)
Show SMILES CCN(CC)CCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H33Cl2N7O/c1-6-34(7-2)13-9-12-28-23-29-15-16-14-17(20-18(26)10-8-11-19(20)27)22(30-21(16)31-23)32-24(35)33-25(3,4)5/h8,10-11,14-15H,6-7,9,12-13H2,1-5H3,(H3,28,29,30,31,32,33,35)
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n/an/a 660n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3432
PNG
(6-(2,6-dimethylphenyl)pyrido[2,3-d]pyrimidine-2,7-...)
Show SMILES Cc1cccc(C)c1-c1cc2cnc(N)nc2nc1N
Show InChI InChI=1S/C15H15N5/c1-8-4-3-5-9(2)12(8)11-6-10-7-18-15(17)20-14(10)19-13(11)16/h3-7H,1-2H3,(H4,16,17,18,19,20)
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n/an/a 2.90E+4n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
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