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Compile Data Set for Download or QSAR

Found 9 hits of ph data with Target = 'Prostaglandin E2 receptor EP4 subtype'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119448
PNG
(US8686018, 107)
Show SMILES C[C@H](NC(=O)c1c(nn(C)c1Oc1cccc(c1)C(F)(F)F)C(F)F)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30(2)20(16)34-15-5-3-4-14(10-15)22(25,26)27/h3-11,18H,1-2H3,(H,28,31)(H,32,33)/t11-/m0/s1
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8n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119450
PNG
(US8686018, 109)
Show SMILES Cn1nc(C(F)F)c(C(=O)NC2(CC2)c2ccc(cc2)C(O)=O)c1Oc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C23H18F5N3O4/c1-31-20(35-15-4-2-3-14(11-15)23(26,27)28)16(17(30-31)18(24)25)19(32)29-22(9-10-22)13-7-5-12(6-8-13)21(33)34/h2-8,11,18H,9-10H2,1H3,(H,29,32)(H,33,34)
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8n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119451
PNG
(US8686018, 110)
Show SMILES C[C@H](NC(=O)c1c(nn(C)c1Oc1cccc(OC(F)F)c1)C(F)F)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H19F4N3O5/c1-11(12-6-8-13(9-7-12)21(31)32)27-19(30)16-17(18(23)24)28-29(2)20(16)33-14-4-3-5-15(10-14)34-22(25)26/h3-11,18,22H,1-2H3,(H,27,30)(H,31,32)/t11-/m0/s1
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10n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119449
PNG
(US8686018, 108)
Show SMILES C[C@H](NC(=O)c1c(Oc2ccc(Cl)c(Cl)c2)n(C)nc1C(F)(F)F)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H16Cl2F3N3O4/c1-10(11-3-5-12(6-4-11)20(31)32)27-18(30)16-17(21(24,25)26)28-29(2)19(16)33-13-7-8-14(22)15(23)9-13/h3-10H,1-2H3,(H,27,30)(H,31,32)/t10-/m0/s1
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13n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119444
PNG
(US8686018, 103)
Show SMILES C[C@H](NC(=O)c1c(C)nn(C)c1Oc1cccc(c1)C(F)(F)F)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H20F3N3O4/c1-12(14-7-9-15(10-8-14)21(30)31)26-19(29)18-13(2)27-28(3)20(18)32-17-6-4-5-16(11-17)22(23,24)25/h4-12H,1-3H3,(H,26,29)(H,30,31)/t12-/m0/s1
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14n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119446
PNG
(US8686018, 105)
Show SMILES Cn1nc(c(C(=O)NC2(CC2)c2ccc(cc2)C(O)=O)c1Oc1cccc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H17F6N3O4/c1-32-19(36-15-4-2-3-14(11-15)22(24,25)26)16(17(31-32)23(27,28)29)18(33)30-21(9-10-21)13-7-5-12(6-8-13)20(34)35/h2-8,11H,9-10H2,1H3,(H,30,33)(H,34,35)
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16n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119452
PNG
(US8686018, 111)
Show SMILES C[C@H](NC(=O)c1c(nn(C)c1Oc1cccc(c1)C(F)F)C(F)F)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H19F4N3O4/c1-11(12-6-8-13(9-7-12)22(31)32)27-20(30)16-17(19(25)26)28-29(2)21(16)33-15-5-3-4-14(10-15)18(23)24/h3-11,18-19H,1-2H3,(H,27,30)(H,31,32)/t11-/m0/s1
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26n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119445
PNG
(US8686018, 104)
Show SMILES Cc1nn(C)c(Oc2cccc(c2)C(F)(F)F)c1C(=O)NC1(CC1)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C23H20F3N3O4/c1-13-18(19(30)27-22(10-11-22)15-8-6-14(7-9-15)21(31)32)20(29(2)28-13)33-17-5-3-4-16(12-17)23(24,25)26/h3-9,12H,10-11H2,1-2H3,(H,27,30)(H,31,32)
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43n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))
BDBM119447
PNG
(US8686018, 106)
Show SMILES C[C@H](NC(=O)c1c(Oc2cccc(Cl)c2)n(C)nc1C(F)F)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H18ClF2N3O4/c1-11(12-6-8-13(9-7-12)21(29)30)25-19(28)16-17(18(23)24)26-27(2)20(16)31-15-5-3-4-14(22)10-15/h3-11,18H,1-2H3,(H,25,28)(H,29,30)/t11-/m0/s1
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50n/an/an/an/an/an/a7.4n/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The radioligand EP4 binding assay was performed using ChemiScreen recombinant human EP4 receptor membrane preparations from Millipore, according to m...


US Patent US8686018 (2014)


BindingDB Entry DOI: 10.7270/Q2513WVM
More data for this
Ligand-Target Pair