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Compile Data Set for Download or QSAR

Found 6 hits of ph data with Target = 'Protein Kinase C, alpha'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Kinase C, alpha


(Bos taurus (bovine))
BDBM3003
PNG
(1,3-diphenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine |...)
Show SMILES Nc1ncnc2n(nc(-c3ccccc3)c12)-c1ccccc1
Show InChI InChI=1S/C17H13N5/c18-16-14-15(12-7-3-1-4-8-12)21-22(17(14)20-11-19-16)13-9-5-2-6-10-13/h1-11H,(H2,18,19,20)
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PubMed
n/an/a>1.00E+5n/an/an/an/a7.5n/a



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair
Protein Kinase C, alpha


(Bos taurus (bovine))
BDBM3004
PNG
(3-((3-Chlorophenyl)amino)-4,6-diamino-1H-pyrazolo[...)
Show SMILES Nc1nc(N)c2c(Nc3cccc(Cl)c3)[nH]nc2n1
Show InChI InChI=1S/C11H10ClN7/c12-5-2-1-3-6(4-5)15-9-7-8(13)16-11(14)17-10(7)19-18-9/h1-4H,(H6,13,14,15,16,17,18,19)
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n/an/a>1.00E+5n/an/an/an/a7.5n/a



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair
Protein Kinase C, alpha


(Bos taurus (bovine))
BDBM3008
PNG
(3,4-Bis((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]p...)
Show SMILES Clc1cccc(Nc2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)c1
Show InChI InChI=1S/C17H12Cl2N6/c18-10-3-1-5-12(7-10)22-15-14-16(21-9-20-15)24-25-17(14)23-13-6-2-4-11(19)8-13/h1-9H,(H3,20,21,22,23,24,25)
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n/an/a 5.90E+3n/an/an/an/a7.5n/a



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair
Protein Kinase C, alpha


(Bos taurus (bovine))
BDBM3006
PNG
(3,4-Di-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidine ...)
Show SMILES N(c1[nH]nc2ncnc(Nc3ccccc3)c12)c1ccccc1
Show InChI InChI=1S/C17H14N6/c1-3-7-12(8-4-1)20-15-14-16(19-11-18-15)22-23-17(14)21-13-9-5-2-6-10-13/h1-11H,(H3,18,19,20,21,22,23)
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n/an/a 6.90E+3n/an/an/an/a7.5n/a



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair
Protein Kinase C, alpha


(Bos taurus (bovine))
BDBM3007
PNG
(3-((3-Chlorophenyl)amino)-4-(phenylamino)-1H-pyraz...)
Show SMILES Clc1cccc(Nc2[nH]nc3ncnc(Nc4ccccc4)c23)c1
Show InChI InChI=1S/C17H13ClN6/c18-11-5-4-8-13(9-11)22-17-14-15(19-10-20-16(14)23-24-17)21-12-6-2-1-3-7-12/h1-10H,(H3,19,20,21,22,23,24)
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PubMed
n/an/a 7.80E+3n/an/an/an/a7.5n/a



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair
Protein Kinase C, alpha


(Bos taurus (bovine))
BDBM3005
PNG
(3-((3-Chlorophenyl)amino)-4-amino-1H-pyrazolo[3,4-...)
Show SMILES Nc1ncnc2n[nH]c(Nc3cccc(Cl)c3)c12
Show InChI InChI=1S/C11H9ClN6/c12-6-2-1-3-7(4-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
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n/an/a 2.40E+4n/an/an/an/a7.5n/a



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair