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Compile Data Set for Download or QSAR

Found 28 hits of ph data with Target = 'Protein farnesyltransferase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13307
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-{2-[(...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccc1
Show InChI InChI=1S/C25H27N7O2S/c1-29-18-25(28-20-29)35(33,34)32(16-22-6-4-3-5-7-22)13-12-31(17-24-15-27-19-30(24)2)23-10-8-21(14-26)9-11-23/h3-11,15,18-20H,12-13,16-17H2,1-2H3
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PubMed
n/an/a 25n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13373
PNG
((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17-,18-/m0/s1
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n/an/a 600n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13309
PNG
(N-(2-{(4-bromophenyl)[(1-methyl-1H-imidazol-5-yl)m...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(Br)cc1)Cc1ccccn1
Show InChI InChI=1S/C23H26BrN7O2S/c1-28-16-23(27-18-28)34(32,33)31(14-20-5-3-4-10-26-20)12-11-30(15-22-13-25-17-29(22)2)21-8-6-19(24)7-9-21/h3-10,13,16-18H,11-12,14-15H2,1-2H3
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n/an/a 83n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13310
PNG
(N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)m...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccn1
Show InChI InChI=1S/C24H26N8O2S/c1-29-17-24(28-19-29)35(33,34)32(15-21-5-3-4-10-27-21)12-11-31(16-23-14-26-18-30(23)2)22-8-6-20(13-25)7-9-22/h3-10,14,17-19H,11-12,15-16H2,1-2H3
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n/an/a 43n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13311
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Show SMILES Cc1ccccc1CN(CCN(Cc1cncn1C)c1ccc(cc1)C#N)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C26H29N7O2S/c1-21-6-4-5-7-23(21)16-33(36(34,35)26-18-30(2)20-29-26)13-12-32(17-25-15-28-19-31(25)3)24-10-8-22(14-27)9-11-24/h4-11,15,18-20H,12-13,16-17H2,1-3H3
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n/an/a 15.5n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13312
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[Biphenyl...)
Show SMILES Cc1ccccc1CN(CCN(Cc1cncn1C)c1ccc(cc1)-c1ccccc1)S(=O)(=O)c1cn(C)cn1
Show InChI InChI=1S/C31H34N6O2S/c1-25-9-7-8-12-28(25)20-37(40(38,39)31-22-34(2)24-33-31)18-17-36(21-30-19-32-23-35(30)3)29-15-13-27(14-16-29)26-10-5-4-6-11-26/h4-16,19,22-24H,17-18,20-21H2,1-3H3
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n/an/a>1.00E+3n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13313
PNG
(N-Benzyl-N-{2-[(4-cyanophenyl)-(3-methyl-3H-imidaz...)
Show SMILES Cn1cncc1CN(CCN(Cc1ccccc1)S(=O)(=O)c1ccccc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H27N5O2S/c1-30-22-29-19-26(30)21-31(25-14-12-23(18-28)13-15-25)16-17-32(20-24-8-4-2-5-9-24)35(33,34)27-10-6-3-7-11-27/h2-15,19,22H,16-17,20-21H2,1H3
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n/an/a 13n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13314
PNG
(5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccc1
Show InChI InChI=1S/C33H34N6O2S/c1-36(2)32-13-7-12-31-30(32)11-8-14-33(31)42(40,41)39(23-27-9-5-4-6-10-27)20-19-38(24-29-22-35-25-37(29)3)28-17-15-26(21-34)16-18-28/h4-18,22,25H,19-20,23-24H2,1-3H3
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n/an/a 180n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13315
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid {2-[(4-Cyano...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)CC1CCCCC1
Show InChI InChI=1S/C25H33N7O2S/c1-29-18-25(28-20-29)35(33,34)32(16-22-6-4-3-5-7-22)13-12-31(17-24-15-27-19-30(24)2)23-10-8-21(14-26)9-11-23/h8-11,15,18-20,22H,3-7,12-13,16-17H2,1-2H3
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n/an/a 7.5n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13316
PNG
(1-Methyl-1H-imidazole-4-sulfonic Acid Biphenyl-4-y...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C31H31N7O2S/c1-35-22-31(34-24-35)41(39,40)38(20-26-8-12-28(13-9-26)27-6-4-3-5-7-27)17-16-37(21-30-19-33-23-36(30)2)29-14-10-25(18-32)11-15-29/h3-15,19,22-24H,16-17,20-21H2,1-2H3
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n/an/a 880n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13317
PNG
(N-tert-butyl-2-({2-[(4-cyanophenyl)[(1-methyl-1H-i...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)CC(=O)NC(C)(C)C
Show InChI InChI=1S/C24H32N8O3S/c1-24(2,3)28-22(33)15-32(36(34,35)23-16-29(4)18-27-23)11-10-31(14-21-13-26-17-30(21)5)20-8-6-19(12-25)7-9-20/h6-9,13,16-18H,10-11,14-15H2,1-5H3,(H,28,33)
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n/an/a>1.00E+3n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13318
PNG
(N-(4-cyanobenzyl)-N-(2-{(4-cyanophenyl)[(1-methyl-...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccc(cc1)C#N
Show InChI InChI=1S/C26H26N8O2S/c1-31-18-26(30-20-31)37(35,36)34(16-23-5-3-21(13-27)4-6-23)12-11-33(17-25-15-29-19-32(25)2)24-9-7-22(14-28)8-10-24/h3-10,15,18-20H,11-12,16-17H2,1-2H3
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n/an/a 350n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13358
PNG
((2S)-2-{[(2R)-1-[(2S)-2-[(2R)-2-amino-3-sulfanylpr...)
Show SMILES CSCC[C@H](NC(=O)[C@H]1CC2CCCCC2N1C(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C22H38N4O5S2/c1-12(2)18(25-19(27)14(23)11-32)21(29)26-16-7-5-4-6-13(16)10-17(26)20(28)24-15(22(30)31)8-9-33-3/h12-18,32H,4-11,23H2,1-3H3,(H,24,28)(H,25,27)(H,30,31)/t13?,14-,15-,16?,17+,18-/m0/s1
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n/an/a 1.00E+3n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13359
PNG
((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(C)cc1C)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C24H38N4O5S2/c1-13(2)20(28-21(29)17(25)12-34)23(31)27-19(11-16-7-6-14(3)10-15(16)4)22(30)26-18(24(32)33)8-9-35-5/h6-7,10,13,17-20,34H,8-9,11-12,25H2,1-5H3,(H,26,30)(H,27,31)(H,28,29)(H,32,33)/t17-,18-,19-,20-/m0/s1
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n/an/a 2.20E+3n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13360
PNG
((2S)-2-[(2R)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](Cc1ccc(C)cc1C)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C24H38N4O5S2/c1-13(2)20(28-21(29)17(25)12-34)23(31)27-19(11-16-7-6-14(3)10-15(16)4)22(30)26-18(24(32)33)8-9-35-5/h6-7,10,13,17-20,34H,8-9,11-12,25H2,1-5H3,(H,26,30)(H,27,31)(H,28,29)(H,32,33)/t17-,18-,19+,20-/m0/s1
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n/an/a 4.30E+3n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13361
PNG
((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)c(C)c1C)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C24H38N4O6S2/c1-12(2)20(28-21(30)16(25)11-35)23(32)27-18(10-15-6-7-19(29)14(4)13(15)3)22(31)26-17(24(33)34)8-9-36-5/h6-7,12,16-18,20,29,35H,8-11,25H2,1-5H3,(H,26,31)(H,27,32)(H,28,30)(H,33,34)/t16-,17-,18-,20-/m0/s1
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n/an/a 100n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13362
PNG
((2S)-2-[(2R)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](Cc1ccc(O)c(C)c1C)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C24H38N4O6S2/c1-12(2)20(28-21(30)16(25)11-35)23(32)27-18(10-15-6-7-19(29)14(4)13(15)3)22(31)26-17(24(33)34)8-9-36-5/h6-7,12,16-18,20,29,35H,8-11,25H2,1-5H3,(H,26,31)(H,27,32)(H,28,30)(H,33,34)/t16-,17-,18+,20-/m0/s1
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n/an/a 4.30E+3n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13363
PNG
((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1cc(C)c(O)cc1C)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C24H38N4O6S2/c1-12(2)20(28-21(30)16(25)11-35)23(32)27-18(10-15-8-14(4)19(29)9-13(15)3)22(31)26-17(24(33)34)6-7-36-5/h8-9,12,16-18,20,29,35H,6-7,10-11,25H2,1-5H3,(H,26,31)(H,27,32)(H,28,30)(H,33,34)/t16-,17-,18-,20-/m0/s1
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n/an/a 2.50E+3n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13364
PNG
((2S)-2-[(2R)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](Cc1cc(C)c(O)cc1C)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C24H38N4O6S2/c1-12(2)20(28-21(30)16(25)11-35)23(32)27-18(10-15-8-14(4)19(29)9-13(15)3)22(31)26-17(24(33)34)6-7-36-5/h8-9,12,16-18,20,29,35H,6-7,10-11,25H2,1-5H3,(H,26,31)(H,27,32)(H,28,30)(H,33,34)/t16-,17-,18+,20-/m0/s1
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n/an/a 1.05E+4n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13365
PNG
((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C23H36N4O6S2/c1-12(2)19(27-20(29)16(24)11-34)22(31)26-18(10-14-5-6-15(28)9-13(14)3)21(30)25-17(23(32)33)7-8-35-4/h5-6,9,12,16-19,28,34H,7-8,10-11,24H2,1-4H3,(H,25,30)(H,26,31)(H,27,29)(H,32,33)/t16-,17-,18-,19-/m0/s1
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n/an/a 4.30E+3n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13366
PNG
((2S)-2-[(2R)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O
Show InChI InChI=1S/C23H36N4O6S2/c1-12(2)19(27-20(29)16(24)11-34)22(31)26-18(10-14-5-6-15(28)9-13(14)3)21(30)25-17(23(32)33)7-8-35-4/h5-6,9,12,16-19,28,34H,7-8,10-11,24H2,1-4H3,(H,25,30)(H,26,31)(H,27,29)(H,32,33)/t16-,17-,18+,19-/m0/s1
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n/an/a 1.14E+4n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13367
PNG
((2S)-2-[(2S)-3-(4-hydroxy-2,3-dimethylphenyl)-2-[(...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)c(C)c1C)NC(=O)[C@@H](NC(=O)[C@H](CS)NC=O)C(C)C)C(O)=O
Show InChI InChI=1S/C25H38N4O7S2/c1-13(2)21(29-23(33)19(11-37)26-12-30)24(34)28-18(10-16-6-7-20(31)15(4)14(16)3)22(32)27-17(25(35)36)8-9-38-5/h6-7,12-13,17-19,21,31,37H,8-11H2,1-5H3,(H,26,30)(H,27,32)(H,28,34)(H,29,33)(H,35,36)/t17-,18-,19-,21-/m0/s1
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n/an/a 1.03E+4n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13368
PNG
((2S)-2-[(2R)-3-(4-hydroxy-2,3-dimethylphenyl)-2-[(...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](Cc1ccc(O)c(C)c1C)NC(=O)[C@@H](NC(=O)[C@H](CS)NC=O)C(C)C)C(O)=O
Show InChI InChI=1S/C25H38N4O7S2/c1-13(2)21(29-23(33)19(11-37)26-12-30)24(34)28-18(10-16-6-7-20(31)15(4)14(16)3)22(32)27-17(25(35)36)8-9-38-5/h6-7,12-13,17-19,21,31,37H,8-11H2,1-5H3,(H,26,30)(H,27,32)(H,28,34)(H,29,33)(H,35,36)/t17-,18+,19-,21-/m0/s1
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n/an/a>1.00E+5n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13369
PNG
((2S)-2-[(2S)-3-(4-hydroxy-2,5-dimethylphenyl)-2-[(...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1cc(C)c(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CS)NC=O)C(C)C)C(O)=O
Show InChI InChI=1S/C25H38N4O7S2/c1-13(2)21(29-23(33)19(11-37)26-12-30)24(34)28-18(10-16-8-15(4)20(31)9-14(16)3)22(32)27-17(25(35)36)6-7-38-5/h8-9,12-13,17-19,21,31,37H,6-7,10-11H2,1-5H3,(H,26,30)(H,27,32)(H,28,34)(H,29,33)(H,35,36)/t17-,18-,19-,21-/m0/s1
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n/an/a 5.50E+3n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13370
PNG
((2S)-2-[(2R)-3-(4-hydroxy-2,5-dimethylphenyl)-2-[(...)
Show SMILES CSCC[C@H](NC(=O)[C@@H](Cc1cc(C)c(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CS)NC=O)C(C)C)C(O)=O
Show InChI InChI=1S/C25H38N4O7S2/c1-13(2)21(29-23(33)19(11-37)26-12-30)24(34)28-18(10-16-8-15(4)20(31)9-14(16)3)22(32)27-17(25(35)36)6-7-38-5/h8-9,12-13,17-19,21,31,37H,6-7,10-11H2,1-5H3,(H,26,30)(H,27,32)(H,28,34)(H,29,33)(H,35,36)/t17-,18+,19-,21-/m0/s1
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n/an/a 1.02E+4n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13371
PNG
(CAAX Analogue 14 | Compound XIV | methyl (2S)-2-[(...)
Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)c(C)c1C)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C
Show InChI InChI=1S/C25H40N4O6S2/c1-13(2)21(29-22(31)17(26)12-36)24(33)28-19(11-16-7-8-20(30)15(4)14(16)3)23(32)27-18(9-10-37-6)25(34)35-5/h7-8,13,17-19,21,30,36H,9-12,26H2,1-6H3,(H,27,32)(H,28,33)(H,29,31)/t17-,18-,19-,21-/m0/s1
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n/an/a 2.04E+4n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Bos taurus (bovine))
BDBM13372
PNG
(CAAX Analogue 15 | Compound XV | methyl (2S)-2-[(2...)
Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@@H](Cc1ccc(O)c(C)c1C)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C
Show InChI InChI=1S/C25H40N4O6S2/c1-13(2)21(29-22(31)17(26)12-36)24(33)28-19(11-16-7-8-20(30)15(4)14(16)3)23(32)27-18(9-10-37-6)25(34)35-5/h7-8,13,17-19,21,30,36H,9-12,26H2,1-6H3,(H,27,32)(H,28,33)(H,29,31)/t17-,18-,19+,21-/m0/s1
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n/an/a 7.05E+4n/an/an/an/a7.537



Universita di Napoli Federico II



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 1882-90 (2006)


Article DOI: 10.1021/jm0506165
BindingDB Entry DOI: 10.7270/Q22V2DCH
More data for this
Ligand-Target Pair
Protein farnesyltransferase


(Rattus norvegicus (rat))
BDBM13308
PNG
(N-benzyl-N-(2-{(4-bromophenyl)[(1-methyl-1H-imidaz...)
Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(Br)cc1)Cc1ccccc1
Show InChI InChI=1S/C24H27BrN6O2S/c1-28-17-24(27-19-28)34(32,33)31(15-20-6-4-3-5-7-20)13-12-30(16-23-14-26-18-29(23)2)22-10-8-21(25)9-11-22/h3-11,14,17-19H,12-13,15-16H2,1-2H3
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n/an/a 290n/an/an/an/a7.537



Yale University



Assay Description
Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...


J Med Chem 49: 5710-27 (2006)


Article DOI: 10.1021/jm060081v
BindingDB Entry DOI: 10.7270/Q2G44NJW
More data for this
Ligand-Target Pair