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Compile Data Set for Download or QSAR

Found 8 hits of ph data with Target = 'Protein-Tyrosine Phosphatase SHP-1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-Tyrosine Phosphatase SHP-1


(Homo sapiens (human))
BDBM24531
PNG
((3Z)-3-[2-(2-nitrophenyl)hydrazin-1-ylidene]-2-oxo...)
Show SMILES OS([O-])(=O)=c1ccc2[nH+]c(=O)\c(=N/Nc3ccccc3[N+]([O-])=O)c2c1
Show InChI InChI=1S/C14H10N4O6S/c19-14-13(17-16-11-3-1-2-4-12(11)18(20)21)9-7-8(25(22,23)24)5-6-10(9)15-14/h1-7,16H,(H2,22,23,24)/b17-13-
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Article
PubMed
n/an/a 6.80E+4n/an/an/an/a7.022



Moffitt Cancer Center



Assay Description
PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...


J Med Chem 51: 4948-56 (2008)


Article DOI: 10.1021/jm8002526
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
More data for this
Ligand-Target Pair
Protein-Tyrosine Phosphatase SHP-1


(Homo sapiens (human))
BDBM24533
PNG
((3Z)-3-[2-(2-carboxyphenyl)hydrazin-1-ylidene]-2-o...)
Show SMILES OC(=O)c1ccc2NC(=O)C(=NNc3ccccc3C(O)=O)c2c1
Show InChI InChI=1S/C16H11N3O5/c20-14-13(10-7-8(15(21)22)5-6-11(10)17-14)19-18-12-4-2-1-3-9(12)16(23)24/h1-7,18H,(H,21,22)(H,23,24)(H,17,19,20)
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Article
PubMed
n/an/a 1.54E+4n/an/an/an/a7.022



Moffitt Cancer Center



Assay Description
PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...


J Med Chem 51: 4948-56 (2008)


Article DOI: 10.1021/jm8002526
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
More data for this
Ligand-Target Pair
Protein-Tyrosine Phosphatase SHP-1


(Homo sapiens (human))
BDBM24534
PNG
((3Z)-3-[2-(3-carboxyphenyl)hydrazin-1-ylidene]-2-o...)
Show SMILES OC(=O)c1ccc2NC(=O)C(=NNc3cccc(c3)C(O)=O)c2c1
Show InChI InChI=1S/C16H11N3O5/c20-14-13(11-7-9(16(23)24)4-5-12(11)17-14)19-18-10-3-1-2-8(6-10)15(21)22/h1-7,18H,(H,21,22)(H,23,24)(H,17,19,20)
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Article
PubMed
n/an/a 7.25E+4n/an/an/an/a7.022



Moffitt Cancer Center



Assay Description
PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...


J Med Chem 51: 4948-56 (2008)


Article DOI: 10.1021/jm8002526
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
More data for this
Ligand-Target Pair
Protein-Tyrosine Phosphatase SHP-1


(Homo sapiens (human))
BDBM24539
PNG
((3Z)-N-[(4-chlorophenyl)methyl]-3-[2-(2-nitropheny...)
Show SMILES [O-][N+](=O)c1ccccc1NN=C1C(=O)Nc2ccc(cc12)S(=O)(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H16ClN5O5S/c22-14-7-5-13(6-8-14)12-23-33(31,32)15-9-10-17-16(11-15)20(21(28)24-17)26-25-18-3-1-2-4-19(18)27(29)30/h1-11,23,25H,12H2,(H,24,26,28)
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Article
PubMed
n/an/a 4.09E+4n/an/an/an/a7.022



Moffitt Cancer Center



Assay Description
PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...


J Med Chem 51: 4948-56 (2008)


Article DOI: 10.1021/jm8002526
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
More data for this
Ligand-Target Pair
Protein-Tyrosine Phosphatase SHP-1


(Homo sapiens (human))
BDBM24536
PNG
(3-{2-[(3Z)-2-oxo-5-(propan-2-ylsulfamoyl)-2,3-dihy...)
Show SMILES CC(C)NS(=O)(=O)c1ccc2NC(=O)C(=NNc3cccc(c3)C(O)=O)c2c1
Show InChI InChI=1S/C18H18N4O5S/c1-10(2)22-28(26,27)13-6-7-15-14(9-13)16(17(23)19-15)21-20-12-5-3-4-11(8-12)18(24)25/h3-10,20,22H,1-2H3,(H,24,25)(H,19,21,23)
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Article
PubMed
n/an/a 1.57E+4n/an/an/an/a7.022



Moffitt Cancer Center



Assay Description
PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...


J Med Chem 51: 4948-56 (2008)


Article DOI: 10.1021/jm8002526
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
More data for this
Ligand-Target Pair
Protein-Tyrosine Phosphatase SHP-1


(Homo sapiens (human))
BDBM24537
PNG
(4-{2-[(3Z)-2-oxo-5-(propan-2-ylsulfamoyl)-2,3-dihy...)
Show SMILES CC(C)NS(=O)(=O)c1ccc2NC(=O)C(=NNc3ccc(cc3)C(O)=O)c2c1
Show InChI InChI=1S/C18H18N4O5S/c1-10(2)22-28(26,27)13-7-8-15-14(9-13)16(17(23)19-15)21-20-12-5-3-11(4-6-12)18(24)25/h3-10,20,22H,1-2H3,(H,24,25)(H,19,21,23)
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Article
PubMed
n/an/a 2.77E+4n/an/an/an/a7.022



Moffitt Cancer Center



Assay Description
PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...


J Med Chem 51: 4948-56 (2008)


Article DOI: 10.1021/jm8002526
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
More data for this
Ligand-Target Pair
Protein-Tyrosine Phosphatase SHP-1


(Homo sapiens (human))
BDBM24538
PNG
((3Z)-3-[2-(2-nitrophenyl)hydrazin-1-ylidene]-2-oxo...)
Show SMILES NS(=O)(=O)c1ccc2NC(=O)C(=NNc3ccccc3[N+]([O-])=O)c2c1
Show InChI InChI=1S/C14H11N5O5S/c15-25(23,24)8-5-6-10-9(7-8)13(14(20)16-10)18-17-11-3-1-2-4-12(11)19(21)22/h1-7,17H,(H2,15,23,24)(H,16,18,20)
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Article
PubMed
n/an/a 1.04E+5n/an/an/an/a7.022



Moffitt Cancer Center



Assay Description
PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...


J Med Chem 51: 4948-56 (2008)


Article DOI: 10.1021/jm8002526
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
More data for this
Ligand-Target Pair
Protein-Tyrosine Phosphatase SHP-1


(Homo sapiens (human))
BDBM24535
PNG
(3-{2-[(3Z)-5-{[(4-chlorophenyl)methyl]carbamoyl}-2...)
Show SMILES OC(=O)c1cccc(NN=C2C(=O)Nc3ccc(cc23)C(=O)NCc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C23H17ClN4O4/c24-16-7-4-13(5-8-16)12-25-21(29)14-6-9-19-18(11-14)20(22(30)26-19)28-27-17-3-1-2-15(10-17)23(31)32/h1-11,27H,12H2,(H,25,29)(H,31,32)(H,26,28,30)
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Article
PubMed
n/an/a 1.94E+4n/an/an/an/a7.022



Moffitt Cancer Center



Assay Description
PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...


J Med Chem 51: 4948-56 (2008)


Article DOI: 10.1021/jm8002526
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8
More data for this
Ligand-Target Pair