BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 301 hits of ph data with Target = 'Proto-oncogene tyrosine-protein kinase Src'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6619
PNG
(3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...)
Show SMILES O=C(Nc1ccccn1)Nc1cccc2C(=O)N3CCC[C@@H]3c12
Show InChI InChI=1S/C17H16N4O2/c22-16-11-5-3-6-12(15(11)13-7-4-10-21(13)16)19-17(23)20-14-8-1-2-9-18-14/h1-3,5-6,8-9,13H,4,7,10H2,(H2,18,19,20,23)/t13-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a>5.00E+3n/an/an/an/a7.022



Banyu Tsukuba Research Institute



Assay Description
Src, Lck, Flt-1, ZAP, EGFR, FGFR1, and PFGFR-beta were assayed in the Merck research laboratory (Homogeneous proximity tyrosine kinase assays: scinti...


J Med Chem 44: 4628-40 (2001)


Article DOI: 10.1021/jm010326y
BindingDB Entry DOI: 10.7270/Q2BV7DS8
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12223
PNG
(AZD0530 analogue 1 | N-(2-Chloro-5-methoxyphenyl)-...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cccc(OC4CCN(C)CC4)c23)c1
Show InChI InChI=1S/C21H23ClN4O2/c1-26-10-8-14(9-11-26)28-19-5-3-4-17-20(19)21(24-13-23-17)25-18-12-15(27-2)6-7-16(18)22/h3-7,12-14H,8-11H2,1-2H3,(H,23,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 300n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12224
PNG
(AZD0530 analogue 2 | N-(2-chloro-5-methoxyphenyl)-...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cccc(OC4CCOCC4)c23)c1
Show InChI InChI=1S/C20H20ClN3O3/c1-25-14-5-6-15(21)17(11-14)24-20-19-16(22-12-23-20)3-2-4-18(19)27-13-7-9-26-10-8-13/h2-6,11-13H,7-10H2,1H3,(H,22,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 400n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12225
PNG
(AZD0530 analogue 3 | N-(5-Chloro-1,3-benzodioxol-4...)
Show SMILES CN1CCC(CC1)Oc1cccc2ncnc(Nc3c4OCOc4ccc3Cl)c12
Show InChI InChI=1S/C21H21ClN4O3/c1-26-9-7-13(8-10-26)29-16-4-2-3-15-18(16)21(24-11-23-15)25-19-14(22)5-6-17-20(19)28-12-27-17/h2-6,11,13H,7-10,12H2,1H3,(H,23,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12226
PNG
(AZD0530 analogue 4 | N-(2-Chloro-5-methoxyphenyl)-...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OC)cc(OCCCN4CCOCC4)c23)c1
Show InChI InChI=1S/C23H27ClN4O4/c1-29-16-4-5-18(24)19(12-16)27-23-22-20(25-15-26-23)13-17(30-2)14-21(22)32-9-3-6-28-7-10-31-11-8-28/h4-5,12-15H,3,6-11H2,1-2H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 230n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12227
PNG
(AZD0530 analogue 5 | N-(2-Chloro-5-methoxyphenyl)-...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OC)cc(OC4CCN(C)CC4)c23)c1
Show InChI InChI=1S/C22H25ClN4O3/c1-27-8-6-14(7-9-27)30-20-12-16(29-3)11-19-21(20)22(25-13-24-19)26-18-10-15(28-2)4-5-17(18)23/h4-5,10-14H,6-9H2,1-3H3,(H,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 30n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12228
PNG
(AZD0530 analogue 6 | N-(5-chloro-2H-1,3-benzodioxo...)
Show SMILES COc1cc(OC2CCN(C)CC2)c2c(Nc3c4OCOc4ccc3Cl)ncnc2c1
Show InChI InChI=1S/C22H23ClN4O4/c1-27-7-5-13(6-8-27)31-18-10-14(28-2)9-16-19(18)22(25-11-24-16)26-20-15(23)3-4-17-21(20)30-12-29-17/h3-4,9-11,13H,5-8,12H2,1-2H3,(H,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12229
PNG
(AZD0530 analogue 7 | CHEMBL200217 | N-(2-Chloro-5-...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)cc(OC4CCOCC4)c23)c1
Show InChI InChI=1S/C27H33ClN4O5/c1-33-20-3-4-22(28)23(15-20)31-27-26-24(29-18-30-27)16-21(17-25(26)37-19-5-11-34-12-6-19)36-10-2-7-32-8-13-35-14-9-32/h3-4,15-19H,2,5-14H2,1H3,(H,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 20n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12230
PNG
(AZD0530 analogue 8 | N-(2-chloro-5-methoxyphenyl)-...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)cc(OC4CCCCC4)c23)c1
Show InChI InChI=1S/C28H35ClN4O4/c1-34-21-8-9-23(29)24(16-21)32-28-27-25(30-19-31-28)17-22(18-26(27)37-20-6-3-2-4-7-20)36-13-5-10-33-11-14-35-15-12-33/h8-9,16-20H,2-7,10-15H2,1H3,(H,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 20n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12231
PNG
(AZD0530 analogue 9 | N-(2-chloro-5-methoxyphenyl)-...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)cc(OC4CCOC4)c23)c1
Show InChI InChI=1S/C26H31ClN4O5/c1-32-18-3-4-21(27)22(13-18)30-26-25-23(28-17-29-26)14-20(15-24(25)36-19-5-10-34-16-19)35-9-2-6-31-7-11-33-12-8-31/h3-4,13-15,17,19H,2,5-12,16H2,1H3,(H,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12232
PNG
(AZD0530 analogue 10 | CHEMBL381206 | N-(2-chloro-5...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)cc(OC(C)C)c23)c1
Show InChI InChI=1S/C25H31ClN4O4/c1-17(2)34-23-15-19(33-10-4-7-30-8-11-32-12-9-30)14-22-24(23)25(28-16-27-22)29-21-13-18(31-3)5-6-20(21)26/h5-6,13-17H,4,7-12H2,1-3H3,(H,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12233
PNG
(AZD0530 analogue 11 | N-(2H-1,3-benzodioxol-4-yl)-...)
Show SMILES C(COc1cc(OC2CCOCC2)c2c(Nc3cccc4OCOc34)ncnc2c1)CN1CCCC1
Show InChI InChI=1S/C27H32N4O5/c1-2-10-31(9-1)11-4-12-33-20-15-22-25(24(16-20)36-19-7-13-32-14-8-19)27(29-17-28-22)30-21-5-3-6-23-26(21)35-18-34-23/h3,5-6,15-17,19H,1-2,4,7-14,18H2,(H,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12234
PNG
(AZD0530 analogue 12 | N-(2H-1,3-benzodioxol-4-yl)-...)
Show SMILES COc1cc(OC2CCN(C)CC2)c2c(Nc3cccc4OCOc34)ncnc2c1
Show InChI InChI=1S/C22H24N4O4/c1-26-8-6-14(7-9-26)30-19-11-15(27-2)10-17-20(19)22(24-12-23-17)25-16-4-3-5-18-21(16)29-13-28-18/h3-5,10-12,14H,6-9,13H2,1-2H3,(H,23,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 150n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12235
PNG
(AZD0530 analogue 13 | N-(2,3-dihydro-1,4-benzodiox...)
Show SMILES COc1cc(OC2CCN(C)CC2)c2c(Nc3cccc4OCCOc34)ncnc2c1
Show InChI InChI=1S/C23H26N4O4/c1-27-8-6-15(7-9-27)31-20-13-16(28-2)12-18-21(20)23(25-14-24-18)26-17-4-3-5-19-22(17)30-11-10-29-19/h3-5,12-15H,6-11H2,1-2H3,(H,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 570n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12236
PNG
(AZD0530 analogue 14 | N-(2H-1,3-benzodioxol-4-yl)-...)
Show SMILES C(CN1CCCC1)Oc1cc(OC2CCOCC2)c2c(Nc3cccc4OCOc34)ncnc2c1
Show InChI InChI=1S/C26H30N4O5/c1-2-9-30(8-1)10-13-32-19-14-21-24(23(15-19)35-18-6-11-31-12-7-18)26(28-16-27-21)29-20-4-3-5-22-25(20)34-17-33-22/h3-5,14-16,18H,1-2,6-13,17H2,(H,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 80n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM27216
PNG
((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Show SMILES CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 240n/an/an/an/a7.44



ARIAD Pharmaceuticals



Assay Description
Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...


Chem Biol Drug Des 67: 46-57 (2006)


Article DOI: 10.1111/j.1747-0285.2005.00316.x
BindingDB Entry DOI: 10.7270/Q2M61HRQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50113707
PNG
(2,6,9-Trisubstitute purine, 2 | 2-(2-hydroxyethyla...)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(NCCO)nc12
Show InChI InChI=1S/C16H19ClN6O/c1-10(2)23-9-19-13-14(20-12-5-3-4-11(17)8-12)21-16(18-6-7-24)22-15(13)23/h3-5,8-10,24H,6-7H2,1-2H3,(H2,18,20,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.59E+3n/an/an/an/a7.44



ARIAD Pharmaceuticals



Assay Description
Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...


Chem Biol Drug Des 67: 46-57 (2006)


Article DOI: 10.1111/j.1747-0285.2005.00316.x
BindingDB Entry DOI: 10.7270/Q2M61HRQ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM81618
PNG
(2,6,9-Trisubstitute purine, 3)
Show SMILES OCCNc1nc(Nc2cccc(Cl)c2)c2ncn(CCc3cccc(O)c3)c2n1
Show InChI InChI=1S/C21H21ClN6O2/c22-15-4-2-5-16(12-15)25-19-18-20(27-21(26-19)23-8-10-29)28(13-24-18)9-7-14-3-1-6-17(30)11-14/h1-6,11-13,29-30H,7-10H2,(H2,23,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 25n/an/an/an/a7.44



ARIAD Pharmaceuticals



Assay Description
Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...


Chem Biol Drug Des 67: 46-57 (2006)


Article DOI: 10.1111/j.1747-0285.2005.00316.x
BindingDB Entry DOI: 10.7270/Q2M61HRQ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM81619
PNG
(2,6,9-Trisubstitute purine, 4)
Show SMILES OCCNc1nc(Nc2ccccc2)c2ncn(CCc3cccc(O)c3)c2n1
Show InChI InChI=1S/C21H22N6O2/c28-12-10-22-21-25-19(24-16-6-2-1-3-7-16)18-20(26-21)27(14-23-18)11-9-15-5-4-8-17(29)13-15/h1-8,13-14,28-29H,9-12H2,(H2,22,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 26n/an/an/an/a7.44



ARIAD Pharmaceuticals



Assay Description
Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...


Chem Biol Drug Des 67: 46-57 (2006)


Article DOI: 10.1111/j.1747-0285.2005.00316.x
BindingDB Entry DOI: 10.7270/Q2M61HRQ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM81620
PNG
(2,6,9-Trisubstitute purine, 5)
Show SMILES Oc1cccc(CCn2cnc3c(Nc4ccccc4)nc(nc23)C2CCCC2)c1
Show InChI InChI=1S/C24H25N5O/c30-20-12-6-7-17(15-20)13-14-29-16-25-21-23(26-19-10-2-1-3-11-19)27-22(28-24(21)29)18-8-4-5-9-18/h1-3,6-7,10-12,15-16,18,30H,4-5,8-9,13-14H2,(H,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 34n/an/an/an/a7.44



ARIAD Pharmaceuticals



Assay Description
Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...


Chem Biol Drug Des 67: 46-57 (2006)


Article DOI: 10.1111/j.1747-0285.2005.00316.x
BindingDB Entry DOI: 10.7270/Q2M61HRQ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50314074
PNG
(2,6,9-Trisubstitute purine, 6 (AP23464) | 3-(2-(2-...)
Show SMILES CP(C)(=O)c1ccc(Nc2nc(nc3n(CCc4cccc(O)c4)cnc23)C2CCCC2)cc1
Show InChI InChI=1S/C26H30N5O2P/c1-34(2,33)22-12-10-20(11-13-22)28-25-23-26(30-24(29-25)19-7-3-4-8-19)31(17-27-23)15-14-18-6-5-9-21(32)16-18/h5-6,9-13,16-17,19,32H,3-4,7-8,14-15H2,1-2H3,(H,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 0.450n/an/an/an/a7.44



ARIAD Pharmaceuticals



Assay Description
Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...


Chem Biol Drug Des 67: 46-57 (2006)


Article DOI: 10.1111/j.1747-0285.2005.00316.x
BindingDB Entry DOI: 10.7270/Q2M61HRQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM81621
PNG
(2,6,9-Trisubstitute purine, 7)
Show SMILES CC(C)n1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(NCCO)nc12
Show InChI InChI=1S/C17H24N6O6P2/c1-11(2)23-9-19-14-15(21-17(18-7-8-24)22-16(14)23)20-12-3-5-13(6-4-12)30(25,26)10-31(27,28)29/h3-6,9,11,24H,7-8,10H2,1-2H3,(H,25,26)(H2,27,28,29)(H2,18,20,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.11E+3n/an/an/an/a7.44



ARIAD Pharmaceuticals



Assay Description
Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...


Chem Biol Drug Des 67: 46-57 (2006)


Article DOI: 10.1111/j.1747-0285.2005.00316.x
BindingDB Entry DOI: 10.7270/Q2M61HRQ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM81622
PNG
(2,6,9-Trisubstitute purine, 8)
Show SMILES CC(C)n1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(NC3CCC(N)CC3)nc12
Show InChI InChI=1S/C21H31N7O5P2/c1-13(2)28-11-23-18-19(26-21(27-20(18)28)25-16-5-3-14(22)4-6-16)24-15-7-9-17(10-8-15)34(29,30)12-35(31,32)33/h7-11,13-14,16H,3-6,12,22H2,1-2H3,(H,29,30)(H2,31,32,33)(H2,24,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 239n/an/an/an/a7.44



ARIAD Pharmaceuticals



Assay Description
Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...


Chem Biol Drug Des 67: 46-57 (2006)


Article DOI: 10.1111/j.1747-0285.2005.00316.x
BindingDB Entry DOI: 10.7270/Q2M61HRQ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM81623
PNG
(2,6,9-Trisubstitute purine, 9 (AP23451))
Show SMILES CCn1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(NC3CCC(N)CC3)nc12
Show InChI InChI=1S/C20H29N7O5P2/c1-2-27-11-22-17-18(25-20(26-19(17)27)24-15-5-3-13(21)4-6-15)23-14-7-9-16(10-8-14)33(28,29)12-34(30,31)32/h7-11,13,15H,2-6,12,21H2,1H3,(H,28,29)(H2,30,31,32)(H2,23,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 67n/an/an/an/a7.44



ARIAD Pharmaceuticals



Assay Description
Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...


Chem Biol Drug Des 67: 46-57 (2006)


Article DOI: 10.1111/j.1747-0285.2005.00316.x
BindingDB Entry DOI: 10.7270/Q2M61HRQ
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3050
PNG
(2-Amino-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-...)
Show SMILES Cn1c2nc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C14H10Cl2N4O/c1-20-12-7(6-18-14(17)19-12)5-8(13(20)21)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H2,17,18,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 260n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3051
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 5 | N-[6-(...)
Show SMILES CC(=O)Nc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C16H12Cl2N4O2/c1-8(23)20-16-19-7-9-6-10(15(24)22(2)14(9)21-16)13-11(17)4-3-5-12(13)18/h3-7H,1-2H3,(H,19,20,21,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4.20E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3052
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 19 | 6-(2,...)
Show SMILES Cc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C15H11Cl2N3O/c1-8-18-7-9-6-10(15(21)20(2)14(9)19-8)13-11(16)4-3-5-12(13)17/h3-7H,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3053
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 20 | 6-(2,...)
Show SMILES Cn1c2nc(=O)[nH]cc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C14H9Cl2N3O2/c1-19-12-7(6-17-14(21)18-12)5-8(13(19)20)11-9(15)3-2-4-10(11)16/h2-6H,1H3,(H,17,18,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3054
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 21 | 6-(2,...)
Show SMILES CNc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C15H12Cl2N4O/c1-18-15-19-7-8-6-9(14(22)21(2)13(8)20-15)12-10(16)4-3-5-11(12)17/h3-7H,1-2H3,(H,18,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 750n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3055
PNG
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 22 | 6-(2,...)
Show SMILES CCNc1ncc2cc(-c3c(Cl)cccc3Cl)c(=O)n(C)c2n1
Show InChI InChI=1S/C16H14Cl2N4O/c1-3-19-16-20-8-9-7-10(15(23)22(2)14(9)21-16)13-11(17)5-4-6-12(13)18/h4-8H,3H2,1-2H3,(H,19,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 590n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 41: 3276-92 (1998)


Article DOI: 10.1021/jm9802259
BindingDB Entry DOI: 10.7270/Q27P8WK3
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3428
PNG
(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C18H18Cl2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 220n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3429
PNG
(6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-...)
Show SMILES Nc1ncc2cc(c(N)nc2n1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C13H9Cl2N5/c14-8-2-1-3-9(15)10(8)7-4-6-5-18-13(17)20-12(6)19-11(7)16/h1-5H,(H4,16,17,18,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 210n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3430
PNG
(6-(2,6-dichlorophenyl)-2-N-[3-(diethylamino)propyl...)
Show SMILES CCN(CC)CCCNc1ncc2cc(c(N)nc2n1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C20H24Cl2N6/c1-3-28(4-2)10-6-9-24-20-25-12-13-11-14(18(23)26-19(13)27-20)17-15(21)7-5-8-16(17)22/h5,7-8,11-12H,3-4,6,9-10H2,1-2H3,(H3,23,24,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 750n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3431
PNG
(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[3-(diet...)
Show SMILES CCN(CC)CCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H33Cl2N7O/c1-6-34(7-2)13-9-12-28-23-29-15-16-14-17(20-18(26)10-8-11-19(20)27)22(30-21(16)31-23)32-24(35)33-25(3,4)5/h8,10-11,14-15H,6-7,9,12-13H2,1-5H3,(H3,28,29,30,31,32,33,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 73n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3432
PNG
(6-(2,6-dimethylphenyl)pyrido[2,3-d]pyrimidine-2,7-...)
Show SMILES Cc1cccc(C)c1-c1cc2cnc(N)nc2nc1N
Show InChI InChI=1S/C15H15N5/c1-8-4-3-5-9(2)12(8)11-6-10-7-18-15(17)20-14(10)19-13(11)16/h3-7H,1-2H3,(H4,16,17,18,19,20)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 430n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3433
PNG
(1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyri...)
Show SMILES Cc1cccc(C)c1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O/c1-11-7-6-8-12(2)15(11)14-9-13-10-22-18(21)24-16(13)23-17(14)25-19(27)26-20(3,4)5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 110n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3434
PNG
(2-N-[3-(diethylamino)propyl]-6-(2,6-dimethylphenyl...)
Show SMILES CCN(CC)CCCNc1ncc2cc(c(N)nc2n1)-c1c(C)cccc1C
Show InChI InChI=1S/C22H30N6/c1-5-28(6-2)12-8-11-24-22-25-14-17-13-18(20(23)26-21(17)27-22)19-15(3)9-7-10-16(19)4/h7,9-10,13-14H,5-6,8,11-12H2,1-4H3,(H3,23,24,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 450n/an/an/an/a7.425



Pfizer



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 44: 1915-26 (2001)


Article DOI: 10.1021/jm0004291
BindingDB Entry DOI: 10.7270/Q29K48DG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6198
PNG
(AZD0530 analogue 35 | M475271 | Methoxy Aniline 7 ...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCC4CCN(C)CC4)c(OC)cc23)c1
Show InChI InChI=1S/C23H27ClN4O3/c1-28-8-6-15(7-9-28)13-31-22-12-19-17(11-21(22)30-3)23(26-14-25-19)27-20-10-16(29-2)4-5-18(20)24/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 10n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6199
PNG
(Benzofuran deriv. 8 | N-(1-Benzofuran-4-yl)-6-meth...)
Show SMILES COc1cc2c(Nc3cccc4occc34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C24H26N4O4/c1-29-22-14-18-20(15-23(22)31-10-3-7-28-8-12-30-13-9-28)25-16-26-24(18)27-19-4-2-5-21-17(19)6-11-32-21/h2,4-6,11,14-16H,3,7-10,12-13H2,1H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 16n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6200
PNG
(Benzofuran deriv. 9 | N-(5-Chloro-1-benzofuran-4-y...)
Show SMILES COc1cc2c(Nc3c(Cl)ccc4occc34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C24H25ClN4O4/c1-30-21-13-17-19(14-22(21)32-9-2-6-29-7-11-31-12-8-29)26-15-27-24(17)28-23-16-5-10-33-20(16)4-3-18(23)25/h3-5,10,13-15H,2,6-9,11-12H2,1H3,(H,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6201
PNG
(Benzofuran deriv. 10 | N-(1-Benzofuran-7-yl)-6-met...)
Show SMILES COc1cc2c(Nc3cccc4ccoc34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C24H26N4O4/c1-29-21-14-18-20(15-22(21)31-10-3-7-28-8-12-30-13-9-28)25-16-26-24(18)27-19-5-2-4-17-6-11-32-23(17)19/h2,4-6,11,14-16H,3,7-10,12-13H2,1H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 30n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6202
PNG
(Benzofuran deriv. 11 | N-(6-Chloro-1-benzofuran-7-...)
Show SMILES COc1cc2c(Nc3c(Cl)ccc4ccoc34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C24H25ClN4O4/c1-30-20-13-17-19(14-21(20)32-9-2-6-29-7-11-31-12-8-29)26-15-27-24(17)28-22-18(25)4-3-16-5-10-33-23(16)22/h3-5,10,13-15H,2,6-9,11-12H2,1H3,(H,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6203
PNG
(Benzofuran deriv. 12 | N-(2,3-Dihydro-1-benzofuran...)
Show SMILES COc1cc2c(Nc3cccc4CCOc34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C24H28N4O4/c1-29-21-14-18-20(15-22(21)31-10-3-7-28-8-12-30-13-9-28)25-16-26-24(18)27-19-5-2-4-17-6-11-32-23(17)19/h2,4-5,14-16H,3,6-13H2,1H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 433n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6204
PNG
(Benzofuran deriv. 13 | N-(3-Chloro-1-benzofuran-7-...)
Show SMILES COc1cc2c(Nc3cccc4c(Cl)coc34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C24H25ClN4O4/c1-30-21-12-17-20(13-22(21)32-9-3-6-29-7-10-31-11-8-29)26-15-27-24(17)28-19-5-2-4-16-18(25)14-33-23(16)19/h2,4-5,12-15H,3,6-11H2,1H3,(H,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6205
PNG
(Indole deriv. 14 | N-(1H-indol-4-yl)-6-methoxy-7-(...)
Show SMILES COc1cc2c(Nc3cccc4[nH]ccc34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C24H27N5O3/c1-30-22-14-18-21(15-23(22)32-11-3-8-29-9-12-31-13-10-29)26-16-27-24(18)28-20-5-2-4-19-17(20)6-7-25-19/h2,4-7,14-16,25H,3,8-13H2,1H3,(H,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 177n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6206
PNG
(6-Methoxy-N-(1-methyl-1H-indol-4-yl)-7-(3-morpholi...)
Show SMILES COc1cc2c(Nc3cccc4n(C)ccc34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C25H29N5O3/c1-29-9-7-18-20(5-3-6-22(18)29)28-25-19-15-23(31-2)24(16-21(19)26-17-27-25)33-12-4-8-30-10-13-32-14-11-30/h3,5-7,9,15-17H,4,8,10-14H2,1-2H3,(H,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6207
PNG
(Indole deriv. 16 | N-(1H-indol-7-yl)-6-methoxy-7-(...)
Show SMILES COc1cc2c(Nc3cccc4cc[nH]c34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C24H27N5O3/c1-30-21-14-18-20(15-22(21)32-11-3-8-29-9-12-31-13-10-29)26-16-27-24(18)28-19-5-2-4-17-6-7-25-23(17)19/h2,4-7,14-16,25H,3,8-13H2,1H3,(H,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 260n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6208
PNG
(Indole deriv. 17 | N-(3-Chloro-1H-indol-7-yl)-6-me...)
Show SMILES COc1cc2c(Nc3cccc4c(Cl)c[nH]c34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C24H26ClN5O3/c1-31-21-12-17-20(13-22(21)33-9-3-6-30-7-10-32-11-8-30)27-15-28-24(17)29-19-5-2-4-16-18(25)14-26-23(16)19/h2,4-5,12-15,26H,3,6-11H2,1H3,(H,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 20n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6209
PNG
(Benzodioxole deriv. 18 | N-(1,3-Benzodioxol-4-yl)-...)
Show SMILES COc1cc2c(Nc3cccc4OCOc34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C23H26N4O5/c1-28-20-12-16-18(13-21(20)30-9-3-6-27-7-10-29-11-8-27)24-14-25-23(16)26-17-4-2-5-19-22(17)32-15-31-19/h2,4-5,12-14H,3,6-11,15H2,1H3,(H,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6210
PNG
(Benzodioxole deriv. 19 | N-(5-Chloro-1,3-benzodiox...)
Show SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C23H25ClN4O5/c1-29-19-11-15-17(12-20(19)31-8-2-5-28-6-9-30-10-7-28)25-13-26-23(15)27-21-16(24)3-4-18-22(21)33-14-32-18/h3-4,11-13H,2,5-10,14H2,1H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 301 total )  |  Next  |  Last  >>
Jump to: