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Compile Data Set for Download or QSAR

Found 69 hits of ph data with Target = 'Serine/threonine-protein kinase AKT'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16211
PNG
(5-methyl-4-phenyl-1H-pyrazole | CHEMBL228114 | pyr...)
Show SMILES Cc1[nH]ncc1-c1ccccc1
Show InChI InChI=1S/C10H10N2/c1-8-10(7-11-12-8)9-5-3-2-4-6-9/h2-7H,1H3,(H,11,12)
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n/an/a 8.00E+4n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2293-2296 (2007)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2QV3JST
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16222
PNG
(CCT077373 | N-[2-({2-[(4-chlorobenzyl)oxy]ethyl}am...)
Show SMILES Clc1ccc(COCCNCCNS(=O)(=O)c2cccc3cnccc23)cc1
Show InChI InChI=1S/C20H22ClN3O3S/c21-18-6-4-16(5-7-18)15-27-13-12-22-10-11-24-28(25,26)20-3-1-2-17-14-23-9-8-19(17)20/h1-9,14,22,24H,10-13,15H2
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n/an/a 230n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Mol Biol 367: 882-94 (2007)


Article DOI: 10.1016/j.jmb.2007.01.004
BindingDB Entry DOI: 10.7270/Q29Z934H
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16213
PNG
(2-[4-(5-methyl-1H-pyrazol-4-yl)phenyl]ethan-1-amin...)
Show SMILES Cc1[nH]ncc1-c1ccc(CCN)cc1
Show InChI InChI=1S/C12H15N3/c1-9-12(8-14-15-9)11-4-2-10(3-5-11)6-7-13/h2-5,8H,6-7,13H2,1H3,(H,14,15)
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n/an/a 5.20E+3n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2293-2296 (2007)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2QV3JST
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16214
PNG
(3-[4-(1H-pyrazol-4-yl)phenyl]propan-1-amine | pyra...)
Show SMILES NCCCc1ccc(cc1)-c1cn[nH]c1
Show InChI InChI=1S/C12H15N3/c13-7-1-2-10-3-5-11(6-4-10)12-8-14-15-9-12/h3-6,8-9H,1-2,7,13H2,(H,14,15)
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n/an/a 3.00E+3n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2293-2296 (2007)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2QV3JST
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16215
PNG
(4-phenyl-1H-pyrazole | CHEMBL390066 | JMC514968 Co...)
Show SMILES c1n[nH]cc1-c1ccccc1
Show InChI InChI=1S/C9H8N2/c1-2-4-8(5-3-1)9-6-10-11-7-9/h1-7H,(H,10,11)
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n/an/a 1.35E+5n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2293-2296 (2007)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2QV3JST
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16216
PNG
(2-phenyl-2-[4-(1H-pyrazol-4-yl)phenyl]ethan-1-amin...)
Show SMILES NCC(c1ccccc1)c1ccc(cc1)-c1cn[nH]c1
Show InChI InChI=1S/C17H17N3/c18-10-17(14-4-2-1-3-5-14)15-8-6-13(7-9-15)16-11-19-20-12-16/h1-9,11-12,17H,10,18H2,(H,19,20)
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n/an/a 510n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2293-2296 (2007)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2QV3JST
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16217
PNG
(4-phenyl-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine |...)
Show SMILES C1CC(CCN1)(c1ccccc1)c1ccc(cc1)-c1cn[nH]c1
Show InChI InChI=1S/C20H21N3/c1-2-4-18(5-3-1)20(10-12-21-13-11-20)19-8-6-16(7-9-19)17-14-22-23-15-17/h1-9,14-15,21H,10-13H2,(H,22,23)
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n/an/a 200n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2293-2296 (2007)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2QV3JST
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16218
PNG
(2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]et...)
Show SMILES NCC(c1ccc(Cl)cc1)c1ccc(cc1)-c1cn[nH]c1
Show InChI InChI=1S/C17H16ClN3/c18-16-7-5-14(6-8-16)17(9-19)13-3-1-12(2-4-13)15-10-20-21-11-15/h1-8,10-11,17H,9,19H2,(H,20,21)
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n/an/a 31n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2293-2296 (2007)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2QV3JST
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16219
PNG
(4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]pi...)
Show SMILES Clc1ccc(cc1)C1(CCNCC1)c1ccc(cc1)-c1cn[nH]c1
Show InChI InChI=1S/C20H20ClN3/c21-19-7-5-18(6-8-19)20(9-11-22-12-10-20)17-3-1-15(2-4-17)16-13-23-24-14-16/h1-8,13-14,22H,9-12H2,(H,23,24)
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n/an/a 18n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2293-2296 (2007)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2QV3JST
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16220
PNG
((2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phen...)
Show SMILES NC[C@@H](c1ccc(Cl)cc1)c1ccc(cc1)-c1cn[nH]c1
Show InChI InChI=1S/C17H16ClN3/c18-16-7-5-14(6-8-16)17(9-19)13-3-1-12(2-4-13)15-10-20-21-11-15/h1-8,10-11,17H,9,19H2,(H,20,21)/t17-/m1/s1
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n/an/a 34n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2293-2296 (2007)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2QV3JST
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16221
PNG
((2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phen...)
Show SMILES NC[C@H](c1ccc(Cl)cc1)c1ccc(cc1)-c1cn[nH]c1
Show InChI InChI=1S/C17H16ClN3/c18-16-7-5-14(6-8-16)17(9-19)13-3-1-12(2-4-13)15-10-20-21-11-15/h1-8,10-11,17H,9,19H2,(H,20,21)/t17-/m0/s1
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n/an/a 280n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2293-2296 (2007)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2QV3JST
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15211
PNG
(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Show SMILES Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1
Show InChI InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+
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n/an/a 590n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2289-92 (2007)


Article DOI: 10.1021/jm0700924
BindingDB Entry DOI: 10.7270/Q2M32T1C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16222
PNG
(CCT077373 | N-[2-({2-[(4-chlorobenzyl)oxy]ethyl}am...)
Show SMILES Clc1ccc(COCCNCCNS(=O)(=O)c2cccc3cnccc23)cc1
Show InChI InChI=1S/C20H22ClN3O3S/c21-18-6-4-16(5-7-18)15-27-13-12-22-10-11-24-28(25,26)20-3-1-2-17-14-23-9-8-19(17)20/h1-9,14,22,24H,10-13,15H2
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n/an/a 260n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2289-92 (2007)


Article DOI: 10.1021/jm0700924
BindingDB Entry DOI: 10.7270/Q2M32T1C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16223
PNG
(1H-pyrrolo[2,3-b]pyridine | 7-azaindole | compound...)
Show SMILES c1cc2cccnc2[nH]1
Show InChI InChI=1S/C7H6N2/c1-2-6-3-5-9-7(6)8-4-1/h1-5H,(H,8,9)
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n/an/a>1.00E+5n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2289-92 (2007)


Article DOI: 10.1021/jm0700924
BindingDB Entry DOI: 10.7270/Q2M32T1C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16224
PNG
(6-phenylpurine compound 6 | N-methyl-1-[4-(9H-puri...)
Show SMILES CNCc1ccc(cc1)-c1ncnc2nc[nH]c12
Show InChI InChI=1S/C13H13N5/c1-14-6-9-2-4-10(5-3-9)11-12-13(17-7-15-11)18-8-16-12/h2-5,7-8,14H,6H2,1H3,(H,15,16,17,18)
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n/an/a 6.90E+3n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2289-92 (2007)


Article DOI: 10.1021/jm0700924
BindingDB Entry DOI: 10.7270/Q2M32T1C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16225
PNG
(6-phenylpurine compound 7 | N-methyl-1-[3-(9H-puri...)
Show SMILES CNCc1cccc(c1)-c1ncnc2nc[nH]c12
Show InChI InChI=1S/C13H13N5/c1-14-6-9-3-2-4-10(5-9)11-12-13(17-7-15-11)18-8-16-12/h2-5,7-8,14H,6H2,1H3,(H,15,16,17,18)
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n/an/a 1.60E+3n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2289-92 (2007)


Article DOI: 10.1021/jm0700924
BindingDB Entry DOI: 10.7270/Q2M32T1C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16226
PNG
(2-[4-(9H-purin-6-yl)phenyl]ethan-1-amine | 2-[4-(9...)
Show SMILES NCCc1ccc(cc1)-c1ncnc2nc[nH]c12
Show InChI InChI=1S/C13H13N5/c14-6-5-9-1-3-10(4-2-9)11-12-13(17-7-15-11)18-8-16-12/h1-4,7-8H,5-6,14H2,(H,15,16,17,18)
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n/an/a 9.50E+3n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2289-92 (2007)


Article DOI: 10.1021/jm0700924
BindingDB Entry DOI: 10.7270/Q2M32T1C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16227
PNG
(2-[3-(9H-purin-6-yl)phenyl]ethan-1-amine | 2-[3-(9...)
Show SMILES NCCc1cccc(c1)-c1ncnc2nc[nH]c12
Show InChI InChI=1S/C13H13N5/c14-5-4-9-2-1-3-10(6-9)11-12-13(17-7-15-11)18-8-16-12/h1-3,6-8H,4-5,14H2,(H,15,16,17,18)
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n/an/a 3.20E+3n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2289-92 (2007)


Article DOI: 10.1021/jm0700924
BindingDB Entry DOI: 10.7270/Q2M32T1C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16228
PNG
(1-phenyl-1-[4-(9H-purin-6-yl)phenyl]methanamine | ...)
Show SMILES NC(c1ccccc1)c1ccc(cc1)-c1ncnc2nc[nH]c12
Show InChI InChI=1S/C18H15N5/c19-15(12-4-2-1-3-5-12)13-6-8-14(9-7-13)16-17-18(22-10-20-16)23-11-21-17/h1-11,15H,19H2,(H,20,21,22,23)
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n/an/a 400n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2289-92 (2007)


Article DOI: 10.1021/jm0700924
BindingDB Entry DOI: 10.7270/Q2M32T1C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16229
PNG
(2-phenyl-1-[4-(9H-purin-6-yl)phenyl]ethan-1-amine ...)
Show SMILES NC(Cc1ccccc1)c1ccc(cc1)-c1ncnc2nc[nH]c12
Show InChI InChI=1S/C19H17N5/c20-16(10-13-4-2-1-3-5-13)14-6-8-15(9-7-14)17-18-19(23-11-21-17)24-12-22-18/h1-9,11-12,16H,10,20H2,(H,21,22,23,24)
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n/an/a 430n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2289-92 (2007)


Article DOI: 10.1021/jm0700924
BindingDB Entry DOI: 10.7270/Q2M32T1C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16230
PNG
((4-chlorophenyl)[4-(9H-purin-6-yl)phenyl]methanami...)
Show SMILES NC(c1ccc(Cl)cc1)c1ccc(cc1)-c1ncnc2nc[nH]c12
Show InChI InChI=1S/C18H14ClN5/c19-14-7-5-12(6-8-14)15(20)11-1-3-13(4-2-11)16-17-18(23-9-21-16)24-10-22-17/h1-10,15H,20H2,(H,21,22,23,24)
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n/an/a 9n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2289-92 (2007)


Article DOI: 10.1021/jm0700924
BindingDB Entry DOI: 10.7270/Q2M32T1C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16231
PNG
(2-(4-chlorophenyl)-N-methyl-2-[4-(9H-purin-6-yl)ph...)
Show SMILES CNCC(c1ccc(Cl)cc1)c1ccc(cc1)-c1ncnc2nc[nH]c12
Show InChI InChI=1S/C20H18ClN5/c1-22-10-17(14-6-8-16(21)9-7-14)13-2-4-15(5-3-13)18-19-20(25-11-23-18)26-12-24-19/h2-9,11-12,17,22H,10H2,1H3,(H,23,24,25,26)
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n/an/a 10n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2289-92 (2007)


Article DOI: 10.1021/jm0700924
BindingDB Entry DOI: 10.7270/Q2M32T1C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16232
PNG
(6-phenylpurine compound 20 | 6-{4-[4-(4-chlorophen...)
Show SMILES Clc1ccc(cc1)C1(CCNCC1)c1ccc(cc1)-c1ncnc2nc[nH]c12
Show InChI InChI=1S/C22H20ClN5/c23-18-7-5-17(6-8-18)22(9-11-24-12-10-22)16-3-1-15(2-4-16)19-20-21(27-13-25-19)28-14-26-20/h1-8,13-14,24H,9-12H2,(H,25,26,27,28)
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n/an/a 20n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2289-92 (2007)


Article DOI: 10.1021/jm0700924
BindingDB Entry DOI: 10.7270/Q2M32T1C
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15191
PNG
(Isoquinoline-5-sulfonic acid (2-(2-benzyloxyethyla...)
Show SMILES O=S(=O)(NCCNCCOCc1ccccc1)c1cccc2cnccc12
Show InChI InChI=1S/C20H23N3O3S/c24-27(25,20-8-4-7-18-15-22-10-9-19(18)20)23-12-11-21-13-14-26-16-17-5-2-1-3-6-17/h1-10,15,21,23H,11-14,16H2
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n/an/a 1.17E+3n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15192
PNG
(Isoquinoline-5-sulfonic acid (2-(2-(2-methylbenzyl...)
Show SMILES Cc1ccccc1COCCNCCNS(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C21H25N3O3S/c1-17-5-2-3-6-19(17)16-27-14-13-22-11-12-24-28(25,26)21-8-4-7-18-15-23-10-9-20(18)21/h2-10,15,22,24H,11-14,16H2,1H3
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n/an/a 570n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15193
PNG
(Isoquinoline-5-sulfonic acid (2-(2-(3-methylbenzyl...)
Show SMILES Cc1cccc(COCCNCCNS(=O)(=O)c2cccc3cnccc23)c1
Show InChI InChI=1S/C21H25N3O3S/c1-17-4-2-5-18(14-17)16-27-13-12-22-10-11-24-28(25,26)21-7-3-6-19-15-23-9-8-20(19)21/h2-9,14-15,22,24H,10-13,16H2,1H3
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n/an/a 1.10E+3n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15194
PNG
(Isoquinoline-5-sulfonic acid (2-(2-(4-methylbenzyl...)
Show SMILES Cc1ccc(COCCNCCNS(=O)(=O)c2cccc3cnccc23)cc1
Show InChI InChI=1S/C21H25N3O3S/c1-17-5-7-18(8-6-17)16-27-14-13-22-11-12-24-28(25,26)21-4-2-3-19-15-23-10-9-20(19)21/h2-10,15,22,24H,11-14,16H2,1H3
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n/an/a 1.53E+3n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15195
PNG
(Isoquinoline-5-sulfonic acid (2-(2-(2-chlorobenzyl...)
Show SMILES Clc1ccccc1COCCNCCNS(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C20H22ClN3O3S/c21-19-6-2-1-4-17(19)15-27-13-12-22-10-11-24-28(25,26)20-7-3-5-16-14-23-9-8-18(16)20/h1-9,14,22,24H,10-13,15H2
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n/an/a 960n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15196
PNG
(Isoquinoline-5-sulfonic acid (2-(2-(3-chlorobenzyl...)
Show SMILES Clc1cccc(COCCNCCNS(=O)(=O)c2cccc3cnccc23)c1
Show InChI InChI=1S/C20H22ClN3O3S/c21-18-5-1-3-16(13-18)15-27-12-11-22-9-10-24-28(25,26)20-6-2-4-17-14-23-8-7-19(17)20/h1-8,13-14,22,24H,9-12,15H2
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n/an/a 370n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16222
PNG
(CCT077373 | N-[2-({2-[(4-chlorobenzyl)oxy]ethyl}am...)
Show SMILES Clc1ccc(COCCNCCNS(=O)(=O)c2cccc3cnccc23)cc1
Show InChI InChI=1S/C20H22ClN3O3S/c21-18-6-4-16(5-7-18)15-27-13-12-22-10-11-24-28(25,26)20-3-1-2-17-14-23-9-8-19(17)20/h1-9,14,22,24H,10-13,15H2
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n/an/a 260n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15198
PNG
(Isoquinoline-5-sulfonic acid (2-(2-(3,4-dichlorobe...)
Show SMILES Clc1ccc(COCCNCCNS(=O)(=O)c2cccc3cnccc23)cc1Cl
Show InChI InChI=1S/C20H21Cl2N3O3S/c21-18-5-4-15(12-19(18)22)14-28-11-10-23-8-9-25-29(26,27)20-3-1-2-16-13-24-7-6-17(16)20/h1-7,12-13,23,25H,8-11,14H2
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n/an/a 210n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15199
PNG
(Isoquinoline-5-sulfonic acid (2-(2-(2-methoxybenzy...)
Show SMILES COc1ccccc1COCCNCCNS(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C21H25N3O4S/c1-27-20-7-3-2-5-18(20)16-28-14-13-22-11-12-24-29(25,26)21-8-4-6-17-15-23-10-9-19(17)21/h2-10,15,22,24H,11-14,16H2,1H3
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n/an/a 6.60E+3n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15200
PNG
(Isoquinoline-5-sulfonic acid (2-(2-(3-methoxybenzy...)
Show SMILES COc1cccc(COCCNCCNS(=O)(=O)c2cccc3cnccc23)c1
Show InChI InChI=1S/C21H25N3O4S/c1-27-19-6-2-4-17(14-19)16-28-13-12-22-10-11-24-29(25,26)21-7-3-5-18-15-23-9-8-20(18)21/h2-9,14-15,22,24H,10-13,16H2,1H3
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n/an/a 2.20E+3n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15201
PNG
(N-[2-({2-[(4-methoxyphenyl)methoxy]ethyl}amino)eth...)
Show SMILES COc1ccc(COCCNCCNS(=O)(=O)c2cccc3cnccc23)cc1
Show InChI InChI=1S/C21H25N3O4S/c1-27-19-7-5-17(6-8-19)16-28-14-13-22-11-12-24-29(25,26)21-4-2-3-18-15-23-10-9-20(18)21/h2-10,15,22,24H,11-14,16H2,1H3
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n/an/a 2.90E+3n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15202
PNG
(N-(3-aminopropyl)isoquinoline-5-sulfonamide | isoq...)
Show SMILES NCCCNS(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C12H15N3O2S/c13-6-2-7-15-18(16,17)12-4-1-3-10-9-14-8-5-11(10)12/h1,3-5,8-9,15H,2,6-7,13H2
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n/an/a 4.80E+3n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15203
PNG
(5-(piperazine-1-sulfonyl)isoquinoline | CHEMBL7577...)
Show SMILES O=S(=O)(N1CCNCC1)c1cccc2cnccc12
Show InChI InChI=1S/C13H15N3O2S/c17-19(18,16-8-6-14-7-9-16)13-3-1-2-11-10-15-5-4-12(11)13/h1-5,10,14H,6-9H2
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PubMed
n/an/a 2.30E+4n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15204
PNG
(Isoquinoline-5-sulfonic acid piperidin-4-ylamide |...)
Show SMILES O=S(=O)(NC1CCNCC1)c1cccc2cnccc12
Show InChI InChI=1S/C14H17N3O2S/c18-20(19,17-12-4-7-15-8-5-12)14-3-1-2-11-10-16-9-6-13(11)14/h1-3,6,9-10,12,15,17H,4-5,7-8H2
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PubMed
n/an/a 8.70E+3n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15205
PNG
(1-(isoquinoline-5-sulfonyl)piperidin-4-amine | Iso...)
Show SMILES NC1CCN(CC1)S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C14H17N3O2S/c15-12-5-8-17(9-6-12)20(18,19)14-3-1-2-11-10-16-7-4-13(11)14/h1-4,7,10,12H,5-6,8-9,15H2
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n/an/a>3.00E+4n/an/an/an/a7.222



UK Centre for Cancer Therapeutics



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


Bioorg Med Chem 14: 1255-73 (2006)


Article DOI: 10.1016/j.bmc.2005.09.055
BindingDB Entry DOI: 10.7270/Q2FN14F2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15131
PNG
(5-indazolyl pyridine 3 | 5-{5-[(2S)-2-amino-3-(1H-...)
Show SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C24H23N5O/c1-15-22-10-16(6-7-24(22)29-28-15)17-9-20(13-26-11-17)30-14-19(25)8-18-12-27-23-5-3-2-4-21(18)23/h2-7,9-13,19,27H,8,14,25H2,1H3,(H,28,29)/t19-/m0/s1
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n/an/a 0.5n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Mol Biol 367: 882-94 (2007)


Article DOI: 10.1016/j.jmb.2007.01.004
BindingDB Entry DOI: 10.7270/Q29Z934H
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16212
PNG
(1-[4-(5-methyl-1H-pyrazol-4-yl)phenyl]methanamine ...)
Show SMILES Cc1[nH]ncc1-c1ccc(CN)cc1
Show InChI InChI=1S/C11H13N3/c1-8-11(7-13-14-8)10-4-2-9(6-12)3-5-10/h2-5,7H,6,12H2,1H3,(H,13,14)
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n/an/a 1.20E+4n/an/an/an/a7.222



Astex



Assay Description
The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I...


J Med Chem 50: 2293-2296 (2007)


Article DOI: 10.1021/jm070091b
BindingDB Entry DOI: 10.7270/Q2QV3JST
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16954
PNG
(6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-2-chl...)
Show SMILES N[C@H](COc1cnc(Cl)c(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H21ClN4O/c26-25-23(17-5-6-18-12-28-8-7-16(18)9-17)11-21(14-30-25)31-15-20(27)10-19-13-29-24-4-2-1-3-22(19)24/h1-9,11-14,20,29H,10,15,27H2/t20-/m0/s1
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n/an/a 5n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 3150-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.041
BindingDB Entry DOI: 10.7270/Q2F769TT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16954
PNG
(6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-2-chl...)
Show SMILES N[C@H](COc1cnc(Cl)c(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C25H21ClN4O/c26-25-23(17-5-6-18-12-28-8-7-16(18)9-17)11-21(14-30-25)31-15-20(27)10-19-13-29-24-4-2-1-3-22(19)24/h1-9,11-14,20,29H,10,15,27H2/t20-/m0/s1
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n/an/a 73n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 3150-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.041
BindingDB Entry DOI: 10.7270/Q2F769TT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16958
PNG
(6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-2-eth...)
Show SMILES N[C@H](COc1cnc(C#C)c(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C27H22N4O/c1-2-26-25(19-7-8-20-14-29-10-9-18(20)11-19)13-23(16-31-26)32-17-22(28)12-21-15-30-27-6-4-3-5-24(21)27/h1,3-11,13-16,22,30H,12,17,28H2/t22-/m0/s1
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n/an/a 5n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 3150-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.041
BindingDB Entry DOI: 10.7270/Q2F769TT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM16958
PNG
(6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-2-eth...)
Show SMILES N[C@H](COc1cnc(C#C)c(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C27H22N4O/c1-2-26-25(19-7-8-20-14-29-10-9-18(20)11-19)13-23(16-31-26)32-17-22(28)12-21-15-30-27-6-4-3-5-24(21)27/h1,3-11,13-16,22,30H,12,17,28H2/t22-/m0/s1
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n/an/a 39n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 3150-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.041
BindingDB Entry DOI: 10.7270/Q2F769TT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15022
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1
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n/an/a 257n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM15022
PNG
(3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1
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n/an/a 354n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 6.5n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 10n/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24884
PNG
(2,3,5-trisubstituted pyridine, 3 | 9-[1-({4-[3-phe...)
Show SMILES Nc1ncnc2n(cnc12)C1CCN(Cc2ccc(cc2)-c2ncc(cc2-c2ccccc2)-c2nnn[nH]2)CC1
Show InChI InChI=1S/C29H27N11/c30-27-26-29(33-17-32-27)40(18-34-26)23-10-12-39(13-11-23)16-19-6-8-21(9-7-19)25-24(20-4-2-1-3-5-20)14-22(15-31-25)28-35-37-38-36-28/h1-9,14-15,17-18,23H,10-13,16H2,(H2,30,32,33)(H,35,36,37,38)
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n/an/a 105n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)


Article DOI: 10.1016/j.bmcl.2007.12.040
BindingDB Entry DOI: 10.7270/Q2BG2M8B
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT


(Homo sapiens (human))
BDBM24885
PNG
(2,3,5-trisubstituted pyridine, 10a | 5-{5-phenyl-6...)
Show SMILES Nc1nnc(s1)-c1cnc(-c2ccc(CN3CCC(CC3)c3cc(n[nH]3)-c3ccncc3)cc2)c(c1)-c1ccccc1
Show InChI InChI=1S/C33H30N8S/c34-33-40-39-32(42-33)27-18-28(23-4-2-1-3-5-23)31(36-20-27)26-8-6-22(7-9-26)21-41-16-12-25(13-17-41)30-19-29(37-38-30)24-10-14-35-15-11-24/h1-11,14-15,18-20,25H,12-13,16-17,21H2,(H2,34,40)(H,37,38)
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n/an/a 38n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...


Bioorg Med Chem Lett 18: 2194-7 (2008)


Article DOI: 10.1016/j.bmcl.2007.12.040
BindingDB Entry DOI: 10.7270/Q2BG2M8B
More data for this
Ligand-Target Pair
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