BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 77 hits of ph data with Target = 'Sphingosine 1-phosphate receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22222
PNG
(3-(3-methyl-4-{5-[4-(propan-2-yloxy)-3-(trifluorom...)
Show SMILES CC(C)Oc1ccc(cc1C(F)(F)F)-c1nc(no1)-c1ccc(CCC(O)=O)cc1C
Show InChI InChI=1S/C22H21F3N2O4/c1-12(2)30-18-8-6-15(11-17(18)22(23,24)25)21-26-20(27-31-21)16-7-4-14(10-13(16)3)5-9-19(28)29/h4,6-8,10-12H,5,9H2,1-3H3,(H,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0800n/an/a7.422



Merck Research Laboratories



Assay Description
EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...


Bioorg Med Chem Lett 17: 828-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.057
BindingDB Entry DOI: 10.7270/Q22N50JV
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221929
PNG
(US9315492, 31 | US9315492, 32)
Show SMILES CC(C)Oc1ccc(cc1C)-c1cn(nn1)-c1ccc2CC(N)(CO)CCc2c1
Show InChI InChI=1S/C23H28N4O2/c1-15(2)29-22-7-5-18(10-16(22)3)21-13-27(26-25-21)20-6-4-19-12-23(24,14-28)9-8-17(19)11-20/h4-7,10-11,13,15,28H,8-9,12,14,24H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 125n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22224
PNG
(2-methyl-3-(3-methyl-4-{5-[4-(propan-2-yloxy)-3-(t...)
Show SMILES CC(C)Oc1ccc(cc1C(F)(F)F)-c1nc(no1)-c1ccc(CC(C)C(O)=O)cc1C
Show InChI InChI=1S/C23H23F3N2O4/c1-12(2)31-19-8-6-16(11-18(19)23(24,25)26)21-27-20(28-32-21)17-7-5-15(9-13(17)3)10-14(4)22(29)30/h5-9,11-12,14H,10H2,1-4H3,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.300n/an/a7.422



Merck Research Laboratories



Assay Description
EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...


Bioorg Med Chem Lett 17: 828-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.057
BindingDB Entry DOI: 10.7270/Q22N50JV
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22225
PNG
(3-(3-methyl-4-{5-[4-(propan-2-yloxy)-3-(trifluorom...)
Show SMILES CC(C)Oc1ccc(cc1C(F)(F)F)-c1nc(no1)-c1ccc(cc1C)C(C)CC(O)=O
Show InChI InChI=1S/C23H23F3N2O4/c1-12(2)31-19-8-6-16(11-18(19)23(24,25)26)22-27-21(28-32-22)17-7-5-15(9-14(17)4)13(3)10-20(29)30/h5-9,11-13H,10H2,1-4H3,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.120n/an/a7.422



Merck Research Laboratories



Assay Description
EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...


Bioorg Med Chem Lett 17: 828-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.057
BindingDB Entry DOI: 10.7270/Q22N50JV
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22226
PNG
(3-(5-{5-[3-cyano-4-(propan-2-yloxy)phenyl]-1,2,4-o...)
Show SMILES CC(C)Oc1ccc(cc1C#N)-c1nc(no1)-c1ccc(CCC(O)=O)nc1C
Show InChI InChI=1S/C21H20N4O4/c1-12(2)28-18-8-4-14(10-15(18)11-22)21-24-20(25-29-21)17-7-5-16(23-13(17)3)6-9-19(26)27/h4-5,7-8,10,12H,6,9H2,1-3H3,(H,26,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 0.440n/an/a7.422



Merck Research Laboratories



Assay Description
EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...


Bioorg Med Chem Lett 17: 828-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.057
BindingDB Entry DOI: 10.7270/Q22N50JV
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22227
PNG
((1S,2S)-2-(3-methyl-4-{5-[4-(propan-2-yloxy)-3-(tr...)
Show SMILES CC(C)Oc1ccc(cc1C(F)(F)F)-c1nc(no1)-c1ccc(cc1C)[C@H]1C[C@@H]1C(O)=O
Show InChI InChI=1S/C23H21F3N2O4/c1-11(2)31-19-7-5-14(9-18(19)23(24,25)26)21-27-20(28-32-21)15-6-4-13(8-12(15)3)16-10-17(16)22(29)30/h4-9,11,16-17H,10H2,1-3H3,(H,29,30)/t16-,17+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.210n/an/a7.422



Merck Research Laboratories



Assay Description
EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...


Bioorg Med Chem Lett 17: 828-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.057
BindingDB Entry DOI: 10.7270/Q22N50JV
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22228
PNG
((1S,2S)-2-(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]...)
Show SMILES CC(C)Oc1ccc(cc1C#N)-c1nc(no1)-c1ccc(cc1C)[C@H]1C[C@@H]1C(O)=O
Show InChI InChI=1S/C23H21N3O4/c1-12(2)29-20-7-5-15(9-16(20)11-24)22-25-21(26-30-22)17-6-4-14(8-13(17)3)18-10-19(18)23(27)28/h4-9,12,18-19H,10H2,1-3H3,(H,27,28)/t18-,19+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.450n/an/a7.422



Merck Research Laboratories



Assay Description
EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...


Bioorg Med Chem Lett 17: 828-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.057
BindingDB Entry DOI: 10.7270/Q22N50JV
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22229
PNG
((1S,2R)-2-(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]...)
Show SMILES CC(C)Oc1ccc(cc1C#N)-c1nc(no1)-c1ccc(cc1C)[C@@H]1C[C@@H]1C(O)=O
Show InChI InChI=1S/C23H21N3O4/c1-12(2)29-20-7-5-15(9-16(20)11-24)22-25-21(26-30-22)17-6-4-14(8-13(17)3)18-10-19(18)23(27)28/h4-9,12,18-19H,10H2,1-3H3,(H,27,28)/t18-,19-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.800n/an/a7.422



Merck Research Laboratories



Assay Description
EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...


Bioorg Med Chem Lett 17: 828-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.057
BindingDB Entry DOI: 10.7270/Q22N50JV
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22223
PNG
(3-(4-{5-[3-cyano-4-(propan-2-yloxy)phenyl]-1,2,4-o...)
Show SMILES CC(C)Oc1ccc(cc1C#N)-c1nc(no1)-c1ccc(CCC(O)=O)cc1C
Show InChI InChI=1S/C22H21N3O4/c1-13(2)28-19-8-6-16(11-17(19)12-23)22-24-21(25-29-22)18-7-4-15(10-14(18)3)5-9-20(26)27/h4,6-8,10-11,13H,5,9H2,1-3H3,(H,26,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 0.0800n/an/a7.422



Merck Research Laboratories



Assay Description
EC50s were determined by measuring the binding of [35S]-GTP-gamma-S to S1P receptors expressed in transfected Chinese hamster ovary (CHO) cell membr...


Bioorg Med Chem Lett 17: 828-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.057
BindingDB Entry DOI: 10.7270/Q22N50JV
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221929
PNG
(US9315492, 31 | US9315492, 32)
Show SMILES CC(C)Oc1ccc(cc1C)-c1cn(nn1)-c1ccc2CC(N)(CO)CCc2c1
Show InChI InChI=1S/C23H28N4O2/c1-15(2)29-22-7-5-18(10-16(22)3)21-13-27(26-25-21)20-6-4-19-12-23(24,14-28)9-8-17(19)11-20/h4-7,10-11,13,15,28H,8-9,12,14,24H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 5n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221927
PNG
(US9315492, 28 | US9315492, 30)
Show SMILES CC(C)Oc1ccc(cc1C)-c1nc(no1)-c1ccc2CC(N)(CO)CCc2c1
Show InChI InChI=1S/C23H27N3O3/c1-14(2)28-20-7-6-18(10-15(20)3)22-25-21(26-29-22)17-4-5-19-12-23(24,13-27)9-8-16(19)11-17/h4-7,10-11,14,27H,8-9,12-13,24H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 749n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221928
PNG
(US9315492, 29)
Show SMILES CC(C)Oc1ccc(cc1C)C1=NC(N=N1)c1ccc2CCC(N)(CO)Cc2c1
Show InChI InChI=1S/C23H28N4O2/c1-14(2)29-20-7-6-17(10-15(20)3)21-25-22(27-26-21)18-5-4-16-8-9-23(24,13-28)12-19(16)11-18/h4-7,10-11,14,22,28H,8-9,12-13,24H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 0.400n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221913
PNG
(US9315492, 10)
Show SMILES COCCOc1ccc(cc1)-c1nnc(o1)-c1ccc2CCC(N)(CO)Cc2c1
Show InChI InChI=1S/C22H25N3O4/c1-27-10-11-28-19-6-4-16(5-7-19)20-24-25-21(29-20)17-3-2-15-8-9-22(23,14-26)13-18(15)12-17/h2-7,12,26H,8-11,13-14,23H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 31.7n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221914
PNG
(US9315492, 11)
Show SMILES CC(C)Oc1ccc(cc1C(F)(F)F)-c1nnc(o1)-c1ccc2CCC(N)(CO)Cc2c1
Show InChI InChI=1S/C23H24F3N3O3/c1-13(2)31-19-6-5-16(10-18(19)23(24,25)26)21-29-28-20(32-21)15-4-3-14-7-8-22(27,12-30)11-17(14)9-15/h3-6,9-10,13,30H,7-8,11-12,27H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 0.400n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221915
PNG
(US9315492, 12)
Show SMILES NC1(CO)CCc2cc(ccc2C1)-c1nc(no1)-c1ccnc(c1)[N+]([O-])=O
Show InChI InChI=1S/C18H17N5O4/c19-18(10-24)5-3-11-7-13(1-2-14(11)9-18)17-21-16(22-27-17)12-4-6-20-15(8-12)23(25)26/h1-2,4,6-8,24H,3,5,9-10,19H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 620n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221916
PNG
(US9315492, 15)
Show SMILES COc1ccc(cc1C)-c1nnc(o1)-c1ccc2CCC(N)(CO)Cc2c1
Show InChI InChI=1S/C21H23N3O3/c1-13-9-15(5-6-18(13)26-2)19-23-24-20(27-19)16-4-3-14-7-8-21(22,12-25)11-17(14)10-16/h3-6,9-10,25H,7-8,11-12,22H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 16n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221917
PNG
(US9315492, 16)
Show SMILES CC(C)Oc1ccc(cc1)-c1nnc(o1)-c1ccc2CCC(N)(CO)Cc2c1
Show InChI InChI=1S/C22H25N3O3/c1-14(2)27-19-7-5-16(6-8-19)20-24-25-21(28-20)17-4-3-15-9-10-22(23,13-26)12-18(15)11-17/h3-8,11,14,26H,9-10,12-13,23H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 46n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221918
PNG
(US9315492, 17)
Show SMILES COCCOc1ccc(cc1C(F)(F)F)-c1nnc(o1)-c1ccc2CCC(N)(CO)Cc2c1
Show InChI InChI=1S/C23H24F3N3O4/c1-31-8-9-32-19-5-4-16(11-18(19)23(24,25)26)21-29-28-20(33-21)15-3-2-14-6-7-22(27,13-30)12-17(14)10-15/h2-5,10-11,30H,6-9,12-13,27H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 10.2n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221919
PNG
(US9315492, 18)
Show SMILES COCCOc1ccc(cc1C)-c1nnc(o1)-c1ccc2CCC(N)(CO)Cc2c1
Show InChI InChI=1S/C23H27N3O4/c1-15-11-17(5-6-20(15)29-10-9-28-2)21-25-26-22(30-21)18-4-3-16-7-8-23(24,14-27)13-19(16)12-18/h3-6,11-12,27H,7-10,13-14,24H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 41.1n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221920
PNG
(US9315492, 19)
Show SMILES CC(C)Oc1ccc(cn1)-c1nnc(o1)-c1ccc2CCC(N)(CO)Cc2c1
Show InChI InChI=1S/C21H24N4O3/c1-13(2)27-18-6-5-16(11-23-18)20-25-24-19(28-20)15-4-3-14-7-8-21(22,12-26)10-17(14)9-15/h3-6,9,11,13,26H,7-8,10,12,22H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 61.2n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221921
PNG
(US9315492, 20)
Show SMILES CCOc1ccc(cc1OCC)-c1nnc(o1)-c1ccc2CCC(N)(CO)Cc2c1
Show InChI InChI=1S/C23H27N3O4/c1-3-28-19-8-7-17(12-20(19)29-4-2)22-26-25-21(30-22)16-6-5-15-9-10-23(24,14-27)13-18(15)11-16/h5-8,11-12,27H,3-4,9-10,13-14,24H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 179n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221931
PNG
(US9315492, 21)
Show SMILES CC(C)Oc1ccc(cc1C)-c1nnc(o1)-c1ccc2CCC(CO)(Cc2c1)NCc1ccccc1
Show InChI InChI=1S/C30H33N3O3/c1-20(2)35-27-12-11-24(15-21(27)3)28-32-33-29(36-28)25-10-9-23-13-14-30(19-34,17-26(23)16-25)31-18-22-7-5-4-6-8-22/h4-12,15-16,20,31,34H,13-14,17-19H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 179n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221932
PNG
(US9315492, 22)
Show SMILES CC(C)Oc1ccc(cc1C)-c1nnc(o1)-c1ccc2CCC(N)(CO)Cc2c1
Show InChI InChI=1S/C23H27N3O3/c1-14(2)28-20-7-6-17(10-15(20)3)21-25-26-22(29-21)18-5-4-16-8-9-23(24,13-27)12-19(16)11-18/h4-7,10-11,14,27H,8-9,12-13,24H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 3n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221922
PNG
(US9315492, 23)
Show SMILES CCNC1(CO)CCc2ccc(cc2C1)-c1nnc(o1)-c1ccc(OC(C)C)c(C)c1
Show InChI InChI=1S/C25H31N3O3/c1-5-26-25(15-29)11-10-18-6-7-20(13-21(18)14-25)24-28-27-23(31-24)19-8-9-22(17(4)12-19)30-16(2)3/h6-9,12-13,16,26,29H,5,10-11,14-15H2,1-4H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 37.6n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221923
PNG
(US9315492, 24)
Show SMILES CC(C)Oc1ccc(cc1C)-c1nnc(o1)-c1ccc2CCC(CO)(Cc2c1)N(C)C
Show InChI InChI=1S/C25H31N3O3/c1-16(2)30-22-9-8-19(12-17(22)3)23-26-27-24(31-23)20-7-6-18-10-11-25(15-29,28(4)5)14-21(18)13-20/h6-9,12-13,16,29H,10-11,14-15H2,1-5H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 46n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221924
PNG
(US9315492, 25)
Show SMILES CC(C)Oc1ccc(cc1C)-c1nnc(o1)-c1ccc2CCC(CO)(Cc2c1)NC(C)=O
Show InChI InChI=1S/C25H29N3O4/c1-15(2)31-22-8-7-19(11-16(22)3)23-27-28-24(32-23)20-6-5-18-9-10-25(14-29,26-17(4)30)13-21(18)12-20/h5-8,11-12,15,29H,9-10,13-14H2,1-4H3,(H,26,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 45.5n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221925
PNG
(US9315492, 26)
Show SMILES CC(C)Oc1ccc(cc1C)-c1nnc(o1)-c1ccc2CCC(CO)(Cc2c1)NS(C)(=O)=O
Show InChI InChI=1S/C24H29N3O5S/c1-15(2)31-21-8-7-18(11-16(21)3)22-25-26-23(32-22)19-6-5-17-9-10-24(14-28,13-20(17)12-19)27-33(4,29)30/h5-8,11-12,15,27-28H,9-10,13-14H2,1-4H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 86n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221926
PNG
(US9315492, 27)
Show SMILES CC(C)Oc1ccc(cc1C)-c1noc(n1)-c1ccc2CC(N)(CO)CCc2c1
Show InChI InChI=1S/C23H27N3O3/c1-14(2)28-20-7-6-17(10-15(20)3)21-25-22(29-26-21)18-4-5-19-12-23(24,13-27)9-8-16(19)11-18/h4-7,10-11,14,27H,8-9,12-13,24H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 1.20n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM221927
PNG
(US9315492, 28 | US9315492, 30)
Show SMILES CC(C)Oc1ccc(cc1C)-c1nc(no1)-c1ccc2CC(N)(CO)CCc2c1
Show InChI InChI=1S/C23H27N3O3/c1-14(2)28-20-7-6-18(10-15(20)3)22-25-21(26-29-22)17-4-5-19-12-23(24,13-27)9-8-16(19)11-17/h4-7,10-11,14,27H,8-9,12-13,24H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 473n/an/an/an/a7.4n/a



Beijing Foreland Biopharma Co., Ltd.

US Patent


Assay Description
Test method: wetting membranes by saponin solution, and preparing [35S]-GTPγS in binding solution (4). The test compound was prepared as 4 of ...


US Patent US9315492 (2016)


BindingDB Entry DOI: 10.7270/Q2154FW6
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22202
PNG
(S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphat...)
Show SMILES CCCCCCCCCCCCC\C=C/C(O)C(N)COP(O)(O)=O
Show InChI InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14-
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
1.20 -47.3n/an/an/an/an/a7.54



Mitsubishi Pharma Corporation



Assay Description
Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...


Bioorg Med Chem 13: 425-32 (2005)


Article DOI: 10.1016/j.bmc.2004.10.008
BindingDB Entry DOI: 10.7270/Q257199Q
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM23165
PNG
(CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...)
Show SMILES CCCCCCCCc1ccc(CC[C@](N)(CO)COP(O)(O)=O)cc1
Show InChI InChI=1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-25-26(22,23)24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)/t19-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.10 -46.0n/an/an/an/an/a7.54



Mitsubishi Pharma Corporation



Assay Description
Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...


Bioorg Med Chem 13: 425-32 (2005)


Article DOI: 10.1016/j.bmc.2004.10.008
BindingDB Entry DOI: 10.7270/Q257199Q
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM23163
PNG
(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Show SMILES CCCCCCCCc1ccc(CCC(N)(CO)COP(O)(O)=O)cc1
Show InChI InChI=1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-25-26(22,23)24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
4.10 -44.5n/an/an/an/an/a7.54



Mitsubishi Pharma Corporation



Assay Description
Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...


Bioorg Med Chem 13: 425-32 (2005)


Article DOI: 10.1016/j.bmc.2004.10.008
BindingDB Entry DOI: 10.7270/Q257199Q
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM23164
PNG
(CHEMBL190006 | FTY720-phosphate, (R)-2 | [(2R)-2-a...)
Show SMILES CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(O)(O)=O)cc1
Show InChI InChI=1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-25-26(22,23)24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
277 -34.8n/an/an/an/an/a7.54



Mitsubishi Pharma Corporation



Assay Description
Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...


Bioorg Med Chem 13: 425-32 (2005)


Article DOI: 10.1016/j.bmc.2004.10.008
BindingDB Entry DOI: 10.7270/Q257199Q
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22201
PNG
(1,3,4-oxadiazole based compound, 9 | 1-({4-[5-(4-t...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1nnc(o1)-c1ccc(CN2CC(C2)C(O)=O)cc1
Show InChI InChI=1S/C23H25N3O3/c1-23(2,3)19-10-8-17(9-11-19)21-25-24-20(29-21)16-6-4-15(5-7-16)12-26-13-18(14-26)22(27)28/h4-11,18H,12-14H2,1-3H3,(H,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 100n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22203
PNG
(1,2,4-oxadiazole based compound, 13 | 1-({4-[3-(4-...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1noc(n1)-c1ccc(CN2CC(C2)C(O)=O)cc1
Show InChI InChI=1S/C23H25N3O3/c1-23(2,3)19-10-8-16(9-11-19)20-24-21(29-25-20)17-6-4-15(5-7-17)12-26-13-18(14-26)22(27)28/h4-11,18H,12-14H2,1-3H3,(H,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.20n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22204
PNG
(1,2,4-oxadiazole based compound, 21 | 1-({4-[5-(4-...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1nc(no1)-c1ccc(CN2CC(C2)C(O)=O)cc1
Show InChI InChI=1S/C23H25N3O3/c1-23(2,3)19-10-8-17(9-11-19)21-24-20(25-29-21)16-6-4-15(5-7-16)12-26-13-18(14-26)22(27)28/h4-11,18H,12-14H2,1-3H3,(H,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.80n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22205
PNG
(1,2,4-oxadiazole based compound, 22 | 1-[(4-{5-[4-...)
Show SMILES CCC(C)(C)c1ccc(cc1)-c1nc(no1)-c1ccc(CN2CC(C2)C(O)=O)cc1
Show InChI InChI=1S/C24H27N3O3/c1-4-24(2,3)20-11-9-18(10-12-20)22-25-21(26-30-22)17-7-5-16(6-8-17)13-27-14-19(15-27)23(28)29/h5-12,19H,4,13-15H2,1-3H3,(H,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.30n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22206
PNG
(1,2,4-oxadiazole based compound, 23 | 1-({4-[5-(4-...)
Show SMILES CCCc1ccc(cc1)-c1nc(no1)-c1ccc(CN2CC(C2)C(O)=O)cc1
Show InChI InChI=1S/C22H23N3O3/c1-2-3-15-4-10-18(11-5-15)21-23-20(24-28-21)17-8-6-16(7-9-17)12-25-13-19(14-25)22(26)27/h4-11,19H,2-3,12-14H2,1H3,(H,26,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.30n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22207
PNG
(1,2,4-oxadiazole based compound, 24 | 1-({4-[5-(4-...)
Show SMILES CCCCc1ccc(cc1)-c1nc(no1)-c1ccc(CN2CC(C2)C(O)=O)cc1
Show InChI InChI=1S/C23H25N3O3/c1-2-3-4-16-5-11-19(12-6-16)22-24-21(25-29-22)18-9-7-17(8-10-18)13-26-14-20(15-26)23(27)28/h5-12,20H,2-4,13-15H2,1H3,(H,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.90n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22208
PNG
(1,2,4-oxadiazole based compound, 25 | 1-({4-[5-(4-...)
Show SMILES CCCCCCc1ccc(cc1)-c1nc(no1)-c1ccc(CN2CC(C2)C(O)=O)cc1
Show InChI InChI=1S/C25H29N3O3/c1-2-3-4-5-6-18-7-13-21(14-8-18)24-26-23(27-31-24)20-11-9-19(10-12-20)15-28-16-22(17-28)25(29)30/h7-14,22H,2-6,15-17H2,1H3,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 29n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22209
PNG
(1,2,4-oxadiazole based compound, 26 | 1-[(4-{5-[4-...)
Show SMILES CC(C)Cc1ccc(cc1)-c1nc(no1)-c1ccc(CN2CC(C2)C(O)=O)cc1
Show InChI InChI=1S/C23H25N3O3/c1-15(2)11-16-3-9-19(10-4-16)22-24-21(25-29-22)18-7-5-17(6-8-18)12-26-13-20(14-26)23(27)28/h3-10,15,20H,11-14H2,1-2H3,(H,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.600n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22210
PNG
(1,2,4-oxadiazole based compound, 27 | 1-[(4-{5-[4-...)
Show SMILES CC(C)(C)Cc1ccc(cc1)-c1nc(no1)-c1ccc(CN2CC(C2)C(O)=O)cc1
Show InChI InChI=1S/C24H27N3O3/c1-24(2,3)12-16-4-10-19(11-5-16)22-25-21(26-30-22)18-8-6-17(7-9-18)13-27-14-20(15-27)23(28)29/h4-11,20H,12-15H2,1-3H3,(H,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.80n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22211
PNG
(1,2,4-oxadiazole based compound, 28 | 1-({4-[5-(4-...)
Show SMILES CCOc1ccc(cc1)-c1nc(no1)-c1ccc(CN2CC(C2)C(O)=O)cc1
Show InChI InChI=1S/C21H21N3O4/c1-2-27-18-9-7-16(8-10-18)20-22-19(23-28-20)15-5-3-14(4-6-15)11-24-12-17(13-24)21(25)26/h3-10,17H,2,11-13H2,1H3,(H,25,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.10n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22212
PNG
(1,2,4-oxadiazole based compound, 29 | 1-[(4-{5-[4-...)
Show SMILES CC(C)Oc1ccc(cc1)-c1nc(no1)-c1ccc(CN2CC(C2)C(O)=O)cc1
Show InChI InChI=1S/C22H23N3O4/c1-14(2)28-19-9-7-17(8-10-19)21-23-20(24-29-21)16-5-3-15(4-6-16)11-25-12-18(13-25)22(26)27/h3-10,14,18H,11-13H2,1-2H3,(H,26,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.80n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22213
PNG
(1,2,4-oxadiazole based compound, 30 | 1-({4-[5-(4-...)
Show SMILES OC(=O)C1CN(Cc2ccc(cc2)-c2noc(n2)-c2ccc(cc2)C2CC2)C1
Show InChI InChI=1S/C22H21N3O3/c26-22(27)19-12-25(13-19)11-14-1-3-17(4-2-14)20-23-21(28-24-20)18-9-7-16(8-10-18)15-5-6-15/h1-4,7-10,15,19H,5-6,11-13H2,(H,26,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.5n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22214
PNG
(1,2,4-oxadiazole based compound, 31 | 1-({4-[5-(4-...)
Show SMILES OC(=O)C1CN(Cc2ccc(cc2)-c2noc(n2)-c2ccc(cc2)C2CCC2)C1
Show InChI InChI=1S/C23H23N3O3/c27-23(28)20-13-26(14-20)12-15-4-6-18(7-5-15)21-24-22(29-25-21)19-10-8-17(9-11-19)16-2-1-3-16/h4-11,16,20H,1-3,12-14H2,(H,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22215
PNG
(1,2,4-oxadiazole based compound, 32 | 1-({4-[5-(4-...)
Show SMILES OC(=O)C1CN(Cc2ccc(cc2)-c2noc(n2)-c2ccc(cc2)C2CCCC2)C1
Show InChI InChI=1S/C24H25N3O3/c28-24(29)21-14-27(15-21)13-16-5-7-19(8-6-16)22-25-23(30-26-22)20-11-9-18(10-12-20)17-3-1-2-4-17/h5-12,17,21H,1-4,13-15H2,(H,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.400n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22216
PNG
(1,2,4-oxadiazole based compound, 33 | 1-({4-[5-(4-...)
Show SMILES OC(=O)C1CN(Cc2ccc(cc2)-c2noc(n2)-c2ccc(cc2)C2CCCCC2)C1
Show InChI InChI=1S/C25H27N3O3/c29-25(30)22-15-28(16-22)14-17-6-8-20(9-7-17)23-26-24(31-27-23)21-12-10-19(11-13-21)18-4-2-1-3-5-18/h6-13,18,22H,1-5,14-16H2,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.40n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22217
PNG
(1,2,4-oxadiazole based compound, 34 | 1-({4-[5-(4-...)
Show SMILES OC(=O)C1CN(Cc2ccc(cc2)-c2noc(n2)-c2ccc(cc2)-c2ccccc2)C1
Show InChI InChI=1S/C25H21N3O3/c29-25(30)22-15-28(16-22)14-17-6-8-20(9-7-17)23-26-24(31-27-23)21-12-10-19(11-13-21)18-4-2-1-3-5-18/h1-13,22H,14-16H2,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.70n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor


(Homo sapiens (Human))
BDBM22218
PNG
(1,2,4-oxadiazole based compound, 35 | 1-[(4-{5-[4-...)
Show SMILES OC(=O)C1CN(Cc2ccc(cc2)-c2noc(n2)-c2ccc(CCC(F)(F)F)cc2)C1
Show InChI InChI=1S/C22H20F3N3O3/c23-22(24,25)10-9-14-1-7-17(8-2-14)20-26-19(27-31-20)16-5-3-15(4-6-16)11-28-12-18(13-28)21(29)30/h1-8,18H,9-13H2,(H,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 0.400n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
The assay measures the displacement of [33P]-labeled sphingosine-1-phosphate (S1P) by test compounds from human S1P receptors expressed on CHO cell m...


J Med Chem 48: 6169-73 (2005)


Article DOI: 10.1021/jm0503244
BindingDB Entry DOI: 10.7270/Q26971W9
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 77 total )  |  Next  |  Last  >>
Jump to: