BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 26 hits of ph data with Target = 'Tryptase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tryptase


(Homo sapiens)
BDBM14307
PNG
((2R)-N-[(1S)-1-{[6-amino-1-(1,3-benzothiazol-2-yl)...)
Show SMILES NCCCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NS(=O)(=O)Cc1ccccc1)C(=O)c1nc2ccccc2s1
Show InChI InChI=1S/C38H41N5O5S2/c39-23-13-12-21-31(35(44)38-42-30-20-10-11-22-34(30)49-38)40-36(45)32(24-27-14-4-1-5-15-27)41-37(46)33(25-28-16-6-2-7-17-28)43-50(47,48)26-29-18-8-3-9-19-29/h1-11,14-20,22,31-33,43H,12-13,21,23-26,39H2,(H,40,45)(H,41,46)/t31?,32-,33+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
23 -43.2n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Biochemistry 45: 5964-73 (2006)


Article DOI: 10.1021/bi060173m
BindingDB Entry DOI: 10.7270/Q2W09450
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14169
PNG
(4-Iodobenzo[b]thiophene-2-carboxamidine | APC-6860...)
Show SMILES NC(=[NH2+])c1cc2c(I)cccc2s1
Show InChI InChI=1S/C9H7IN2S/c10-6-2-1-3-7-5(6)4-8(13-7)9(11)12/h1-4H,(H3,11,12)/p+1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
1.50E+3 -32.9n/an/an/an/an/a7.422



Axys Pharmaceutical



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Chem Biol 7: 299-312 (2000)


Article DOI: 10.1016/S1074-5521(00)00104-6
BindingDB Entry DOI: 10.7270/Q2NG4NWC
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14297
PNG
(benzthiazole analog 1 | benzyl N-[(2S)-6-amino-1-(...)
Show SMILES NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)c1nc2ccccc2s1
Show InChI InChI=1S/C21H23N3O3S/c22-13-7-6-11-17(24-21(26)27-14-15-8-2-1-3-9-15)19(25)20-23-16-10-4-5-12-18(16)28-20/h1-5,8-10,12,17H,6-7,11,13-14,22H2,(H,24,26)/t17-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
7.30E+3 -29.0n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Biochemistry 45: 5964-73 (2006)


Article DOI: 10.1021/bi060173m
BindingDB Entry DOI: 10.7270/Q2W09450
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14170
PNG
(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)
Show SMILES NC(=[NH2+])c1cc2ccccc2s1
Show InChI InChI=1S/C9H8N2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5H,(H3,10,11)/p+1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
9.90E+3 -28.3n/an/an/an/an/a7.422



Axys Pharmaceutical



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Chem Biol 7: 299-312 (2000)


Article DOI: 10.1016/S1074-5521(00)00104-6
BindingDB Entry DOI: 10.7270/Q2NG4NWC
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14299
PNG
(benzthiazole analog 2 | benzyl N-[(2S)-1-(1,3-benz...)
Show SMILES O=C(N[C@@H](Cc1cc2cnccc2[nH]1)C(=O)c1nc2ccccc2s1)OCc1ccccc1
Show InChI InChI=1S/C25H20N4O3S/c30-23(24-28-20-8-4-5-9-22(20)33-24)21(13-18-12-17-14-26-11-10-19(17)27-18)29-25(31)32-15-16-6-2-1-3-7-16/h1-12,14,21,27H,13,15H2,(H,29,31)/t21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.20E+4 -27.8n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Biochemistry 45: 5964-73 (2006)


Article DOI: 10.1021/bi060173m
BindingDB Entry DOI: 10.7270/Q2W09450
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14308
PNG
((2S)-N-[3-(2-amino-1H-1,3-benzodiazol-5-yl)-1-(1,3...)
Show SMILES Nc1nc2ccc(CC(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccccc3)NS(=O)(=O)Cc3ccccc3)C(=O)c3nc4ccccc4s3)cc2[nH]1
Show InChI InChI=1S/C42H39N7O5S2/c43-42-47-31-21-20-30(24-33(31)48-42)25-34(38(50)41-46-32-18-10-11-19-37(32)55-41)44-39(51)35(22-27-12-4-1-5-13-27)45-40(52)36(23-28-14-6-2-7-15-28)49-56(53,54)26-29-16-8-3-9-17-29/h1-21,24,34-36,49H,22-23,25-26H2,(H,44,51)(H,45,52)(H3,43,47,48)/t34?,35-,36+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.80E+4 -26.8n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Biochemistry 45: 5964-73 (2006)


Article DOI: 10.1021/bi060173m
BindingDB Entry DOI: 10.7270/Q2W09450
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM772
PNG
(Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...)
Show SMILES NC(=[NH2+])c1ccccc1
Show InChI InChI=1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9)/p+1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
2.00E+4 -26.6n/an/an/an/an/a7.422



Axys Pharmaceutical



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Chem Biol 7: 299-312 (2000)


Article DOI: 10.1016/S1074-5521(00)00104-6
BindingDB Entry DOI: 10.7270/Q2NG4NWC
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14300
PNG
(benzthiazole analog 3 | benzyl N-[(2S,4E)-6-amino-...)
Show SMILES NCCCCC(=NC(=O)OCc1ccccc1)C(=O)c1nc2ccccc2s1
Show InChI InChI=1S/C21H21N3O3S/c22-13-7-6-11-17(24-21(26)27-14-15-8-2-1-3-9-15)19(25)20-23-16-10-4-5-12-18(16)28-20/h1-5,8-10,12H,6-7,11,13-14,22H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.50E+4 -26.0n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Biochemistry 45: 5964-73 (2006)


Article DOI: 10.1021/bi060173m
BindingDB Entry DOI: 10.7270/Q2W09450
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14309
PNG
(2-Aminobenzimidazole Compound 13 | N-[3-(2-amino-1...)
Show SMILES CC(=O)NC(Cc1ccc2nc(N)[nH]c2c1)C(=O)c1nc2ccccc2s1
Show InChI InChI=1S/C19H17N5O2S/c1-10(25)21-15(9-11-6-7-12-14(8-11)24-19(20)23-12)17(26)18-22-13-4-2-3-5-16(13)27-18/h2-8,15H,9H2,1H3,(H,21,25)(H3,20,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
3.10E+4 -25.5n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Biochemistry 45: 5964-73 (2006)


Article DOI: 10.1021/bi060173m
BindingDB Entry DOI: 10.7270/Q2W09450
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14171
PNG
(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)
Show SMILES NC(=[NH2+])c1cc2cccnc2s1
Show InChI InChI=1S/C8H7N3S/c9-7(10)6-4-5-2-1-3-11-8(5)12-6/h1-4H,(H3,9,10)/p+1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Article
PubMed
3.40E+4 -25.2n/an/an/an/an/a7.422



Axys Pharmaceutical



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Chem Biol 7: 299-312 (2000)


Article DOI: 10.1016/S1074-5521(00)00104-6
BindingDB Entry DOI: 10.7270/Q2NG4NWC
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14301
PNG
(benzthiazole analog 4 | benzyl N-[(2S)-1-(1,3-benz...)
Show SMILES O=C(N[C@@H](Cc1cc2ccncc2[nH]1)C(=O)c1nc2ccccc2s1)OCc1ccccc1
Show InChI InChI=1S/C25H20N4O3S/c30-23(24-28-19-8-4-5-9-22(19)33-24)20(13-18-12-17-10-11-26-14-21(17)27-18)29-25(31)32-15-16-6-2-1-3-7-16/h1-12,14,20,27H,13,15H2,(H,29,31)/t20-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.50E+4 -24.6n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Biochemistry 45: 5964-73 (2006)


Article DOI: 10.1021/bi060173m
BindingDB Entry DOI: 10.7270/Q2W09450
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14310
PNG
(2-Aminobenzimidazole Compound 14 | 3-(2-amino-1H-1...)
Show SMILES Nc1nc2ccc(CCC(=O)c3nc4ccccc4s3)cc2[nH]1
Show InChI InChI=1S/C17H14N4OS/c18-17-20-11-7-5-10(9-13(11)21-17)6-8-14(22)16-19-12-3-1-2-4-15(12)23-16/h1-5,7,9H,6,8H2,(H3,18,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
9.40E+4 -22.8n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Biochemistry 45: 5964-73 (2006)


Article DOI: 10.1021/bi060173m
BindingDB Entry DOI: 10.7270/Q2W09450
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM7960
PNG
(1H-1,3-benzodiazol-2-amine | 2-Aminobenzimidazole ...)
Show SMILES Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C7H7N3/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4H,(H3,8,9,10)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
1.10E+5 -22.4n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Biochemistry 45: 5964-73 (2006)


Article DOI: 10.1021/bi060173m
BindingDB Entry DOI: 10.7270/Q2W09450
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14305
PNG
(benzthiazole analog 8 | benzyl N-[(2S)-1-(1,3-benz...)
Show SMILES Clc1ccc(C[C@H](NC(=O)OCc2ccccc2)C(=O)c2nc3ccccc3s2)cn1
Show InChI InChI=1S/C23H18ClN3O3S/c24-20-11-10-16(13-25-20)12-18(27-23(29)30-14-15-6-2-1-3-7-15)21(28)22-26-17-8-4-5-9-19(17)31-22/h1-11,13,18H,12,14H2,(H,27,29)/t18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.50E+5>-21.6n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Biochemistry 45: 5964-73 (2006)


Article DOI: 10.1021/bi060173m
BindingDB Entry DOI: 10.7270/Q2W09450
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14304
PNG
(benzthiazole analog 7 | benzyl N-[(2S)-3-(3-amino-...)
Show SMILES Nc1n[nH]c2ccc(C[C@H](NC(=O)OCc3ccccc3)C(=O)c3nc4ccccc4s3)cc12
Show InChI InChI=1S/C25H21N5O3S/c26-23-17-12-16(10-11-18(17)29-30-23)13-20(28-25(32)33-14-15-6-2-1-3-7-15)22(31)24-27-19-8-4-5-9-21(19)34-24/h1-12,20H,13-14H2,(H,28,32)(H3,26,29,30)/t20-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.50E+5>-21.6n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Biochemistry 45: 5964-73 (2006)


Article DOI: 10.1021/bi060173m
BindingDB Entry DOI: 10.7270/Q2W09450
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14303
PNG
(benzthiazole analog 6 | benzyl N-[(2S)-3-[(3R)-3-a...)
Show SMILES N[C@@H]1CCN(C[C@H](NC(=O)OCc2ccccc2)C(=O)c2nc3ccccc3s2)C1
Show InChI InChI=1S/C22H24N4O3S/c23-16-10-11-26(12-16)13-18(25-22(28)29-14-15-6-2-1-3-7-15)20(27)21-24-17-8-4-5-9-19(17)30-21/h1-9,16,18H,10-14,23H2,(H,25,28)/t16-,18+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.50E+5>-21.6n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Biochemistry 45: 5964-73 (2006)


Article DOI: 10.1021/bi060173m
BindingDB Entry DOI: 10.7270/Q2W09450
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM14302
PNG
(benzthiazole analog 5 | benzyl N-[(2S)-3-(6-aminop...)
Show SMILES Nc1ccc(C[C@H](NC(=O)OCc2ccccc2)C(=O)c2nc3ccccc3s2)cn1
Show InChI InChI=1S/C23H20N4O3S/c24-20-11-10-16(13-25-20)12-18(27-23(29)30-14-15-6-2-1-3-7-15)21(28)22-26-17-8-4-5-9-19(17)31-22/h1-11,13,18H,12,14H2,(H2,24,25)(H,27,29)/t18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.50E+5>-21.6n/an/an/an/an/a7.422



Celera



Assay Description
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...


Biochemistry 45: 5964-73 (2006)


Article DOI: 10.1021/bi060173m
BindingDB Entry DOI: 10.7270/Q2W09450
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM16127
PNG
(2,2 -methanediylbis(1H-benzimidazole-6-carboximida...)
Show SMILES NC(=N)c1ccc2nc(Cc3nc4ccc(cc4[nH]3)C(N)=N)[nH]c2c1
Show InChI InChI=1S/C17H16N8/c18-16(19)8-1-3-10-12(5-8)24-14(22-10)7-15-23-11-4-2-9(17(20)21)6-13(11)25-15/h1-6H,7H2,(H3,18,19)(H3,20,21)(H,22,24)(H,23,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
5 -46.9n/an/an/an/an/a8.222



Arris



Assay Description
Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...


Nature 391: 608-12 (1998)


Article DOI: 10.1038/35422
BindingDB Entry DOI: 10.7270/Q29P2ZW9
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM16304
PNG
(2-(1H-1,3-benzodiazol-2-ylcarbonyl)-1H-1,3-benzodi...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)C(=O)c1nc2ccccc2[nH]1
Show InChI InChI=1S/C16H12N6O/c17-14(18)8-5-6-11-12(7-8)22-16(21-11)13(23)15-19-9-3-1-2-4-10(9)20-15/h1-7H,(H3,17,18)(H,19,20)(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
50 -41.3n/an/an/an/an/a8.222



Arris



Assay Description
Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...


Nature 391: 608-12 (1998)


Article DOI: 10.1038/35422
BindingDB Entry DOI: 10.7270/Q29P2ZW9
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM16303
PNG
(2-(1H-1,3-benzodiazol-2-ylmethyl)-1H-1,3-benzodiaz...)
Show SMILES NC(=N)c1ccc2nc(Cc3nc4ccccc4[nH]3)[nH]c2c1
Show InChI InChI=1S/C16H14N6/c17-16(18)9-5-6-12-13(7-9)22-15(21-12)8-14-19-10-3-1-2-4-11(10)20-14/h1-7H,8H2,(H3,17,18)(H,19,20)(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
69.5 -40.4n/an/an/an/an/a8.222



Arris



Assay Description
Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...


Nature 391: 608-12 (1998)


Article DOI: 10.1038/35422
BindingDB Entry DOI: 10.7270/Q29P2ZW9
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM16307
PNG
(2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carbo...)
Show SMILES NC(=N)c1ccc2nc(Cc3ccccn3)[nH]c2c1
Show InChI InChI=1S/C14H13N5/c15-14(16)9-4-5-11-12(7-9)19-13(18-11)8-10-3-1-2-6-17-10/h1-7H,8H2,(H3,15,16)(H,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
310 -36.8n/an/an/an/an/a8.222



Arris



Assay Description
Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...


Nature 391: 608-12 (1998)


Article DOI: 10.1038/35422
BindingDB Entry DOI: 10.7270/Q29P2ZW9
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM16306
PNG
(2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximida...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H11N5/c14-12(15)8-4-5-9-11(7-8)18-13(17-9)10-3-1-2-6-16-10/h1-7H,(H3,14,15)(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.60E+3 -32.7n/an/an/an/an/a8.222



Arris



Assay Description
Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...


Nature 391: 608-12 (1998)


Article DOI: 10.1038/35422
BindingDB Entry DOI: 10.7270/Q29P2ZW9
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM16305
PNG
(2-(1H-imidazol-2-ylmethyl)-1H-1,3-benzodiazole-6-c...)
Show SMILES NC(=N)c1ccc2nc(Cc3ncc[nH]3)[nH]c2c1
Show InChI InChI=1S/C12H12N6/c13-12(14)7-1-2-8-9(5-7)18-11(17-8)6-10-15-3-4-16-10/h1-5H,6H2,(H3,13,14)(H,15,16)(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.65E+3 -32.7n/an/an/an/an/a8.222



Arris



Assay Description
Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...


Nature 391: 608-12 (1998)


Article DOI: 10.1038/35422
BindingDB Entry DOI: 10.7270/Q29P2ZW9
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM16309
PNG
(2-(quinolin-8-yl)-1H-1,3-benzodiazole-6-carboximid...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cccc2cccnc12
Show InChI InChI=1S/C17H13N5/c18-16(19)11-6-7-13-14(9-11)22-17(21-13)12-5-1-3-10-4-2-8-20-15(10)12/h1-9H,(H3,18,19)(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
1.10E+4 -28.0n/an/an/an/an/a8.222



Arris



Assay Description
Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...


Nature 391: 608-12 (1998)


Article DOI: 10.1038/35422
BindingDB Entry DOI: 10.7270/Q29P2ZW9
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM16308
PNG
(2-(isoquinolin-1-yl)-1H-1,3-benzodiazole-6-carboxi...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1nccc2ccccc12
Show InChI InChI=1S/C17H13N5/c18-16(19)11-5-6-13-14(9-11)22-17(21-13)15-12-4-2-1-3-10(12)7-8-20-15/h1-9H,(H3,18,19)(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
5.45E+4 -24.1n/an/an/an/an/a8.222



Arris



Assay Description
Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...


Nature 391: 608-12 (1998)


Article DOI: 10.1038/35422
BindingDB Entry DOI: 10.7270/Q29P2ZW9
More data for this
Ligand-Target Pair
Tryptase


(Homo sapiens)
BDBM16310
PNG
(2-(isoquinolin-3-yl)-1H-1,3-benzodiazole-6-carboxi...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc2ccccc2cn1
Show InChI InChI=1S/C17H13N5/c18-16(19)11-5-6-13-14(8-11)22-17(21-13)15-7-10-3-1-2-4-12(10)9-20-15/h1-9H,(H3,18,19)(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
6.33E+4 -23.7n/an/an/an/an/a8.222



Arris



Assay Description
Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...


Nature 391: 608-12 (1998)


Article DOI: 10.1038/35422
BindingDB Entry DOI: 10.7270/Q29P2ZW9
More data for this
Ligand-Target Pair