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Compile Data Set for Download or QSAR

Found 30 hits of ph data with Target = 'Tyrosine Kinase EphB4'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM6219
PNG
(BMCL182776 Compound 1 | Chlorobenzodioxole deriv. ...)
Show SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C24H27ClN4O4/c1-30-20-12-16-18(13-21(20)31-11-5-10-29-8-3-2-4-9-29)26-14-27-24(16)28-22-17(25)6-7-19-23(22)33-15-32-19/h6-7,12-14H,2-5,8-11,15H2,1H3,(H,26,27,28)
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n/an/a 350n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25230
PNG
(2,4-Pyrimidine derivative, 32 | 4-N-(5-chloro-2H-1...)
Show SMILES Clc1ccc2OCOc2c1Nc1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C21H20ClN5O3/c22-16-5-6-17-20(30-13-29-17)19(16)25-18-7-8-23-21(26-18)24-14-1-3-15(4-2-14)27-9-11-28-12-10-27/h1-8H,9-13H2,(H2,23,24,25,26)
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n/an/a 1.00E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25203
PNG
(2-N-(5-chloro-2H-1,3-benzodioxol-4-yl)-4-N-(3,4,5-...)
Show SMILES COc1cc(Nc2ncnc(Nc3c4OCOc4ccc3Cl)n2)cc(OC)c1OC
Show InChI InChI=1S/C19H18ClN5O5/c1-26-13-6-10(7-14(27-2)16(13)28-3)23-18-21-8-22-19(25-18)24-15-11(20)4-5-12-17(15)30-9-29-12/h4-8H,9H2,1-3H3,(H2,21,22,23,24,25)
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n/an/a 2.96E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25204
PNG
(4,6-Pyrimidine derivative, 6 | 4-N-(5-chloro-2H-1,...)
Show SMILES COc1cc(Nc2cc(Nc3c4OCOc4ccc3Cl)ncn2)cc(OC)c1OC
Show InChI InChI=1S/C20H19ClN4O5/c1-26-14-6-11(7-15(27-2)19(14)28-3)24-16-8-17(23-9-22-16)25-18-12(21)4-5-13-20(18)30-10-29-13/h4-9H,10H2,1-3H3,(H2,22,23,24,25)
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n/an/a 2.54E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25205
PNG
(2,4-Pyrimidine derivative, 7 | 4-N-(5-chloro-2H-1,...)
Show SMILES COc1cc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc(OC)c1OC
Show InChI InChI=1S/C20H19ClN4O5/c1-26-14-8-11(9-15(27-2)18(14)28-3)23-20-22-7-6-16(25-20)24-17-12(21)4-5-13-19(17)30-10-29-13/h4-9H,10H2,1-3H3,(H2,22,23,24,25)
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n/an/a 240n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25206
PNG
(2,4-Pyrimidine derivative, 8 | 4-N-(5-chloro-2H-1,...)
Show SMILES Clc1ccc2OCOc2c1Nc1ccnc(Nc2ccccc2)n1
Show InChI InChI=1S/C17H13ClN4O2/c18-12-6-7-13-16(24-10-23-13)15(12)21-14-8-9-19-17(22-14)20-11-4-2-1-3-5-11/h1-9H,10H2,(H2,19,20,21,22)
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n/an/a 1.55E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25207
PNG
(2,4-Pyrimidine derivative, 9 | 4-N-(5-chloro-2H-1,...)
Show SMILES Fc1ccccc1Nc1nccc(Nc2c3OCOc3ccc2Cl)n1
Show InChI InChI=1S/C17H12ClFN4O2/c18-10-5-6-13-16(25-9-24-13)15(10)22-14-7-8-20-17(23-14)21-12-4-2-1-3-11(12)19/h1-8H,9H2,(H2,20,21,22,23)
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n/an/a 5.00E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25208
PNG
(2,4-Pyrimidine derivative, 10 | 4-N-(5-chloro-2H-1...)
Show SMILES Fc1cccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)c1
Show InChI InChI=1S/C17H12ClFN4O2/c18-12-4-5-13-16(25-9-24-13)15(12)22-14-6-7-20-17(23-14)21-11-3-1-2-10(19)8-11/h1-8H,9H2,(H2,20,21,22,23)
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n/an/a 1.15E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25209
PNG
(2,4-Pyrimidine derivative, 11 | 4-N-(5-chloro-2H-1...)
Show SMILES Fc1ccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc1
Show InChI InChI=1S/C17H12ClFN4O2/c18-12-5-6-13-16(25-9-24-13)15(12)22-14-7-8-20-17(23-14)21-11-3-1-10(19)2-4-11/h1-8H,9H2,(H2,20,21,22,23)
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n/an/a 2.30E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25210
PNG
(2,4-Pyrimidine derivative, 12 | 4-N-(5-chloro-2H-1...)
Show SMILES Clc1ccccc1Nc1nccc(Nc2c3OCOc3ccc2Cl)n1
Show InChI InChI=1S/C17H12Cl2N4O2/c18-10-3-1-2-4-12(10)21-17-20-8-7-14(23-17)22-15-11(19)5-6-13-16(15)25-9-24-13/h1-8H,9H2,(H2,20,21,22,23)
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n/an/a 1.13E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25211
PNG
(2,4-Pyrimidine derivative, 13 | 4-N-(5-chloro-2H-1...)
Show SMILES Clc1cccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)c1
Show InChI InChI=1S/C17H12Cl2N4O2/c18-10-2-1-3-11(8-10)21-17-20-7-6-14(23-17)22-15-12(19)4-5-13-16(15)25-9-24-13/h1-8H,9H2,(H2,20,21,22,23)
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n/an/a 1.33E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25212
PNG
(2,4-Pyrimidine derivative, 14 | 4-N-(5-chloro-2H-1...)
Show SMILES Clc1ccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc1
Show InChI InChI=1S/C17H12Cl2N4O2/c18-10-1-3-11(4-2-10)21-17-20-8-7-14(23-17)22-15-12(19)5-6-13-16(15)25-9-24-13/h1-8H,9H2,(H2,20,21,22,23)
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n/an/a 6.00E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25213
PNG
(2,4-Pyrimidine derivative, 15 | 4-N-(5-chloro-2H-1...)
Show SMILES Cc1ccccc1Nc1nccc(Nc2c3OCOc3ccc2Cl)n1
Show InChI InChI=1S/C18H15ClN4O2/c1-11-4-2-3-5-13(11)21-18-20-9-8-15(23-18)22-16-12(19)6-7-14-17(16)25-10-24-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 1.40E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25214
PNG
(2,4-Pyrimidine derivative, 16 | 4-N-(5-chloro-2H-1...)
Show SMILES Cc1cccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)c1
Show InChI InChI=1S/C18H15ClN4O2/c1-11-3-2-4-12(9-11)21-18-20-8-7-15(23-18)22-16-13(19)5-6-14-17(16)25-10-24-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 460n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25215
PNG
(2,4-Pyrimidine derivative, 17 | 4-N-(5-chloro-2H-1...)
Show SMILES Cc1ccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc1
Show InChI InChI=1S/C18H15ClN4O2/c1-11-2-4-12(5-3-11)21-18-20-9-8-15(23-18)22-16-13(19)6-7-14-17(16)25-10-24-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 1.60E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25216
PNG
(2,4-Pyrimidine derivative, 18 | 4-N-(5-chloro-2H-1...)
Show SMILES COc1ccccc1Nc1nccc(Nc2c3OCOc3ccc2Cl)n1
Show InChI InChI=1S/C18H15ClN4O3/c1-24-13-5-3-2-4-12(13)21-18-20-9-8-15(23-18)22-16-11(19)6-7-14-17(16)26-10-25-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 3.88E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25217
PNG
(2,4-Pyrimidine derivative, 19 | 4-N-(5-chloro-2H-1...)
Show SMILES COc1cccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)c1
Show InChI InChI=1S/C18H15ClN4O3/c1-24-12-4-2-3-11(9-12)21-18-20-8-7-15(23-18)22-16-13(19)5-6-14-17(16)26-10-25-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 640n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25218
PNG
(2,4-Pyrimidine derivative, 20 | 4-N-(5-chloro-2H-1...)
Show SMILES COc1ccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc1
Show InChI InChI=1S/C18H15ClN4O3/c1-24-12-4-2-11(3-5-12)21-18-20-9-8-15(23-18)22-16-13(19)6-7-14-17(16)26-10-25-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 1.94E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25219
PNG
(2,4-Pyrimidine derivative, 21 | 2-({4-[(5-chloro-2...)
Show SMILES Clc1ccc2OCOc2c1Nc1ccnc(Nc2ccccc2C#N)n1
Show InChI InChI=1S/C18H12ClN5O2/c19-12-5-6-14-17(26-10-25-14)16(12)23-15-7-8-21-18(24-15)22-13-4-2-1-3-11(13)9-20/h1-8H,10H2,(H2,21,22,23,24)
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n/an/a 2.05E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25220
PNG
(2,4-Pyrimidine derivative, 22 | 3-({4-[(5-chloro-2...)
Show SMILES Clc1ccc2OCOc2c1Nc1ccnc(Nc2cccc(c2)C#N)n1
Show InChI InChI=1S/C18H12ClN5O2/c19-13-4-5-14-17(26-10-25-14)16(13)23-15-6-7-21-18(24-15)22-12-3-1-2-11(8-12)9-20/h1-8H,10H2,(H2,21,22,23,24)
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n/an/a 550n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25221
PNG
(2,4-Pyrimidine derivative, 23 | 4-({4-[(5-chloro-2...)
Show SMILES Clc1ccc2OCOc2c1Nc1ccnc(Nc2ccc(cc2)C#N)n1
Show InChI InChI=1S/C18H12ClN5O2/c19-13-5-6-14-17(26-10-25-14)16(13)23-15-7-8-21-18(24-15)22-12-3-1-11(9-20)2-4-12/h1-8H,10H2,(H2,21,22,23,24)
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n/an/a 1.25E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25222
PNG
(2,4-Pyrimidine derivative, 24 | 2-({4-[(5-chloro-2...)
Show SMILES NS(=O)(=O)c1ccccc1Nc1nccc(Nc2c3OCOc3ccc2Cl)n1
Show InChI InChI=1S/C17H14ClN5O4S/c18-10-5-6-12-16(27-9-26-12)15(10)22-14-7-8-20-17(23-14)21-11-3-1-2-4-13(11)28(19,24)25/h1-8H,9H2,(H2,19,24,25)(H2,20,21,22,23)
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n/an/a 3.55E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25223
PNG
(2,4-Pyrimidine derivative, 25 | 3-({4-[(5-chloro-2...)
Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)c1
Show InChI InChI=1S/C17H14ClN5O4S/c18-12-4-5-13-16(27-9-26-13)15(12)22-14-6-7-20-17(23-14)21-10-2-1-3-11(8-10)28(19,24)25/h1-8H,9H2,(H2,19,24,25)(H2,20,21,22,23)
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n/an/a 40n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25224
PNG
(2,4-Pyrimidine derivative, 26 | 4-({4-[(5-chloro-2...)
Show SMILES NS(=O)(=O)c1ccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc1
Show InChI InChI=1S/C17H14ClN5O4S/c18-12-5-6-13-16(27-9-26-13)15(12)22-14-7-8-20-17(23-14)21-10-1-3-11(4-2-10)28(19,24)25/h1-8H,9H2,(H2,19,24,25)(H2,20,21,22,23)
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n/an/a 300n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25225
PNG
(2,4-Pyrimidine derivative, 27 | 4-N-(5-chloro-2H-1...)
Show SMILES CS(=O)(=O)c1ccccc1Nc1nccc(Nc2c3OCOc3ccc2Cl)n1
Show InChI InChI=1S/C18H15ClN4O4S/c1-28(24,25)14-5-3-2-4-12(14)21-18-20-9-8-15(23-18)22-16-11(19)6-7-13-17(16)27-10-26-13/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 4.10E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25226
PNG
(2,4-Pyrimidine derivative, 28 | 4-N-(5-chloro-2H-1...)
Show SMILES CS(=O)(=O)c1cccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)c1
Show InChI InChI=1S/C18H15ClN4O4S/c1-28(24,25)12-4-2-3-11(9-12)21-18-20-8-7-15(23-18)22-16-13(19)5-6-14-17(16)27-10-26-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 90n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25227
PNG
(2,4-Pyrimidine derivative, 29 | 4-N-(5-chloro-2H-1...)
Show SMILES CS(=O)(=O)c1ccc(Nc2nccc(Nc3c4OCOc4ccc3Cl)n2)cc1
Show InChI InChI=1S/C18H15ClN4O4S/c1-28(24,25)12-4-2-11(3-5-12)21-18-20-9-8-15(23-18)22-16-13(19)6-7-14-17(16)27-10-26-14/h2-9H,10H2,1H3,(H2,20,21,22,23)
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n/an/a 630n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25228
PNG
(2,4-Pyrimidine derivative, 30 | 4-N-(5-chloro-2H-1...)
Show SMILES Clc1ccc2OCOc2c1Nc1ccnc(Nc2ccccc2N2CCOCC2)n1
Show InChI InChI=1S/C21H20ClN5O3/c22-14-5-6-17-20(30-13-29-17)19(14)25-18-7-8-23-21(26-18)24-15-3-1-2-4-16(15)27-9-11-28-12-10-27/h1-8H,9-13H2,(H2,23,24,25,26)
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n/an/a 7.85E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25229
PNG
(2,4-Pyrimidine derivative, 31 | 4-N-(5-chloro-2H-1...)
Show SMILES Clc1ccc2OCOc2c1Nc1ccnc(Nc2cccc(c2)N2CCOCC2)n1
Show InChI InChI=1S/C21H20ClN5O3/c22-16-4-5-17-20(30-13-29-17)19(16)25-18-6-7-23-21(26-18)24-14-2-1-3-15(12-14)27-8-10-28-11-9-27/h1-7,12H,8-11,13H2,(H2,23,24,25,26)
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n/an/a 580n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine Kinase EphB4


(Homo sapiens (Human))
BDBM25202
PNG
(2-N-(3-chloro-4-methoxyphenyl)-4-N-(3,4,5-trimetho...)
Show SMILES COc1ccc(Nc2ncnc(Nc3cc(OC)c(OC)c(OC)c3)n2)cc1Cl
Show InChI InChI=1S/C19H20ClN5O4/c1-26-14-6-5-11(7-13(14)20)23-18-21-10-22-19(25-18)24-12-8-15(27-2)17(29-4)16(9-12)28-3/h5-10H,1-4H3,(H2,21,22,23,24,25)
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n/an/a 1.60E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...


Bioorg Med Chem Lett 18: 2776-80 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.015
BindingDB Entry DOI: 10.7270/Q2C827MH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)