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Compile Data Set for Download or QSAR

Found 132 hits of ph data with Target = 'Tyrosine-protein kinase BTK'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM1773
PNG
(US8476284, 4 | US8497277, 13 | US8497277, 4 | US91...)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)
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n/an/a 0.720n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8497277 (2013)


BindingDB Entry DOI: 10.7270/Q2MW2FR5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134251
PNG
(US8846673, 262)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4cccc(F)c4)cc3)c12)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H17FN4O3/c26-17-2-1-3-19(12-17)33-18-10-8-15(9-11-18)23-22-21(29-30-24(22)27)13-20(28-23)14-4-6-16(7-5-14)25(31)32/h1-13H,(H,31,32)(H3,27,29,30)
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n/an/a 2n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97673
PNG
(US8476284, 41 | US8497277, 6)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)S(=O)(=O)C=C
Show InChI InChI=1S/C24H24N6O3S/c1-2-34(31,32)29-14-6-7-18(15-29)30-24-21(23(25)26-16-27-24)22(28-30)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,25,26,27)
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n/an/a 0.520n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8497277 (2013)


BindingDB Entry DOI: 10.7270/Q2MW2FR5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97677
PNG
(US8476284, 7 | US8497277, 7 | US9133201, 7)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)CCl
Show InChI InChI=1S/C24H23ClN6O2/c25-13-20(32)30-12-4-5-17(14-30)31-24-21(23(26)27-15-28-24)22(29-31)16-8-10-19(11-9-16)33-18-6-2-1-3-7-18/h1-3,6-11,15,17H,4-5,12-14H2,(H2,26,27,28)
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n/an/a 0.580n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8497277 (2013)


BindingDB Entry DOI: 10.7270/Q2MW2FR5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97674
PNG
(US8476284, 42 | US8497277, 8 | US9133201, 8)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C#C
Show InChI InChI=1S/C25H22N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h1,3-5,8-13,16,18H,6-7,14-15H2,(H2,26,27,28)
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n/an/a 0.720n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8497277 (2013)


BindingDB Entry DOI: 10.7270/Q2MW2FR5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97678
PNG
(US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-12-18(13-15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-8-10-20(11-9-17)33-19-6-4-3-5-7-19/h2-11,16,18H,1,12-15H2,(H2,26,27,28)
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n/an/a 3.60n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8497277 (2013)


BindingDB Entry DOI: 10.7270/Q2MW2FR5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97678
PNG
(US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-12-18(13-15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-8-10-20(11-9-17)33-19-6-4-3-5-7-19/h2-11,16,18H,1,12-15H2,(H2,26,27,28)
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n/an/a 0.580n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8497277 (2013)


BindingDB Entry DOI: 10.7270/Q2MW2FR5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM98655
PNG
(US8497277, 11 | US8497277, 12)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H22N6O2/c1-2-20(31)29-13-12-17(14-29)30-24-21(23(25)26-15-27-24)22(28-30)16-8-10-19(11-9-16)32-18-6-4-3-5-7-18/h2-11,15,17H,1,12-14H2,(H2,25,26,27)
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n/an/a 1.60n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8497277 (2013)


BindingDB Entry DOI: 10.7270/Q2MW2FR5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM98655
PNG
(US8497277, 11 | US8497277, 12)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H22N6O2/c1-2-20(31)29-13-12-17(14-29)30-24-21(23(25)26-15-27-24)22(28-30)16-8-10-19(11-9-16)32-18-6-4-3-5-7-18/h2-11,15,17H,1,12-14H2,(H2,25,26,27)
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n/an/a 1.90n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8497277 (2013)


BindingDB Entry DOI: 10.7270/Q2MW2FR5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM1773
PNG
(US8476284, 4 | US8497277, 13 | US8497277, 4 | US91...)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)
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n/an/a<0.5n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8497277 (2013)


BindingDB Entry DOI: 10.7270/Q2MW2FR5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97669
PNG
(US8476284, 37 | US8497277, 14)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m0/s1
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n/an/a 1.40n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8497277 (2013)


BindingDB Entry DOI: 10.7270/Q2MW2FR5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97675
PNG
(US8476284, 43 | US8497277, 15 | US9133201, 15 | US...)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12
Show InChI InChI=1S/C28H31N7O2/c1-33(2)16-7-11-24(36)34-17-6-8-21(18-34)35-28-25(27(29)30-19-31-28)26(32-35)20-12-14-23(15-13-20)37-22-9-4-3-5-10-22/h3-5,7,9-15,19,21H,6,8,16-18H2,1-2H3,(H2,29,30,31)/b11-7+/t21-/m1/s1
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n/an/a 2.5n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8497277 (2013)


BindingDB Entry DOI: 10.7270/Q2MW2FR5
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM1773
PNG
(US8476284, 4 | US8497277, 13 | US8497277, 4 | US91...)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)
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n/an/a 0.720n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97676
PNG
(US8476284, 5 | US8497277, 5 | US9133201, 5)
Show SMILES C\C=C\C(=O)N1CCCC(C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12
Show InChI InChI=1S/C26H26N6O2/c1-2-7-22(33)31-15-6-8-19(16-31)32-26-23(25(27)28-17-29-26)24(30-32)18-11-13-21(14-12-18)34-20-9-4-3-5-10-20/h2-5,7,9-14,17,19H,6,8,15-16H2,1H3,(H2,27,28,29)/b7-2+
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n/an/a 20n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97673
PNG
(US8476284, 41 | US8497277, 6)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)S(=O)(=O)C=C
Show InChI InChI=1S/C24H24N6O3S/c1-2-34(31,32)29-14-6-7-18(15-29)30-24-21(23(25)26-16-27-24)22(28-30)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,25,26,27)
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n/an/a 0.520n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97677
PNG
(US8476284, 7 | US8497277, 7 | US9133201, 7)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)CCl
Show InChI InChI=1S/C24H23ClN6O2/c25-13-20(32)30-12-4-5-17(14-30)31-24-21(23(26)27-15-28-24)22(29-31)16-8-10-19(11-9-16)33-18-6-2-1-3-7-18/h1-3,6-11,15,17H,4-5,12-14H2,(H2,26,27,28)
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n/an/a 0.580n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97674
PNG
(US8476284, 42 | US8497277, 8 | US9133201, 8)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C#C
Show InChI InChI=1S/C25H22N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h1,3-5,8-13,16,18H,6-7,14-15H2,(H2,26,27,28)
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n/an/a 0.720n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97678
PNG
(US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-12-18(13-15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-8-10-20(11-9-17)33-19-6-4-3-5-7-19/h2-11,16,18H,1,12-15H2,(H2,26,27,28)
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n/an/a 3.60n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97672
PNG
(US8476284, 40 | US9133201, 10 | US9181263, 9 | US9...)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CC[C@@H](CC1)NC(=O)C=C
Show InChI InChI=1S/C26H26N6O2/c1-2-22(33)30-18-10-12-19(13-11-18)32-26-23(25(27)28-16-29-26)24(31-32)17-8-14-21(15-9-17)34-20-6-4-3-5-7-20/h2-9,14-16,18-19H,1,10-13H2,(H,30,33)(H2,27,28,29)/t18-,19+
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n/an/a 0.580n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97671
PNG
(US8476284, 39 | US9133201, 11)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H22N6O2/c1-2-20(31)29-13-12-17(14-29)30-24-21(23(25)26-15-27-24)22(28-30)16-8-10-19(11-9-16)32-18-6-4-3-5-7-18/h2-11,15,17H,1,12-14H2,(H2,25,26,27)/t17-/m1/s1
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n/an/a 1.60n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97670
PNG
(US8476284, 38 | US9133201, 12)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H22N6O2/c1-2-20(31)29-13-12-17(14-29)30-24-21(23(25)26-15-27-24)22(28-30)16-8-10-19(11-9-16)32-18-6-4-3-5-7-18/h2-11,15,17H,1,12-14H2,(H2,25,26,27)/t17-/m0/s1
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n/an/a 1.90n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM1774
PNG
(US8476284, 13)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m0/s1
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Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97669
PNG
(US8476284, 37 | US8497277, 14)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m0/s1
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n/an/a 1.40n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM97675
PNG
(US8476284, 43 | US8497277, 15 | US9133201, 15 | US...)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12
Show InChI InChI=1S/C28H31N7O2/c1-33(2)16-7-11-24(36)34-17-6-8-21(18-34)35-28-25(27(29)30-19-31-28)26(32-35)20-12-14-23(15-13-20)37-22-9-4-3-5-10-22/h3-5,7,9-15,19,21H,6,8,16-18H2,1-2H3,(H2,29,30,31)/b11-7+/t21-/m1/s1
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n/an/a 2.5n/an/an/an/a7.4n/a



Pharmacyclics, Inc.

US Patent


Assay Description
Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.


US Patent US8476284 (2013)


BindingDB Entry DOI: 10.7270/Q2CJ8C3G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134214
PNG
(US8846673, 5)
Show SMILES Cc1cccc(Oc2ccc(cc2)-c2cc(nc(N)c2C(N)=N)C2CCCC2)c1
Show InChI InChI=1S/C24H26N4O/c1-15-5-4-8-19(13-15)29-18-11-9-16(10-12-18)20-14-21(17-6-2-3-7-17)28-24(27)22(20)23(25)26/h4-5,8-14,17H,2-3,6-7H2,1H3,(H3,25,26)(H2,27,28)
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n/an/a 290n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134215
PNG
(US8846673, 17)
Show SMILES CC(C)(C)OC(=O)NC1CCN(C1)c1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c2n1
Show InChI InChI=1S/C27H30N6O3/c1-27(2,3)36-26(34)29-18-13-14-33(16-18)22-15-21(23-24(28)31-32-25(23)30-22)17-9-11-20(12-10-17)35-19-7-5-4-6-8-19/h4-12,15,18H,13-14,16H2,1-3H3,(H,29,34)(H3,28,30,31,32)
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n/an/a 8.64E+3n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134216
PNG
(US8846673, 20)
Show SMILES COc1ccc(Oc2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c3n2)cc1
Show InChI InChI=1S/C25H20N4O3/c1-30-17-11-13-20(14-12-17)32-22-15-21(23-24(26)28-29-25(23)27-22)16-7-9-19(10-8-16)31-18-5-3-2-4-6-18/h2-15H,1H3,(H3,26,27,28,29)
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n/an/a 2.79E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134217
PNG
(US8846673, 31)
Show SMILES Cc1csc(NC(=O)NC2CCN(C2)c2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c3n2)n1
Show InChI InChI=1S/C27H26N8O2S/c1-16-15-38-27(29-16)32-26(36)30-18-11-12-35(14-18)22-13-21(23-24(28)33-34-25(23)31-22)17-7-9-20(10-8-17)37-19-5-3-2-4-6-19/h2-10,13,15,18H,11-12,14H2,1H3,(H3,28,31,33,34)(H2,29,30,32,36)
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n/an/a 9.41E+3n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134218
PNG
(US8846673, 43)
Show SMILES CC(C)Oc1ccc(cc1)-c1cncc2[nH]nc(N)c12
Show InChI InChI=1S/C15H16N4O/c1-9(2)20-11-5-3-10(4-6-11)12-7-17-8-13-14(12)15(16)19-18-13/h3-9H,1-2H3,(H3,16,18,19)
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n/an/a 9.31E+3n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134219
PNG
(US8846673, 44)
Show SMILES Nc1n[nH]c2cncc(-c3ccc(OC4CCCC4)cc3)c12
Show InChI InChI=1S/C17H18N4O/c18-17-16-14(9-19-10-15(16)20-21-17)11-5-7-13(8-6-11)22-12-3-1-2-4-12/h5-10,12H,1-4H2,(H3,18,20,21)
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n/an/a 9.49E+3n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134220
PNG
(US8846673, 47)
Show SMILES Nc1n[nH]c2cncc(-c3ccc(cc3)C(=O)N3CCCC3)c12
Show InChI InChI=1S/C17H17N5O/c18-16-15-13(9-19-10-14(15)20-21-16)11-3-5-12(6-4-11)17(23)22-7-1-2-8-22/h3-6,9-10H,1-2,7-8H2,(H3,18,20,21)
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n/an/a 4.06E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134221
PNG
(US8846673, 61)
Show SMILES Nc1n[nH]c2c(ncc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C31H23N5O2/c32-30-27-26(20-13-17-25(18-14-20)38-24-9-5-2-6-10-24)19-33-28(29(27)35-36-30)21-11-15-23(16-12-21)34-31(37)22-7-3-1-4-8-22/h1-19H,(H,34,37)(H3,32,35,36)
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n/an/a 1.49E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134222
PNG
(US8846673, 62)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ncc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C25H21N5O3S/c1-34(31,32)30-18-7-5-6-17(14-18)23-24-22(25(26)29-28-24)21(15-27-23)16-10-12-20(13-11-16)33-19-8-3-2-4-9-19/h2-15,30H,1H3,(H3,26,28,29)
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n/an/a 270n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134223
PNG
(US8846673, 82)
Show SMILES Nc1n[nH]c2c(ncc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H16Cl2N4O/c25-19-11-8-15(12-20(19)26)22-23-21(24(27)30-29-23)18(13-28-22)14-6-9-17(10-7-14)31-16-4-2-1-3-5-16/h1-13H,(H3,27,29,30)
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n/an/a 9.18E+3n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134224
PNG
(US8846673, 92)
Show SMILES Nc1n[nH]c2c(ncc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(O)cc1
Show InChI InChI=1S/C24H18N4O2/c25-24-21-20(15-8-12-19(13-9-15)30-18-4-2-1-3-5-18)14-26-22(23(21)27-28-24)16-6-10-17(29)11-7-16/h1-14,29H,(H3,25,27,28)
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n/an/a 280n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134225
PNG
(US8846673, 95)
Show SMILES Nc1n[nH]c2c(ncc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C26H19N5O/c27-26-23-21(16-6-9-20(10-7-16)32-19-4-2-1-3-5-19)15-29-24(25(23)30-31-26)18-8-11-22-17(14-18)12-13-28-22/h1-15,28H,(H3,27,30,31)
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n/an/a 250n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134226
PNG
(US8846673, 96)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ncc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C25H21N5O3S/c1-34(31,32)30-18-11-7-17(8-12-18)23-24-22(25(26)29-28-24)21(15-27-23)16-9-13-20(14-10-16)33-19-5-3-2-4-6-19/h2-15,30H,1H3,(H3,26,28,29)
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n/an/a 280n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134227
PNG
(US8846673, 102)
Show SMILES CC(C)COc1cccc(c1)-c1ncc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C28H26N4O2/c1-18(2)17-33-23-10-6-7-20(15-23)26-27-25(28(29)32-31-27)24(16-30-26)19-11-13-22(14-12-19)34-21-8-4-3-5-9-21/h3-16,18H,17H2,1-2H3,(H3,29,31,32)
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n/an/a 1.40E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134228
PNG
(US8846673, 107)
Show SMILES Cc1ccccc1-c1ncc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c12
Show InChI InChI=1S/C25H20N4O/c1-16-7-5-6-10-20(16)23-24-22(25(26)29-28-24)21(15-27-23)17-11-13-19(14-12-17)30-18-8-3-2-4-9-18/h2-15H,1H3,(H3,26,28,29)
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n/an/a 1.27E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134229
PNG
(US8846673, 108)
Show SMILES Nc1n[nH]c2c(ncc(-c3ccc(Oc4ccccc4)cc3)c12)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H17F3N4O/c26-25(27,28)17-6-4-5-16(13-17)22-23-21(24(29)32-31-23)20(14-30-22)15-9-11-19(12-10-15)33-18-7-2-1-3-8-18/h1-14H,(H3,29,31,32)
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n/an/a 1.61E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134230
PNG
(US8846673, 113)
Show SMILES Nc1n[nH]c2c(ncc(-c3ccc(Oc4ccccc4)cc3)c12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C25H17F3N4O2/c26-25(27,28)34-19-8-4-5-16(13-19)22-23-21(24(29)32-31-23)20(14-30-22)15-9-11-18(12-10-15)33-17-6-2-1-3-7-17/h1-14H,(H3,29,31,32)
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n/an/a 1.38E+4n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134231
PNG
(US8846673, 120)
Show SMILES Nc1n[nH]c2nc(nc(-c3ccc(Oc4ccccc4)cc3)c12)-c1cccs1
Show InChI InChI=1S/C21H15N5OS/c22-19-17-18(23-20(16-7-4-12-28-16)24-21(17)26-25-19)13-8-10-15(11-9-13)27-14-5-2-1-3-6-14/h1-12H,(H3,22,23,24,25,26)
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n/an/a 240n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134232
PNG
(US8846673, 128)
Show SMILES COc1cccc(c1)-c1cnc(Nc2ccccc2)c2[nH]nc(N)c12
Show InChI InChI=1S/C19H17N5O/c1-25-14-9-5-6-12(10-14)15-11-21-19(17-16(15)18(20)24-23-17)22-13-7-3-2-4-8-13/h2-11H,1H3,(H,21,22)(H3,20,23,24)
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n/an/a 290n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134233
PNG
(US8846673, 130)
Show SMILES COc1cccc(c1)-c1cnc(Nc2ccccc2Cl)c(Cl)c1C#N
Show InChI InChI=1S/C19H13Cl2N3O/c1-25-13-6-4-5-12(9-13)15-11-23-19(18(21)14(15)10-22)24-17-8-3-2-7-16(17)20/h2-9,11H,1H3,(H,23,24)
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n/an/a 230n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134234
PNG
(US8846673, 132)
Show SMILES COc1ccc(cc1)-c1cnc(Nc2ccccc2C)c2[nH]nc(N)c12
Show InChI InChI=1S/C20H19N5O/c1-12-5-3-4-6-16(12)23-20-18-17(19(21)25-24-18)15(11-22-20)13-7-9-14(26-2)10-8-13/h3-11H,1-2H3,(H,22,23)(H3,21,24,25)
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n/an/a 260n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134235
PNG
(US8846673, 137)
Show SMILES CC(C)Oc1cccc(c1)-c1cnc(Nc2ccccc2C)c2[nH]nc(N)c12
Show InChI InChI=1S/C22H23N5O/c1-13(2)28-16-9-6-8-15(11-16)17-12-24-22(20-19(17)21(23)27-26-20)25-18-10-5-4-7-14(18)3/h4-13H,1-3H3,(H,24,25)(H3,23,26,27)
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n/an/a 240n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134236
PNG
(US8846673, 155)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc2ccccc2c1
Show InChI InChI=1S/C28H20N4O/c29-28-26-25(31-32-28)17-24(21-11-10-18-6-4-5-7-20(18)16-21)30-27(26)19-12-14-23(15-13-19)33-22-8-2-1-3-9-22/h1-17H,(H3,29,31,32)
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n/an/a 260n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134237
PNG
(US8846673, 193)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H18N4O3/c26-24-22-21(28-29-24)14-20(15-6-8-17(9-7-15)25(30)31)27-23(22)16-10-12-19(13-11-16)32-18-4-2-1-3-5-18/h1-14H,(H,30,31)(H3,26,28,29)
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n/an/a 1n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134238
PNG
(US8846673, 216)
Show SMILES CNC(=O)c1ccc(cc1)-c1cc2[nH]nc(N)c2c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H21N5O2/c1-28-26(32)18-9-7-16(8-10-18)21-15-22-23(25(27)31-30-22)24(29-21)17-11-13-20(14-12-17)33-19-5-3-2-4-6-19/h2-15H,1H3,(H,28,32)(H3,27,30,31)
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n/an/a 2n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (human))
BDBM134239
PNG
(US8846673, 217)
Show SMILES Nc1n[nH]c2cc(nc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(cc1)C(=O)Nc1nnn[nH]1
Show InChI InChI=1S/C26H19N9O2/c27-24-22-21(30-31-24)14-20(15-6-8-17(9-7-15)25(36)29-26-32-34-35-33-26)28-23(22)16-10-12-19(13-11-16)37-18-4-2-1-3-5-18/h1-14H,(H3,27,30,31)(H2,29,32,33,34,35,36)
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n/an/a 0.700n/an/an/an/a7.40



Bristol-Myers Squibb Company

US Patent


Assay Description
To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 uM), ATP (2...


US Patent US8846673 (2014)


BindingDB Entry DOI: 10.7270/Q26M35HM
More data for this
Ligand-Target Pair
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