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Found 39 of ph data with Target = 'Tyrosine-protein kinase ZAP-70'
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM6619(3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...)
Affinity DataIC50: >1.00E+4nMpH: 7.0 T: 2°CAssay Description:Src, Lck, Flt-1, ZAP, EGFR, FGFR1, and PFGFR-beta were assayed in the Merck research laboratory (Homogeneous proximity tyrosine kinase assays: scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM5062(1,2,4-Oxadiazole Analogue 4h | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50: >5.00E+5nMpH: 7.4 T: 2°CAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM5061(1,2,4-Oxadiazole Analogue 4g | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50:  1.84E+5nMpH: 7.4 T: 2°CAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM5063(1,2,4-Oxadiazole Analogue 4i | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50:  5.50E+4nMpH: 7.4 T: 2°CAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM5060(1,2,4-Oxadiazole Analogue 4e | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50:  9.40E+4nMpH: 7.4 T: 2°CAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM5057(1,2,4-Oxadiazole Analogue 4b | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50:  6.50E+4nMpH: 7.4 T: 2°CAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM5059(1,2,4-Oxadiazole Analogue 4d | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50:  2.60E+4nMpH: 7.4 T: 2°CAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM5058(1,2,4-Oxadiazole Analogue 4c | 4-[(2S)-2-{[(1S)-3-...)
Affinity DataIC50:  3.60E+4nMpH: 7.4 T: 2°CAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM236557(US9365572, 5)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Agents: 1-fold kinase buffer without MnCl2: 50 mM HEPES, pH 7.5, 0.0015% Brij-35, 10 mM MgCl2, 2 mM DTT. 1-fold kinase buffer with MnCl2: 50 mM HEPES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ZAP-70(Mus musculus)
Amgen

LigandPNGBDBM17744(2,6-dimethylphenyl N-[2-({3,5-dimethoxy-4-[3-(4-me...)
Affinity DataIC50:  370nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26412(7-[(3,5-dimethoxyphenyl)amino]-5-{[(3-methoxypheny...)
Affinity DataIC50:  530nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26413(7-[(3,5-dimethoxyphenyl)amino]-5-{[(2-methoxypheny...)
Affinity DataIC50:  340nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26414(5-{[(3,5-difluorophenyl)methyl]amino}-7-[(3,5-dime...)
Affinity DataIC50:  910nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26415(5-{[(2,4-difluorophenyl)methyl]amino}-7-[(3,5-dime...)
Affinity DataIC50:  150nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26416(7-[(3,5-dimethoxyphenyl)amino]-5-[(pyridin-4-ylmet...)
Affinity DataIC50:  250nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26417(7-[(3,5-dimethoxyphenyl)amino]-5-[(furan-2-ylmethy...)
Affinity DataIC50:  920nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26418(5-[(1H-1,3-benzodiazol-2-ylmethyl)amino]-7-[(3,5-d...)
Affinity DataIC50:  200nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26419(7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-sulfamoylphe...)
Affinity DataIC50:  150nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26420(7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-methanesulfo...)
Affinity DataIC50:  190nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26421(imidazo[1,2-c]pyrimidine-8-carboxamide, 10t | meth...)
Affinity DataIC50:  420nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26422(4-[({8-carbamoyl-7-[(3,5-dimethoxyphenyl)amino]imi...)
Affinity DataIC50:  180nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26423(5-{[(4-carbamoylphenyl)methyl]amino}-7-[(3,5-dimet...)
Affinity DataIC50:  660nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26424(7-[(3,5-dimethoxyphenyl)amino]-5-({[4-(hydroxymeth...)
Affinity DataIC50:  690nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26425(imidazo[1,2-c]pyrimidine-8-carboxamide, 20 | tert-...)
Affinity DataIC50:  3.20E+3nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26426(2-{4-[({8-carbamoyl-7-[(3,5-dimethoxyphenyl)amino]...)
Affinity DataIC50:  240nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26427(5-({[4-(carbamoylmethyl)phenyl]methyl}amino)-7-[(3...)
Affinity DataIC50:  480nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26428(ethyl (2E)-3-{4-[({8-carbamoyl-7-[(3,5-dimethoxyph...)
Affinity DataIC50:  88nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26429((2E)-3-{4-[({8-carbamoyl-7-[(3,5-dimethoxyphenyl)a...)
Affinity DataIC50:  47nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26410(7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-fluorophenyl...)
Affinity DataIC50:  220nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26409(7-[(3,5-dimethoxyphenyl)amino]-5-{[(1S)-1-phenylet...)
Affinity DataIC50:  930nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26408(7-[(3,5-dimethoxyphenyl)amino]-5-{[(1R)-1-phenylet...)
Affinity DataIC50:  410nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26407(7-[(3,5-dimethoxyphenyl)amino]-5-[(2-phenylethyl)a...)
Affinity DataIC50:  5.10E+3nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26406(5-[benzyl(methyl)amino]-7-[(3,5-dimethoxyphenyl)am...)
Affinity DataIC50:  5.50E+3nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26405(5-(benzylamino)-7-[(3,5-dimethoxyphenyl)amino]imid...)
Affinity DataIC50:  400nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26404(5-[(2-aminoethyl)amino]-7-[(3,5-dimethoxyphenyl)am...)
Affinity DataIC50:  3.50E+3nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26403(7-[(3,5-dimethoxyphenyl)amino]-5-[(2-hydroxyethyl)...)
Affinity DataIC50:  1.90E+3nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26402(5-amino-7-[(3,5-dimethoxyphenyl)amino]imidazo[1,2-...)
Affinity DataIC50:  1.00E+4nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26401(7-[(3,5-dimethoxyphenyl)amino]-5-(methylsulfanyl)i...)
Affinity DataIC50:  3.00E+3nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Banyu Tsukuba Research Institute

LigandPNGBDBM26411(7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-methoxypheny...)
Affinity DataIC50:  230nMpH: 7.6 T: 2°CAssay Description:A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed