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Compile Data Set for Download or QSAR

Found 231 hits of ph data with Target = 'c-Jun N-terminal kinase, JNK'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM92522
PNG
(Aminopyrazole inhibitor, 3451)
Show SMILES COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3)cn2)cc(OC)c1OC
Show InChI InChI=1S/C26H25N5O5/c1-34-22-13-19(14-23(35-2)24(22)36-3)28-25(32)17-8-7-11-21(12-17)31-16-20(15-27-31)30-26(33)29-18-9-5-4-6-10-18/h4-16H,1-3H3,(H,28,32)(H2,29,30,33)
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Article
PubMed
n/an/a 400n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM92523
PNG
(Aminopyrazole inhibitor, 3528)
Show SMILES COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cc(OC)c1OC
Show InChI InChI=1S/C26H24ClN5O5/c1-35-22-12-17(13-23(36-2)24(22)37-3)29-25(33)16-7-6-8-19(11-16)32-15-18(14-28-32)30-26(34)31-21-10-5-4-9-20(21)27/h4-15H,1-3H3,(H,29,33)(H2,30,31,34)
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n/an/a 560n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM92524
PNG
(Aminopyrazole inhibitor, 3576)
Show SMILES COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3cccc(C)c3)cn2)cc(OC)c1OC
Show InChI InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34)
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n/an/a 170n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM92529
PNG
(Aminopyrazole inhibitor, 4018)
Show SMILES Cc1cccc(NC(=O)Nc2cnn(c2)-c2cccc(c2)C(=O)NCCN2CCOCC2)c1
Show InChI InChI=1S/C24H28N6O3/c1-18-4-2-6-20(14-18)27-24(32)28-21-16-26-30(17-21)22-7-3-5-19(15-22)23(31)25-8-9-29-10-12-33-13-11-29/h2-7,14-17H,8-13H2,1H3,(H,25,31)(H2,27,28,32)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM92527
PNG
(Aminopyrazole inhibitor, 4642)
Show SMILES CN(C)c1cc(cc(c1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1)C(=O)Nc1cncc(C)c1
Show InChI InChI=1S/C25H24ClN7O2/c1-16-8-18(13-27-12-16)29-24(34)17-9-20(32(2)3)11-21(10-17)33-15-19(14-28-33)30-25(35)31-23-7-5-4-6-22(23)26/h4-15H,1-3H3,(H,29,34)(H2,30,31,35)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM92528
PNG
(Aminopyrazole inhibitor, 4643)
Show SMILES Cc1cncc(NC(=O)c2cc(cc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)N2CCOCC2)c1
Show InChI InChI=1S/C27H26ClN7O3/c1-18-10-20(15-29-14-18)31-26(36)19-11-22(34-6-8-38-9-7-34)13-23(12-19)35-17-21(16-30-35)32-27(37)33-25-5-3-2-4-24(25)28/h2-5,10-17H,6-9H2,1H3,(H,31,36)(H2,32,33,37)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM92526
PNG
(Aminopyrazole inhibitor, 4326)
Show SMILES Cc1cncc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)c1
Show InChI InChI=1S/C23H19ClN6O2/c1-15-9-17(12-25-11-15)27-22(31)16-5-4-6-19(10-16)30-14-18(13-26-30)28-23(32)29-21-8-3-2-7-20(21)24/h2-14H,1H3,(H,27,31)(H2,28,29,32)
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n/an/a 1.40E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15868
PNG
(6-chloro-9-hydroxy-1,3-dimethyl-1H,4H,9H-pyrazolo[...)
Show SMILES Cc1nn(C)c2n(O)c3ccc(Cl)cc3c(=O)c12
Show InChI InChI=1S/C12H10ClN3O2/c1-6-10-11(17)8-5-7(13)3-4-9(8)16(18)12(10)15(2)14-6/h3-5,18H,1-2H3
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n/an/a 1.22E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15869
PNG
(6-chloro-9-hydroxy-1-methyl-3-(trifluoromethyl)-1H...)
Show SMILES Cn1nc(c2c1n(O)c1ccc(Cl)cc1c2=O)C(F)(F)F
Show InChI InChI=1S/C12H7ClF3N3O2/c1-18-11-8(10(17-18)12(14,15)16)9(20)6-4-5(13)2-3-7(6)19(11)21/h2-4,21H,1H3
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n/an/a 980n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15870
PNG
(6-bromo-9-hydroxy-1,3-dimethyl-1H,4H,9H-pyrazolo[3...)
Show SMILES Cc1nn(C)c2n(O)c3ccc(Br)cc3c(=O)c12
Show InChI InChI=1S/C12H10BrN3O2/c1-6-10-11(17)8-5-7(13)3-4-9(8)16(18)12(10)15(2)14-6/h3-5,18H,1-2H3
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n/an/a 920n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15871
PNG
(5,6-dichloro-9-hydroxy-1-methyl-3-(trifluoromethyl...)
Show SMILES Cn1nc(c2c1n(O)c1ccc(Cl)c(Cl)c1c2=O)C(F)(F)F
Show InChI InChI=1S/C12H6Cl2F3N3O2/c1-19-11-7(10(18-19)12(15,16)17)9(21)6-5(20(11)22)3-2-4(13)8(6)14/h2-3,22H,1H3
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n/an/a>1.00E+4n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15872
PNG
(6,7-dichloro-9-hydroxy-1-methyl-3-(trifluoromethyl...)
Show SMILES Cn1nc(c2c1n(O)c1cc(Cl)c(Cl)cc1c2=O)C(F)(F)F
Show InChI InChI=1S/C12H6Cl2F3N3O2/c1-19-11-8(10(18-19)12(15,16)17)9(21)4-2-5(13)6(14)3-7(4)20(11)22/h2-3,22H,1H3
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n/an/a 5.14E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15873
PNG
(6-chloro-9-hydroxy-8-methoxy-1-methyl-3-(trifluoro...)
Show SMILES COc1cc(Cl)cc2c1n(O)c1n(C)nc(c1c2=O)C(F)(F)F
Show InChI InChI=1S/C13H9ClF3N3O3/c1-19-12-8(11(18-19)13(15,16)17)10(21)6-3-5(14)4-7(23-2)9(6)20(12)22/h3-4,22H,1-2H3
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n/an/a>1.00E+4n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15874
PNG
(6-chloro-7-(dimethylamino)-9-hydroxy-1-methyl-3-(t...)
Show SMILES CN(C)c1cc2n(O)c3n(C)nc(c3c(=O)c2cc1Cl)C(F)(F)F
Show InChI InChI=1S/C14H12ClF3N4O2/c1-20(2)9-5-8-6(4-7(9)15)11(23)10-12(14(16,17)18)19-21(3)13(10)22(8)24/h4-5,24H,1-3H3
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n/an/a>1.00E+4n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15875
PNG
(9-hydroxy pyrazoloquinolinone 12a | 9-hydroxy-1,3-...)
Show SMILES Cc1nn(C)c2n(O)c3ccccc3c(=O)c12
Show InChI InChI=1S/C12H11N3O2/c1-7-10-11(16)8-5-3-4-6-9(8)15(17)12(10)14(2)13-7/h3-6,17H,1-2H3
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n/an/a>1.00E+4n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15876
PNG
(9-hydroxy pyrazoloquinolinone 12b | 9-hydroxy-1,3-...)
Show SMILES Cc1nn(C)c2n(O)c3ccc(cc3c(=O)c12)-c1ccccc1
Show InChI InChI=1S/C18H15N3O2/c1-11-16-17(22)14-10-13(12-6-4-3-5-7-12)8-9-15(14)21(23)18(16)20(2)19-11/h3-10,23H,1-2H3
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n/an/a>1.00E+4n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15877
PNG
(9-hydroxy pyrazoloquinolinone 12c | 9-hydroxy-1,3-...)
Show SMILES Cc1nn(C)c2n(O)c3ccc(cc3c(=O)c12)-c1cc[nH]n1
Show InChI InChI=1S/C15H13N5O2/c1-8-13-14(21)10-7-9(11-5-6-16-17-11)3-4-12(10)20(22)15(13)19(2)18-8/h3-7,22H,1-2H3,(H,16,17)
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n/an/a>1.00E+4n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15878
PNG
(6-chloro-9-methoxy-1,3-dimethyl-1H,4H,9H-pyrazolo[...)
Show SMILES COn1c2n(C)nc(C)c2c(=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C13H12ClN3O2/c1-7-11-12(18)9-6-8(14)4-5-10(9)17(19-3)13(11)16(2)15-7/h4-6H,1-3H3
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n/an/a 4.59E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15879
PNG
(6-chloro-9-ethoxy-1,3-dimethyl-1H,4H,9H-pyrazolo[3...)
Show SMILES CCOn1c2n(C)nc(C)c2c(=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C14H14ClN3O2/c1-4-20-18-11-6-5-9(15)7-10(11)13(19)12-8(2)16-17(3)14(12)18/h5-7H,4H2,1-3H3
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n/an/a 2.78E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15880
PNG
(6-chloro-1,3-dimethyl-9-propoxy-1H,4H,9H-pyrazolo[...)
Show SMILES CCCOn1c2n(C)nc(C)c2c(=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C15H16ClN3O2/c1-4-7-21-19-12-6-5-10(16)8-11(12)14(20)13-9(2)17-18(3)15(13)19/h5-6,8H,4,7H2,1-3H3
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n/an/a 5.43E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15881
PNG
(6-chloro-1,3-dimethyl-9-(propan-2-yloxy)-1H,4H,9H-...)
Show SMILES CC(C)On1c2n(C)nc(C)c2c(=O)c2cc(Cl)ccc12
Show InChI InChI=1S/C15H16ClN3O2/c1-8(2)21-19-12-6-5-10(16)7-11(12)14(20)13-9(3)17-18(4)15(13)19/h5-8H,1-4H3
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n/an/a>1.00E+4n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15882
PNG
(6-chloro-9-(cyclopentyloxy)-1,3-dimethyl-1H,4H,9H-...)
Show SMILES Cc1nn(C)c2n(OC3CCCC3)c3ccc(Cl)cc3c(=O)c12
Show InChI InChI=1S/C17H18ClN3O2/c1-10-15-16(22)13-9-11(18)7-8-14(13)21(17(15)20(2)19-10)23-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15883
PNG
(9-(alk)oxy pyrazoloquinolinone 14f | 9-(benzyloxy)...)
Show SMILES Cc1nn(C)c2n(OCc3ccccc3)c3ccc(Cl)cc3c(=O)c12
Show InChI InChI=1S/C19H16ClN3O2/c1-12-17-18(24)15-10-14(20)8-9-16(15)23(19(17)22(2)21-12)25-11-13-6-4-3-5-7-13/h3-10H,11H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15884
PNG
(6-chloro-1,3-dimethyl-1H,4H,9H-pyrazolo[3,4-b]quin...)
Show SMILES Cc1nn(C)c2nc3ccc(Cl)cc3c(O)c12
Show InChI InChI=1S/C12H10ClN3O/c1-6-10-11(17)8-5-7(13)3-4-9(8)14-12(10)16(2)15-6/h3-5H,1-2H3,(H,14,17)
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n/an/a>1.00E+4n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


Bioorg Med Chem Lett 16: 2590-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.046
BindingDB Entry DOI: 10.7270/Q2XK8CSR
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15907
PNG
(Aminopyridine-Based Inhibitor 6a | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C10H12N4O2/c1-3-16-10-7(5-11)8(12)4-9(14-10)13-6(2)15/h4H,3H2,1-2H3,(H3,12,13,14,15)
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n/an/a 840n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15908
PNG
(Aminopyridine-Based Inhibitor 6o | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N
Show InChI InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23)
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n/an/a 45n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15909
PNG
(2-pyridinecarboxamide deriv. 3 | 4-Amino-5-cyano-6...)
Show SMILES CCOc1nc(cc(N)c1C#N)C(=O)NCc1cc(OC)ccc1OC
Show InChI InChI=1S/C18H20N4O4/c1-4-26-18-13(9-19)14(20)8-15(22-18)17(23)21-10-11-7-12(24-2)5-6-16(11)25-3/h5-8H,4,10H2,1-3H3,(H2,20,22)(H,21,23)
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n/an/a 71n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15910
PNG
(4-Amino-6-(2,5-dimethoxy-benzylamino)-2-ethoxy-nic...)
Show SMILES CCOc1nc(NCc2cc(OC)ccc2OC)cc(N)c1C#N
Show InChI InChI=1S/C17H20N4O3/c1-4-24-17-13(9-18)14(19)8-16(21-17)20-10-11-7-12(22-2)5-6-15(11)23-3/h5-8H,4,10H2,1-3H3,(H3,19,20,21)
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n/an/a>1.00E+4n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15911
PNG
(2-pyridinecarboxamide deriv. 8a | 4-Amino-5-cyano-...)
Show SMILES CCOc1nc(cc(N)c1C#N)C(=O)NC
Show InChI InChI=1S/C10H12N4O2/c1-3-16-10-6(5-11)7(12)4-8(14-10)9(15)13-2/h4H,3H2,1-2H3,(H2,12,14)(H,13,15)
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n/an/a 1.20E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15912
PNG
(2-pyridinecarboxamide deriv. 8b | 4-Amino-5-cyano-...)
Show SMILES CCOc1nc(cc(N)c1C#N)C(=O)NCc1ccccc1
Show InChI InChI=1S/C16H16N4O2/c1-2-22-16-12(9-17)13(18)8-14(20-16)15(21)19-10-11-6-4-3-5-7-11/h3-8H,2,10H2,1H3,(H2,18,20)(H,19,21)
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n/an/a 270n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15913
PNG
(2-pyridinecarboxamide deriv. 8c | 4-Amino-5-cyano-...)
Show SMILES CCOc1nc(cc(N)c1C#N)C(=O)NCc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C17H18N4O4S/c1-3-25-17-13(9-18)14(19)8-15(21-17)16(22)20-10-11-4-6-12(7-5-11)26(2,23)24/h4-8H,3,10H2,1-2H3,(H2,19,21)(H,20,22)
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n/an/a 19n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15914
PNG
(2-pyridinecarboxamide deriv. 8d | 4-Amino-5-cyano-...)
Show SMILES CCOc1nc(cc(N)c1C#N)C(=O)NCc1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C16H17N5O4S/c1-2-25-16-11(8-17)12(18)7-13(21-16)15(22)20-9-10-5-3-4-6-14(10)26(19,23)24/h3-7H,2,9H2,1H3,(H2,18,21)(H,20,22)(H2,19,23,24)
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n/an/a 12n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15915
PNG
(2-pyridinecarboxamide deriv. 8e | 4-Amino-5-cyano-...)
Show SMILES CCOc1nc(cc(N)c1C#N)C(=O)NCc1cccnc1
Show InChI InChI=1S/C15H15N5O2/c1-2-22-15-11(7-16)12(17)6-13(20-15)14(21)19-9-10-4-3-5-18-8-10/h3-6,8H,2,9H2,1H3,(H2,17,20)(H,19,21)
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n/an/a 26n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15916
PNG
(2-pyridinecarboxamide deriv. 8f | 4-(5-{[(4-Amino-...)
Show SMILES CCOc1nc(cc(N)c1C#N)C(=O)NCc1ccc(nc1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C22H19N5O4/c1-2-31-21-16(10-23)17(24)9-19(27-21)20(28)26-12-13-3-8-18(25-11-13)14-4-6-15(7-5-14)22(29)30/h3-9,11H,2,12H2,1H3,(H2,24,27)(H,26,28)(H,29,30)
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n/an/a 4n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15917
PNG
(2-pyridinecarboxamide deriv. 8g | 4-amino-5-cyano-...)
Show SMILES CCOc1nc(cc(N)c1C#N)C(=O)N(C)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C18H20N4O4S/c1-4-26-17-14(10-19)15(20)9-16(21-17)18(23)22(2)11-12-5-7-13(8-6-12)27(3,24)25/h5-9H,4,11H2,1-3H3,(H2,20,21)
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n/an/a 6.40E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15918
PNG
(2-pyridinecarboxamide deriv. 12 | 4-Amino-5-chloro...)
Show SMILES CCOc1nc(cc(N)c1Cl)C(=O)NCc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C16H18ClN3O4S/c1-3-24-16-14(17)12(18)8-13(20-16)15(21)19-9-10-4-6-11(7-5-10)25(2,22)23/h4-8H,3,9H2,1-2H3,(H2,18,20)(H,19,21)
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n/an/a 24n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15919
PNG
(2-pyridinecarboxamide deriv. 13 | 4-Amino-5-chloro...)
Show SMILES CC(C)Oc1nc(cc(N)c1Cl)C(=O)NCc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C17H20ClN3O4S/c1-10(2)25-17-15(18)13(19)8-14(21-17)16(22)20-9-11-4-6-12(7-5-11)26(3,23)24/h4-8,10H,9H2,1-3H3,(H2,19,21)(H,20,22)
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n/an/a 75n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15920
PNG
(2-pyridinecarboxamide deriv. 15 | 4-Amino-6-chloro...)
Show SMILES CS(=O)(=O)c1ccc(CNC(=O)c2cc(N)c(C#N)c(Cl)n2)cc1
Show InChI InChI=1S/C15H13ClN4O3S/c1-24(22,23)10-4-2-9(3-5-10)8-19-15(21)13-6-12(18)11(7-17)14(16)20-13/h2-6H,8H2,1H3,(H2,18,20)(H,19,21)
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n/an/a 1.50E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15921
PNG
(2-pyridinecarboxamide deriv. 17a | 5-Cyano-6-ethox...)
Show SMILES CCOc1nc(ccc1C#N)C(=O)NCc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C17H17N3O4S/c1-3-24-17-13(10-18)6-9-15(20-17)16(21)19-11-12-4-7-14(8-5-12)25(2,22)23/h4-9H,3,11H2,1-2H3,(H,19,21)
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n/an/a 390n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15922
PNG
(2-pyridinecarboxamide deriv. 17b | 5-cyano-N-[(2,5...)
Show SMILES CCOc1nc(ccc1C#N)C(=O)NCc1cc(OC)ccc1OC
Show InChI InChI=1S/C18H19N3O4/c1-4-25-18-12(10-19)5-7-15(21-18)17(22)20-11-13-9-14(23-2)6-8-16(13)24-3/h5-9H,4,11H2,1-3H3,(H,20,22)
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n/an/a 230n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 4455-8 (2006)


Article DOI: 10.1021/jm060465l
BindingDB Entry DOI: 10.7270/Q2ST7N3W
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15907
PNG
(Aminopyridine-Based Inhibitor 6a | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(C)=O)cc(N)c1C#N
Show InChI InChI=1S/C10H12N4O2/c1-3-16-10-7(5-11)8(12)4-9(14-10)13-6(2)15/h4H,3H2,1-2H3,(H3,12,13,14,15)
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n/an/a 750n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15923
PNG
(Aminopyridine-Based Inhibitor 6b | N-(4-amino-5-cy...)
Show SMILES CCCCC(=O)Nc1cc(N)c(C#N)c(OCC)n1
Show InChI InChI=1S/C13H18N4O2/c1-3-5-6-12(18)16-11-7-10(15)9(8-14)13(17-11)19-4-2/h7H,3-6H2,1-2H3,(H3,15,16,17,18)
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n/an/a 350n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15924
PNG
(Aminopyridine-Based Inhibitor 6c | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)C(C)C)cc(N)c1C#N
Show InChI InChI=1S/C12H16N4O2/c1-4-18-12-8(6-13)9(14)5-10(16-12)15-11(17)7(2)3/h5,7H,4H2,1-3H3,(H3,14,15,16,17)
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n/an/a 4.00E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15925
PNG
(Aminopyridine-Based Inhibitor 6d | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)CC(C)C)cc(N)c1C#N
Show InChI InChI=1S/C13H18N4O2/c1-4-19-13-9(7-14)10(15)6-11(17-13)16-12(18)5-8(2)3/h6,8H,4-5H2,1-3H3,(H3,15,16,17,18)
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n/an/a 1.40E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15926
PNG
(Aminopyridine-Based Inhibitor 6e | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccccc2)cc(N)c1C#N
Show InChI InChI=1S/C16H16N4O2/c1-2-22-16-12(10-17)13(18)9-14(20-16)19-15(21)8-11-6-4-3-5-7-11/h3-7,9H,2,8H2,1H3,(H3,18,19,20,21)
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n/an/a 570n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15927
PNG
(Aminopyridine-Based Inhibitor 6f | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccccc2Cl)cc(N)c1C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-2-23-16-11(9-18)13(19)8-14(21-16)20-15(22)7-10-5-3-4-6-12(10)17/h3-6,8H,2,7H2,1H3,(H3,19,20,21,22)
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n/an/a 1.10E+3n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15928
PNG
(Aminopyridine-Based Inhibitor 6g | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cccc(Cl)c2)cc(N)c1C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-2-23-16-12(9-18)13(19)8-14(21-16)20-15(22)7-10-4-3-5-11(17)6-10/h3-6,8H,2,7H2,1H3,(H3,19,20,21,22)
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n/an/a 300n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15929
PNG
(Aminopyridine-Based Inhibitor 6h | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccc(Cl)cc2)cc(N)c1C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-2-23-16-12(9-18)13(19)8-14(21-16)20-15(22)7-10-3-5-11(17)6-4-10/h3-6,8H,2,7H2,1H3,(H3,19,20,21,22)
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n/an/a 580n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15930
PNG
(Aminopyridine-Based Inhibitor 6i | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2ccccc2C)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O2/c1-3-23-17-13(10-18)14(19)9-15(21-17)20-16(22)8-12-7-5-4-6-11(12)2/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 400n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM15931
PNG
(Aminopyridine-Based Inhibitor 6j | N-(4-Amino-5-cy...)
Show SMILES CCOc1nc(NC(=O)Cc2cccc(C)c2)cc(N)c1C#N
Show InChI InChI=1S/C17H18N4O2/c1-3-23-17-13(10-18)14(19)9-15(21-17)20-16(22)8-12-6-4-5-11(2)7-12/h4-7,9H,3,8H2,1-2H3,(H3,19,20,21,22)
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n/an/a 420n/an/an/an/a7.220



Abbott Laboratories



Assay Description
In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...


J Med Chem 49: 3563-80 (2006)


Article DOI: 10.1021/jm060199b
BindingDB Entry DOI: 10.7270/Q2P26WDX
More data for this
Ligand-Target Pair
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