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Compile Data Set for Download or QSAR

Found 97 hits of ph data with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119835
PNG
(US8691986, 1)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2ccc(Cl)cc2n1
Show InChI InChI=1S/C26H23ClFN5O/c1-29-26(34)20-6-3-18(14-21(20)28)25-24(30-10-11-31-25)17-8-12-33(13-9-17)23-7-4-16-2-5-19(27)15-22(16)32-23/h2-7,10-11,14-15,17H,8-9,12-13H2,1H3,(H,29,34)
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n/an/a 28.7n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119850
PNG
(US8691986, 17 | US9718803, 5.19)
Show SMILES CNC(=O)c1cccc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21N5O/c1-25-24(30)18-7-4-6-17(13-18)22-23(27-12-11-26-22)19-14-29(15-19)21-10-9-16-5-2-3-8-20(16)28-21/h2-13,19H,14-15H2,1H3,(H,25,30)
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n/an/a 2n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119837
PNG
(US8691986, 3)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2ccccc2n1
Show InChI InChI=1S/C26H24FN5O/c1-28-26(33)20-8-6-19(16-21(20)27)25-24(29-12-13-30-25)18-10-14-32(15-11-18)23-9-7-17-4-2-3-5-22(17)31-23/h2-9,12-13,16,18H,10-11,14-15H2,1H3,(H,28,33)
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n/an/a 3.10n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119838
PNG
(US8691986, 4)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2cc(F)ccc2n1
Show InChI InChI=1S/C26H23F2N5O/c1-29-26(34)20-5-2-18(15-21(20)28)25-24(30-10-11-31-25)16-8-12-33(13-9-16)23-7-3-17-14-19(27)4-6-22(17)32-23/h2-7,10-11,14-16H,8-9,12-13H2,1H3,(H,29,34)
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n/an/a 2.80n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119839
PNG
(US8691986, 5)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2cccc(F)c2n1
Show InChI InChI=1S/C26H23F2N5O/c1-29-26(34)19-7-5-18(15-21(19)28)25-24(30-11-12-31-25)17-9-13-33(14-10-17)22-8-6-16-3-2-4-20(27)23(16)32-22/h2-8,11-12,15,17H,9-10,13-14H2,1H3,(H,29,34)
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n/an/a 7.5n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119840
PNG
(US8691986, 6)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2ccccc2n1
Show InChI InChI=1S/C23H19FN6O/c1-25-22(31)17-7-6-14(10-18(17)24)20-21(27-9-8-26-20)16-12-30(13-16)23-28-11-15-4-2-3-5-19(15)29-23/h2-11,16H,12-13H2,1H3,(H,25,31)
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n/an/a 7.60n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119841
PNG
(US8691986, 7)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H20FN5O/c1-26-24(31)18-8-6-16(12-19(18)25)22-23(28-11-10-27-22)17-13-30(14-17)21-9-7-15-4-2-3-5-20(15)29-21/h2-12,17H,13-14H2,1H3,(H,26,31)
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n/an/a 4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119842
PNG
(US8691986, 8)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccc(F)cc2n1
Show InChI InChI=1S/C24H19F2N5O/c1-27-24(32)18-6-3-15(10-19(18)26)22-23(29-9-8-28-22)16-12-31(13-16)21-7-4-14-2-5-17(25)11-20(14)30-21/h2-11,16H,12-13H2,1H3,(H,27,32)
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n/an/a 0.5n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119843
PNG
(US8691986, 9)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2ccc(F)cc2n1
Show InChI InChI=1S/C23H18F2N6O/c1-26-22(32)17-5-3-13(8-18(17)25)20-21(28-7-6-27-20)15-11-31(12-15)23-29-10-14-2-4-16(24)9-19(14)30-23/h2-10,15H,11-12H2,1H3,(H,26,32)
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n/an/a 30.9n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119844
PNG
(US8691986, 10)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2ccc(Cl)cc2n1
Show InChI InChI=1S/C23H18ClFN6O/c1-26-22(32)17-5-3-13(8-18(17)25)20-21(28-7-6-27-20)15-11-31(12-15)23-29-10-14-2-4-16(24)9-19(14)30-23/h2-10,15H,11-12H2,1H3,(H,26,32)
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n/an/a 5.90n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119845
PNG
(US8691986, 11)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2cc(F)ccc2n1
Show InChI InChI=1S/C23H18F2N6O/c1-26-22(32)17-4-2-13(9-18(17)25)20-21(28-7-6-27-20)15-11-31(12-15)23-29-10-14-8-16(24)3-5-19(14)30-23/h2-10,15H,11-12H2,1H3,(H,26,32)
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n/an/a 16.6n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119846
PNG
(US8691986, 12)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2cc(F)c(Cl)cc2n1
Show InChI InChI=1S/C23H17ClF2N6O/c1-27-22(33)15-3-2-12(6-17(15)25)20-21(29-5-4-28-20)14-10-32(11-14)23-30-9-13-7-18(26)16(24)8-19(13)31-23/h2-9,14H,10-11H2,1H3,(H,27,33)
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n/an/a 3.90n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119847
PNG
(US8691986, 13)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2cc(F)ccc2n1
Show InChI InChI=1S/C24H19F2N5O/c1-27-24(32)18-5-2-15(11-19(18)26)22-23(29-9-8-28-22)16-12-31(13-16)21-7-3-14-10-17(25)4-6-20(14)30-21/h2-11,16H,12-13H2,1H3,(H,27,32)
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n/an/a 1.70n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119848
PNG
(US8691986, 14)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ncc(Cl)cc2n1
Show InChI InChI=1S/C23H18ClFN6O/c1-26-23(32)16-3-2-13(8-17(16)25)21-22(28-7-6-27-21)14-11-31(12-14)20-5-4-18-19(30-20)9-15(24)10-29-18/h2-10,14H,11-12H2,1H3,(H,26,32)
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n/an/a 3.60n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119851
PNG
(US8691986, 15 | US9718803, 30.2)
Show SMILES NC(=O)c1ccc(cc1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19N5O/c24-23(29)17-7-5-16(6-8-17)21-22(26-12-11-25-21)18-13-28(14-18)20-10-9-15-3-1-2-4-19(15)27-20/h1-12,18H,13-14H2,(H2,24,29)
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n/an/a 1.30n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119849
PNG
(US8691986, 16 | US9718803, 30.4)
Show SMILES NC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H18FN5O/c24-18-11-15(5-7-17(18)23(25)30)21-22(27-10-9-26-21)16-12-29(13-16)20-8-6-14-3-1-2-4-19(14)28-20/h1-11,16H,12-13H2,(H2,25,30)
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n/an/a 2.60n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119836
PNG
(US8691986, 2)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2ccc(F)cc2n1
Show InChI InChI=1S/C26H23F2N5O/c1-29-26(34)20-6-3-18(14-21(20)28)25-24(30-10-11-31-25)17-8-12-33(13-9-17)23-7-4-16-2-5-19(27)15-22(16)32-23/h2-7,10-11,14-15,17H,8-9,12-13H2,1H3,(H,29,34)
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n/an/a 6.30n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97492
PNG
(US8470820, 1)
Show SMILES Cc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1ccn(n1)-c1ccccc1
Show InChI InChI=1S/C20H17N7O/c1-14-7-8-17(24-15-11-21-13-22-12-15)19(23-14)20(28)25-18-9-10-27(26-18)16-5-3-2-4-6-16/h2-13,24H,1H3,(H,25,26,28)
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n/an/a 90n/an/an/an/a7.5n/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97493
PNG
(US8470820, 4)
Show SMILES Cc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1ccn(n1)-c1ccccn1
Show InChI InChI=1S/C19H16N8O/c1-13-5-6-15(24-14-10-20-12-21-11-14)18(23-13)19(28)25-16-7-9-27(26-16)17-4-2-3-8-22-17/h2-12,24H,1H3,(H,25,26,28)
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n/an/a 368n/an/an/an/a7.5n/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97494
PNG
(US8470820, 5)
Show SMILES Cc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1ccn(n1)-c1ccncc1
Show InChI InChI=1S/C19H16N8O/c1-13-2-3-16(24-14-10-21-12-22-11-14)18(23-13)19(28)25-17-6-9-27(26-17)15-4-7-20-8-5-15/h2-12,24H,1H3,(H,25,26,28)
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n/an/a 48n/an/an/an/a7.5n/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97495
PNG
(US8470820, 6)
Show SMILES Fc1ccc(cc1)-n1ccc(NC(=O)c2nc(ccc2Nc2cncnc2)C2CC2)n1
Show InChI InChI=1S/C22H18FN7O/c23-15-3-5-17(6-4-15)30-10-9-20(29-30)28-22(31)21-19(26-16-11-24-13-25-12-16)8-7-18(27-21)14-1-2-14/h3-14,26H,1-2H2,(H,28,29,31)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97496
PNG
(US8470820, 7)
Show SMILES O=C(Nc1ccn(n1)-c1ccncc1)c1nc(ccc1Nc1cncnc1)C1CC1
Show InChI InChI=1S/C21H18N8O/c30-21(27-19-7-10-29(28-19)16-5-8-22-9-6-16)20-18(25-15-11-23-13-24-12-15)4-3-17(26-20)14-1-2-14/h3-14,25H,1-2H2,(H,27,28,30)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97497
PNG
(US8470820, 8)
Show SMILES Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1
Show InChI InChI=1S/C22H20N8O/c1-30-20(10-19(29-30)17-4-2-3-9-25-17)28-22(31)21-18(26-15-11-23-13-24-12-15)8-7-16(27-21)14-5-6-14/h2-4,7-14,26H,5-6H2,1H3,(H,28,31)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97498
PNG
(US8470820, 9)
Show SMILES OCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccc1
Show InChI InChI=1S/C24H23N7O2/c32-11-10-31-22(12-21(30-31)16-4-2-1-3-5-16)29-24(33)23-20(27-18-13-25-15-26-14-18)9-8-19(28-23)17-6-7-17/h1-5,8-9,12-15,17,27,32H,6-7,10-11H2,(H,29,33)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97499
PNG
(US8470820, 10)
Show SMILES OCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1
Show InChI InChI=1S/C23H22N8O2/c32-10-9-31-21(11-20(30-31)18-3-1-2-8-26-18)29-23(33)22-19(27-16-12-24-14-25-13-16)7-6-17(28-22)15-4-5-15/h1-3,6-8,11-15,27,32H,4-5,9-10H2,(H,29,33)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97500
PNG
(US8470820, 11)
Show SMILES COCc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1CCO)-c1ccccn1
Show InChI InChI=1S/C22H22N8O3/c1-33-13-15-5-6-18(26-16-11-23-14-24-12-16)21(27-15)22(32)28-20-10-19(29-30(20)8-9-31)17-4-2-3-7-25-17/h2-7,10-12,14,26,31H,8-9,13H2,1H3,(H,28,32)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97501
PNG
(US8470820, 12)
Show SMILES CN(C)CCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1
Show InChI InChI=1S/C25H27N9O/c1-33(2)11-12-34-23(13-22(32-34)20-5-3-4-10-28-20)31-25(35)24-21(29-18-14-26-16-27-15-18)9-8-19(30-24)17-6-7-17/h3-5,8-10,13-17,29H,6-7,11-12H2,1-2H3,(H,31,35)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97502
PNG
(US8470820, 13)
Show SMILES COCc1ncc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1C)-c1ccccn1
Show InChI InChI=1S/C20H19N9O2/c1-29-18(7-15(28-29)14-5-3-4-6-23-14)27-20(30)19-16(10-24-17(26-19)11-31-2)25-13-8-21-12-22-9-13/h3-10,12,25H,11H2,1-2H3,(H,27,30)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97503
PNG
(BDBM97509 | US8470820, 14)
Show SMILES O=C(Nc1cc(nn1C1CCCCC1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1
Show InChI InChI=1S/C27H28N8O/c36-27(26-23(31-19-15-28-17-29-16-19)12-11-21(32-26)18-9-10-18)33-25-14-24(22-8-4-5-13-30-22)34-35(25)20-6-2-1-3-7-20/h4-5,8,11-18,20,31H,1-3,6-7,9-10H2,(H,33,36)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97504
PNG
(US8470820, 15)
Show SMILES CCOC(=O)Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1
Show InChI InChI=1S/C25H24N8O3/c1-2-36-23(34)14-33-22(11-21(32-33)19-5-3-4-10-28-19)31-25(35)24-20(29-17-12-26-15-27-13-17)9-8-18(30-24)16-6-7-16/h3-5,8-13,15-16,29H,2,6-7,14H2,1H3,(H,31,35)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97505
PNG
(US8470820, 16)
Show SMILES O=C(Nc1cc(nn1CCN1CCOCC1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1
Show InChI InChI=1S/C27H29N9O2/c37-27(26-23(31-20-16-28-18-29-17-20)7-6-21(32-26)19-4-5-19)33-25-15-24(22-3-1-2-8-30-22)34-36(25)10-9-35-11-13-38-14-12-35/h1-3,6-8,15-19,31H,4-5,9-14H2,(H,33,37)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97506
PNG
(US8470820, 17)
Show SMILES O=C(Nc1cc(nn1CCc1ccccc1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1
Show InChI InChI=1S/C29H26N8O/c38-29(28-25(33-22-17-30-19-31-18-22)12-11-23(34-28)21-9-10-21)35-27-16-26(24-8-4-5-14-32-24)36-37(27)15-13-20-6-2-1-3-7-20/h1-8,11-12,14,16-19,21,33H,9-10,13,15H2,(H,35,38)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97507
PNG
(US8470820, 18)
Show SMILES CC(C)(C)n1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1
Show InChI InChI=1S/C25H26N8O/c1-25(2,3)33-22(12-21(32-33)19-6-4-5-11-28-19)31-24(34)23-20(29-17-13-26-15-27-14-17)10-9-18(30-23)16-7-8-16/h4-6,9-16,29H,7-8H2,1-3H3,(H,31,34)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97508
PNG
(US8470820, 19)
Show SMILES CCc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1C)-c1ccccn1
Show InChI InChI=1S/C21H20N8O/c1-3-14-7-8-17(25-15-11-22-13-23-12-15)20(26-14)21(30)27-19-10-18(28-29(19)2)16-6-4-5-9-24-16/h4-13,25H,3H2,1-2H3,(H,27,30)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97503
PNG
(BDBM97509 | US8470820, 14)
Show SMILES O=C(Nc1cc(nn1C1CCCCC1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1
Show InChI InChI=1S/C27H28N8O/c36-27(26-23(31-19-15-28-17-29-16-19)12-11-21(32-26)18-9-10-18)33-25-14-24(22-8-4-5-13-30-22)34-35(25)20-6-2-1-3-7-20/h4-5,8,11-18,20,31H,1-3,6-7,9-10H2,(H,33,36)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97510
PNG
(US8470820, 21)
Show SMILES Cn1nc(cc1NC(=O)c1nc(cnc1Nc1cncnc1)C1CC1)-c1ccccn1
Show InChI InChI=1S/C21H19N9O/c1-30-18(8-16(29-30)15-4-2-3-7-24-15)28-21(31)19-20(26-14-9-22-12-23-10-14)25-11-17(27-19)13-5-6-13/h2-4,7-13H,5-6H2,1H3,(H,25,26)(H,28,31)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97511
PNG
(US8470820, 22)
Show SMILES FC(F)(F)Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1
Show InChI InChI=1S/C23H19F3N8O/c24-23(25,26)12-34-20(9-19(33-34)17-3-1-2-8-29-17)32-22(35)21-18(30-15-10-27-13-28-11-15)7-6-16(31-21)14-4-5-14/h1-3,6-11,13-14,30H,4-5,12H2,(H,32,35)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97512
PNG
(US8470820, 23)
Show SMILES CCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1
Show InChI InChI=1S/C24H24N8O/c1-2-11-32-22(12-21(31-32)19-5-3-4-10-27-19)30-24(33)23-20(28-17-13-25-15-26-14-17)9-8-18(29-23)16-6-7-16/h3-5,8-10,12-16,28H,2,6-7,11H2,1H3,(H,30,33)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97513
PNG
(US8470820, 24)
Show SMILES OCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1cccc(Cl)n1
Show InChI InChI=1S/C23H21ClN8O2/c24-20-3-1-2-17(28-20)19-10-21(32(31-19)8-9-33)30-23(34)22-18(27-15-11-25-13-26-12-15)7-6-16(29-22)14-4-5-14/h1-3,6-7,10-14,27,33H,4-5,8-9H2,(H,30,34)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97514
PNG
(US8470820, 25)
Show SMILES OCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccc2ccccc2n1
Show InChI InChI=1S/C27H24N8O2/c36-12-11-35-25(13-24(34-35)22-8-7-17-3-1-2-4-20(17)31-22)33-27(37)26-23(30-19-14-28-16-29-15-19)10-9-21(32-26)18-5-6-18/h1-4,7-10,13-16,18,30,36H,5-6,11-12H2,(H,33,37)
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n/an/a<1n/an/an/an/a7.5n/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97515
PNG
(US8470820, 26)
Show SMILES OCCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccc(Cl)cn1
Show InChI InChI=1S/C23H21ClN8O2/c24-15-3-4-18(27-10-15)20-9-21(32(31-20)7-8-33)30-23(34)22-19(28-16-11-25-13-26-12-16)6-5-17(29-22)14-1-2-14/h3-6,9-14,28,33H,1-2,7-8H2,(H,30,34)
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n/an/a 2n/an/an/an/a7.5n/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97516
PNG
(US8470820, 27)
Show SMILES CC(C)n1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1
Show InChI InChI=1S/C24H24N8O/c1-15(2)32-22(11-21(31-32)19-5-3-4-10-27-19)30-24(33)23-20(28-17-12-25-14-26-13-17)9-8-18(29-23)16-6-7-16/h3-5,8-16,28H,6-7H2,1-2H3,(H,30,33)
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n/an/a 3n/an/an/an/a7.5n/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97517
PNG
(US8470820, 28)
Show SMILES CC(C)Cn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1
Show InChI InChI=1S/C25H26N8O/c1-16(2)14-33-23(11-22(32-33)20-5-3-4-10-28-20)31-25(34)24-21(29-18-12-26-15-27-13-18)9-8-19(30-24)17-6-7-17/h3-5,8-13,15-17,29H,6-7,14H2,1-2H3,(H,31,34)
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n/an/a 1n/an/an/an/a7.5n/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97518
PNG
(US8470820, 29)
Show SMILES O=C(Nc1cc(nn1Cc1ccccc1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1
Show InChI InChI=1S/C28H24N8O/c37-28(27-24(32-21-15-29-18-30-16-21)12-11-22(33-27)20-9-10-20)34-26-14-25(23-8-4-5-13-31-23)35-36(26)17-19-6-2-1-3-7-19/h1-8,11-16,18,20,32H,9-10,17H2,(H,34,37)
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n/an/a 2n/an/an/an/a7.5n/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97519
PNG
(US8470820, 30)
Show SMILES CCn1nc(cc1NC(=O)c1nc(ccc1Nc1cncnc1)C1CC1)-c1ccccn1
Show InChI InChI=1S/C23H22N8O/c1-2-31-21(11-20(30-31)18-5-3-4-10-26-18)29-23(32)22-19(27-16-12-24-14-25-13-16)9-8-17(28-22)15-6-7-15/h3-5,8-15,27H,2,6-7H2,1H3,(H,29,32)
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n/an/a 5n/an/an/an/a7.5n/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97520
PNG
(US8470820, 31)
Show SMILES O=C(Nc1cc(nn1CC1CCCC1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1
Show InChI InChI=1S/C27H28N8O/c36-27(26-23(31-20-14-28-17-29-15-20)11-10-21(32-26)19-8-9-19)33-25-13-24(22-7-3-4-12-30-22)34-35(25)16-18-5-1-2-6-18/h3-4,7,10-15,17-19,31H,1-2,5-6,8-9,16H2,(H,33,36)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97521
PNG
(US8470820, 32)
Show SMILES O=C(Nc1cc(nn1CC1CCCCC1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1
Show InChI InChI=1S/C28H30N8O/c37-28(27-24(32-21-15-29-18-30-16-21)12-11-22(33-27)20-9-10-20)34-26-14-25(23-8-4-5-13-31-23)35-36(26)17-19-6-2-1-3-7-19/h4-5,8,11-16,18-20,32H,1-3,6-7,9-10,17H2,(H,34,37)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97522
PNG
(US8470820, 33)
Show SMILES O=C(Nc1cc(nn1CCC#N)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1
Show InChI InChI=1S/C24H21N9O/c25-9-3-11-33-22(12-21(32-33)19-4-1-2-10-28-19)31-24(34)23-20(29-17-13-26-15-27-14-17)8-7-18(30-23)16-5-6-16/h1-2,4,7-8,10,12-16,29H,3,5-6,11H2,(H,31,34)
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n/an/a 170n/an/an/an/a7.5n/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97523
PNG
(US8470820, 34)
Show SMILES CCc1ccc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1CCO)-c1ccccn1
Show InChI InChI=1S/C22H22N8O2/c1-2-15-6-7-18(26-16-12-23-14-24-13-16)21(27-15)22(32)28-20-11-19(29-30(20)9-10-31)17-5-3-4-8-25-17/h3-8,11-14,26,31H,2,9-10H2,1H3,(H,28,32)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM97524
PNG
(US8470820, 35)
Show SMILES Cc1cnc(Nc2cncnc2)c(n1)C(=O)Nc1cc(nn1C)-c1ccccn1
Show InChI InChI=1S/C19H17N9O/c1-12-8-23-18(25-13-9-20-11-21-10-13)17(24-12)19(29)26-16-7-15(27-28(16)2)14-5-3-4-6-22-14/h3-11H,1-2H3,(H,23,25)(H,26,29)
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n/an/a 21n/an/an/an/a7.5n/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Scintillation proximity assay using human PDE10A.


US Patent US8470820 (2013)


BindingDB Entry DOI: 10.7270/Q2J96501
More data for this
Ligand-Target Pair
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