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Compile Data Set for Download or QSAR

Found 21 hits of ph data with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM14359
PNG
((+)-1 | (S)-(+)-3-{2-[(3-Cyclopropyloxy-4-diflurom...)
Show SMILES OC(c1cnc(s1)[C@@H](Cc1ccc[n+]([O-])c1)c1ccc(OC(F)F)c(OC2CC2)c1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H18F8N2O4S/c24-20(25)37-16-6-3-13(9-17(16)36-14-4-5-14)15(8-12-2-1-7-33(35)11-12)19-32-10-18(38-19)21(34,22(26,27)28)23(29,30)31/h1-3,6-7,9-11,14-15,20,34H,4-5,8H2/t15-/m0/s1
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n/an/a 0.400n/an/an/an/a7.522



University of North Carolina at Chapel Hill



Assay Description
PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...


J Med Chem 49: 1867-73 (2006)


Article DOI: 10.1021/jm051273d
BindingDB Entry DOI: 10.7270/Q2MK6B48
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31651
PNG
(tetrahydrobenzothiophene (THBT), 18)
Show SMILES Cc1cccc(C)c1C(=O)C1CCCc2sc(NC(=O)c3ccccc3[N+]([O-])=O)c(C(N)=O)c12
Show InChI InChI=1S/C25H23N3O5S/c1-13-7-5-8-14(2)19(13)22(29)16-10-6-12-18-20(16)21(23(26)30)25(34-18)27-24(31)15-9-3-4-11-17(15)28(32)33/h3-5,7-9,11,16H,6,10,12H2,1-2H3,(H2,26,30)(H,27,31)
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n/an/a 5.01E+3n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM14360
PNG
((-)-1 | (R)-(-)-3-{2-[(3-cyclopropyloxy-4-diflurom...)
Show SMILES OC(c1cnc(s1)[C@H](Cc1ccc[n+]([O-])c1)c1ccc(OC(F)F)c(OC2CC2)c1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H18F8N2O4S/c24-20(25)37-16-6-3-13(9-17(16)36-14-4-5-14)15(8-12-2-1-7-33(35)11-12)19-32-10-18(38-19)21(34,22(26,27)28)23(29,30)31/h1-3,6-7,9-11,14-15,20,34H,4-5,8H2/t15-/m1/s1
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n/an/a 40n/an/an/an/a7.522



University of North Carolina at Chapel Hill



Assay Description
PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...


J Med Chem 49: 1867-73 (2006)


Article DOI: 10.1021/jm051273d
BindingDB Entry DOI: 10.7270/Q2MK6B48
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31650
PNG
(tetrahydrobenzothiophene (THBT), 25)
Show SMILES NC(=O)c1c(NC(=O)c2ccccc2[N+]([O-])=O)sc2CC(CCc12)c1ccccc1
Show InChI InChI=1S/C22H19N3O4S/c23-20(26)19-16-11-10-14(13-6-2-1-3-7-13)12-18(16)30-22(19)24-21(27)15-8-4-5-9-17(15)25(28)29/h1-9,14H,10-12H2,(H2,23,26)(H,24,27)
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n/an/a 398n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31649
PNG
(tetrahydrobenzothiophene (THBT), 24)
Show SMILES CCCC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C19H21N3O4S/c1-2-5-11-8-9-13-15(10-11)27-19(16(13)17(20)23)21-18(24)12-6-3-4-7-14(12)22(25)26/h3-4,6-7,11H,2,5,8-10H2,1H3,(H2,20,23)(H,21,24)
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n/an/a 100n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31636
PNG
(tetrahydrobenzothiophene (THBT), 4)
Show SMILES CC(C)(C)C1CCc2c(C1)sc(NC(=O)c1ccncc1)c2C(N)=O
Show InChI InChI=1S/C19H23N3O2S/c1-19(2,3)12-4-5-13-14(10-12)25-18(15(13)16(20)23)22-17(24)11-6-8-21-9-7-11/h6-9,12H,4-5,10H2,1-3H3,(H2,20,23)(H,22,24)
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n/an/a 200n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31637
PNG
(tetrahydrobenzothiophene (THBT), 6)
Show SMILES CC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C17H17N3O4S/c1-9-6-7-11-13(8-9)25-17(14(11)15(18)21)19-16(22)10-4-2-3-5-12(10)20(23)24/h2-5,9H,6-8H2,1H3,(H2,18,21)(H,19,22)
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n/an/a 50n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31638
PNG
(tetrahydrobenzothiophene (THBT), 13a)
Show SMILES CC(C)(C)C1CCc2c(C1)sc(NC(=O)c1c(F)cccc1F)c2C(N)=O
Show InChI InChI=1S/C20H22F2N2O2S/c1-20(2,3)10-7-8-11-14(9-10)27-19(15(11)17(23)25)24-18(26)16-12(21)5-4-6-13(16)22/h4-6,10H,7-9H2,1-3H3,(H2,23,25)(H,24,26)
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n/an/a 79n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31639
PNG
(tetrahydrobenzothiophene (THBT), 13b)
Show SMILES CNC(=O)c1c(NC(=O)c2c(F)cccc2F)sc2CC(CCc12)C(C)(C)C
Show InChI InChI=1S/C21H24F2N2O2S/c1-21(2,3)11-8-9-12-15(10-11)28-20(16(12)18(26)24-4)25-19(27)17-13(22)6-5-7-14(17)23/h5-7,11H,8-10H2,1-4H3,(H,24,26)(H,25,27)
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n/an/a>1.00E+4n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31640
PNG
(tetrahydrobenzothiophene (THBT), 14)
Show SMILES CC1CCc2c(C1)sc(NC(=O)c1cccc(c1)[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C17H17N3O4S/c1-9-5-6-12-13(7-9)25-17(14(12)15(18)21)19-16(22)10-3-2-4-11(8-10)20(23)24/h2-4,8-9H,5-7H2,1H3,(H2,18,21)(H,19,22)
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n/an/a 631n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31641
PNG
(tetrahydrobenzothiophene (THBT), 15)
Show SMILES CC1CCc2c(C1)sc(NC(=O)c1ccc(cc1)[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C17H17N3O4S/c1-9-2-7-12-13(8-9)25-17(14(12)15(18)21)19-16(22)10-3-5-11(6-4-10)20(23)24/h3-6,9H,2,7-8H2,1H3,(H2,18,21)(H,19,22)
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n/an/a>2.51E+3n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31642
PNG
(tetrahydrobenzothiophene (THBT), 16)
Show SMILES NC(=O)c1c(NC(=O)c2ccccc2[N+]([O-])=O)sc2CCCCc12
Show InChI InChI=1S/C16H15N3O4S/c17-14(20)13-10-6-2-4-8-12(10)24-16(13)18-15(21)9-5-1-3-7-11(9)19(22)23/h1,3,5,7H,2,4,6,8H2,(H2,17,20)(H,18,21)
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n/an/a 1.26E+3n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31643
PNG
(tetrahydrobenzothiophene (THBT), 17)
Show SMILES CC1CCCc2sc(NC(=O)c3ccccc3[N+]([O-])=O)c(C(N)=O)c12
Show InChI InChI=1S/C17H17N3O4S/c1-9-5-4-8-12-13(9)14(15(18)21)17(25-12)19-16(22)10-6-2-3-7-11(10)20(23)24/h2-3,6-7,9H,4-5,8H2,1H3,(H2,18,21)(H,19,22)
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n/an/a 5.01E+3n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31644
PNG
(tetrahydrobenzothiophene (THBT), 23)
Show SMILES CC1(C)CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C18H19N3O4S/c1-18(2)8-7-11-13(9-18)26-17(14(11)15(19)22)20-16(23)10-5-3-4-6-12(10)21(24)25/h3-6H,7-9H2,1-2H3,(H2,19,22)(H,20,23)
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n/an/a 50n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31645
PNG
(tetrahydrobenzothiophene (THBT), 19)
Show SMILES CC1CCc2sc(NC(=O)c3ccccc3[N+]([O-])=O)c(C(N)=O)c2C1
Show InChI InChI=1S/C17H17N3O4S/c1-9-6-7-13-11(8-9)14(15(18)21)17(25-13)19-16(22)10-4-2-3-5-12(10)20(23)24/h2-5,9H,6-8H2,1H3,(H2,18,21)(H,19,22)
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n/an/a 2.00E+3n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31646
PNG
(tetrahydrobenzothiophene (THBT), 20)
Show SMILES CC(C)(C)C1CCc2sc(NC(=O)c3ccccc3[N+]([O-])=O)c(C(N)=O)c2C1
Show InChI InChI=1S/C20H23N3O4S/c1-20(2,3)11-8-9-15-13(10-11)16(17(21)24)19(28-15)22-18(25)12-6-4-5-7-14(12)23(26)27/h4-7,11H,8-10H2,1-3H3,(H2,21,24)(H,22,25)
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n/an/a 1.26E+3n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31647
PNG
(tetrahydrobenzothiophene (THBT), 21)
Show SMILES CCC1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C18H19N3O4S/c1-2-10-7-8-12-14(9-10)26-18(15(12)16(19)22)20-17(23)11-5-3-4-6-13(11)21(24)25/h3-6,10H,2,7-9H2,1H3,(H2,19,22)(H,20,23)
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n/an/a 10n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM31648
PNG
(tetrahydrobenzothiophene (THBT), 22)
Show SMILES CC(C)(C)C1CCc2c(C1)sc(NC(=O)c1ccccc1[N+]([O-])=O)c2C(N)=O
Show InChI InChI=1S/C20H23N3O4S/c1-20(2,3)11-8-9-13-15(10-11)28-19(16(13)17(21)24)22-18(25)12-6-4-5-7-14(12)23(26)27/h4-7,11H,8-10H2,1-3H3,(H2,21,24)(H,22,25)
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n/an/a 25n/an/an/an/a7.523



GSK



Assay Description
Inhibition of PDE4 is measured using a luminescence-coupled assay system developed by Cambrex. This assay system couples the formation of AMP, derive...


Bioorg Med Chem 17: 5336-41 (2009)


Article DOI: 10.1016/j.bmc.2009.03.061
BindingDB Entry DOI: 10.7270/Q21G0JMF
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM30128
PNG
(phthalazinone, 21)
Show SMILES COc1ccc(F)c(CCC2CCC(CCNCCCCCN3N=C(C4CC=CCC4C3=O)c3ccc(OC)c(OC)c3)O2)c1
Show InChI InChI=1S/C36H48FN3O5/c1-42-29-16-17-32(37)25(23-29)11-13-27-14-15-28(45-27)19-21-38-20-7-4-8-22-40-36(41)31-10-6-5-9-30(31)35(39-40)26-12-18-33(43-2)34(24-26)44-3/h5-6,12,16-18,23-24,27-28,30-31,38H,4,7-11,13-15,19-22H2,1-3H3
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199 -39.4n/an/an/an/an/a8.034



Human BioMolecular Research Institute



Assay Description
The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...


J Med Chem 52: 1530-9 (2009)


Article DOI: 10.1021/jm8010993
BindingDB Entry DOI: 10.7270/Q2MK6B7M
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM30126
PNG
(CHEMBL313041 | phthalazinone, 19)
Show SMILES COc1ccc(cc1OC)C1=NNC(=O)C2CC=CCC12
Show InChI InChI=1S/C16H18N2O3/c1-20-13-8-7-10(9-14(13)21-2)15-11-5-3-4-6-12(11)16(19)18-17-15/h3-4,7-9,11-12H,5-6H2,1-2H3,(H,18,19)
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UniProtKB/SwissProt

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UniChem

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Article
PubMed
250 -38.8n/an/an/an/an/a8.034



Human BioMolecular Research Institute



Assay Description
The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...


J Med Chem 52: 1530-9 (2009)


Article DOI: 10.1021/jm8010993
BindingDB Entry DOI: 10.7270/Q2MK6B7M
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM30129
PNG
(phthalazinone, 22)
Show SMILES COc1ccc(F)c(CCCC2CCC(CCNCCCCCN3N=C(C4CC=CCC4C3=O)c3ccc(OC)c(OC)c3)O2)c1
Show InChI InChI=1S/C37H50FN3O5/c1-43-30-17-18-33(38)26(24-30)10-9-11-28-15-16-29(46-28)20-22-39-21-7-4-8-23-41-37(42)32-13-6-5-12-31(32)36(40-41)27-14-19-34(44-2)35(25-27)45-3/h5-6,14,17-19,24-25,28-29,31-32,39H,4,7-13,15-16,20-23H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

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Article
PubMed
500 -37.0n/an/an/an/an/a8.034



Human BioMolecular Research Institute



Assay Description
The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...


J Med Chem 52: 1530-9 (2009)


Article DOI: 10.1021/jm8010993
BindingDB Entry DOI: 10.7270/Q2MK6B7M
More data for this
Ligand-Target Pair