BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 33 hits of ph data with Target = 'p110α/p85α'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM15234
PNG
((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)
Show SMILES COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C([C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O)C3=O
Show InChI InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 99n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 5.70E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25084
PNG
(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)
Show SMILES Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25083
PNG
(6-(1H-indol-4-yl)-pteridin-2,4-diamine | 6-(1H-ind...)
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C14H11N7/c15-12-11-13(21-14(16)20-12)18-6-10(19-11)7-2-1-3-9-8(7)4-5-17-9/h1-6,17H,(H4,15,16,18,20,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 1.20E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25082
PNG
(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 165n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM15234
PNG
((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)
Show SMILES COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C([C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O)C3=O
Show InChI InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
PubMed
n/an/a 4.20n/an/an/an/a7.422



MRC



Assay Description
Ptdlns 3-kinase enzyme activity was assayed by its converting Ptdlns(4,5)P2 into PtdIns(3,4,5)P3 in the presence of radioactive ATP. After reaction,...


Mol Cell 6: 909-19 (2000)


BindingDB Entry DOI: 10.7270/Q22F7KPC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25084
PNG
(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)
Show SMILES Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21034
PNG
((1R,3R,5S,6S,18S)-6-hydroxy-18-(methoxymethyl)-1,5...)
Show SMILES COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C2CC[C@H](O)[C@@]2(C)C[C@H]1OC(C)=O)C3=O
Show InChI InChI=1S/C23H26O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-15,25H,5-7,9H2,1-4H3/t12?,13-,14+,15-,22+,23+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.70n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21035
PNG
((2R,3S,6E,15S,17R)-6-{[bis(prop-2-en-1-yl)amino]me...)
Show SMILES COC[C@H]1OC(=O)C(=CN(CC=C)CC=C)C2C(=O)C(=O)C3=C([C@@H](C[C@@]4(C)C3CCC4=O)OC(C)=O)[C@@]12C
Show InChI InChI=1S/C29H35NO8/c1-7-11-30(12-8-2)14-17-23-26(34)25(33)22-18-9-10-20(32)28(18,4)13-19(37-16(3)31)24(22)29(23,5)21(15-36-6)38-27(17)35/h7-8,14,18-19,21,23H,1-2,9-13,15H2,3-6H3/t18?,19-,21-,23?,28+,29+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 88n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21036
PNG
((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...)
Show SMILES COC[C@H]1OC(=O)C(=CN(C)CCCN(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C
Show InChI InChI=1S/C29H42N2O8/c1-16(32)38-19-13-28(2)18(9-10-20(28)33)22-24(19)29(3)21(15-37-7)39-27(36)17(23(29)26(35)25(22)34)14-31(6)12-8-11-30(4)5/h14,18-21,23,33H,8-13,15H2,1-7H3/t18?,19-,20+,21-,23?,28+,29+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.40n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21037
PNG
((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...)
Show SMILES COC[C@H]1OC(=O)C(=CNCCCN(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C
Show InChI InChI=1S/C28H40N2O8/c1-15(31)37-18-12-27(2)17(8-9-19(27)32)21-23(18)28(3)20(14-36-6)38-26(35)16(22(28)25(34)24(21)33)13-29-10-7-11-30(4)5/h13,17-20,22,29,32H,7-12,14H2,1-6H3/t17?,18-,19+,20-,22?,27+,28+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21038
PNG
((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...)
Show SMILES COC[C@H]1OC(=O)C(=CN(C)CCCN(C)C)C2C(=O)C(=O)C3=C([C@H](O)C[C@]4(C)[C@@H](O)CCC34)[C@@]12C
Show InChI InChI=1S/C27H40N2O7/c1-26-12-17(30)22-20(16(26)8-9-18(26)31)23(32)24(33)21-15(13-29(5)11-7-10-28(3)4)25(34)36-19(14-35-6)27(21,22)2/h13,16-19,21,30-31H,7-12,14H2,1-6H3/t16?,17-,18+,19-,21?,26+,27+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 638n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21039
PNG
((2R,3S,6Z,14S,15S,17R)-6-({tert-butyl[2-(dimethyla...)
Show SMILES COC[C@H]1OC(=O)C(=CN(CCN(C)C)C(C)(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C
Show InChI InChI=1S/C31H46N2O8/c1-17(34)40-20-14-30(5)19(10-11-21(30)35)23-25(20)31(6)22(16-39-9)41-28(38)18(24(31)27(37)26(23)36)15-33(29(2,3)4)13-12-32(7)8/h15,19-22,24,35H,10-14,16H2,1-9H3/t19?,20-,21+,22-,24?,30+,31+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.60n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21040
PNG
((2R,3S,6Z,14S,15S,17R)-6-({benzyl[2-(dimethylamino...)
Show SMILES COC[C@H]1OC(=O)C(=CN(CCN(C)C)Cc2ccccc2)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C
Show InChI InChI=1S/C34H44N2O8/c1-20(37)43-24-16-33(2)23(12-13-25(33)38)27-29(24)34(3)26(19-42-6)44-32(41)22(28(34)31(40)30(27)39)18-36(15-14-35(4)5)17-21-10-8-7-9-11-21/h7-11,18,23-26,28,38H,12-17,19H2,1-6H3/t23?,24-,25+,26-,28?,33+,34+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 66n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25018
PNG
(3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phe...)
Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2sccc2n1
Show InChI InChI=1S/C16H15N3O2S/c20-12-3-1-2-11(10-12)15-17-13-4-9-22-14(13)16(18-15)19-5-7-21-8-6-19/h1-4,9-10,20H,5-8H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 8n/an/an/an/a7.522



Piramed Pharma



Assay Description
Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...


J Med Chem 51: 5522-32 (2008)


Article DOI: 10.1021/jm800295d
BindingDB Entry DOI: 10.7270/Q2222S23
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25019
PNG
(3-[6-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimid...)
Show SMILES Cc1cc2nc(nc(N3CCOCC3)c2s1)-c1cccc(O)c1
Show InChI InChI=1S/C17H17N3O2S/c1-11-9-14-15(23-11)17(20-5-7-22-8-6-20)19-16(18-14)12-3-2-4-13(21)10-12/h2-4,9-10,21H,5-8H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/a7.522



Piramed Pharma



Assay Description
Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...


J Med Chem 51: 5522-32 (2008)


Article DOI: 10.1021/jm800295d
BindingDB Entry DOI: 10.7270/Q2222S23
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25020
PNG
(3-[7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimid...)
Show SMILES Cc1csc2c(nc(nc12)-c1cccc(O)c1)N1CCOCC1
Show InChI InChI=1S/C17H17N3O2S/c1-11-10-23-15-14(11)18-16(12-3-2-4-13(21)9-12)19-17(15)20-5-7-22-8-6-20/h2-4,9-10,21H,5-8H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 21n/an/an/an/a7.522



Piramed Pharma



Assay Description
Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...


J Med Chem 51: 5522-32 (2008)


Article DOI: 10.1021/jm800295d
BindingDB Entry DOI: 10.7270/Q2222S23
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25021
PNG
(3-{6-[(dimethylamino)methyl]-4-(morpholin-4-yl)thi...)
Show SMILES CN(C)Cc1cc2nc(nc(N3CCOCC3)c2s1)-c1cccc(O)c1
Show InChI InChI=1S/C19H22N4O2S/c1-22(2)12-15-11-16-17(26-15)19(23-6-8-25-9-7-23)21-18(20-16)13-4-3-5-14(24)10-13/h3-5,10-11,24H,6-9,12H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3n/an/an/an/a7.522



Piramed Pharma



Assay Description
Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...


J Med Chem 51: 5522-32 (2008)


Article DOI: 10.1021/jm800295d
BindingDB Entry DOI: 10.7270/Q2222S23
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25022
PNG
(3-(6-{[(2-methoxyethyl)(methyl)amino]methyl}-4-(mo...)
Show SMILES COCCN(C)Cc1cc2nc(nc(N3CCOCC3)c2s1)-c1cccc(O)c1
Show InChI InChI=1S/C21H26N4O3S/c1-24(6-9-27-2)14-17-13-18-19(29-17)21(25-7-10-28-11-8-25)23-20(22-18)15-4-3-5-16(26)12-15/h3-5,12-13,26H,6-11,14H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/a7.522



Piramed Pharma



Assay Description
Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...


J Med Chem 51: 5522-32 (2008)


Article DOI: 10.1021/jm800295d
BindingDB Entry DOI: 10.7270/Q2222S23
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25023
PNG
(3-{6-[(4-methylpiperazin-1-yl)methyl]-4-(morpholin...)
Show SMILES CN1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc(O)c2)CC1
Show InChI InChI=1S/C22H27N5O2S/c1-25-5-7-26(8-6-25)15-18-14-19-20(30-18)22(27-9-11-29-12-10-27)24-21(23-19)16-3-2-4-17(28)13-16/h2-4,13-14,28H,5-12,15H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 10n/an/an/an/a7.522



Piramed Pharma



Assay Description
Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...


J Med Chem 51: 5522-32 (2008)


Article DOI: 10.1021/jm800295d
BindingDB Entry DOI: 10.7270/Q2222S23
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25024
PNG
(3-(6-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-4-...)
Show SMILES OCCN1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc(O)c2)CC1
Show InChI InChI=1S/C23H29N5O3S/c29-11-8-26-4-6-27(7-5-26)16-19-15-20-21(32-19)23(28-9-12-31-13-10-28)25-22(24-20)17-2-1-3-18(30)14-17/h1-3,14-15,29-30H,4-13,16H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7n/an/an/an/a7.522



Piramed Pharma



Assay Description
Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...


J Med Chem 51: 5522-32 (2008)


Article DOI: 10.1021/jm800295d
BindingDB Entry DOI: 10.7270/Q2222S23
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25025
PNG
(4-[2-(1H-indazol-4-yl)thieno[3,2-d]pyrimidin-4-yl]...)
Show SMILES C1CN(CCO1)c1nc(nc2ccsc12)-c1cccc2[nH]ncc12
Show InChI InChI=1S/C17H15N5OS/c1-2-11(12-10-18-21-13(12)3-1)16-19-14-4-9-24-15(14)17(20-16)22-5-7-23-8-6-22/h1-4,9-10H,5-8H2,(H,18,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 102n/an/an/an/a7.522



Piramed Pharma



Assay Description
Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...


J Med Chem 51: 5522-32 (2008)


Article DOI: 10.1021/jm800295d
BindingDB Entry DOI: 10.7270/Q2222S23
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25026
PNG
(4-[2-(1H-indazol-6-yl)thieno[3,2-d]pyrimidin-4-yl]...)
Show SMILES C1CN(CCO1)c1nc(nc2ccsc12)-c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C17H15N5OS/c1-2-12-10-18-21-14(12)9-11(1)16-19-13-3-8-24-15(13)17(20-16)22-4-6-23-7-5-22/h1-3,8-10H,4-7H2,(H,18,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.45E+3n/an/an/an/a7.522



Piramed Pharma



Assay Description
Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...


J Med Chem 51: 5522-32 (2008)


Article DOI: 10.1021/jm800295d
BindingDB Entry DOI: 10.7270/Q2222S23
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25027
PNG
(4-[2-(1H-indazol-4-yl)-6-[(4-methylpiperazin-1-yl)...)
Show SMILES CN1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1
Show InChI InChI=1S/C23H27N7OS/c1-28-5-7-29(8-6-28)15-16-13-20-21(32-16)23(30-9-11-31-12-10-30)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 44n/an/an/an/a7.522



Piramed Pharma



Assay Description
Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...


J Med Chem 51: 5522-32 (2008)


Article DOI: 10.1021/jm800295d
BindingDB Entry DOI: 10.7270/Q2222S23
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25028
PNG
(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Show SMILES CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1
Show InChI InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 3n/an/an/an/a7.522



Piramed Pharma



Assay Description
Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...


J Med Chem 51: 5522-32 (2008)


Article DOI: 10.1021/jm800295d
BindingDB Entry DOI: 10.7270/Q2222S23
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21033
PNG
((2R,3S,6Z,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Show SMILES COC[C@H]1OC(=O)C(=CN2CCCC2)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C
Show InChI InChI=1S/C27H35NO8/c1-14(29)35-17-11-26(2)16(7-8-18(26)30)20-22(17)27(3)19(13-34-4)36-25(33)15(12-28-9-5-6-10-28)21(27)24(32)23(20)31/h12,16-19,21,30H,5-11,13H2,1-4H3/t16?,17-,18+,19-,21?,26+,27+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 496n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21032
PNG
((2R,3S,6Z,14S,15S,17R)-6-{[butyl(methyl)amino]meth...)
Show SMILES CCCCN(C)C=C1C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]2(C)[C@@H](COC)OC1=O
Show InChI InChI=1S/C28H39NO8/c1-7-8-11-29(5)13-16-22-25(33)24(32)21-17-9-10-19(31)27(17,3)12-18(36-15(2)30)23(21)28(22,4)20(14-35-6)37-26(16)34/h13,17-20,22,31H,7-12,14H2,1-6H3/t17?,18-,19+,20-,22?,27+,28+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 635n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21031
PNG
((2R,3S,6Z,14S,15S,17R)-6-[(tert-butylamino)methyli...)
Show SMILES COC[C@H]1OC(=O)C(=CNC(C)(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C
Show InChI InChI=1S/C27H37NO8/c1-13(29)35-16-10-26(5)15(8-9-17(26)30)19-21(16)27(6)18(12-34-7)36-24(33)14(11-28-25(2,3)4)20(27)23(32)22(19)31/h11,15-18,20,28,30H,8-10,12H2,1-7H3/t15?,16-,17+,18-,20?,26+,27+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21030
PNG
((2R,3S,6Z,14S,15S,17R)-6-{[tert-butyl(methyl)amino...)
Show SMILES COC[C@H]1OC(=O)C(=CN(C)C(C)(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C
Show InChI InChI=1S/C28H39NO8/c1-14(30)36-17-11-27(5)16(9-10-18(27)31)20-22(17)28(6)19(13-35-8)37-25(34)15(12-29(7)26(2,3)4)21(28)24(33)23(20)32/h12,16-19,21,31H,9-11,13H2,1-8H3/t16?,17-,18+,19-,21?,27+,28+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 440n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21029
PNG
((2R,3S,6Z,14S,15S,17R)-6-{[tert-butyl(2-hydroxyeth...)
Show SMILES COC[C@H]1OC(=O)C(=CN(CCO)C(C)(C)C)C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]12C
Show InChI InChI=1S/C29H41NO9/c1-15(32)38-18-12-28(5)17(8-9-19(28)33)21-23(18)29(6)20(14-37-7)39-26(36)16(22(29)25(35)24(21)34)13-30(10-11-31)27(2,3)4/h13,17-20,22,31,33H,8-12,14H2,1-7H3/t17?,18-,19+,20-,22?,28+,29+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.11E+3n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21028
PNG
((2R,3S,6Z,14S,15S,17R)-6-[(ethylamino)methylidene]...)
Show SMILES CCNC=C1C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]2(C)[C@@H](COC)OC1=O
Show InChI InChI=1S/C25H33NO8/c1-6-26-10-13-19-22(30)21(29)18-14-7-8-16(28)24(14,3)9-15(33-12(2)27)20(18)25(19,4)17(11-32-5)34-23(13)31/h10,14-17,19,26,28H,6-9,11H2,1-5H3/t14?,15-,16+,17-,19?,24+,25+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21027
PNG
((2R,3S,6Z,14S,15S,17R)-6-[(diethylamino)methyliden...)
Show SMILES CCN(CC)C=C1C2C(=O)C(=O)C3=C([C@H](O)C[C@]4(C)[C@@H](O)CCC34)[C@@]2(C)[C@@H](COC)OC1=O
Show InChI InChI=1S/C25H35NO7/c1-6-26(7-2)11-13-19-22(30)21(29)18-14-8-9-16(28)24(14,3)10-15(27)20(18)25(19,4)17(12-32-5)33-23(13)31/h11,14-17,19,27-28H,6-10,12H2,1-5H3/t14?,15-,16+,17-,19?,24+,25+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.85E+3n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM21026
PNG
((2R,3S,6Z,14S,15S,17R)-6-[(diethylamino)methyliden...)
Show SMILES CCN(CC)C=C1C2C(=O)C(=O)C3=C([C@@H](C[C@]4(C)[C@@H](O)CCC34)OC(C)=O)[C@@]2(C)[C@@H](COC)OC1=O
Show InChI InChI=1S/C27H37NO8/c1-7-28(8-2)12-15-21-24(32)23(31)20-16-9-10-18(30)26(16,4)11-17(35-14(3)29)22(20)27(21,5)19(13-34-6)36-25(15)33/h12,16-19,21,30H,7-11,13H2,1-6H3/t16?,17-,18+,19-,21?,26+,27+/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 382n/an/an/an/a7.522



Wyeth Research



Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.


J Med Chem 51: 1319-23 (2008)


Article DOI: 10.1021/jm7012858
BindingDB Entry DOI: 10.7270/Q2NP22QD
More data for this
Ligand-Target Pair