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Compile Data Set for Download or QSAR

Found 366 hits of ph data with Target = 'p110delta/p85alpha'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
p110delta/p85alpha


(Homo sapiens (human))
BDBM261151
PNG
(5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)C1CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H28ClN7O2/c1-13-20(27)9-19(15(3)34-25-22(14(2)32-34)24(28)30-12-31-25)23(36-5)21(13)16-8-17(11-29-10-16)26(35)33(4)18-6-7-18/h8-12,15,18H,6-7H2,1-5H3,(H2,28,30,31)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261152
PNG
(5-{3-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O3/c1-13-19(26)9-18(15(3)33-24-21(14(2)31-33)23(27)29-12-30-24)22(36-5)20(13)16-8-17(11-28-10-16)25(35)32(4)6-7-34/h8-12,15,34H,6-7H2,1-5H3,(H2,27,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261153
PNG
(1-[(5-{3-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]p...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N1CCC(O)CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C27H30ClN7O3/c1-14-21(28)10-20(16(3)35-26-23(15(2)33-35)25(29)31-13-32-26)24(38-4)22(14)17-9-18(12-30-11-17)27(37)34-7-5-19(36)6-8-34/h9-13,16,19,36H,5-8H2,1-4H3,(H2,29,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261154
PNG
(1-[(5-{3-[1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]p...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N1CC(C1)C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H25ClN8O2/c1-13-20(27)6-19(15(3)35-25-22(14(2)33-35)24(29)31-12-32-25)23(37-4)21(13)17-5-18(9-30-8-17)26(36)34-10-16(7-28)11-34/h5-6,8-9,12,15-16H,10-11H2,1-4H3,(H2,29,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261155
PNG
(5-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)CCN)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H29ClN8O2/c1-13-19(26)9-18(15(3)34-24-21(14(2)32-34)23(28)30-12-31-24)22(36-5)20(13)16-8-17(11-29-10-16)25(35)33(4)7-6-27/h8-12,15H,6-7,27H2,1-5H3,(H2,28,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261156
PNG
(3-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CNC(=O)CCc1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1S/C20H25ClN6O2/c1-10-13(6-7-16(28)23-4)18(29-5)14(8-15(10)21)12(3)27-20-17(11(2)26-27)19(22)24-9-25-20/h8-9,12H,6-7H2,1-5H3,(H,23,28)(H2,22,24,25)
PDB

UniProtKB/SwissProt

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AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261157
PNG
(3-(3-(1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1CCC(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H27ClN6O2/c1-11-14(7-8-17(29)27(4)5)19(30-6)15(9-16(11)22)13(3)28-21-18(12(2)26-28)20(23)24-10-25-21/h9-10,13H,7-8H2,1-6H3,(H2,23,24,25)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261158
PNG
(1-(1-(5-Chloro-2-methoxy-4-methyl-3-(1-(1-methylpi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(c1)C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H31ClN8O/c1-14-20(26)10-19(16(3)34-25-22(15(2)31-34)24(27)28-13-29-25)23(35-5)21(14)17-11-30-33(12-17)18-6-8-32(4)9-7-18/h10-13,16,18H,6-9H2,1-5H3,(H2,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261159
PNG
(1-(1-{3-[1-(1-Acetylpiperidin-4-yl)-1H-pyrazol-4-y...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(c1)C1CCN(CC1)C(C)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C26H31ClN8O2/c1-14-21(27)10-20(16(3)35-26-23(15(2)32-35)25(28)29-13-30-26)24(37-5)22(14)18-11-31-34(12-18)19-6-8-33(9-7-19)17(4)36/h10-13,16,19H,6-9H2,1-5H3,(H2,28,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261160
PNG
(1-[1-(5-Chloro-3-{1-[2-(dimethylamino)ethyl]-1H-py...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(CCN(C)C)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H29ClN8O/c1-13-18(24)9-17(15(3)32-23-20(14(2)29-32)22(25)26-12-27-23)21(33-6)19(13)16-10-28-31(11-16)8-7-30(4)5/h9-12,15H,7-8H2,1-6H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261161
PNG
(2-[(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(NCCO)nc1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C23H28ClN7O2/c1-12-17(24)9-16(14(3)31-23-20(13(2)25)22(26)29-11-30-23)21(33-4)19(12)15-5-6-18(28-10-15)27-7-8-32/h5-6,9-11,14,25,32H,7-8H2,1-4H3,(H,27,28)(H3,26,29,30,31)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261162
PNG
(1-(1-(5-chloro-3-(6- (dimethylamino)pyridin-3-yl)-...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H26ClN7O/c1-12-17(24)9-16(14(3)31-23-20(13(2)29-31)22(25)27-11-28-23)21(32-6)19(12)15-7-8-18(26-10-15)30(4)5/h7-11,14H,1-6H3,(H2,25,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261163
PNG
(1-(1-(5-chloro-3-(2- (dimethylamino)pyridin-4-yl)-...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)N(C)C)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C23H28ClN7O/c1-12-18(24)8-17(14(3)30-23-20(13(2)25)22(26)28-11-29-23)21(32-6)19(12)15-7-16(31(4)5)10-27-9-15/h7-11,14,25H,1-6H3,(H3,26,28,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261164
PNG
(1-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)N1CC(O)C1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C24H28ClN7O2/c1-12-19(25)6-18(14(3)31-24-21(13(2)26)23(27)29-11-30-24)22(34-4)20(12)15-5-16(8-28-7-15)32-9-17(33)10-32/h5-8,11,14,17,26,33H,9-10H2,1-4H3,(H3,27,29,30,31)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261165
PNG
(2-(5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(OCCO)nc1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C23H27ClN6O3/c1-12-17(24)9-16(14(3)30-23-20(13(2)25)22(26)28-11-29-23)21(32-4)19(12)15-5-6-18(27-10-15)33-8-7-31/h5-6,9-11,14,25,31H,7-8H2,1-4H3,(H3,26,28,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261166
PNG
(5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CC(Nc1ncnc(N)c1C(C)=N)c1cc(Cl)c(C)c(-c2ccc(nc2)C(=O)N(C)C)c1OCC(F)F
Show InChI InChI=1S/C25H28ClF2N7O2/c1-12-17(26)8-16(14(3)34-24-21(13(2)29)23(30)32-11-33-24)22(37-10-19(27)28)20(12)15-6-7-18(31-9-15)25(36)35(4)5/h6-9,11,14,19,29H,10H2,1-5H3,(H3,30,32,33,34)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261167
PNG
(5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CC(Nc1ncnc(N)c1C(C)=N)c1cc(Cl)c(C)c(-c2ccc(nc2)C(=O)N(C)C)c1OCC1CC1
Show InChI InChI=1S/C27H32ClN7O2/c1-14-20(28)10-19(16(3)34-26-23(15(2)29)25(30)32-13-33-26)24(37-12-17-6-7-17)22(14)18-8-9-21(31-11-18)27(36)35(4)5/h8-11,13,16-17,29H,6-7,12H2,1-5H3,(H3,30,32,33,34)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261168
PNG
(5-(3-{1-[4-Amino-3-(difluoromethyl)-1H-pyrazolo[3,...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)Nc1ncnc(N)c1C(=N)C(F)F
Show InChI InChI=1S/C24H26ClF2N7O2/c1-11-15(25)8-14(12(2)33-23-18(19(28)21(26)27)22(29)31-10-32-23)20(36-5)17(11)13-6-7-16(30-9-13)24(35)34(3)4/h6-10,12,21,28H,1-5H3,(H3,29,31,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261169
PNG
(1-[1-(5-Chloro-3-cyclopropyl-2-methoxy-4-methylphe...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CC1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C19H24ClN5O/c1-9-14(20)7-13(17(26-4)15(9)12-5-6-12)11(3)25-19-16(10(2)21)18(22)23-8-24-19/h7-8,11-12,21H,5-6H2,1-4H3,(H3,22,23,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261170
PNG
(1-{1-[5-Chloro-3- (cyclopropylmethyl)-2-methoxy-4-...)
Show SMILES COc1c(CC2CC2)c(C)c(Cl)cc1C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C20H26ClN5O/c1-10-14(7-13-5-6-13)18(27-4)15(8-16(10)21)12(3)26-20-17(11(2)22)19(23)24-9-25-20/h8-9,12-13,22H,5-7H2,1-4H3,(H3,23,24,25,26)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 125n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261171
PNG
(US10092570, Example 194 | US9707233, 194 | {3-[1-(...)
Show SMILES COc1c(CC#N)c(C)c(Cl)cc1C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C18H21ClN6O/c1-9-12(5-6-20)16(26-4)13(7-14(9)19)11(3)25-18-15(10(2)21)17(22)23-8-24-18/h7-8,11,21H,5H2,1-4H3,(H3,22,23,24,25)
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US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255803
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-17(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)10-18(26)13(2)20(22)16-8-9-19(28-11-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)
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US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261173
PNG
(5-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O2/c1-7-35-22-18(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)9-19(26)13(2)20(22)16-8-17(11-28-10-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)
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US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261174
PNG
(1-(1-(5-chloro-2-ethoxy-4-methyl- 3-(1-methyl-1H-p...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(C)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O/c1-6-30-19-15(7-16(22)11(2)17(19)14-8-26-28(5)9-14)13(4)29-21-18(12(3)27-29)20(23)24-10-25-21/h7-10,13H,6H2,1-5H3,(H2,23,24,25)
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US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261175
PNG
(1-(1-(5-chloro-2-ethoxy-4-methyl- 3-(5-(methylsulf...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H25ClN6O3S/c1-6-33-21-17(14(4)30-23-20(13(3)29-30)22(25)27-11-28-23)8-18(24)12(2)19(21)15-7-16(10-26-9-15)34(5,31)32/h7-11,14H,6H2,1-5H3,(H2,25,27,28)
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US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261176
PNG
(5-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)NC)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN7O2/c1-6-34-21-16(14(4)32-23-20(13(3)31-32)22(26)29-11-30-23)9-17(25)12(2)19(21)15-7-8-18(28-10-15)24(33)27-5/h7-11,14H,6H2,1-5H3,(H,27,33)(H2,26,29,30)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261177
PNG
(4-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)C)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C24H28ClN7O2/c1-12-17(25)10-16(14(3)31-23-20(13(2)26)22(27)29-11-30-23)21(34-6)19(12)15-7-8-28-18(9-15)24(33)32(4)5/h7-11,14,26H,1-6H3,(H3,27,29,30,31)
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US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261178
PNG
(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H26ClN7O2/c1-12-17(25)10-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-27-18(9-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM255808
PNG
(4-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H28ClN7O3/c1-13-18(26)11-17(15(3)33-24-21(14(2)31-33)23(27)29-12-30-24)22(36-5)20(13)16-6-7-28-19(10-16)25(35)32(4)8-9-34/h6-7,10-12,15,34H,8-9H2,1-5H3,(H2,27,29,30)
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US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261180
PNG
(2-(4-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(N)=O)c1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C22H27ClN8O2/c1-5-33-20-15(13(4)30-22-19(12(3)24)21(26)27-10-28-22)6-16(23)11(2)18(20)14-7-29-31(8-14)9-17(25)32/h6-8,10,13,24H,5,9H2,1-4H3,(H2,25,32)(H3,26,27,28,30)
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US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261181
PNG
(2-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(=O)NC)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H27ClN8O2/c1-6-34-21-16(14(4)32-23-20(13(3)30-32)22(25)27-11-28-23)7-17(24)12(2)19(21)15-8-29-31(9-15)10-18(33)26-5/h7-9,11,14H,6,10H2,1-5H3,(H,26,33)(H2,25,27,28)
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US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261182
PNG
(2-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(=O)N(C)C)c1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C24H31ClN8O2/c1-7-35-22-17(15(4)31-24-21(14(3)26)23(27)28-12-29-24)8-18(25)13(2)20(22)16-9-30-33(10-16)11-19(34)32(5)6/h8-10,12,15,26H,7,11H2,1-6H3,(H3,27,28,29,31)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261183
PNG
(2-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(=O)N(C)C)c1)C(C)C1N=C(C)c2c1ncnc2N
Show InChI InChI=1S/C25H30ClN7O2/c1-7-35-24-17(13(2)22-23-21(15(4)31-22)25(27)29-12-28-23)8-18(26)14(3)20(24)16-9-30-33(10-16)11-19(34)32(5)6/h8-10,12-13,22H,7,11H2,1-6H3,(H2,27,28,29)
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US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261184
PNG
(2-(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]py...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(c1)C(C)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H31ClN8O2/c1-8-36-22-18(15(4)34-24-21(14(3)31-34)23(27)28-12-29-24)9-19(26)13(2)20(22)17-10-30-33(11-17)16(5)25(35)32(6)7/h9-12,15-16H,8H2,1-7H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261185
PNG
(6-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(cn1)C(=O)N(C)C)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C25H30ClN7O2/c1-7-35-22-17(15(4)32-24-21(14(3)27)23(28)30-12-31-24)10-18(26)13(2)20(22)19-9-8-16(11-29-19)25(34)33(5)6/h8-12,15,27H,7H2,1-6H3,(H3,28,30,31,32)
PDB

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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261186
PNG
(5-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(C#N)c(C)c1-c1cnn(C)c1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C21H24N8O/c1-11-14(7-22)6-16(19(30-5)17(11)15-8-27-29(4)9-15)13(3)28-21-18(12(2)23)20(24)25-10-26-21/h6,8-10,13,23H,1-5H3,(H3,24,25,26,28)
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n/an/a 30n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261187
PNG
(5-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Show SMILES CCOc1c(cc(C#N)c(C)c1-c1cnn(C)c1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C22H26N8O/c1-6-31-20-17(14(4)29-22-19(13(3)24)21(25)26-11-27-22)7-15(8-23)12(2)18(20)16-9-28-30(5)10-16/h7,9-11,14,24H,6H2,1-5H3,(H3,25,26,27,29)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261188
PNG
(3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C#N)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1S/C18H21ClN6O/c1-5-26-16-12(6-14(19)9(2)13(16)7-20)11(4)25-18-15(10(3)21)17(22)23-8-24-18/h6,8,11,21H,5H2,1-4H3,(H3,22,23,24,25)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261189
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C20H22ClN7O/c1-4-29-18-13(5-15(21)14(6-22)17(18)12-7-24-8-12)11(3)28-20-16(10(2)27-28)19(23)25-9-26-20/h5,9,11-12,24H,4,7-8H2,1-3H3,(H2,23,25,26)
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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261190
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H24ClN7O/c1-5-30-19-14(6-16(22)15(7-23)18(19)13-8-28(4)9-13)12(3)29-21-17(11(2)27-29)20(24)25-10-26-21/h6,10,12-13H,5,8-9H2,1-4H3,(H2,24,25,26)
PDB

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n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261191
PNG
(US10092570, Example 214 | US9707233, 214)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(CC)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O/c1-5-29-9-14(10-29)19-16(8-24)17(23)7-15(20(19)31-6-2)13(4)30-22-18(12(3)28-30)21(25)26-11-27-22/h7,11,13-14H,5-6,9-10H2,1-4H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261192
PNG
(US10092570, Example 215 | US9707233, 215)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O/c1-6-32-21-16(14(5)31-23-19(13(4)29-31)22(26)27-11-28-23)7-18(24)17(8-25)20(21)15-9-30(10-15)12(2)3/h7,11-12,14-15H,6,9-10H2,1-5H3,(H2,26,27,28)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261193
PNG
(US10092570, Example 216 | US9707233, 216)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(CC(C)C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H30ClN7O/c1-6-33-22-17(15(5)32-24-20(14(4)30-32)23(27)28-12-29-24)7-19(25)18(8-26)21(22)16-10-31(11-16)9-13(2)3/h7,12-13,15-16H,6,9-11H2,1-5H3,(H2,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261194
PNG
(US10092570, Example 217 | US9707233, 217)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(CC2CC2)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H28ClN7O/c1-4-33-22-17(14(3)32-24-20(13(2)30-32)23(27)28-12-29-24)7-19(25)18(8-26)21(22)16-10-31(11-16)9-15-5-6-15/h7,12,14-16H,4-6,9-11H2,1-3H3,(H2,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261195
PNG
(US10092570, Example 218 | US9707233, 218)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C1CCC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H28ClN7O/c1-4-33-22-17(14(3)32-24-20(13(2)30-32)23(27)28-12-29-24)8-19(25)18(9-26)21(22)15-10-31(11-15)16-6-5-7-16/h8,12,14-16H,4-7,10-11H2,1-3H3,(H2,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261196
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-4-32-20-15(13(3)30-22-18(12(2)28-30)21(25)26-11-27-22)7-17(23)16(8-24)19(20)14-9-29(10-14)5-6-31/h7,11,13-14,31H,4-6,9-10H2,1-3H3,(H2,25,26,27)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261197
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O2/c1-5-33-21-16(14(4)31-23-19(13(3)29-31)22(26)27-11-28-23)6-18(24)17(7-25)20(21)15-9-30(10-15)8-12(2)32/h6,11-12,14-15,32H,5,8-10H2,1-4H3,(H2,26,27,28)/t12-,14?/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261198
PNG
(US10092570, Example 221 | US9707233, 221)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O2/c1-5-33-21-16(14(4)31-23-19(13(3)29-31)22(26)27-11-28-23)6-18(24)17(7-25)20(21)15-9-30(10-15)8-12(2)32/h6,11-12,14-15,32H,5,8-10H2,1-4H3,(H2,26,27,28)/t12-,14?/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261199
PNG
(US10092570, Example 222 | US9707233, 222)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C24H30ClN7O2/c1-6-34-21-16(14(3)32-23-19(13(2)30-32)22(27)28-12-29-23)7-18(25)17(8-26)20(21)15-9-31(10-15)11-24(4,5)33/h7,12,14-15,33H,6,9-11H2,1-5H3,(H2,27,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
p110delta/p85alpha


(Homo sapiens (human))
BDBM261200
PNG
(US9707233, 223)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)CO)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H28ClN7O2/c1-5-33-21-16(14(4)31-23-19(13(3)29-31)22(26)27-11-28-23)6-18(24)17(7-25)20(21)15-8-30(9-15)12(2)10-32/h6,11-12,14-15,32H,5,8-10H2,1-4H3,(H2,26,27,28)/t12?,14-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a6.725



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...


US Patent US9707233 (2017)

More data for this
Ligand-Target Pair
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