BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 112 hits of ec50 data for polymerid = 2259,50007210   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009002
PNG
(2-Methyl-1,2-dihydro-indazol-3-one | CHEMBL3144583...)
Show SMILES Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C8H8N2O/c1-10-8(11)6-4-2-3-5-7(6)9-10/h2-5,9H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 1n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50172379
PNG
((8E,10E)-(5S,9R)-20,20,20-Trifluoro-5,12-dihydroxy...)
Show SMILES O[C@@H](CCCC(O)=O)\C=C/C=C/C=C/[C@H](O)C\C=C/CCCCC(F)(F)F
Show InChI InChI=1S/C20H29F3O4/c21-20(22,23)16-9-5-1-2-6-11-17(24)12-7-3-4-8-13-18(25)14-10-15-19(26)27/h2-4,6-8,12-13,17-18,24-25H,1,5,9-11,14-16H2,(H,26,27)/b4-3+,6-2-,12-7+,13-8-/t17-,18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 3n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit 5-lipoxygenase by 50%


J Med Chem 48: 5613-38 (2005)


Article DOI: 10.1021/jm050524f
BindingDB Entry DOI: 10.7270/Q2V988V1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50008992
PNG
(2-Pyridin-3-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2cccnc2)[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O/c17-13-11-5-1-2-6-12(11)15-16(13)9-10-4-3-7-14-8-10/h1-8,15H,9H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 3n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50172379
PNG
((8E,10E)-(5S,9R)-20,20,20-Trifluoro-5,12-dihydroxy...)
Show SMILES O[C@@H](CCCC(O)=O)\C=C/C=C/C=C/[C@H](O)C\C=C/CCCCC(F)(F)F
Show InChI InChI=1S/C20H29F3O4/c21-20(22,23)16-9-5-1-2-6-11-17(24)12-7-3-4-8-13-18(25)14-10-15-19(26)27/h2-4,6-8,12-13,17-18,24-25H,1,5,9-11,14-16H2,(H,26,27)/b4-3+,6-2-,12-7+,13-8-/t17-,18-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 3n/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Effective concentration required to inhibit 5-lipoxygenase by 50%


J Med Chem 48: 5613-38 (2005)


Article DOI: 10.1021/jm050524f
BindingDB Entry DOI: 10.7270/Q2V988V1
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009004
PNG
((phenidone)1-Phenyl-pyrazolidin-3-one | 1-Phenyl-p...)
Show SMILES O=C1CCN(N1)c1ccccc1
Show InChI InChI=1S/C9H10N2O/c12-9-6-7-11(10-9)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,12)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009017
PNG
(2-(4-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1ccncc1Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C14H13N3O/c1-10-6-7-15-8-11(10)9-17-14(18)12-4-2-3-5-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009015
PNG
(2-(2-Chloro-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Clc1ncccc1Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C13H10ClN3O/c14-12-9(4-3-7-15-12)8-17-13(18)10-5-1-2-6-11(10)16-17/h1-7,16H,8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50008996
PNG
(2-Thiazol-5-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2cncs2)[nH]c2ccccc12
Show InChI InChI=1S/C11H9N3OS/c15-11-9-3-1-2-4-10(9)13-14(11)6-8-5-12-7-16-8/h1-5,7,13H,6H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 5n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50008989
PNG
(2-Thiophen-2-ylmethyl-1,2-dihydro-indazol-3-one | ...)
Show SMILES O=c1n(Cc2cccs2)[nH]c2ccccc12
Show InChI InChI=1S/C12H10N2OS/c15-12-10-5-1-2-6-11(10)13-14(12)8-9-4-3-7-16-9/h1-7,13H,8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 8n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50229182
PNG
(CHEMBL3144723)
Show SMILES COc1ccc(Cn2[nH]c3ccccc3c2=O)cn1
Show InChI InChI=1S/C14H13N3O2/c1-19-13-7-6-10(8-15-13)9-17-14(18)11-4-2-3-5-12(11)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 10n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50008994
PNG
(2-Pyridin-4-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2ccncc2)[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O/c17-13-11-3-1-2-4-12(11)15-16(13)9-10-5-7-14-8-6-10/h1-8,15H,9H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 10n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009019
PNG
(2-(6-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1ccc(Cn2[nH]c3ccccc3c2=O)cn1
Show InChI InChI=1S/C14H13N3O/c1-10-6-7-11(8-15-10)9-17-14(18)12-4-2-3-5-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 10n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009003
PNG
(2-(2-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1ncccc1Cn1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C14H13N3O/c1-10-11(5-4-8-15-10)9-17-14(18)12-6-2-3-7-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 10n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50008987
PNG
(2-(5-Bromo-pyridin-3-ylmethyl)-1,2-dihydro-indazol...)
Show SMILES Brc1cncc(Cn2[nH]c3ccccc3c2=O)c1
Show InChI InChI=1S/C13H10BrN3O/c14-10-5-9(6-15-7-10)8-17-13(18)11-3-1-2-4-12(11)16-17/h1-7,16H,8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 10n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50229183
PNG
(CHEMBL3144587)
Show SMILES Clc1ccc(Cn2[nH]c3ccccc3c2=O)cn1
Show InChI InChI=1S/C13H10ClN3O/c14-12-6-5-9(7-15-12)8-17-13(18)10-3-1-2-4-11(10)16-17/h1-7,16H,8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 15n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009008
PNG
(2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one | CHE...)
Show SMILES O=c1n(Cc2ccco2)[nH]c2ccccc12
Show InChI InChI=1S/C12H10N2O2/c15-12-10-5-1-2-6-11(10)13-14(12)8-9-4-3-7-16-9/h1-7,13H,8H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 15n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009011
PNG
(2-(5-Methyl-pyridin-3-ylmethyl)-1,2-dihydro-indazo...)
Show SMILES Cc1cncc(Cn2[nH]c3ccccc3c2=O)c1
Show InChI InChI=1S/C14H13N3O/c1-10-6-11(8-15-7-10)9-17-14(18)12-4-2-3-5-13(12)16-17/h2-8,16H,9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 15n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009000
PNG
(2-Benzyl-1,2-dihydro-indazol-3-one | CHEMBL1984519...)
Show SMILES O=c1n(Cc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C14H12N2O/c17-14-12-8-4-5-9-13(12)15-16(14)10-11-6-2-1-3-7-11/h1-9,15H,10H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 20n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50001187
PNG
(3-(5-Chloro-benzothiazol-2-ylsulfanyl)-N-hydroxy-N...)
Show SMILES CN(O)C(=O)CCSc1nc2cc(Cl)ccc2s1
Show InChI InChI=1S/C11H11ClN2O2S2/c1-14(16)10(15)4-5-17-11-13-8-6-7(12)2-3-9(8)18-11/h2-3,6,16H,4-5H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 20n/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.


J Med Chem 35: 3180-3 (1992)


Article DOI: 10.1021/jm00095a012
BindingDB Entry DOI: 10.7270/Q2542P68
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50001176
PNG
(2-(5-Chloro-benzothiazol-2-ylsulfanyl)-ethylamine-...)
Show SMILES CN(O)C(=O)NCCSc1nc2cc(Cl)ccc2s1
Show InChI InChI=1S/C11H12ClN3O2S2/c1-15(17)10(16)13-4-5-18-11-14-8-6-7(12)2-3-9(8)19-11/h2-3,6,17H,4-5H2,1H3,(H,13,16)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 20n/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.


J Med Chem 35: 3180-3 (1992)


Article DOI: 10.1021/jm00095a012
BindingDB Entry DOI: 10.7270/Q2542P68
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009014
PNG
(2-(1H-Indol-3-ylmethyl)-1,2-dihydro-indazol-3-one ...)
Show SMILES O=c1n(Cc2c[nH]c3ccccc23)[nH]c2ccccc12
Show InChI InChI=1S/C16H13N3O/c20-16-13-6-2-4-8-15(13)18-19(16)10-11-9-17-14-7-3-1-5-12(11)14/h1-9,17-18H,10H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 30n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009010
PNG
(2-Pyridin-2-ylmethyl-1,2-dihydro-indazol-3-one | C...)
Show SMILES O=c1n(Cc2ccccn2)[nH]c2ccccc12
Show InChI InChI=1S/C13H11N3O/c17-13-11-6-1-2-7-12(11)15-16(13)9-10-5-3-4-8-14-10/h1-8,15H,9H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 30n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50000540
PNG
(1-(3-Trifluoromethyl-phenyl)-4,5-dihydro-1H-pyrazo...)
Show SMILES NC1=NN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 30n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50001181
PNG
(3-(Benzothiazol-2-ylsulfanyl)-N-hydroxy-N-methyl-p...)
Show SMILES CN(O)C(=O)CCSc1nc2ccccc2s1
Show InChI InChI=1S/C11H12N2O2S2/c1-13(15)10(14)6-7-16-11-12-8-4-2-3-5-9(8)17-11/h2-5,15H,6-7H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 39n/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.


J Med Chem 35: 3180-3 (1992)


Article DOI: 10.1021/jm00095a012
BindingDB Entry DOI: 10.7270/Q2542P68
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50001171
PNG
(3-(Benzothiazol-2-ylsulfanyl)-propylamine-N-hydrox...)
Show SMILES CN(O)C(=O)NCCCSc1nc2ccccc2s1
Show InChI InChI=1S/C12H15N3O2S2/c1-15(17)11(16)13-7-4-8-18-12-14-9-5-2-3-6-10(9)19-12/h2-3,5-6,17H,4,7-8H2,1H3,(H,13,16)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 45n/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.


J Med Chem 35: 3180-3 (1992)


Article DOI: 10.1021/jm00095a012
BindingDB Entry DOI: 10.7270/Q2542P68
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50001182
PNG
(2-(5-Chloro-benzothiazol-2-ylsulfanyl)-ethylamine-...)
Show SMILES CC(C)N(O)C(=O)NCCSc1nc2cc(Cl)ccc2s1
Show InChI InChI=1S/C13H16ClN3O2S2/c1-8(2)17(19)12(18)15-5-6-20-13-16-10-7-9(14)3-4-11(10)21-13/h3-4,7-8,19H,5-6H2,1-2H3,(H,15,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 70n/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.


J Med Chem 35: 3180-3 (1992)


Article DOI: 10.1021/jm00095a012
BindingDB Entry DOI: 10.7270/Q2542P68
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50001180
PNG
(2-(Benzothiazol-2-ylsulfanyl)-N-hydroxy-N-methyl-a...)
Show SMILES CN(O)C(=O)CSc1nc2ccccc2s1
Show InChI InChI=1S/C10H10N2O2S2/c1-12(14)9(13)6-15-10-11-7-4-2-3-5-8(7)16-10/h2-5,14H,6H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 70n/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.


J Med Chem 35: 3180-3 (1992)


Article DOI: 10.1021/jm00095a012
BindingDB Entry DOI: 10.7270/Q2542P68
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50001168
PNG
(3-(Benzothiazol-2-ylsulfanyl)-propylamine-N-hydrox...)
Show SMILES CC(C)N(O)C(=O)NCCCSc1nc2ccccc2s1
Show InChI InChI=1S/C14H19N3O2S2/c1-10(2)17(19)13(18)15-8-5-9-20-14-16-11-6-3-4-7-12(11)21-14/h3-4,6-7,10,19H,5,8-9H2,1-2H3,(H,15,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 70n/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.


J Med Chem 35: 3180-3 (1992)


Article DOI: 10.1021/jm00095a012
BindingDB Entry DOI: 10.7270/Q2542P68
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50001183
PNG
(3-[5-(4-Chloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyr...)
Show SMILES COc1ccc(cc1)-n1nc(CCC(=O)N(C)O)cc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H20ClN3O3/c1-23(26)20(25)12-7-16-13-19(14-3-5-15(21)6-4-14)24(22-16)17-8-10-18(27-2)11-9-17/h3-6,8-11,13,26H,7,12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a 70n/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.


J Med Chem 35: 3180-3 (1992)


Article DOI: 10.1021/jm00095a012
BindingDB Entry DOI: 10.7270/Q2542P68
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50001169
PNG
(2-benzo[d][1,3]thiazol-2-ylsulfanyl-1-ethanamino-N...)
Show SMILES CN(O)C(=O)NCCSc1nc2ccccc2s1
Show InChI InChI=1S/C11H13N3O2S2/c1-14(16)10(15)12-6-7-17-11-13-8-4-2-3-5-9(8)18-11/h2-5,16H,6-7H2,1H3,(H,12,15)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 90n/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.


J Med Chem 35: 3180-3 (1992)


Article DOI: 10.1021/jm00095a012
BindingDB Entry DOI: 10.7270/Q2542P68
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009009
PNG
(2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one | CH...)
Show SMILES O=c1n(CCCc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C16H16N2O/c19-16-14-10-4-5-11-15(14)17-18(16)12-6-9-13-7-2-1-3-8-13/h1-5,7-8,10-11,17H,6,9,12H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50008993
PNG
(1-Benzyl-1,2-dihydro-indazol-3-one | CHEMBL8612)
Show SMILES O=c1[nH]n(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C14H12N2O/c17-14-12-8-4-5-9-13(12)16(15-14)10-11-6-2-1-3-7-11/h1-9H,10H2,(H,15,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50406480
PNG
(CHEMBL276476)
Show SMILES Cn1n(Cc2ccccc2)c(=O)c2ccccc12
Show InChI InChI=1S/C15H14N2O/c1-16-14-10-6-5-9-13(14)15(18)17(16)11-12-7-3-2-4-8-12/h2-10H,11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009016
PNG
(2-(4-Phenyl-butyl)-1,2-dihydro-indazol-3-one | CHE...)
Show SMILES O=c1n(CCCCc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C17H18N2O/c20-17-15-11-4-5-12-16(15)18-19(17)13-7-6-10-14-8-2-1-3-9-14/h1-5,8-9,11-12,18H,6-7,10,13H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50008999
PNG
(5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihy...)
Show SMILES Cc1cc(=O)n(CCOc2ccc3ccccc3c2)[nH]1
Show InChI InChI=1S/C16H16N2O2/c1-12-10-16(19)18(17-12)8-9-20-15-7-6-13-4-2-3-5-14(13)11-15/h2-7,10-11,17H,8-9H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009007
PNG
(2-Phenethyl-1,2-dihydro-indazol-3-one | CHEMBL3144...)
Show SMILES O=c1n(CCc2ccccc2)[nH]c2ccccc12
Show InChI InChI=1S/C15H14N2O/c18-15-13-8-4-5-9-14(13)16-17(15)11-10-12-6-2-1-3-7-12/h1-9,16H,10-11H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50012434
PNG
((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...)
Show SMILES CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1
Show InChI InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50008990
PNG
(1,2-Dihydro-indazol-3-one | 1H-indazol-3-ol | CHEM...)
Show SMILES O=c1[nH][nH]c2ccccc12
Show InChI InChI=1S/C7H6N2O/c10-7-5-3-1-2-4-6(5)8-9-7/h1-4H,(H2,8,9,10)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009001
PNG
(5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...)
Show SMILES Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1
Show InChI InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM22372
PNG
(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Show SMILES C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50008985
PNG
(2-Naphthalen-1-ylmethyl-1,2-dihydro-indazol-3-one ...)
Show SMILES O=c1n(Cc2cccc3ccccc23)[nH]c2ccccc12
Show InChI InChI=1S/C18H14N2O/c21-18-16-10-3-4-11-17(16)19-20(18)12-14-8-5-7-13-6-1-2-9-15(13)14/h1-11,19H,12H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM46671
PNG
(2-Phenyl-1,2-dihydro-indazol-3-one | 2-phenyl-1H-i...)
Show SMILES O=c1n([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-13-11-8-4-5-9-12(11)14-15(13)10-6-2-1-3-7-10/h1-9,14H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50008997
PNG
(1-Methyl-1,2-dihydro-indazol-3-one | CHEMBL412905)
Show SMILES Cn1[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C8H8N2O/c1-10-7-5-3-2-4-6(7)8(11)9-10/h2-5H,1H3,(H,9,11)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50008986
PNG
(2-(1-Naphthalen-1-yl-ethyl)-1,2-dihydro-indazol-3-...)
Show SMILES C[C@H](c1cccc2ccccc12)n1[nH]c2ccccc2c1=O
Show InChI InChI=1S/C19H16N2O/c1-13(15-11-6-8-14-7-2-3-9-16(14)15)21-19(22)17-10-4-5-12-18(17)20-21/h2-13,20H,1H3/t13-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50009006
PNG
(2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one ...)
Show SMILES O=c1n(Cc2ccc3ccccc3c2)[nH]c2ccccc12
Show InChI InChI=1S/C18H14N2O/c21-18-16-7-3-4-8-17(16)19-20(18)12-13-9-10-14-5-1-2-6-15(14)11-13/h1-11,19H,12H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>100n/an/an/an/a



ICI Pharma

Curated by ChEMBL


Assay Description
Ex vivo inhibition of LTB4 production was measured in dog blood


J Med Chem 34: 1028-36 (1991)


Article DOI: 10.1021/jm00107a023
BindingDB Entry DOI: 10.7270/Q28G8MXH
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50001170
PNG
(5-ethyloxy-2-benzo[d][1,3]thiazol-2-ylsulfanyl-1-e...)
Show SMILES CCOc1ccc2nc(SCCNC(=O)N(C)O)sc2c1
Show InChI InChI=1S/C13H17N3O3S2/c1-3-19-9-4-5-10-11(8-9)21-13(15-10)20-7-6-14-12(17)16(2)18/h4-5,8,18H,3,6-7H2,1-2H3,(H,14,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 110n/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.


J Med Chem 35: 3180-3 (1992)


Article DOI: 10.1021/jm00095a012
BindingDB Entry DOI: 10.7270/Q2542P68
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50001179
PNG
(3-(Benzothiazol-2-ylsulfanyl)-N-hydroxy-N-methyl-a...)
Show SMILES CN(O)C(=O)\C=C\Sc1nc2ccccc2s1
Show InChI InChI=1S/C11H10N2O2S2/c1-13(15)10(14)6-7-16-11-12-8-4-2-3-5-9(8)17-11/h2-7,15H,1H3/b7-6+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 130n/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.


J Med Chem 35: 3180-3 (1992)


Article DOI: 10.1021/jm00095a012
BindingDB Entry DOI: 10.7270/Q2542P68
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50001172
PNG
(2-benzo[d][1,3]thiazol-2-ylsulfanyl-1-ethanamino-N...)
Show SMILES CC(C)N(O)C(=O)NCCSc1nc2ccccc2s1
Show InChI InChI=1S/C13H17N3O2S2/c1-9(2)16(18)12(17)14-7-8-19-13-15-10-5-3-4-6-11(10)20-13/h3-6,9,18H,7-8H2,1-2H3,(H,14,17)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 130n/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.


J Med Chem 35: 3180-3 (1992)


Article DOI: 10.1021/jm00095a012
BindingDB Entry DOI: 10.7270/Q2542P68
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (human))
BDBM50001184
PNG
(2-(6-Isopropyl-benzothiazol-2-ylsulfanyl)-ethylami...)
Show SMILES CC(C)c1ccc2nc(SCCNC(=O)N(C)O)sc2c1
Show InChI InChI=1S/C14H19N3O2S2/c1-9(2)10-4-5-11-12(8-10)21-14(16-11)20-7-6-15-13(18)17(3)19/h4-5,8-9,19H,6-7H2,1-3H3,(H,15,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 160n/an/an/an/a



R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of ionophore stimulated LTB4 release from human peripheral blood leukocytes.


J Med Chem 35: 3180-3 (1992)


Article DOI: 10.1021/jm00095a012
BindingDB Entry DOI: 10.7270/Q2542P68
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 112 total )  |  Next  |  Last  >>
Jump to: