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Compile Data Set for Download or QSAR

Found 63 hits of ec50 data for polymerid = 2556   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase


(Homo sapiens (human))
BDBM50151378
PNG
(CHEMBL3775521)
Show SMILES CN(c1ccc(OCC(=O)NO)cc1)c1nc(C)nc2ccccc12
Show InChI InChI=1S/C18H18N4O3/c1-12-19-16-6-4-3-5-15(16)18(20-12)22(2)13-7-9-14(10-8-13)25-11-17(23)21-24/h3-10,24H,11H2,1-2H3,(H,21,23)
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n/an/an/an/a 26n/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...


J Med Chem 59: 1455-70 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01342
BindingDB Entry DOI: 10.7270/Q2T155H3
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50150951
PNG
(CHEMBL3774793)
Show SMILES CN(c1ccc(OCC(=O)NO)cc1)c1ncnc2ccccc12
Show InChI InChI=1S/C17H16N4O3/c1-21(17-14-4-2-3-5-15(14)18-11-19-17)12-6-8-13(9-7-12)24-10-16(22)20-23/h2-9,11,23H,10H2,1H3,(H,20,22)
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n/an/an/an/a 49n/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...


J Med Chem 59: 1455-70 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01342
BindingDB Entry DOI: 10.7270/Q2T155H3
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50150959
PNG
(CHEMBL3775581)
Show SMILES CN(c1ccc(OCC(=O)NO)cc1)c1nc(C)nc2CCCc12
Show InChI InChI=1S/C17H20N4O3/c1-11-18-15-5-3-4-14(15)17(19-11)21(2)12-6-8-13(9-7-12)24-10-16(22)20-23/h6-9,23H,3-5,10H2,1-2H3,(H,20,22)
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n/an/an/an/a 51n/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...


J Med Chem 59: 1455-70 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01342
BindingDB Entry DOI: 10.7270/Q2T155H3
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50151375
PNG
(CHEMBL3774414)
Show SMILES COc1ccc(cc1OCCCC(=O)NO)N(C)c1nc(C)nc2ccccc12
Show InChI InChI=1S/C21H24N4O4/c1-14-22-17-8-5-4-7-16(17)21(23-14)25(2)15-10-11-18(28-3)19(13-15)29-12-6-9-20(26)24-27/h4-5,7-8,10-11,13,27H,6,9,12H2,1-3H3,(H,24,26)
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n/an/an/an/a 59n/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His-tagged KDM4A (1 to 359 residues) expressed in Escherichia coli using biotin-H3K9me3 as substrate preincubated for ...


J Med Chem 59: 1455-70 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01342
BindingDB Entry DOI: 10.7270/Q2T155H3
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50188959
PNG
(CHEMBL3827894)
Show SMILES CN(Cc1nc2c(nc(nc2n1C)-c1cnc(N)nc1)N1CCOCC1)c1ncc(cn1)C(=O)NO
Show InChI InChI=1S/C21H24N12O3/c1-31(21-25-9-13(10-26-21)19(34)30-35)11-14-27-15-17(32(14)2)28-16(12-7-23-20(22)24-8-12)29-18(15)33-3-5-36-6-4-33/h7-10,35H,3-6,11H2,1-2H3,(H,30,34)(H2,22,23,24)
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n/an/an/an/a 144n/an/an/an/a



West China Hospital of Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assay


J Med Chem 59: 5488-504 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00579
BindingDB Entry DOI: 10.7270/Q2T155K0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM29589
PNG
(Faridak | LBH-589 | LBH-589B | Panobinostat)
Show SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
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n/an/an/an/a 151n/an/an/an/a



West China Hospital of Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assay


J Med Chem 59: 5488-504 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00579
BindingDB Entry DOI: 10.7270/Q2T155K0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50188899
PNG
(CHEMBL3827517)
Show SMILES CN(Cc1nc2c(nc(nc2n1C)-c1ccncc1)N1CCOCC1)c1ncc(cn1)C(=O)NO
Show InChI InChI=1S/C22H24N10O3/c1-30(22-24-11-15(12-25-22)21(33)29-34)13-16-26-17-19(31(16)2)27-18(14-3-5-23-6-4-14)28-20(17)32-7-9-35-10-8-32/h3-6,11-12,34H,7-10,13H2,1-2H3,(H,29,33)
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n/an/an/an/a 188n/an/an/an/a



West China Hospital of Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assay


J Med Chem 59: 5488-504 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00579
BindingDB Entry DOI: 10.7270/Q2T155K0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50188897
PNG
(CHEMBL3827281)
Show SMILES COc1ccc(cn1)-c1nc(N2CCOCC2)c2nc(CN(C)c3ncc(cn3)C(=O)NO)n(C)c2n1
Show InChI InChI=1S/C23H26N10O4/c1-31(23-25-11-15(12-26-23)22(34)30-35)13-16-27-18-20(32(16)2)28-19(14-4-5-17(36-3)24-10-14)29-21(18)33-6-8-37-9-7-33/h4-5,10-12,35H,6-9,13H2,1-3H3,(H,30,34)
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n/an/an/an/a 199n/an/an/an/a



West China Hospital of Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assay


J Med Chem 59: 5488-504 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00579
BindingDB Entry DOI: 10.7270/Q2T155K0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50188637
PNG
(CHEMBL3827814)
Show SMILES CN(Cc1nc2c(nc(nc2n1C)-c1ccc(N)cc1)N1CCOCC1)c1ncc(cn1)C(=O)NO
Show InChI InChI=1S/C23H26N10O3/c1-31(23-25-11-15(12-26-23)22(34)30-35)13-17-27-18-20(32(17)2)28-19(14-3-5-16(24)6-4-14)29-21(18)33-7-9-36-10-8-33/h3-6,11-12,35H,7-10,13,24H2,1-2H3,(H,30,34)
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n/an/an/an/a 211n/an/an/an/a



West China Hospital of Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assay


J Med Chem 59: 5488-504 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00579
BindingDB Entry DOI: 10.7270/Q2T155K0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50188961
PNG
(CHEMBL3622533)
Show SMILES COc1ccc(cn1)-c1nc(N2CCOCC2)c2sc(CN(C)c3ncc(cn3)C(=O)NO)cc2n1
Show InChI InChI=1S/C23H24N8O4S/c1-30(23-25-11-15(12-26-23)22(32)29-33)13-16-9-17-19(36-16)21(31-5-7-35-8-6-31)28-20(27-17)14-3-4-18(34-2)24-10-14/h3-4,9-12,33H,5-8,13H2,1-2H3,(H,29,32)
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n/an/an/an/a 222n/an/an/an/a



West China Hospital of Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assay


J Med Chem 59: 5488-504 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00579
BindingDB Entry DOI: 10.7270/Q2T155K0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50188891
PNG
(CHEMBL3828518)
Show SMILES COc1ccc(cc1)-c1nc(N2CCOCC2)c2nc(CN(C)c3ncc(cn3)C(=O)NO)n(C)c2n1
Show InChI InChI=1S/C24H27N9O4/c1-31(24-25-12-16(13-26-24)23(34)30-35)14-18-27-19-21(32(18)2)28-20(15-4-6-17(36-3)7-5-15)29-22(19)33-8-10-37-11-9-33/h4-7,12-13,35H,8-11,14H2,1-3H3,(H,30,34)
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n/an/an/an/a 248n/an/an/an/a



West China Hospital of Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assay


J Med Chem 59: 5488-504 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00579
BindingDB Entry DOI: 10.7270/Q2T155K0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078748
PNG
(CHEMBL3415629)
Show SMILES C[C@@]1(CCN(C1=O)c1ccc(Cl)cc1)Nc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C18H18ClN3O3/c1-18(20-14-6-2-12(3-7-14)16(23)21-25)10-11-22(17(18)24)15-8-4-13(19)5-9-15/h2-9,20,25H,10-11H2,1H3,(H,21,23)/t18-/m0/s1
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n/an/an/an/a 300n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078747
PNG
(CHEMBL3415628)
Show SMILES CC1(CCN(C1=O)c1ccc2ncccc2c1)Nc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C21H20N4O3/c1-21(23-16-6-4-14(5-7-16)19(26)24-28)10-12-25(20(21)27)17-8-9-18-15(13-17)3-2-11-22-18/h2-9,11,13,23,28H,10,12H2,1H3,(H,24,26)
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n/an/an/an/a 360n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/an/an/a 399n/an/an/an/a



West China Hospital of Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assay


J Med Chem 59: 5488-504 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00579
BindingDB Entry DOI: 10.7270/Q2T155K0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM120947
PNG
(US8716285, 4)
Show SMILES ONC(=O)c1ccc2CCC(Cc2c1)Nc1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C18H16ClN3O2/c19-17-9-16(6-4-13(17)10-20)21-15-5-3-11-1-2-12(18(23)22-24)7-14(11)8-15/h1-2,4,6-7,9,15,21,24H,3,5,8H2,(H,22,23)
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n/an/an/an/a 460n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078695
PNG
(CHEMBL3415627)
Show SMILES CC1(CCN(C1=O)c1ccc(Cl)cc1)Nc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C18H18ClN3O3/c1-18(20-14-6-2-12(3-7-14)16(23)21-25)10-11-22(17(18)24)15-8-4-13(19)5-9-15/h2-9,20,25H,10-11H2,1H3,(H,21,23)
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n/an/an/an/a 530n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50246033
PNG
(2,2,2-Trifluoro-1-(5-{3-[(methylsulfonyl)methyl]-1...)
Show SMILES CS(=O)(=O)Cc1noc(n1)-c1ccc(s1)C(=O)C(F)(F)F
Show InChI InChI=1S/C10H7F3N2O4S2/c1-21(17,18)4-7-14-9(19-15-7)6-3-2-5(20-6)8(16)10(11,12)13/h2-3H,4H2,1H3
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n/an/an/an/a 640n/an/an/an/a



Istituto Di Ricerche Di Biologia Molecolare

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human HCT116 cells assessed as alpha-tubulin hyperacetylation after 24 hrs


J Med Chem 52: 6782-9 (2009)


Article DOI: 10.1021/jm900555u
BindingDB Entry DOI: 10.7270/Q2J966F8
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50027661
PNG
(CHEMBL3338417)
Show SMILES ONC(=O)c1ccc2CC[C@@H](Cc2c1)Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C20H19N5O2/c26-19(25-27)14-4-3-13-5-6-17(11-16(13)10-14)23-20-22-9-7-18(24-20)15-2-1-8-21-12-15/h1-4,7-10,12,17,27H,5-6,11H2,(H,25,26)(H,22,23,24)/t17-/m0/s1
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n/an/an/an/a 690n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM120950
PNG
(US8716285, 7)
Show SMILES ONC(=O)c1ccc2CCC(Cc2c1)Nc1ncccn1
Show InChI InChI=1S/C15H16N4O2/c20-14(19-21)11-3-2-10-4-5-13(9-12(10)8-11)18-15-16-6-1-7-17-15/h1-3,6-8,13,21H,4-5,9H2,(H,19,20)(H,16,17,18)
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n/an/an/an/a 730n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM120958
PNG
(US8716285, 15)
Show SMILES ONC(=O)c1ccc2CCC(Cc2c1)Nc1nccc(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H19ClN4O2/c22-18-4-2-1-3-17(18)19-9-10-23-21(25-19)24-16-8-7-13-5-6-14(20(27)26-28)11-15(13)12-16/h1-6,9-11,16,28H,7-8,12H2,(H,26,27)(H,23,24,25)
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n/an/an/an/a 930n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM120983
PNG
(US8716285, 40)
Show SMILES ONC(=O)c1ccc2CCC(Cc2c1)NS(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C17H17FN2O4S/c18-14-2-1-3-16(10-14)25(23,24)20-15-7-6-11-4-5-12(17(21)19-22)8-13(11)9-15/h1-5,8,10,15,20,22H,6-7,9H2,(H,19,21)
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n/an/an/an/a 990n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50300003
PNG
(3-[5-(Trifluoroacetyl)thiophen-2-yl]benzoic Acid |...)
Show SMILES OC(=O)c1cccc(c1)-c1ccc(s1)C(=O)C(F)(F)F
Show InChI InChI=1S/C13H7F3O3S/c14-13(15,16)11(17)10-5-4-9(20-10)7-2-1-3-8(6-7)12(18)19/h1-6H,(H,18,19)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Istituto Di Ricerche Di Biologia Molecolare

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human HCT116 cells assessed as alpha-tubulin hyperacetylation after 24 hrs


J Med Chem 52: 6782-9 (2009)


Article DOI: 10.1021/jm900555u
BindingDB Entry DOI: 10.7270/Q2J966F8
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
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n/an/an/an/a 1.03E+3n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078759
PNG
(CHEMBL3415622)
Show SMILES ONC(=O)c1ccc(NC2CCN(C2=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C21H19N3O3/c25-20(23-27)15-5-8-17(9-6-15)22-19-11-12-24(21(19)26)18-10-7-14-3-1-2-4-16(14)13-18/h1-10,13,19,22,27H,11-12H2,(H,23,25)
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n/an/an/an/a 1.10E+3n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM120967
PNG
(US8716285, 24)
Show SMILES ONC(=O)c1ccc2CCC(Cc2c1)Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C20H19N5O2/c26-19(25-27)14-4-3-13-5-6-17(11-16(13)10-14)23-20-22-9-7-18(24-20)15-2-1-8-21-12-15/h1-4,7-10,12,17,27H,5-6,11H2,(H,25,26)(H,22,23,24)
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n/an/an/an/a 1.18E+3n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM120953
PNG
(US8716285, 10)
Show SMILES ONC(=O)c1ccc2CCC(Cc2c1)Nc1nccc(n1)-c1ccccc1
Show InChI InChI=1S/C21H20N4O2/c26-20(25-27)16-7-6-14-8-9-18(13-17(14)12-16)23-21-22-11-10-19(24-21)15-4-2-1-3-5-15/h1-7,10-12,18,27H,8-9,13H2,(H,25,26)(H,22,23,24)
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n/an/an/an/a 1.31E+3n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078757
PNG
(CHEMBL3415453)
Show SMILES ONC(=O)c1ccc(NC2CCN(C2=O)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C17H16ClN3O3/c18-12-3-7-14(8-4-12)21-10-9-15(17(21)23)19-13-5-1-11(2-6-13)16(22)20-24/h1-8,15,19,24H,9-10H2,(H,20,22)
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n/an/an/an/a 1.40E+3n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50027662
PNG
(CHEMBL3338418)
Show SMILES ONC(=O)c1ccc2CC[C@H](Cc2c1)Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C20H19N5O2/c26-19(25-27)14-4-3-13-5-6-17(11-16(13)10-14)23-20-22-9-7-18(24-20)15-2-1-8-21-12-15/h1-4,7-10,12,17,27H,5-6,11H2,(H,25,26)(H,22,23,24)/t17-/m1/s1
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n/an/an/an/a 1.60E+3n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50027662
PNG
(CHEMBL3338418)
Show SMILES ONC(=O)c1ccc2CC[C@H](Cc2c1)Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C20H19N5O2/c26-19(25-27)14-4-3-13-5-6-17(11-16(13)10-14)23-20-22-9-7-18(24-20)15-2-1-8-21-12-15/h1-4,7-10,12,17,27H,5-6,11H2,(H,25,26)(H,22,23,24)/t17-/m1/s1
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n/an/an/an/a 1.64E+3n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM120985
PNG
(US8716285, 42)
Show SMILES ONC(=O)c1ccc2CCC(Cc2c1)NS(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C17H17ClN2O4S/c18-14-2-1-3-16(10-14)25(23,24)20-15-7-6-11-4-5-12(17(21)19-22)8-13(11)9-15/h1-5,8,10,15,20,22H,6-7,9H2,(H,19,21)
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n/an/an/an/a 1.72E+3n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078749
PNG
(CHEMBL3415630)
Show SMILES C[C@]1(CCN(C1=O)c1ccc(Cl)cc1)Nc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C18H18ClN3O3/c1-18(20-14-6-2-12(3-7-14)16(23)21-25)10-11-22(17(18)24)15-8-4-13(19)5-9-15/h2-9,20,25H,10-11H2,1H3,(H,21,23)/t18-/m1/s1
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n/an/an/an/a 1.90E+3n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078758
PNG
(CHEMBL3415455)
Show SMILES CN(C)CCOc1cccc(c1)N1CCC(Nc2ccc(cc2)C(=O)NO)C1=O
Show InChI InChI=1S/C21H26N4O4/c1-24(2)12-13-29-18-5-3-4-17(14-18)25-11-10-19(21(25)27)22-16-8-6-15(7-9-16)20(26)23-28/h3-9,14,19,22,28H,10-13H2,1-2H3,(H,23,26)
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n/an/an/an/a 2.00E+3n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM120979
PNG
(US8716285, 36)
Show SMILES CN(C1CCc2ccc(cc2C1)C(=O)NO)c1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C21H21N5O2/c1-26(21-23-10-8-19(24-21)16-3-2-9-22-13-16)18-7-6-14-4-5-15(20(27)25-28)11-17(14)12-18/h2-5,8-11,13,18,28H,6-7,12H2,1H3,(H,25,27)
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n/an/an/an/a 2.25E+3n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078693
PNG
(CHEMBL3415626)
Show SMILES CC1(CCN(C1=O)c1ccccc1)Nc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C18H19N3O3/c1-18(19-14-9-7-13(8-10-14)16(22)20-24)11-12-21(17(18)23)15-5-3-2-4-6-15/h2-10,19,24H,11-12H2,1H3,(H,20,22)
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n/an/an/an/a 2.60E+3n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078680
PNG
(CHEMBL3415454)
Show SMILES ONC(=O)c1ccc(NC2CCN(C2=O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C17H16ClN3O3/c18-12-2-1-3-14(10-12)21-9-8-15(17(21)23)19-13-6-4-11(5-7-13)16(22)20-24/h1-7,10,15,19,24H,8-9H2,(H,20,22)
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n/an/an/an/a 2.80E+3n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM22449
PNG
(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Show SMILES OCc1ccc(cc1)[C@@H]1C[C@H](CSc2nc(c(o2)-c2ccccc2)-c2ccccc2)O[C@@H](O1)c1ccc(NC(=O)CCCCCCC(=O)NO)cc1
Show InChI InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1
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n/an/an/an/a 2.90E+3n/an/an/an/a



Universit£ degli Studi di Roma"La Sapienza"

Curated by ChEMBL


Assay Description
Tested for inhibition of Histone deacetylase 6 induced acetylated tubulin in mammalian cells.


J Med Chem 46: 4826-9 (2003)


Article DOI: 10.1021/jm034167p
BindingDB Entry DOI: 10.7270/Q28C9X0G
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM22449
PNG
(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Show SMILES OCc1ccc(cc1)[C@@H]1C[C@H](CSc2nc(c(o2)-c2ccccc2)-c2ccccc2)O[C@@H](O1)c1ccc(NC(=O)CCCCCCC(=O)NO)cc1
Show InChI InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1
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n/an/an/an/a 2.90E+3n/an/an/an/a



Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of alpha-tubulin acetylation by fluorescence microscopy


Nat Chem Biol 1: 74-84 (2006)


Article DOI: 10.1038/nchembio0705-74
BindingDB Entry DOI: 10.7270/Q2MC9118
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078690
PNG
(CHEMBL3415621)
Show SMILES ONC(=O)c1ccc(NC2CCN(C2=O)c2ccc(cc2)C#N)cc1
Show InChI InChI=1S/C18H16N4O3/c19-11-12-1-7-15(8-2-12)22-10-9-16(18(22)24)20-14-5-3-13(4-6-14)17(23)21-25/h1-8,16,20,25H,9-10H2,(H,21,23)
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n/an/an/an/a 3.10E+3n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50027664
PNG
(CHEMBL3338404)
Show SMILES ONC(=O)c1ccc2CCN(Cc3ccc(o3)-c3cccc(c3)[N+]([O-])=O)Cc2c1
Show InChI InChI=1S/C21H19N3O5/c25-21(22-26)16-5-4-14-8-9-23(12-17(14)10-16)13-19-6-7-20(29-19)15-2-1-3-18(11-15)24(27)28/h1-7,10-11,26H,8-9,12-13H2,(H,22,25)
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n/an/an/an/a 3.45E+3n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078692
PNG
(CHEMBL3415625)
Show SMILES ONC(=O)c1ccc(NC2CCN(C2)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C17H18ClN3O2/c18-13-3-7-16(8-4-13)21-10-9-15(11-21)19-14-5-1-12(2-6-14)17(22)20-23/h1-8,15,19,23H,9-11H2,(H,20,22)
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n/an/an/an/a 4.30E+3n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078687
PNG
(CHEMBL3415619)
Show SMILES ONC(=O)c1ccc(NC2CCN(C2=O)c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C17H15Cl2N3O3/c18-13-6-5-12(9-14(13)19)22-8-7-15(17(22)24)20-11-3-1-10(2-4-11)16(23)21-25/h1-6,9,15,20,25H,7-8H2,(H,21,23)
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n/an/an/an/a 4.30E+3n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM120957
PNG
(US8716285, 14)
Show SMILES ONC(=O)c1ccc2CCC(Cc2c1)Nc1nccc(n1)-c1cccc(Cl)c1
Show InChI InChI=1S/C21H19ClN4O2/c22-17-3-1-2-14(11-17)19-8-9-23-21(25-19)24-18-7-6-13-4-5-15(20(27)26-28)10-16(13)12-18/h1-5,8-11,18,28H,6-7,12H2,(H,26,27)(H,23,24,25)
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n/an/an/an/a 4.95E+3n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM120948
PNG
(US8716285, 5)
Show SMILES ONC(=O)c1ccc2CCC(Cc2c1)Nc1ccccn1
Show InChI InChI=1S/C16H17N3O2/c20-16(19-21)12-5-4-11-6-7-14(10-13(11)9-12)18-15-3-1-2-8-17-15/h1-5,8-9,14,21H,6-7,10H2,(H,17,18)(H,19,20)
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n/an/an/an/a 5.00E+3n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078750
PNG
(CHEMBL3415446)
Show SMILES ONC(=O)c1ccc(NC2CCN(C2=O)c2ccccc2)cc1
Show InChI InChI=1S/C17H17N3O3/c21-16(19-23)12-6-8-13(9-7-12)18-15-10-11-20(17(15)22)14-4-2-1-3-5-14/h1-9,15,18,23H,10-11H2,(H,19,21)
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n/an/an/an/a 5.90E+3n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078681
PNG
(CHEMBL3415456)
Show SMILES ONC(=O)c1ccc(NC2CCN(C2=O)c2ccccc2Cl)cc1
Show InChI InChI=1S/C17H16ClN3O3/c18-13-3-1-2-4-15(13)21-10-9-14(17(21)23)19-12-7-5-11(6-8-12)16(22)20-24/h1-8,14,19,24H,9-10H2,(H,20,22)
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n/an/an/an/a 6.70E+3n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM120956
PNG
(US8716285, 13)
Show SMILES ONC(=O)c1ccc2CCC(Cc2c1)Nc1nccc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H19ClN4O2/c22-17-6-3-14(4-7-17)19-9-10-23-21(25-19)24-18-8-5-13-1-2-15(20(27)26-28)11-16(13)12-18/h1-4,6-7,9-11,18,28H,5,8,12H2,(H,26,27)(H,23,24,25)
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n/an/an/an/a 8.70E+3n/an/an/an/a



Roche Pharmaceutical Research and Early Development

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assay


J Med Chem 57: 8026-34 (2014)


Article DOI: 10.1021/jm5008962
BindingDB Entry DOI: 10.7270/Q29C700V
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078755
PNG
(CHEMBL3415451)
Show SMILES ONC(=O)c1ccc(NC2CCN(Cc3ccccc3)C2=O)cc1
Show InChI InChI=1S/C18H19N3O3/c22-17(20-24)14-6-8-15(9-7-14)19-16-10-11-21(18(16)23)12-13-4-2-1-3-5-13/h1-9,16,19,24H,10-12H2,(H,20,22)
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n/an/an/an/a 1.14E+4n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM120996
PNG
(US8716285, 53)
Show SMILES ONC(=O)c1ccc2NCC(Cc2c1)Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C19H18N6O2/c26-18(25-27)12-3-4-16-14(8-12)9-15(11-22-16)23-19-21-7-5-17(24-19)13-2-1-6-20-10-13/h1-8,10,15,22,27H,9,11H2,(H,25,26)(H,21,23,24)
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n/an/an/an/a 1.18E+4n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM50078689
PNG
(CHEMBL3415620)
Show SMILES CS(=O)(=O)c1ccc(cc1)N1CCC(Nc2ccc(cc2)C(=O)NO)C1=O
Show InChI InChI=1S/C18H19N3O5S/c1-27(25,26)15-8-6-14(7-9-15)21-11-10-16(18(21)23)19-13-4-2-12(3-5-13)17(22)20-24/h2-9,16,19,24H,10-11H2,1H3,(H,20,22)
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n/an/an/an/a 1.19E+4n/an/an/an/a



Roche Innovation Center Shanghai

Curated by ChEMBL


Assay Description
Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISA


J Med Chem 58: 2809-20 (2015)


Article DOI: 10.1021/jm502011f
BindingDB Entry DOI: 10.7270/Q2B56MF0
More data for this
Ligand-Target Pair
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