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Compile Data Set for Download or QSAR

Found 1053 hits of ec50 data for polymerid = 4795   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apelin receptor


(Homo sapiens)
BDBM270203
PNG
((1R,2S,P)—N-(4-(2,4-dimethoxy-3-pyridinyl)-5-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)ccnc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C24H28N8O6S/c1-14-12-26-21(27-13-14)20(37-5)15(2)39(33,34)31-24-30-29-22(16-8-7-9-18(28-16)36-4)32(24)19-17(35-3)10-11-25-23(19)38-6/h7-13,15,20H,1-6H3,(H,30,31)/t15-,20-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM50078006
PNG
(CHEMBL3417385)
Show SMILES CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)C(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C77H114N22O17/c1-4-5-18-52(73(113)99-36-15-24-60(99)72(112)95-56(75(115)116)38-45-25-27-47(28-26-45)63(103)46-16-7-6-8-17-46)92-70(110)58-22-13-34-97(58)62(102)41-86-64(104)49(19-9-10-31-78)89-68(108)55(39-48-40-83-43-87-48)94-69(109)57(42-100)96-67(107)54(37-44(2)3)93-65(105)50(20-11-32-84-76(79)80)90-71(111)59-23-14-35-98(59)74(114)53(21-12-33-85-77(81)82)91-66(106)51-29-30-61(101)88-51/h6-8,16-17,25-28,40,43-44,49-60,100H,4-5,9-15,18-24,29-39,41-42,78H2,1-3H3,(H,83,87)(H,86,104)(H,88,101)(H,89,108)(H,90,111)(H,91,106)(H,92,110)(H,93,105)(H,94,109)(H,95,112)(H,96,107)(H,115,116)(H4,79,80,84)(H4,81,82,85)/t49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1
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n/an/an/an/a 0.0400n/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated ...


J Med Chem 58: 2431-40 (2015)


Article DOI: 10.1021/jm501916k
BindingDB Entry DOI: 10.7270/Q21V5GNR
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269647
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H28FN7O5S/c1-6-38-21-12-7-9-18(29-21)24-30-31-25(33(24)22-19(36-4)10-8-11-20(22)37-5)32-39(34,35)16(3)15(2)23-27-13-17(26)14-28-23/h7-16H,6H2,1-5H3,(H,31,32)/t15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269658
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H31N7O6S/c1-7-39-21-13-8-10-18(29-21)25-30-31-26(33(25)22-19(36-4)11-9-12-20(22)37-5)32-40(34,35)17(3)23(38-6)24-27-14-16(2)15-28-24/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269666
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-p...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H31N7O5S/c1-7-38-22-13-8-10-19(29-22)25-30-31-26(33(25)23-20(36-5)11-9-12-21(23)37-6)32-39(34,35)18(4)17(3)24-27-14-16(2)15-28-24/h8-15,17-18H,7H2,1-6H3,(H,31,32)/t17-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM50078002
PNG
(CHEMBL3417389)
Show SMILES CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@](C)(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C71H112N22O16/c1-5-6-19-47(66(106)93-33-16-25-54(93)65(105)90-71(4,68(108)109)36-42-17-8-7-9-18-42)86-63(103)52-23-14-31-91(52)56(96)38-80-57(97)44(20-10-11-28-72)83-61(101)50(35-43-37-77-40-81-43)88-62(102)51(39-94)89-60(100)49(34-41(2)3)87-58(98)45(21-12-29-78-69(73)74)84-64(104)53-24-15-32-92(53)67(107)48(22-13-30-79-70(75)76)85-59(99)46-26-27-55(95)82-46/h7-9,17-18,37,40-41,44-54,94H,5-6,10-16,19-36,38-39,72H2,1-4H3,(H,77,81)(H,80,97)(H,82,95)(H,83,101)(H,84,104)(H,85,99)(H,86,103)(H,87,98)(H,88,102)(H,89,100)(H,90,105)(H,108,109)(H4,73,74,78)(H4,75,76,79)/t44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,71-/m0/s1
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Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated ...


J Med Chem 58: 2431-40 (2015)


Article DOI: 10.1021/jm501916k
BindingDB Entry DOI: 10.7270/Q21V5GNR
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269952
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1S/C27H28N6O8S2/c1-38-20-9-7-10-21(39-2)25(20)33-26(19-8-6-11-24(29-19)41-4)30-31-27(33)32-43(36,37)16-22(40-3)18-13-12-17(15-28)14-23(18)42(5,34)35/h6-14,22H,16H2,1-5H3,(H,31,32)/t22-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269596
PNG
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270042
PNG
((1S,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CCO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccnc2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H26ClN7O5S/c1-5-37-21(22-27-13-17(25)14-28-22)15(2)38(33,34)31-24-30-29-23(16-8-7-11-26-12-16)32(24)20-18(35-3)9-6-10-19(20)36-4/h6-15,21H,5H2,1-4H3,(H,30,31)/t15-,21+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269592
PNG
((1S,2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CCO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H31N7O6S/c1-7-39-23(24-27-14-16(2)15-28-24)17(3)40(34,35)32-26-31-30-25(18-10-8-13-21(29-18)38-6)33(26)22-19(36-4)11-9-12-20(22)37-5/h8-15,17,23H,7H2,1-6H3,(H,31,32)/t17-,23-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270120
PNG
((2R,3S)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C24H26ClN7O4S/c1-14-9-17(11-26-10-14)23-29-30-24(32(23)21-19(35-4)7-6-8-20(21)36-5)31-37(33,34)16(3)15(2)22-27-12-18(25)13-28-22/h6-13,15-16H,1-5H3,(H,30,31)/t15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269725
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(F)cn1
Show InChI InChI=1S/C24H26FN7O6S/c1-14(21(38-5)22-26-12-15(25)13-27-22)39(33,34)31-24-30-29-23(16-8-6-11-19(28-16)37-4)32(24)20-17(35-2)9-7-10-18(20)36-3/h6-14,21H,1-5H3,(H,30,31)/t14-,21-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270036
PNG
((1S,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H26ClN7O6S/c1-14(21(38-5)22-26-12-15(25)13-27-22)39(33,34)31-24-30-29-23(16-8-6-11-19(28-16)37-4)32(24)20-17(35-2)9-7-10-18(20)36-3/h6-14,21H,1-5H3,(H,30,31)/t14-,21+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269613
PNG
((2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H26FN7O5S/c1-14(22-26-12-16(25)13-27-22)15(2)38(33,34)31-24-30-29-23(17-8-6-11-20(28-17)37-5)32(24)21-18(35-3)9-7-10-19(21)36-4/h6-15H,1-5H3,(H,30,31)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270191
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COC1CN(C1)[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269952
PNG
((2R)-2-(4-cyano-2-(methylsulfonyl)phenyl)-N-(4-(2,...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(cc1S(C)(=O)=O)C#N
Show InChI InChI=1S/C27H28N6O8S2/c1-38-20-9-7-10-21(39-2)25(20)33-26(19-8-6-11-24(29-19)41-4)30-31-27(33)32-43(36,37)16-22(40-3)18-13-12-17(15-28)14-23(18)42(5,34)35/h6-14,22H,16H2,1-5H3,(H,31,32)/t22-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270129
PNG
((2S,3R)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H26ClN7O5S/c1-14(22-26-12-16(25)13-27-22)15(2)38(33,34)31-24-30-29-23(17-8-6-11-20(28-17)37-5)32(24)21-18(35-3)9-7-10-19(21)36-4/h6-15H,1-5H3,(H,30,31)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270170
PNG
((1S,2S)-1-isopropoxy-1-(5-methylpyrimidin-2-yl)pro...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)nnc1-c1cccc(C)n1
Show InChI InChI=1S/C27H33N7O5S/c1-16(2)39-24(25-28-14-17(3)15-29-25)19(5)40(35,36)33-27-32-31-26(20-11-8-10-18(4)30-20)34(27)23-21(37-6)12-9-13-22(23)38-7/h8-16,19,24H,1-7H3,(H,32,33)/t19-,24+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270036
PNG
((1S,2S)-1-(5-chloropyrimidin-2-yl)-N-(4-(2,6-dimet...)
Show SMILES CO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(Cl)cn1
Show InChI InChI=1S/C24H26ClN7O6S/c1-14(21(38-5)22-26-12-15(25)13-27-22)39(33,34)31-24-30-29-23(16-8-6-11-19(28-16)37-4)32(24)20-17(35-2)9-7-10-18(20)36-3/h6-14,21H,1-5H3,(H,30,31)/t14-,21+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269581
PNG
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H33N7O6S/c1-16(2)40-24(25-28-14-17(3)15-29-25)18(4)41(35,36)33-27-32-31-26(19-10-8-13-22(30-19)39-7)34(27)23-20(37-5)11-9-12-21(23)38-6/h8-16,18,24H,1-7H3,(H,32,33)/t18-,24+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269613
PNG
((2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H26FN7O5S/c1-14(22-26-12-16(25)13-27-22)15(2)38(33,34)31-24-30-29-23(17-8-6-11-20(28-17)37-5)32(24)21-18(35-3)9-7-10-19(21)36-4/h6-15H,1-5H3,(H,30,31)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269869
PNG
((1S,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(5-methy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OCCO)c2ncc(C)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C26H31N7O6S/c1-16-11-19(15-27-12-16)25-30-31-26(33(25)22-20(37-4)7-6-8-21(22)38-5)32-40(35,36)18(3)23(39-10-9-34)24-28-13-17(2)14-29-24/h6-8,11-15,18,23,34H,9-10H2,1-5H3,(H,31,32)/t18-,23-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269753
PNG
(Preparation of (R)—N-(4-(2,6-dimethoxyphenyl)...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(F)cc1S(C)(=O)=O
Show InChI InChI=1S/C26H28FN5O8S2/c1-37-19-9-7-10-20(38-2)24(19)32-25(18-8-6-11-23(28-18)40-4)29-30-26(32)31-42(35,36)15-21(39-3)17-13-12-16(27)14-22(17)41(5,33)34/h6-14,21H,15H2,1-5H3,(H,30,31)/t21-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269628
PNG
((2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethoxy-2-pyri...)
Show SMILES CCOc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H26FN7O5S/c1-5-37-21-11-6-8-17(28-21)23-29-30-24(32(23)22-18(35-3)9-7-10-19(22)36-4)31-38(33,34)15(2)12-20-26-13-16(25)14-27-20/h6-11,13-15H,5,12H2,1-4H3,(H,30,31)/t15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269663
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-4-...)
Show SMILES COc1cc(C)cc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H28FN7O5S/c1-14-10-18(29-21(11-14)38-6)24-30-31-25(33(24)22-19(36-4)8-7-9-20(22)37-5)32-39(34,35)16(3)15(2)23-27-12-17(26)13-28-23/h7-13,15-16H,1-6H3,(H,31,32)/t15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270128
PNG
((1R,2S)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COc1ccc(CN(Cc2ccc(OC)cc2)S(=O)(=O)[C@@H](C)[C@H](O[Si](C)(C)C(C)(C)C)c2ncc(C)cn2)cc1
Show InChI InChI=1S/C30H43N3O5SSi/c1-22-18-31-29(32-19-22)28(38-40(8,9)30(3,4)5)23(2)39(34,35)33(20-24-10-14-26(36-6)15-11-24)21-25-12-16-27(37-7)17-13-25/h10-19,23,28H,20-21H2,1-9H3/t23-,28-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269671
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(2,2,2-tri...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)nnc1-c1cccc(OCC(F)(F)F)n1
Show InChI InChI=1S/C25H25F4N7O5S/c1-14(22-30-11-16(26)12-31-22)15(2)42(37,38)35-24-34-33-23(17-7-5-10-20(32-17)41-13-25(27,28)29)36(24)21-18(39-3)8-6-9-19(21)40-4/h5-12,14-15H,13H2,1-4H3,(H,34,35)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269672
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(2-hydroxy...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)nnc1-c1cccc(OCCO)n1
Show InChI InChI=1S/C25H28FN7O6S/c1-15(23-27-13-17(26)14-28-23)16(2)40(35,36)32-25-31-30-24(18-7-5-10-21(29-18)39-12-11-34)33(25)22-19(37-3)8-6-9-20(22)38-4/h5-10,13-16,34H,11-12H2,1-4H3,(H,31,32)/t15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269664
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-4-...)
Show SMILES COc1cc(C)cc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H31N7O5S/c1-15-11-19(29-22(12-15)38-7)25-30-31-26(33(25)23-20(36-5)9-8-10-21(23)37-6)32-39(34,35)18(4)17(3)24-27-13-16(2)14-28-24/h8-14,17-18H,1-7H3,(H,31,32)/t17-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270127
PNG
((2S,3R)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cccnc1
Show InChI InChI=1S/C23H24ClN7O4S/c1-14(21-26-12-17(24)13-27-21)15(2)36(32,33)30-23-29-28-22(16-7-6-10-25-11-16)31(23)20-18(34-3)8-5-9-19(20)35-4/h5-15H,1-4H3,(H,29,30)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270075
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(methylami...)
Show SMILES CNc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C24H27FN8O4S/c1-14(22-27-12-16(25)13-28-22)15(2)38(34,35)32-24-31-30-23(17-8-6-11-20(26-3)29-17)33(24)21-18(36-4)9-7-10-19(21)37-5/h6-15H,1-5H3,(H,26,29)(H,31,32)/t14-,15-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269521
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-([2H3]meth...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C25H29N7O6S/c1-15-13-26-23(27-14-15)22(38-6)16(2)39(33,34)31-25-30-29-24(17-9-7-12-20(28-17)37-5)32(25)21-18(35-3)10-8-11-19(21)36-4/h7-14,16,22H,1-6H3,(H,30,31)/t16-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269673
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(2,2,2-tri...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OCC(F)(F)F)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C26H28F3N7O6S/c1-15-12-30-23(31-13-15)22(41-5)16(2)43(37,38)35-25-34-33-24(17-8-6-11-20(32-17)42-14-26(27,28)29)36(25)21-18(39-3)9-7-10-19(21)40-4/h6-13,16,22H,14H2,1-5H3,(H,34,35)/t16-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269752
PNG
(Preparation of (R)—N-(4-(2,6-dimethoxyphenyl)...)
Show SMILES CO[C@H](CS(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ccc(F)cc1S(C)(=O)=O
Show InChI InChI=1S/C26H28FN5O8S2/c1-37-19-9-7-10-20(38-2)24(19)32-25(18-8-6-11-23(28-18)40-4)29-30-26(32)31-42(35,36)15-21(39-3)17-13-12-16(27)14-22(17)41(5,33)34/h6-14,21H,15H2,1-5H3,(H,30,31)/t21-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269747
PNG
(Preparation of (R)—N-(4-(2,6-dimethoxyphenyl)...)
Show SMILES COc1cccc(n1)-c1nnc(N(CC[Si](C)(C)C)S(=O)(=O)C[C@@H](O)c2ccc(F)cc2Br)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C29H35BrFN5O6SSi/c1-40-24-10-8-11-25(41-2)27(24)36-28(22-9-7-12-26(32-22)42-3)33-34-29(36)35(15-16-44(4,5)6)43(38,39)18-23(37)20-14-13-19(31)17-21(20)30/h7-14,17,23,37H,15-16,18H2,1-6H3/t23-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269662
PNG
((2S,3R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethyl-2-py...)
Show SMILES CCc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C26H31N7O4S/c1-7-19-10-8-11-20(29-19)25-30-31-26(33(25)23-21(36-5)12-9-13-22(23)37-6)32-38(34,35)18(4)17(3)24-27-14-16(2)15-28-24/h8-15,17-18H,7H2,1-6H3,(H,31,32)/t17-,18-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270257
PNG
((1S,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@@H](OC(C)C)c2cnc(C)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C27H33N7O6S/c1-16(2)40-25(20-15-28-17(3)14-29-20)18(4)41(35,36)33-27-32-31-26(19-10-8-13-23(30-19)39-7)34(27)24-21(37-5)11-9-12-22(24)38-6/h8-16,18,25H,1-7H3,(H,32,33)/t18-,25+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269841
PNG
((1R,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES CO[C@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(O)n2)n1-c1c(O)cccc1OC)c1ncc(F)cn1
Show InChI InChI=1S/C22H22FN7O6S/c1-12(19(36-3)20-24-10-13(23)11-25-20)37(33,34)29-22-28-27-21(14-6-4-9-17(32)26-14)30(22)18-15(31)7-5-8-16(18)35-2/h4-12,19,31H,1-3H3,(H,26,32)(H,28,29)/t12-,19+/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269925
PNG
((2R)-2-(4-chloro-2-(methylsulfonyl)phenyl)-N-(4-(2...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)C[C@@H](O)c2ccc(Cl)cc2S(C)(=O)=O)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C25H26ClN5O7S2/c1-15-10-16(13-27-12-15)24-28-29-25(31(24)23-20(37-2)6-5-7-21(23)38-3)30-40(35,36)14-19(32)18-9-8-17(26)11-22(18)39(4,33)34/h5-13,19,32H,14H2,1-4H3,(H,29,30)/t19-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270218
PNG
((2S,3R)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-diflu...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)n1-c1c(F)cccc1F
Show InChI InChI=1S/C22H20ClF2N7O3S/c1-12(20-26-10-14(23)11-27-20)13(2)36(33,34)31-22-30-29-21(17-8-5-9-18(28-17)35-3)32(22)19-15(24)6-4-7-16(19)25/h4-13H,1-3H3,(H,30,31)/t12-,13-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270193
PNG
((1R,2R)—N-(4-(2,6-dimethoxyphenyl)-5-(6-metho...)
Show SMILES COC1CN(C1)[C@@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(C)cn1
Show InChI InChI=1S/C28H34N8O6S/c1-17-13-29-26(30-14-17)24(35-15-19(16-35)39-3)18(2)43(37,38)34-28-33-32-27(20-9-7-12-23(31-20)42-6)36(28)25-21(40-4)10-8-11-22(25)41-5/h7-14,18-19,24H,15-16H2,1-6H3,(H,33,34)/t18-,24+/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269946
PNG
((1R,2S)-1-(2,4-dicyanophenyl)-N-(4-(2,6-dimethoxyp...)
Show SMILES CO[C@H]([C@@H](C)S(=O)(=O)Nc1nnc(-c2cncc(C)c2)n1-c1c(OC)cccc1OC)c1ccc(cc1C#N)C#N
Show InChI InChI=1S/C28H27N7O5S/c1-17-11-21(16-31-15-17)27-32-33-28(35(27)25-23(38-3)7-6-8-24(25)39-4)34-41(36,37)18(2)26(40-5)22-10-9-19(13-29)12-20(22)14-30/h6-12,15-16,18,26H,1-5H3,(H,33,34)/t18-,26-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269748
PNG
(Preparation of (R)—N-(4-(2,6-dimethoxyphenyl)...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)C[C@@H](O)c2ccc(F)cc2S(C)(=O)=O)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H26FN5O8S2/c1-37-19-8-6-9-20(38-2)23(19)31-24(17-7-5-10-22(27-17)39-3)28-29-25(31)30-41(35,36)14-18(32)16-12-11-15(26)13-21(16)40(4,33)34/h5-13,18,32H,14H2,1-4H3,(H,29,30)/t18-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270138
PNG
((2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](C)c2cnc(OC)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H29N7O6S/c1-15(18-13-27-22(38-6)14-26-18)16(2)39(33,34)31-25-30-29-24(17-9-7-12-21(28-17)37-5)32(25)23-19(35-3)10-8-11-20(23)36-4/h7-16H,1-6H3,(H,30,31)/t15-,16-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270114
PNG
((2R,3S)-3-(5-chloro-2-pyrimidinyl)-N-(4-(2,6-dimet...)
Show SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(Cl)cn2)nnc1-c1cncc(C)c1
Show InChI InChI=1S/C24H26ClN7O4S/c1-14-9-17(11-26-10-14)23-29-30-24(32(23)21-19(35-4)7-6-8-20(21)36-5)31-37(33,34)16(3)15(2)22-27-12-18(25)13-28-22/h6-13,15-16H,1-5H3,(H,30,31)/t15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM50077994
PNG
(CHEMBL3417378)
Show SMILES CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C71H112N22O16/c1-5-6-14-47(67(106)93-32-13-20-55(93)66(105)89-51(69(108)109)34-42-23-21-41(4)22-24-42)86-64(103)53-18-11-30-91(53)57(96)37-80-58(97)44(15-7-8-27-72)83-62(101)50(35-43-36-77-39-81-43)88-63(102)52(38-94)90-61(100)49(33-40(2)3)87-59(98)45(16-9-28-78-70(73)74)84-65(104)54-19-12-31-92(54)68(107)48(17-10-29-79-71(75)76)85-60(99)46-25-26-56(95)82-46/h21-24,36,39-40,44-55,94H,5-20,25-35,37-38,72H2,1-4H3,(H,77,81)(H,80,97)(H,82,95)(H,83,101)(H,84,104)(H,85,99)(H,86,103)(H,87,98)(H,88,102)(H,89,105)(H,90,100)(H,108,109)(H4,73,74,78)(H4,75,76,79)/t44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-/m0/s1
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Article
PubMed
n/an/an/an/a 0.170n/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Agonist activity at human APJ receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced intracellular cAMP production incubated ...


J Med Chem 58: 2431-40 (2015)


Article DOI: 10.1021/jm501916k
BindingDB Entry DOI: 10.7270/Q21V5GNR
More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269533
PNG
((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2cccc(OC)n2)n1-c1c(OC)cccc1OC)c1ncc(OC)cn1
Show InChI InChI=1S/C25H29N7O7S/c1-15(22(39-6)23-26-13-16(35-2)14-27-23)40(33,34)31-25-30-29-24(17-9-7-12-20(28-17)38-5)32(25)21-18(36-3)10-8-11-19(21)37-4/h7-15,22H,1-6H3,(H,30,31)/t15-,22-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM269648
PNG
((2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-ethyl-2-py...)
Show SMILES CCc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)[C@H](C)c2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H28FN7O4S/c1-6-18-9-7-10-19(29-18)24-30-31-25(33(24)22-20(36-4)11-8-12-21(22)37-5)32-38(34,35)16(3)15(2)23-27-13-17(26)14-28-23/h7-16H,6H2,1-5H3,(H,31,32)/t15-,16-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270096
PNG
((2R)-N-(4-(2,6-dimethoxyphenyl)-5-(6-(methylamino)...)
Show SMILES CNc1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C23H25FN8O4S/c1-14(11-20-26-12-15(24)13-27-20)37(33,34)31-23-30-29-22(16-7-5-10-19(25-2)28-16)32(23)21-17(35-3)8-6-9-18(21)36-4/h5-10,12-14H,11H2,1-4H3,(H,25,28)(H,30,31)/t14-/m0/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
Apelin receptor


(Homo sapiens)
BDBM270138
PNG
((2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methoxy-2-...)
Show SMILES COc1cccc(n1)-c1nnc(NS(=O)(=O)[C@H](C)[C@@H](C)c2cnc(OC)cn2)n1-c1c(OC)cccc1OC
Show InChI InChI=1S/C25H29N7O6S/c1-15(18-13-27-22(38-6)14-26-18)16(2)39(33,34)31-25-30-29-24(17-9-7-12-21(28-17)37-5)32(25)23-19(35-3)10-8-11-20(23)36-4/h7-16H,1-6H3,(H,30,31)/t15-,16-/m1/s1
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AMGEN INC.

US Patent


Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si...


US Patent US10058550 (2018)

More data for this
Ligand-Target Pair
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