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Compile Data Set for Download or QSAR

Found 29 hits of ec50 data for polymerid = 49000716,50003003,50004880,50006057,50007167   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GPR24


(RAT)
BDBM50193678
PNG
(1-(6-{13-[4-(trifluoromethyl)phenyl]tridecanamido}...)
Show SMILES FC(F)(F)c1ccc(CCCCCCCCCCCCC(=O)Nc2ccc3nc(ccc3c2)[N+]23CCC(CC2)CC3)cc1
Show InChI InChI=1S/C36H46F3N3O/c37-36(38,39)31-16-13-28(14-17-31)11-9-7-5-3-1-2-4-6-8-10-12-35(43)40-32-18-19-33-30(27-32)15-20-34(41-33)42-24-21-29(22-25-42)23-26-42/h13-20,27,29H,1-12,21-26H2/p+1
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n/an/an/an/a 25n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193675
PNG
(CHEMBL385661 | N-(2-(3-(3-methylureido)pyrrolidin-...)
Show SMILES CNC(=O)NC1CCN(C1)c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C25H26F3N5O2/c1-29-24(35)31-20-12-13-33(15-20)22-10-5-17-14-19(8-9-21(17)32-22)30-23(34)11-4-16-2-6-18(7-3-16)25(26,27)28/h2-3,5-10,14,20H,4,11-13,15H2,1H3,(H,30,34)(H2,29,31,35)
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n/an/an/an/a 30n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193692
PNG
(1-(6-(3-(4-(trifluoromethyl)phenyl)propanamido)qui...)
Show SMILES OS(=O)(=O)NC1CCN(C1)c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H23F3N4O4S/c24-23(25,26)17-5-1-15(2-6-17)3-10-22(31)27-18-7-8-20-16(13-18)4-9-21(28-20)30-12-11-19(14-30)29-35(32,33)34/h1-2,4-9,13,19,29H,3,10-12,14H2,(H,27,31)(H,32,33,34)
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n/an/an/an/a 50n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193688
PNG
(CHEMBL217487 | N-(2-(azetidin-1-yl)quinolin-6-yl)-...)
Show SMILES FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CCC2)cc1
Show InChI InChI=1S/C22H20F3N3O/c23-22(24,25)17-6-2-15(3-7-17)4-11-21(29)26-18-8-9-19-16(14-18)5-10-20(27-19)28-12-1-13-28/h2-3,5-10,14H,1,4,11-13H2,(H,26,29)
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n/an/an/an/a 56n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193684
PNG
(CHEMBL384362 | N-(2-(2-oxa-5-azabicyclo[2.2.1]hept...)
Show SMILES FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CC3CC2CO3)cc1
Show InChI InChI=1S/C24H22F3N3O2/c25-24(26,27)17-5-1-15(2-6-17)3-10-23(31)28-18-7-8-21-16(11-18)4-9-22(29-21)30-13-20-12-19(30)14-32-20/h1-2,4-9,11,19-20H,3,10,12-14H2,(H,28,31)
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n/an/an/an/a 70n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193696
PNG
(CHEMBL385452 | N-(2-(3-isobutyramidopyrrolidin-1-y...)
Show SMILES CC(C)C(=O)NC1CCN(C1)c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C27H29F3N4O2/c1-17(2)26(36)32-22-13-14-34(16-22)24-11-6-19-15-21(9-10-23(19)33-24)31-25(35)12-5-18-3-7-20(8-4-18)27(28,29)30/h3-4,6-11,15,17,22H,5,12-14,16H2,1-2H3,(H,31,35)(H,32,36)
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n/an/an/an/a 90n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193689
PNG
(CHEMBL214984 | N-(2-(dimethylamino)quinolin-6-yl)-...)
Show SMILES CN(C)c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C21H20F3N3O/c1-27(2)19-11-6-15-13-17(9-10-18(15)26-19)25-20(28)12-5-14-3-7-16(8-4-14)21(22,23)24/h3-4,6-11,13H,5,12H2,1-2H3,(H,25,28)
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n/an/an/an/a 110n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193685
PNG
(CHEMBL215981 | N-(1-(6-(3-(4-(trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CCC(C2)NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C30H27F3N4O2/c31-30(32,33)23-10-6-20(7-11-23)8-15-28(38)34-24-12-13-26-22(18-24)9-14-27(36-26)37-17-16-25(19-37)35-29(39)21-4-2-1-3-5-21/h1-7,9-14,18,25H,8,15-17,19H2,(H,34,38)(H,35,39)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193699
PNG
(CHEMBL215662 | N-(2-(piperidin-1-yl)quinolin-6-yl)...)
Show SMILES FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CCCCC2)cc1
Show InChI InChI=1S/C24H24F3N3O/c25-24(26,27)19-8-4-17(5-9-19)6-13-23(31)28-20-10-11-21-18(16-20)7-12-22(29-21)30-14-2-1-3-15-30/h4-5,7-12,16H,1-3,6,13-15H2,(H,28,31)
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n/an/an/an/a 110n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193700
PNG
(CHEMBL217502 | N-(2-(2,7-diazaspiro[4.4]nonan-2-yl...)
Show SMILES FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CCC3(CCNC3)C2)cc1
Show InChI InChI=1S/C26H27F3N4O/c27-26(28,29)20-5-1-18(2-6-20)3-10-24(34)31-21-7-8-22-19(15-21)4-9-23(32-22)33-14-12-25(17-33)11-13-30-16-25/h1-2,4-9,15,30H,3,10-14,16-17H2,(H,31,34)
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n/an/an/an/a 140n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193677
PNG
(CHEMBL384848 | N-(2-(methyl(propyl)amino)quinolin-...)
Show SMILES CCCN(C)c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H24F3N3O/c1-3-14-29(2)21-12-7-17-15-19(10-11-20(17)28-21)27-22(30)13-6-16-4-8-18(9-5-16)23(24,25)26/h4-5,7-12,15H,3,6,13-14H2,1-2H3,(H,27,30)
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n/an/an/an/a 140n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193681
PNG
(CHEMBL215648 | N-(2-(isopropyl(methyl)amino)quinol...)
Show SMILES CC(C)N(C)c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H24F3N3O/c1-15(2)29(3)21-12-7-17-14-19(10-11-20(17)28-21)27-22(30)13-6-16-4-8-18(9-5-16)23(24,25)26/h4-5,7-12,14-15H,6,13H2,1-3H3,(H,27,30)
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n/an/an/an/a 140n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193702
PNG
(CHEMBL217078 | N-(2-(2-azabicyclo[2.2.1]heptan-2-y...)
Show SMILES FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CC3CCC2C3)cc1
Show InChI InChI=1S/C25H24F3N3O/c26-25(27,28)19-6-1-16(2-7-19)4-12-24(32)29-20-8-10-22-18(14-20)5-11-23(30-22)31-15-17-3-9-21(31)13-17/h1-2,5-8,10-11,14,17,21H,3-4,9,12-13,15H2,(H,29,32)
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n/an/an/an/a 150n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193680
PNG
(CHEMBL217207 | N-(2-(2-azabicyclo[2.2.2]octan-2-yl...)
Show SMILES FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CC3CCC2CC3)cc1
Show InChI InChI=1S/C26H26F3N3O/c27-26(28,29)20-7-1-17(2-8-20)5-14-25(33)30-21-9-12-23-19(15-21)6-13-24(31-23)32-16-18-3-10-22(32)11-4-18/h1-2,6-9,12-13,15,18,22H,3-5,10-11,14,16H2,(H,30,33)
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n/an/an/an/a 190n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193703
PNG
(CHEMBL385612 | N-(2-(3-aminopyrrolidin-1-yl)quinol...)
Show SMILES NC1CCN(C1)c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H23F3N4O/c24-23(25,26)17-5-1-15(2-6-17)3-10-22(31)28-19-7-8-20-16(13-19)4-9-21(29-20)30-12-11-18(27)14-30/h1-2,4-9,13,18H,3,10-12,14,27H2,(H,28,31)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193674
PNG
(CHEMBL214125 | N-(2-(2-methylpyrrolidin-1-yl)quino...)
Show SMILES CC1CCCN1c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C24H24F3N3O/c1-16-3-2-14-30(16)22-12-7-18-15-20(10-11-21(18)29-22)28-23(31)13-6-17-4-8-19(9-5-17)24(25,26)27/h4-5,7-12,15-16H,2-3,6,13-14H2,1H3,(H,28,31)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193676
PNG
(CHEMBL215331 | N-(2-(dimethylamino)quinolin-6-yl)-...)
Show SMILES FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CCCC2)cc1
Show InChI InChI=1S/C23H22F3N3O/c24-23(25,26)18-7-3-16(4-8-18)5-12-22(30)27-19-9-10-20-17(15-19)6-11-21(28-20)29-13-1-2-14-29/h3-4,6-11,15H,1-2,5,12-14H2,(H,27,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193695
PNG
(CHEMBL214541 | N-(2-(methylamino)quinolin-6-yl)-3-...)
Show SMILES CNc1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C20H18F3N3O/c1-24-18-10-5-14-12-16(8-9-17(14)26-18)25-19(27)11-4-13-2-6-15(7-3-13)20(21,22)23/h2-3,5-10,12H,4,11H2,1H3,(H,24,26)(H,25,27)
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n/an/an/an/a 330n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193701
PNG
(CHEMBL215082 | N-(2-(cyclopentyl(methyl)amino)quin...)
Show SMILES CN(C1CCCC1)c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C25H26F3N3O/c1-31(21-4-2-3-5-21)23-14-9-18-16-20(12-13-22(18)30-23)29-24(32)15-8-17-6-10-19(11-7-17)25(26,27)28/h6-7,9-14,16,21H,2-5,8,15H2,1H3,(H,29,32)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193679
PNG
(CHEMBL385748 | N-(2-(3-methylpyrrolidin-1-yl)quino...)
Show SMILES CC1CCN(C1)c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C24H24F3N3O/c1-16-12-13-30(15-16)22-10-5-18-14-20(8-9-21(18)29-22)28-23(31)11-4-17-2-6-19(7-3-17)24(25,26)27/h2-3,5-10,14,16H,4,11-13,15H2,1H3,(H,28,31)
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n/an/an/an/a 400n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193687
PNG
(CHEMBL215316 | N-(2-(3-acetamidopyrrolidin-1-yl)qu...)
Show SMILES CC(=O)NC1CCN(C1)c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C25H25F3N4O2/c1-16(33)29-21-12-13-32(15-21)23-10-5-18-14-20(8-9-22(18)31-23)30-24(34)11-4-17-2-6-19(7-3-17)25(26,27)28/h2-3,5-10,14,21H,4,11-13,15H2,1H3,(H,29,33)(H,30,34)
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n/an/an/an/a 440n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193690
PNG
(CHEMBL386548 | N-(2-(2,5-diazabicyclo[2.2.1]heptan...)
Show SMILES FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CC3CC2CN3)cc1
Show InChI InChI=1S/C24H23F3N4O/c25-24(26,27)17-5-1-15(2-6-17)3-10-23(32)29-18-7-8-21-16(11-18)4-9-22(30-21)31-14-19-12-20(31)13-28-19/h1-2,4-9,11,19-20,28H,3,10,12-14H2,(H,29,32)
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n/an/an/an/a 490n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193683
PNG
(CHEMBL383884 | methyl 1-(6-(3-(4-(trifluoromethyl)...)
Show SMILES COC(=O)C1CCCN1c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C25H24F3N3O3/c1-34-24(33)21-3-2-14-31(21)22-12-7-17-15-19(10-11-20(17)30-22)29-23(32)13-6-16-4-8-18(9-5-16)25(26,27)28/h4-5,7-12,15,21H,2-3,6,13-14H2,1H3,(H,29,32)
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n/an/an/an/a 580n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193697
PNG
(CHEMBL217751 | N-(2-aminoquinolin-6-yl)-3-(4-(trif...)
Show SMILES Nc1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C19H16F3N3O/c20-19(21,22)14-5-1-12(2-6-14)3-10-18(26)24-15-7-8-16-13(11-15)4-9-17(23)25-16/h1-2,4-9,11H,3,10H2,(H2,23,25)(H,24,26)
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n/an/an/an/a 720n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193694
PNG
(CHEMBL425098 | N-(2-(diethylamino)quinolin-6-yl)-3...)
Show SMILES CCN(CC)c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C23H24F3N3O/c1-3-29(4-2)21-13-8-17-15-19(11-12-20(17)28-21)27-22(30)14-7-16-5-9-18(10-6-16)23(24,25)26/h5-6,8-13,15H,3-4,7,14H2,1-2H3,(H,27,30)
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n/an/an/an/a 830n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193682
PNG
(CHEMBL386046 | N-(2-(cyclohexyl(methyl)amino)quino...)
Show SMILES CN(C1CCCCC1)c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C26H28F3N3O/c1-32(22-5-3-2-4-6-22)24-15-10-19-17-21(13-14-23(19)31-24)30-25(33)16-9-18-7-11-20(12-8-18)26(27,28)29/h7-8,10-15,17,22H,2-6,9,16H2,1H3,(H,30,33)
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n/an/an/an/a 1.20E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193691
PNG
(CHEMBL216576 | N-(2-(3-phenylpyrrolidin-1-yl)quino...)
Show SMILES FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CCC(C2)c2ccccc2)cc1
Show InChI InChI=1S/C29H26F3N3O/c30-29(31,32)24-10-6-20(7-11-24)8-15-28(36)33-25-12-13-26-22(18-25)9-14-27(34-26)35-17-16-23(19-35)21-4-2-1-3-5-21/h1-7,9-14,18,23H,8,15-17,19H2,(H,33,36)
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n/an/an/an/a 1.77E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50241102
PNG
(CHEMBL216455 | N-(2-(azepan-1-yl)quinolin-6-yl)-3-...)
Show SMILES FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CCCCCC2)cc1
Show InChI InChI=1S/C25H26F3N3O/c26-25(27,28)20-9-5-18(6-10-20)7-14-24(32)29-21-11-12-22-19(17-21)8-13-23(30-22)31-15-3-1-2-4-16-31/h5-6,8-13,17H,1-4,7,14-16H2,(H,29,32)
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n/an/an/an/a 1.80E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair
GPR24


(RAT)
BDBM50193686
PNG
(1-{6-[6-(trifluoromethyl)pyridine-3-amido]quinolin...)
Show SMILES FC(F)(F)c1ccc(cn1)C(=O)Nc1ccc2nc(ccc2c1)[N+]12CCC(CC1)CC2
Show InChI InChI=1S/C23H21F3N4O/c24-23(25,26)20-5-1-17(14-27-20)22(31)28-18-3-4-19-16(13-18)2-6-21(29-19)30-10-7-15(8-11-30)9-12-30/h1-6,13-15H,7-12H2/p+1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Stimulation of IP3-coupled mobilization of calcium in HEK293 cells expressing rat MCH-R1


Bioorg Med Chem Lett 16: 5270-4 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP
More data for this
Ligand-Target Pair