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Compile Data Set for Download or QSAR

Found 554 hits of ec50 data for polymerid = 49000732,50002822,8650   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143061
PNG
(CHEMBL3759901)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2ccc(Cl)cc2C1=O
Show InChI InChI=1S/C11H8N6O3/c12-11-13-8-7(9(18)14-11)15-17(16-8)6-3-1-2-5(4-6)10(19)20/h1-4H,(H,19,20)(H3,12,13,14,16,18)
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n/an/an/an/a 5.40n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Bioorg Med Chem Lett 26: 751-6 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.104
BindingDB Entry DOI: 10.7270/Q261124T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143059
PNG
(CHEMBL3758746)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2ccc(C)cc2C1=O
Show InChI InChI=1S/C12H11Cl2N5O2/c1-6-10(11(20)17-12(15)16-6)19(18-21)5-7-2-3-8(13)9(14)4-7/h2-4H,5H2,1H3,(H3,15,16,17,20)
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n/an/an/an/a 11n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Bioorg Med Chem Lett 26: 751-6 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.104
BindingDB Entry DOI: 10.7270/Q261124T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132797
PNG
(CHEMBL3634445)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H13FN2O4/c1-11-8-9-27-17(11)18(24)22-16-7-6-12(10-15(16)21)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 13n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132797
PNG
(CHEMBL3634445)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H13FN2O4/c1-11-8-9-27-17(11)18(24)22-16-7-6-12(10-15(16)21)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 13n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132795
PNG
(CHEMBL3634447)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1C)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C21H16N2O4/c1-12-9-10-27-18(12)19(24)22-17-8-7-14(11-13(17)2)23-20(25)15-5-3-4-6-16(15)21(23)26/h3-11H,1-2H3,(H,22,24)
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n/an/an/an/a 15n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132789
PNG
(CHEMBL3634415)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1C(=O)c2cccc(C)c2C1=O
Show InChI InChI=1S/C21H16N2O4/c1-12-4-3-5-16-17(12)21(26)23(20(16)25)15-8-6-14(7-9-15)22-19(24)18-13(2)10-11-27-18/h3-11H,1-2H3,(H,22,24)
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n/an/an/an/a 16n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from rat-human hybrid NPY5 receptor expressed in CHO cells


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132800
PNG
(CHEMBL3634442)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c2ccccc12
Show InChI InChI=1S/C25H18N2O4/c1-14-6-5-9-18-21(14)25(30)27(24(18)29)20-11-10-19(16-7-3-4-8-17(16)20)26-23(28)22-15(2)12-13-31-22/h3-13H,1-2H3,(H,26,28)
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n/an/an/an/a 16n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]batrachotoxin from sodium channel in rat brain


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132712
PNG
(CHEMBL3632642)
Show SMILES COc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2cccc(Cl)c2C1=O
Show InChI InChI=1S/C21H15ClN2O5/c1-11-8-9-29-18(11)19(25)23-12-6-7-15(16(10-12)28-2)24-20(26)13-4-3-5-14(22)17(13)21(24)27/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 18n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]hPP from human NPY4 receptor expressed in CHO cells


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50258185
PNG
(CHEMBL522161 | rac-4-fluoro-N-(4-(trifluoromethyl)...)
Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc12
Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)27-15(10)11)16(25)24-17-23-13(8-26-17)18(20,21)22/h1-8,14H,(H,23,24,25)
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n/an/an/an/a 19n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Bioorg Med Chem Lett 19: 1666-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.108
BindingDB Entry DOI: 10.7270/Q20G3K12
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143062
PNG
(CHEMBL3758435)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2ccc(F)cc2C1=O
Show InChI InChI=1S/C11H10BrN3O/c1-15-10(16)8(12)9(14-11(15)13)7-5-3-2-4-6-7/h2-6H,1H3,(H2,13,14)
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n/an/an/an/a 19n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Bioorg Med Chem Lett 26: 751-6 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.104
BindingDB Entry DOI: 10.7270/Q261124T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132801
PNG
(CHEMBL3634441)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c2ccccc12
Show InChI InChI=1S/C24H16N2O4/c1-14-12-13-30-21(14)22(27)25-19-10-11-20(16-7-3-2-6-15(16)19)26-23(28)17-8-4-5-9-18(17)24(26)29/h2-13H,1H3,(H,25,27)
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n/an/an/an/a 20n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR1 by calcium mobilization assay


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50258224
PNG
(CHEMBL522875 | rac-2-fluoro-N-(5-(trifluoromethyl)...)
Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3ncc(o3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)26-13)16(25)24-17-23-8-14(27-17)18(20,21)22/h1-8,15H,(H,23,24,25)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Bioorg Med Chem Lett 19: 1666-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.108
BindingDB Entry DOI: 10.7270/Q20G3K12
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132798
PNG
(CHEMBL3634444)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c2ccccc12
Show InChI InChI=1S/C24H15FN2O4/c1-13-11-12-31-21(13)22(28)26-18-9-10-19(15-6-3-2-5-14(15)18)27-23(29)16-7-4-8-17(25)20(16)24(27)30/h2-12H,1H3,(H,26,28)
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n/an/an/an/a 20n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50258223
PNG
(CHEMBL494960 | rac-4-fluoro-N-(5-(trifluoromethyl)...)
Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3ccccc3Oc12
Show InChI InChI=1S/C18H10F4N2O3/c19-11-6-3-5-10-14(9-4-1-2-7-12(9)26-15(10)11)16(25)24-17-23-8-13(27-17)18(20,21)22/h1-8,14H,(H,23,24,25)
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n/an/an/an/a 21n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Bioorg Med Chem Lett 19: 1666-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.108
BindingDB Entry DOI: 10.7270/Q20G3K12
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132781
PNG
(CHEMBL3634423)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(C)c1
Show InChI InChI=1S/C22H18N2O4/c1-12-5-4-6-16-18(12)22(27)24(21(16)26)17-8-7-15(11-14(17)3)23-20(25)19-13(2)9-10-28-19/h4-11H,1-3H3,(H,23,25)
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n/an/an/an/a 21n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from human NPY1 receptor expressed in CHO cells


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143063
PNG
(CHEMBL3758465)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2cccc(F)c2C1=O
Show InChI InChI=1S/C20H13F6N7O2/c21-19(22,23)11-4-9(5-12(7-11)20(24,25)26)8-28-16(34)10-2-1-3-13(6-10)33-31-14-15(32-33)29-18(27)30-17(14)35/h1-7H,8H2,(H,28,34)(H3,27,29,30,32,35)
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n/an/an/an/a 22n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Bioorg Med Chem Lett 26: 751-6 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.104
BindingDB Entry DOI: 10.7270/Q261124T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143081
PNG
(CHEMBL3759028)
Show SMILES Cc1cn[nH]c1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C19H12ClFN4O3/c1-9-8-22-24-16(9)17(26)23-10-5-6-14(12(20)7-10)25-18(27)11-3-2-4-13(21)15(11)19(25)28/h2-8H,1H3,(H,22,24)(H,23,26)
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n/an/an/an/a 22n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Bioorg Med Chem Lett 26: 751-6 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.104
BindingDB Entry DOI: 10.7270/Q261124T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143166
PNG
(CHEMBL3759038)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14ClN3O3S/c1-10-3-5-13-14(7-10)20(27)24(19(13)26)16-6-4-12(8-15(16)21)23-18(25)17-11(2)28-9-22-17/h3-9H,1-2H3,(H,23,25)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Bioorg Med Chem Lett 26: 751-6 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.104
BindingDB Entry DOI: 10.7270/Q261124T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143166
PNG
(CHEMBL3759038)
Show SMILES Cc1scnc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14ClN3O3S/c1-10-3-5-13-14(7-10)20(27)24(19(13)26)16-6-4-12(8-15(16)21)23-18(25)17-11(2)28-9-22-17/h3-9H,1-2H3,(H,23,25)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Bioorg Med Chem Lett 26: 751-6 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.104
BindingDB Entry DOI: 10.7270/Q261124T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132786
PNG
(CHEMBL3634418)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccccc3C2=O)c(F)c1
Show InChI InChI=1S/C20H13FN2O4/c1-11-8-9-27-17(11)18(24)22-12-6-7-16(15(21)10-12)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 22n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY2 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesis


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132799
PNG
(CHEMBL3634443)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c2ccccc12
Show InChI InChI=1S/C24H15ClN2O4/c1-13-11-12-31-21(13)22(28)26-18-9-10-19(15-6-3-2-5-14(15)18)27-23(29)16-7-4-8-17(25)20(16)24(27)30/h2-12H,1H3,(H,26,28)
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n/an/an/an/a 23n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50128117
PNG
(CHEMBL3628114)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(21)9-12)24-19(26)13-4-2-11(22)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 24n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


J Med Chem 58: 7959-71 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00727
BindingDB Entry DOI: 10.7270/Q2MK6FQ4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50128120
PNG
(CHEMBL3628109)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15ClN2O4/c1-11-4-3-5-14-17(11)21(27)24(20(14)26)16-7-6-13(10-15(16)22)23-19(25)18-12(2)8-9-28-18/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 24n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


J Med Chem 58: 7959-71 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00727
BindingDB Entry DOI: 10.7270/Q2MK6FQ4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50128117
PNG
(CHEMBL3628114)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3ccc(F)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-6-7-28-17(10)18(25)23-12-3-5-16(15(21)9-12)24-19(26)13-4-2-11(22)8-14(13)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 24n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


J Med Chem 58: 7959-71 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00727
BindingDB Entry DOI: 10.7270/Q2MK6FQ4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50258186
PNG
(4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H...)
Show SMILES Fc1cccc2C(C(=O)Nc3ncc(o3)C(F)(F)F)c3cccc(F)c3Oc12
Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-7-12(27-17)18(21,22)23/h1-7,13H,(H,24,25,26)
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n/an/an/an/a 25n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Bioorg Med Chem Lett 19: 1666-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.108
BindingDB Entry DOI: 10.7270/Q20G3K12
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50128120
PNG
(CHEMBL3628109)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C21H15ClN2O4/c1-11-4-3-5-14-17(11)21(27)24(20(14)26)16-7-6-13(10-15(16)22)23-19(25)18-12(2)8-9-28-18/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 25n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


J Med Chem 58: 7959-71 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00727
BindingDB Entry DOI: 10.7270/Q2MK6FQ4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132785
PNG
(CHEMBL3634419)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(C)c3C2=O)c(F)c1
Show InChI InChI=1S/C21H15FN2O4/c1-11-4-3-5-14-17(11)21(27)24(20(14)26)16-7-6-13(10-15(16)22)23-19(25)18-12(2)8-9-28-18/h3-10H,1-2H3,(H,23,25)
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n/an/an/an/a 26n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY4 receptor in HEK293 cells by inhibition of forskolin-stimulated cAMP synthesis


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143060
PNG
(CHEMBL3758305)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2cccc(C)c2C1=O
Show InChI InChI=1S/C7H9N3O3/c1-2-13-6(12)4-3-9-7(8)10-5(4)11/h3H,2H2,1H3,(H3,8,9,10,11)
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n/an/an/an/a 26n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Bioorg Med Chem Lett 26: 751-6 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.104
BindingDB Entry DOI: 10.7270/Q261124T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143059
PNG
(CHEMBL3758746)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1F)N1C(=O)c2ccc(C)cc2C1=O
Show InChI InChI=1S/C12H11Cl2N5O2/c1-6-10(11(20)17-12(15)16-6)19(18-21)5-7-2-3-8(13)9(14)4-7/h2-4H,5H2,1H3,(H3,15,16,17,20)
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n/an/an/an/a 26n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132784
PNG
(CHEMBL3634420)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(F)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(14(22)9-11)24-19(26)12-3-2-4-13(21)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 28n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesis


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132796
PNG
(CHEMBL3634446)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1Cl)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H13ClN2O4/c1-11-8-9-27-17(11)18(24)22-16-7-6-12(10-15(16)21)23-19(25)13-4-2-3-5-14(13)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 29n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of bovine trypsin


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132788
PNG
(CHEMBL3634416)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1C(=O)c2cccc(Cl)c2C1=O
Show InChI InChI=1S/C20H13ClN2O4/c1-11-9-10-27-17(11)18(24)22-12-5-7-13(8-6-12)23-19(25)14-3-2-4-15(21)16(14)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 29n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from rat-human hybrid NPY5 receptor expressed in CHO cells


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 32n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulatory activity at human mGlu1 receptor expressed in wild type T-Rex293 cells assessed as increase in glutamate-induced calci...


Bioorg Med Chem Lett 26: 1869-72 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.031
BindingDB Entry DOI: 10.7270/Q2Z03B11
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 32n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


J Med Chem 58: 7959-71 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00727
BindingDB Entry DOI: 10.7270/Q2MK6FQ4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 32n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


J Med Chem 58: 7959-71 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00727
BindingDB Entry DOI: 10.7270/Q2MK6FQ4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50128118
PNG
(CHEMBL3628111)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(14(22)9-11)24-19(26)12-3-2-4-13(21)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 33n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


J Med Chem 58: 7959-71 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00727
BindingDB Entry DOI: 10.7270/Q2MK6FQ4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50128118
PNG
(CHEMBL3628111)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(Cl)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12Cl2N2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(14(22)9-11)24-19(26)12-3-2-4-13(21)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 33n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliztion by Fluo-4AM ...


J Med Chem 58: 7959-71 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00727
BindingDB Entry DOI: 10.7270/Q2MK6FQ4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132807
PNG
(CHEMBL3634435)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(nc1)N1C(=O)c2cccc(Cl)c2C1=O
Show InChI InChI=1S/C19H12ClN3O4/c1-10-7-8-27-16(10)17(24)22-11-5-6-14(21-9-11)23-18(25)12-3-2-4-13(20)15(12)19(23)26/h2-9H,1H3,(H,22,24)
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n/an/an/an/a 35n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR1 by calcium mobilization assay


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132783
PNG
(CHEMBL3634421)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(F)c1
Show InChI InChI=1S/C20H12F2N2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(14(22)9-11)24-19(26)12-3-2-4-13(21)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 35n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY4 receptor in HEK293 cells by inhibition of forskolin-stimulated cAMP synthesis


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50258226
PNG
(CHEMBL494966 | N-(5-(trifluoromethyl)oxazol-2-yl)-...)
Show SMILES FC(F)(F)c1cnc(NC(=O)C2c3ccccc3Oc3ccccc23)o1
Show InChI InChI=1S/C18H11F3N2O3/c19-18(20,21)14-9-22-17(26-14)23-16(24)15-10-5-1-3-7-12(10)25-13-8-4-2-6-11(13)15/h1-9,15H,(H,22,23,24)
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n/an/an/an/a 38n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Bioorg Med Chem Lett 19: 1666-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.108
BindingDB Entry DOI: 10.7270/Q20G3K12
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50258141
PNG
(CHEMBL492570 | rac-2-fluoro-N-(4-(trifluoromethyl)...)
Show SMILES Fc1ccc2Oc3ccccc3C(C(=O)Nc3nc(co3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-13-11(7-9)15(10-3-1-2-4-12(10)27-13)16(25)24-17-23-14(8-26-17)18(20,21)22/h1-8,15H,(H,23,24,25)
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n/an/an/an/a 40n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Bioorg Med Chem Lett 19: 1666-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.108
BindingDB Entry DOI: 10.7270/Q20G3K12
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50258184
PNG
(CHEMBL492979 | rac-3-fluoro-N-(4-(trifluoromethyl)...)
Show SMILES Fc1ccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3ccccc3Oc2c1
Show InChI InChI=1S/C18H10F4N2O3/c19-9-5-6-11-13(7-9)27-12-4-2-1-3-10(12)15(11)16(25)24-17-23-14(8-26-17)18(20,21)22/h1-8,15H,(H,23,24,25)
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n/an/an/an/a 40n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Bioorg Med Chem Lett 19: 1666-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.108
BindingDB Entry DOI: 10.7270/Q20G3K12
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 41n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay


J Med Chem 58: 7959-71 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00727
BindingDB Entry DOI: 10.7270/Q2MK6FQ4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50127985
PNG
(CHEMBL3628113)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(N2C(=O)c3cccc(F)c3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)
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n/an/an/an/a 41n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assay


J Med Chem 58: 7959-71 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00727
BindingDB Entry DOI: 10.7270/Q2MK6FQ4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143076
PNG
(CHEMBL3758587)
Show SMILES Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14ClN3O4/c1-10-3-5-13-14(7-10)20(27)24(19(13)26)16-6-4-12(8-15(16)21)23-18(25)17-11(2)28-9-22-17/h3-9H,1-2H3,(H,23,25)
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n/an/an/an/a 41n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Bioorg Med Chem Lett 26: 751-6 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.104
BindingDB Entry DOI: 10.7270/Q261124T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50143076
PNG
(CHEMBL3758587)
Show SMILES Cc1ocnc1C(=O)Nc1ccc(N2C(=O)c3ccc(C)cc3C2=O)c(Cl)c1
Show InChI InChI=1S/C20H14ClN3O4/c1-10-3-5-13-14(7-10)20(27)24(19(13)26)16-6-4-12(8-15(16)21)23-18(25)17-11(2)28-9-22-17/h3-9H,1-2H3,(H,23,25)
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n/an/an/an/a 42n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor by cell based calcium mobilization


Bioorg Med Chem Lett 26: 751-6 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.104
BindingDB Entry DOI: 10.7270/Q261124T
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132787
PNG
(CHEMBL3634417)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)N1C(=O)c2cccc(F)c2C1=O
Show InChI InChI=1S/C20H13FN2O4/c1-11-9-10-27-17(11)18(24)22-12-5-7-13(8-6-12)23-19(25)14-3-2-4-15(21)16(14)20(23)26/h2-10H,1H3,(H,22,24)
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n/an/an/an/a 44n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at human NPY4 receptor in HEK293 cells by inhibition of forskolin-stimulated cAMP synthesis


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50258142
PNG
(2,7-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Show SMILES Fc1ccc2Oc3ccc(F)cc3C(C(=O)Nc3nc(co3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H9F5N2O3/c19-8-1-3-12-10(5-8)15(11-6-9(20)2-4-13(11)28-12)16(26)25-17-24-14(7-27-17)18(21,22)23/h1-7,15H,(H,24,25,26)
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n/an/an/an/a 44n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Bioorg Med Chem Lett 19: 1666-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.108
BindingDB Entry DOI: 10.7270/Q20G3K12
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50132774
PNG
(CHEMBL3634430)
Show SMILES COc1cc(NC(=O)c2occc2C)ccc1N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C21H16N2O5/c1-12-9-10-28-18(12)19(24)22-13-7-8-16(17(11-13)27-2)23-20(25)14-5-3-4-6-15(14)21(23)26/h3-11H,1-2H3,(H,22,24)
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n/an/an/an/a 46n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [125I]NPY from rat-human hybrid NPY5 receptor expressed in CHO cells


Bioorg Med Chem Lett 25: 5107-10 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.013
BindingDB Entry DOI: 10.7270/Q20C4XKQ
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(RAT)
BDBM50258227
PNG
(4,5-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H...)
Show SMILES Fc1cccc2C(C(=O)Nc3nc(co3)C(F)(F)F)c3cccc(F)c3Oc12
Show InChI InChI=1S/C18H9F5N2O3/c19-10-5-1-3-8-13(9-4-2-6-11(20)15(9)28-14(8)10)16(26)25-17-24-12(7-27-17)18(21,22)23/h1-7,13H,(H,24,25,26)
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n/an/an/an/a 47n/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay


Bioorg Med Chem Lett 19: 1666-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.108
BindingDB Entry DOI: 10.7270/Q20G3K12
More data for this
Ligand-Target Pair
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