Compile Data Set for Download or QSAR
maximum 50k data
Found 121 of ec50 data for polymerid = 49000798,5102
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50187445(1-(6-bromopyridin-3-yl)-1,5-diazocane | 1-(6-bromo...)
Affinity DataEC50:  1.29nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50264920(3-(2-chloro-6-fluorophenyl)-5-(1-ethyl-2-(4-fluoro...)
Affinity DataEC50:  3nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50264800(3-(2-chloro-6-fluorophenyl)-5-(1-ethyl-2-(piperidi...)
Affinity DataEC50:  3nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50264917(3-(2-chloro-6-fluorophenyl)-5-(5-methyl-1-(piperid...)
Affinity DataEC50:  6nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201064((1R,6S)-2-bromo-5-(3,8-diaza-bicyclo[4.2.0]oct-3-y...)
Affinity DataEC50:  6.17nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201055((1R,6S)-3-(6-chloro-5-methyl-pyridin-3-yl)-3,8-dia...)
Affinity DataEC50:  7.24nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201048((1R,6S)-3-(5,6-dibromo-pyridin-3-yl)-3,8-diaza-bic...)
Affinity DataEC50:  7.76nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50264799(3-(2-chloro-6-fluorophenyl)-5-(1-methyl-2-(piperid...)
Affinity DataEC50:  12nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201061((1R,6S)-3-(5,6-dichloro-pyridin-3-yl)-3,8-diaza-bi...)
Affinity DataEC50:  12.0nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201062((1R,6S)-3-(6-chloro-pyridin-3-yl)-3,8-diaza-bicycl...)
Affinity DataEC50:  12.9nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50187453(1-(6-bromo-5-chloropyridin-3-yl)-1,4-diazepane | 1...)
Affinity DataEC50:  15.1nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50264884(3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-...)
Affinity DataEC50:  18nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50062641(5-((R)-1-Azetidin-2-ylmethoxy)-2-chloro-pyridine |...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201072((1R,6S)-3-(6-bromo-5-methoxy-pyridin-3-yl)-3,8-dia...)
Affinity DataEC50:  20.9nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50411219(CHEMBL479614)
Affinity DataEC50:  24.0nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50264798(3-(2-chlorophenyl)-5-(2-(piperidin-4-yl)thiazol-5-...)
Affinity DataEC50:  33nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50264801(3-(2-chloro-6-fluorophenyl)-5-(2-(4-fluoropiperidi...)
Affinity DataEC50:  34nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50187447(1-(pyridin-3-yl)-1,5-diazocane | 1-pyridin-3-yl-[1...)
Affinity DataEC50:  36.3nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201060((1R,6S)-8-(6-chloro-pyridin-3-yl)-3,8-diaza-bicycl...)
Affinity DataEC50:  37.1nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50279369(CHEMBL460562 | cis-2-(3-Pyridinyl)octahydropyrrolo...)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human recombinant alpha4beta2 nicotinic acetylcholine receptor expressed in HEK293 cells assessed as changes in intracellular cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50411210(CHEMBL481977)
Affinity DataEC50:  46.8nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50264916(3-(2-chloro-6-fluorophenyl)-5-(1-(piperidin-4-yl)-...)
Affinity DataEC50:  48nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50187441(1-(5-bromo-6-chloropyridin-3-yl)-1,4-diazepane | 4...)
Affinity DataEC50:  57.5nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50088454(1-(6-Bromo-pyridin-3-yl)-[1,4]diazepane | 1-(6-bro...)
Affinity DataEC50:  64.6nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201069((1R,6S)-3-(pyridin-3-yl)-3,8-diaza-bicyclo[4.2.0]o...)
Affinity DataEC50:  70.8nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50411228(CHEMBL448457)
Affinity DataEC50:  75.9nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201054((1R,6S)-8-(6-chloro-5-methyl-pyridin-3-yl)-3,8-dia...)
Affinity DataEC50:  75.9nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50411226(CHEMBL506353)
Affinity DataEC50:  81.3nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50088456(1-(6-Chloro-5-methoxy-pyridin-3-yl)-[1,4]diazepane...)
Affinity DataEC50:  91.2nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201056((1R,6S)-3-(6-nitro-pyridin-3-yl)-3,8-diaza-bicyclo...)
Affinity DataEC50:  100nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201053((1R,6S)-2-bromo-5-(3,8-diaza-bicyclo[4.2.0]oct-8-y...)
Affinity DataEC50:  110nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50411220(CHEMBL465916)
Affinity DataEC50:  110nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50187455(1-(6-Bromo-5-vinylpyridin-3-yl)-[1,4]diazepane | 1...)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50264883(3-(2-chlorophenyl)-5-(1-(piperidin-4-yl)-1H-pyrazo...)
Affinity DataEC50:  120nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50187439(1-(5-Methoxypyridin-3-yl)-[1,5]diazocane | 1-(5-me...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201073((1R,6S)-3-(5-methoxy-pyridin-3-yl)-3,8-diaza-bicyc...)
Affinity DataEC50:  129nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50264763(3-(2-chlorothiophen-3-yl)-5-(1-(piperidin-4-yl)-1H...)
Affinity DataEC50:  130nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50411213(CHEMBL468065)
Affinity DataEC50:  135nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50088448(5-(1,4-diazepan-1-yl)pyridin-3-ol | 5-[1,4]Diazepa...)
Affinity DataEC50:  141nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201059((1R,6S)-3-(5-bromo-pyridin-3-yl)-3,8-diaza-bicyclo...)
Affinity DataEC50:  151nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50187437(1-(5-chloropyridin-3-yl)-1,5-diazocane | 1-(5-chlo...)
Affinity DataEC50:  170nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50411209(CHEMBL448697)
Affinity DataEC50:  174nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50411229(CHEMBL450667)
Affinity DataEC50:  178nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50201067((1S,6R)-5-(3,8-diaza-bicyclo[4.2.0]oct-3-yl)-N-hyd...)
Affinity DataEC50:  182nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50187454(1-(5-Bromopyridin-3-yl)-[1,5]diazocane | 1-(5-brom...)
Affinity DataEC50:  182nMAssay Description:Agonist activity at human alpha4beta2 nAChR expressed in HEK293 cells assessed as intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50264762(3-(3-chloropyridin-4-yl)-5-(1-(piperidin-4-yl)-1H-...)
Affinity DataEC50:  200nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50411212(CHEMBL481002)
Affinity DataEC50:  200nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50411230(CHEMBL451075)
Affinity DataEC50:  214nMAssay Description:Agonist activity against human alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Turin

Curated by ChEMBL
LigandPNGBDBM50264919(3-(2-chloro-4-fluorophenyl)-5-(1-(piperidin-4-yl)-...)
Affinity DataEC50:  220nMAssay Description:Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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