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Compile Data Set for Download or QSAR

Found 99 hits of ec50 data for polymerid = 50000606,50001237,50001880,50002487,50002529   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395486
PNG
(CHEMBL2163660)
Show SMILES Clc1cccc(CC(=O)Nc2ccccc2N2CCCC2)c1
Show InChI InChI=1S/C18H19ClN2O/c19-15-7-5-6-14(12-15)13-18(22)20-16-8-1-2-9-17(16)21-10-3-4-11-21/h1-2,5-9,12H,3-4,10-11,13H2,(H,20,22)
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n/an/an/an/a 170n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390916
PNG
(CHEMBL2070953)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1
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n/an/an/an/a 260n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395488
PNG
(CHEMBL1572950)
Show SMILES FC(F)(F)c1cccc(CC(=O)Nc2ccccc2N2CCCC2)c1
Show InChI InChI=1S/C19H19F3N2O/c20-19(21,22)15-7-5-6-14(12-15)13-18(25)23-16-8-1-2-9-17(16)24-10-3-4-11-24/h1-2,5-9,12H,3-4,10-11,13H2,(H,23,25)
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n/an/an/an/a 350n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390878
PNG
(CHEMBL2070970)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C22H22ClN3O4S2/c1-30-17-9-5-15(6-10-17)19-14-31-22(24-19)25-21(27)20-4-2-3-13-26(20)32(28,29)18-11-7-16(23)8-12-18/h5-12,14,20H,2-4,13H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 420n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395493
PNG
(CHEMBL2164065)
Show SMILES Fc1cccc(CC(=O)Nc2ccccc2N2CCCC2)c1
Show InChI InChI=1S/C18H19FN2O/c19-15-7-5-6-14(12-15)13-18(22)20-16-8-1-2-9-17(16)21-10-3-4-11-21/h1-2,5-9,12H,3-4,10-11,13H2,(H,20,22)
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n/an/an/an/a 490n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390895
PNG
(CHEMBL2070988)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CSCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C22H23N3O4S3/c1-15-3-9-18(10-4-15)32(27,28)25-11-12-30-14-20(25)21(26)24-22-23-19(13-31-22)16-5-7-17(29-2)8-6-16/h3-10,13,20H,11-12,14H2,1-2H3,(H,23,24,26)
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n/an/an/an/a 600n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50121051
PNG
(CHEMBL3621437)
Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1
Show InChI InChI=1S/C18H30N4O4/c1-18(2,3)11-13(23)19-14-15(25-5)20-17(21-16(14)26-6)22-9-7-12(24-4)8-10-22/h12H,7-11H2,1-6H3,(H,19,23)
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n/an/an/an/a 625n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Activation of human Kv7.4 expressed in CHOK1 cells


Bioorg Med Chem Lett 25: 4941-4 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50130610
PNG
((E)-N-[(S)-1-(3-Morpholin-4-yl-phenyl)-ethyl]-3-ph...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccccc1)c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C21H24N2O2/c1-17(22-21(24)11-10-18-6-3-2-4-7-18)19-8-5-9-20(16-19)23-12-14-25-15-13-23/h2-11,16-17H,12-15H2,1H3,(H,22,24)/b11-10+/t17-/m0/s1
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n/an/an/an/a 690n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration against Potassium voltage gated channel, KQT-like subfamily, member 2 expressed in SH-SY5Y human neuroblastoma cells


J Med Chem 46: 3778-81 (2003)


Article DOI: 10.1021/jm034111v
BindingDB Entry DOI: 10.7270/Q2RJ4K66
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390922
PNG
(CHEMBL2070954)
Show SMILES CCCc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccc(OC)cc1
Show InChI InChI=1S/C25H29N3O4S2/c1-3-6-18-8-14-21(15-9-18)34(30,31)28-16-5-4-7-23(28)24(29)27-25-26-22(17-33-25)19-10-12-20(32-2)13-11-19/h8-15,17,23H,3-7,16H2,1-2H3,(H,26,27,29)/t23-/m1/s1
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n/an/an/an/a 700n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395491
PNG
(CHEMBL1415708)
Show SMILES Fc1ccc(CC(=O)Nc2ccccc2N2CCCC2)cc1
Show InChI InChI=1S/C18H19FN2O/c19-15-9-7-14(8-10-15)13-18(22)20-16-5-1-2-6-17(16)21-11-3-4-12-21/h1-2,5-10H,3-4,11-13H2,(H,20,22)
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n/an/an/an/a 700n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390876
PNG
(CHEMBL2070968)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2Cl)n1
Show InChI InChI=1S/C22H22ClN3O4S2/c1-30-16-11-9-15(10-12-16)18-14-31-22(24-18)25-21(27)19-7-4-5-13-26(19)32(28,29)20-8-3-2-6-17(20)23/h2-3,6,8-12,14,19H,4-5,7,13H2,1H3,(H,24,25,27)/t19-/m1/s1
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n/an/an/an/a 730n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395496
PNG
(CHEMBL1448089)
Show SMILES O=C(Cc1ccccc1)Nc1ccccc1N1CCCC1
Show InChI InChI=1S/C18H20N2O/c21-18(14-15-8-2-1-3-9-15)19-16-10-4-5-11-17(16)20-12-6-7-13-20/h1-5,8-11H,6-7,12-14H2,(H,19,21)
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n/an/an/an/a 743n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390870
PNG
(CHEMBL2070962)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc3OCOc3c2)n1
Show InChI InChI=1S/C23H23N3O6S2/c1-30-16-7-5-15(6-8-16)18-13-33-23(24-18)25-22(27)19-4-2-3-11-26(19)34(28,29)17-9-10-20-21(12-17)32-14-31-20/h5-10,12-13,19H,2-4,11,14H2,1H3,(H,24,25,27)/t19-/m1/s1
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n/an/an/an/a 780n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395484
PNG
(CHEMBL2163663)
Show SMILES Clc1ccc(CC(=O)Nc2ccccc2N2CCCC2)cc1
Show InChI InChI=1S/C18H19ClN2O/c19-15-9-7-14(8-10-15)13-18(22)20-16-5-1-2-6-17(16)21-11-3-4-12-21/h1-2,5-10H,3-4,11-13H2,(H,20,22)
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n/an/an/an/a 800n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390869
PNG
(CHEMBL2070961)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(OC)c2)n1
Show InChI InChI=1S/C23H25N3O5S2/c1-30-17-11-9-16(10-12-17)20-15-32-23(24-20)25-22(27)21-8-3-4-13-26(21)33(28,29)19-7-5-6-18(14-19)31-2/h5-7,9-12,14-15,21H,3-4,8,13H2,1-2H3,(H,24,25,27)/t21-/m1/s1
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n/an/an/an/a 810n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390872
PNG
(CHEMBL2070964)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(c2)C#N)n1
Show InChI InChI=1S/C23H22N4O4S2/c1-31-18-10-8-17(9-11-18)20-15-32-23(25-20)26-22(28)21-7-2-3-12-27(21)33(29,30)19-6-4-5-16(13-19)14-24/h4-6,8-11,13,15,21H,2-3,7,12H2,1H3,(H,25,26,28)/t21-/m1/s1
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n/an/an/an/a 880n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390921
PNG
(CHEMBL2070952)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(C)c2)n1
Show InChI InChI=1S/C23H25N3O4S2/c1-16-6-5-7-19(14-16)32(28,29)26-13-4-3-8-21(26)22(27)25-23-24-20(15-31-23)17-9-11-18(30-2)12-10-17/h5-7,9-12,14-15,21H,3-4,8,13H2,1-2H3,(H,24,25,27)/t21-/m1/s1
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n/an/an/an/a 890n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395489
PNG
(CHEMBL2163656)
Show SMILES Clc1ccccc1CC(=O)Nc1ccccc1N1CCCC1
Show InChI InChI=1S/C18H19ClN2O/c19-15-8-2-1-7-14(15)13-18(22)20-16-9-3-4-10-17(16)21-11-5-6-12-21/h1-4,7-10H,5-6,11-13H2,(H,20,22)
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n/an/an/an/a 950n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395495
PNG
(CHEMBL2164050)
Show SMILES FC(C(=O)Nc1ccccc1N1CCCC1)c1ccccc1
Show InChI InChI=1S/C18H19FN2O/c19-17(14-8-2-1-3-9-14)18(22)20-15-10-4-5-11-16(15)21-12-6-7-13-21/h1-5,8-11,17H,6-7,12-13H2,(H,20,22)
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Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390928
PNG
(CHEMBL2070958)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C23H22F3N3O4S2/c1-33-17-10-8-15(9-11-17)19-14-34-22(27-19)28-21(30)20-7-2-3-12-29(20)35(31,32)18-6-4-5-16(13-18)23(24,25)26/h4-6,8-11,13-14,20H,2-3,7,12H2,1H3,(H,27,28,30)/t20-/m1/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395473
PNG
(CHEMBL2163666)
Show SMILES Clc1cccc(CC(=O)Nc2cccc(c2)N2CCCC2)c1
Show InChI InChI=1S/C18H19ClN2O/c19-15-6-3-5-14(11-15)12-18(22)20-16-7-4-8-17(13-16)21-9-1-2-10-21/h3-8,11,13H,1-2,9-10,12H2,(H,20,22)
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n/an/an/an/a 1.02E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390875
PNG
(CHEMBL2070967)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(F)cc2)n1
Show InChI InChI=1S/C22H22FN3O4S2/c1-30-17-9-5-15(6-10-17)19-14-31-22(24-19)25-21(27)20-4-2-3-13-26(20)32(28,29)18-11-7-16(23)8-12-18/h5-12,14,20H,2-4,13H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 1.03E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395490
PNG
(CHEMBL1732755)
Show SMILES Clc1ccc(CC(=O)Nc2ccccc2N2CCCC2)cc1Cl
Show InChI InChI=1S/C18H18Cl2N2O/c19-14-8-7-13(11-15(14)20)12-18(23)21-16-5-1-2-6-17(16)22-9-3-4-10-22/h1-2,5-8,11H,3-4,9-10,12H2,(H,21,23)
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n/an/an/an/a 1.07E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390874
PNG
(CHEMBL2070966)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(F)c2)n1
Show InChI InChI=1S/C22H22FN3O4S2/c1-30-17-10-8-15(9-11-17)19-14-31-22(24-19)25-21(27)20-7-2-3-12-26(20)32(28,29)18-6-4-5-16(23)13-18/h4-6,8-11,13-14,20H,2-3,7,12H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 1.16E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50131898
PNG
((E)-N-[1-((S)-4-Fluoro-3-morpholin-4-yl-phenyl)-et...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccc(F)cc1)c1ccc(F)c(c1)N1CCOCC1
Show InChI InChI=1S/C21H22F2N2O2/c1-15(24-21(26)9-4-16-2-6-18(22)7-3-16)17-5-8-19(23)20(14-17)25-10-12-27-13-11-25/h2-9,14-15H,10-13H2,1H3,(H,24,26)/b9-4+/t15-/m0/s1
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n/an/an/an/a 1.20E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration against Potassium voltage gated channel KQT-like subfamily, member 2 expressed in HEK 293 cells


J Med Chem 46: 3778-81 (2003)


Article DOI: 10.1021/jm034111v
BindingDB Entry DOI: 10.7270/Q2RJ4K66
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395492
PNG
(CHEMBL2164067)
Show SMILES Cc1cccc(CC(=O)Nc2ccccc2N2CCCC2)c1
Show InChI InChI=1S/C19H22N2O/c1-15-7-6-8-16(13-15)14-19(22)20-17-9-2-3-10-18(17)21-11-4-5-12-21/h2-3,6-10,13H,4-5,11-12,14H2,1H3,(H,20,22)
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n/an/an/an/a 1.32E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390909
PNG
(CHEMBL2071004)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccc2occc2c1
Show InChI InChI=1S/C24H23N3O4S2/c1-16-5-8-19(9-6-16)33(29,30)27-12-3-2-4-21(27)23(28)26-24-25-20(15-32-24)17-7-10-22-18(14-17)11-13-31-22/h5-11,13-15,21H,2-4,12H2,1H3,(H,25,26,28)/t21-/m1/s1
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n/an/an/an/a 1.32E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390886
PNG
(CHEMBL2070978)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccnc2)n1
Show InChI InChI=1S/C21H22N4O4S2/c1-29-16-9-7-15(8-10-16)18-14-30-21(23-18)24-20(26)19-6-2-3-12-25(19)31(27,28)17-5-4-11-22-13-17/h4-5,7-11,13-14,19H,2-3,6,12H2,1H3,(H,23,24,26)/t19-/m1/s1
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n/an/an/an/a 1.36E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390920
PNG
(CHEMBL2070832)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2C)n1
Show InChI InChI=1S/C23H25N3O4S2/c1-16-7-3-4-9-21(16)32(28,29)26-14-6-5-8-20(26)22(27)25-23-24-19(15-31-23)17-10-12-18(30-2)13-11-17/h3-4,7,9-13,15,20H,5-6,8,14H2,1-2H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 1.38E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390877
PNG
(CHEMBL2070969)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(Cl)c2)n1
Show InChI InChI=1S/C22H22ClN3O4S2/c1-30-17-10-8-15(9-11-17)19-14-31-22(24-19)25-21(27)20-7-2-3-12-26(20)32(28,29)18-6-4-5-16(23)13-18/h4-6,8-11,13-14,20H,2-3,7,12H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 1.41E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390918
PNG
(CHEMBL2070830)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2)n1
Show InChI InChI=1S/C22H23N3O4S2/c1-29-17-12-10-16(11-13-17)19-15-30-22(23-19)24-21(26)20-9-5-6-14-25(20)31(27,28)18-7-3-2-4-8-18/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,23,24,26)/t20-/m1/s1
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n/an/an/an/a 1.47E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50131898
PNG
((E)-N-[1-((S)-4-Fluoro-3-morpholin-4-yl-phenyl)-et...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccc(F)cc1)c1ccc(F)c(c1)N1CCOCC1
Show InChI InChI=1S/C21H22F2N2O2/c1-15(24-21(26)9-4-16-2-6-18(22)7-3-16)17-5-8-19(23)20(14-17)25-10-12-27-13-11-25/h2-9,14-15H,10-13H2,1H3,(H,24,26)/b9-4+/t15-/m0/s1
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n/an/an/an/a 1.55E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration against Potassium voltage gated channel, KQT-like subfamily, member 2 expressed in SH-SY5Y human neuroblastoma cells


J Med Chem 46: 3778-81 (2003)


Article DOI: 10.1021/jm034111v
BindingDB Entry DOI: 10.7270/Q2RJ4K66
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390873
PNG
(CHEMBL2070965)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(cc2)C#N)n1
Show InChI InChI=1S/C23H22N4O4S2/c1-31-18-9-7-17(8-10-18)20-15-32-23(25-20)26-22(28)21-4-2-3-13-27(21)33(29,30)19-11-5-16(14-24)6-12-19/h5-12,15,21H,2-4,13H2,1H3,(H,25,26,28)/t21-/m1/s1
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n/an/an/an/a 1.63E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390917
PNG
(CHEMBL1352968)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CCCCN2S(=O)(=O)c2ccccc2)n1
Show InChI InChI=1S/C22H23N3O4S2/c1-29-17-12-10-16(11-13-17)19-15-30-22(23-19)24-21(26)20-9-5-6-14-25(20)31(27,28)18-7-3-2-4-8-18/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,23,24,26)
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n/an/an/an/a 1.69E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390867
PNG
(CHEMBL2070959)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(cc2)C(F)(F)F)n1
Show InChI InChI=1S/C23H22F3N3O4S2/c1-33-17-9-5-15(6-10-17)19-14-34-22(27-19)28-21(30)20-4-2-3-13-29(20)35(31,32)18-11-7-16(8-12-18)23(24,25)26/h5-12,14,20H,2-4,13H2,1H3,(H,27,28,30)/t20-/m1/s1
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n/an/an/an/a 1.71E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395494
PNG
(CHEMBL2164063)
Show SMILES Fc1ccc(CC(=O)Nc2ccccc2N2CCCC2)cc1F
Show InChI InChI=1S/C18H18F2N2O/c19-14-8-7-13(11-15(14)20)12-18(23)21-16-5-1-2-6-17(16)22-9-3-4-10-22/h1-2,5-8,11H,3-4,9-10,12H2,(H,21,23)
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n/an/an/an/a 1.73E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395485
PNG
(CHEMBL1729184)
Show SMILES COc1ccc(CC(=O)Nc2ccccc2N2CCCC2)cc1
Show InChI InChI=1S/C19H22N2O2/c1-23-16-10-8-15(9-11-16)14-19(22)20-17-6-2-3-7-18(17)21-12-4-5-13-21/h2-3,6-11H,4-5,12-14H2,1H3,(H,20,22)
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n/an/an/an/a 1.75E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390868
PNG
(CHEMBL2070960)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2OC)n1
Show InChI InChI=1S/C23H25N3O5S2/c1-30-17-12-10-16(11-13-17)18-15-32-23(24-18)25-22(27)19-7-5-6-14-26(19)33(28,29)21-9-4-3-8-20(21)31-2/h3-4,8-13,15,19H,5-7,14H2,1-2H3,(H,24,25,27)/t19-/m1/s1
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n/an/an/an/a 1.78E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395487
PNG
(CHEMBL1320944)
Show SMILES COc1cccc(CC(=O)Nc2ccccc2N2CCCC2)c1
Show InChI InChI=1S/C19H22N2O2/c1-23-16-8-6-7-15(13-16)14-19(22)20-17-9-2-3-10-18(17)21-11-4-5-12-21/h2-3,6-10,13H,4-5,11-12,14H2,1H3,(H,20,22)
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n/an/an/an/a 2.35E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50426567
PNG
(BMS-204352 | FLINDOKALNER | MaxiPost)
Show SMILES COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
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n/an/an/an/a 2.40E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive modulatory activity at voltage-gated K channel 7.2 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50426567
PNG
(BMS-204352 | FLINDOKALNER | MaxiPost)
Show SMILES COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
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n/an/an/an/a 2.40E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive modulatory activity at voltage-gated K channel 7.3 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50426567
PNG
(BMS-204352 | FLINDOKALNER | MaxiPost)
Show SMILES COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
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n/an/an/an/a 2.40E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive modulatory activity at voltage-gated K channel 7.4 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50426567
PNG
(BMS-204352 | FLINDOKALNER | MaxiPost)
Show SMILES COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1
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n/an/an/an/a 2.40E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Positive modulatory activity at voltage-gated K channel 7.5 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390923
PNG
(CHEMBL2070955)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(cc2)C(C)C)n1
Show InChI InChI=1S/C25H29N3O4S2/c1-17(2)18-9-13-21(14-10-18)34(30,31)28-15-5-4-6-23(28)24(29)27-25-26-22(16-33-25)19-7-11-20(32-3)12-8-19/h7-14,16-17,23H,4-6,15H2,1-3H3,(H,26,27,29)/t23-/m1/s1
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n/an/an/an/a 2.59E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390892
PNG
(CHEMBL2070985)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C22H23N3O4S2/c1-15-5-11-18(12-6-15)31(27,28)25-13-3-4-20(25)21(26)24-22-23-19(14-30-22)16-7-9-17(29-2)10-8-16/h5-12,14,20H,3-4,13H2,1-2H3,(H,23,24,26)
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n/an/an/an/a 2.86E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50130610
PNG
((E)-N-[(S)-1-(3-Morpholin-4-yl-phenyl)-ethyl]-3-ph...)
Show SMILES C[C@H](NC(=O)\C=C\c1ccccc1)c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C21H24N2O2/c1-17(22-21(24)11-10-18-6-3-2-4-7-18)19-8-5-9-20(16-19)23-12-14-25-15-13-23/h2-11,16-17H,12-15H2,1H3,(H,22,24)/b11-10+/t17-/m0/s1
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n/an/an/an/a 3.00E+3n/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Effective concentration against Potassium voltage gated channel KQT-like subfamily, member 2 expressed in HEK 293 cells


J Med Chem 46: 3778-81 (2003)


Article DOI: 10.1021/jm034111v
BindingDB Entry DOI: 10.7270/Q2RJ4K66
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390894
PNG
(CHEMBL2070987)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2COCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C22H23N3O5S2/c1-15-3-9-18(10-4-15)32(27,28)25-11-12-30-13-20(25)21(26)24-22-23-19(14-31-22)16-5-7-17(29-2)8-6-16/h3-10,14,20H,11-13H2,1-2H3,(H,23,24,26)
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n/an/an/an/a 4.38E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390925
PNG
(CHEMBL2070957)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2C(F)(F)F)n1
Show InChI InChI=1S/C23H22F3N3O4S2/c1-33-16-11-9-15(10-12-16)18-14-34-22(27-18)28-21(30)19-7-4-5-13-29(19)35(31,32)20-8-3-2-6-17(20)23(24,25)26/h2-3,6,8-12,14,19H,4-5,7,13H2,1H3,(H,27,28,30)/t19-/m1/s1
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n/an/an/an/a 4.74E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50390926
PNG
(CHEMBL2070981)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2C(=O)c2cccc(F)c2)n1
Show InChI InChI=1S/C23H22FN3O3S/c1-30-18-10-8-15(9-11-18)19-14-31-23(25-19)26-21(28)20-7-2-3-12-27(20)22(29)16-5-4-6-17(24)13-16/h4-6,8-11,13-14,20H,2-3,7,12H2,1H3,(H,25,26,28)/t20-/m1/s1
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n/an/an/an/a 6.13E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens)
BDBM50395471
PNG
(CHEMBL2163670)
Show SMILES Clc1cccc(CC(=O)Nc2ccccc2N2CCCCC2)c1
Show InChI InChI=1S/C19H21ClN2O/c20-16-8-6-7-15(13-16)14-19(23)21-17-9-2-3-10-18(17)22-11-4-1-5-12-22/h2-3,6-10,13H,1,4-5,11-12,14H2,(H,21,23)
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n/an/an/an/a 7.09E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
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