Found 4 hits of ec50 data for polymerid = 50001237,50006966 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily KQT member 4
(Rattus norvegicus) | BDBM50121051
(CHEMBL3621437)Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1 Show InChI InChI=1S/C18H30N4O4/c1-18(2,3)11-13(23)19-14-15(25-5)20-17(21-16(14)26-6)22-9-7-12(24-4)8-10-22/h12H,7-11H2,1-6H3,(H,19,23) | PDB
UniProtKB/SwissProt
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 376 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of rat Kv7.4 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
KCNQ (Kv7) potassium channel
(Homo sapiens) | BDBM50121051
(CHEMBL3621437)Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1 Show InChI InChI=1S/C18H30N4O4/c1-18(2,3)11-13(23)19-14-15(25-5)20-17(21-16(14)26-6)22-9-7-12(24-4)8-10-22/h12H,7-11H2,1-6H3,(H,19,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 625 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Activation of human Kv7.4 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074
BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this
Ligand-Target Pair | |
KCNQ (Kv7) potassium channel
(Homo sapiens) | BDBM50426567
(BMS-204352 | FLINDOKALNER | MaxiPost)Show SMILES COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F Show InChI InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Positive modulatory activity at voltage-gated K channel 7.4 (unknown origin) |
J Med Chem 56: 593-624 (2013)
Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ |
More data for this
Ligand-Target Pair | |
KCNQ (Kv7) potassium channel
(Homo sapiens) | BDBM50390916
(CHEMBL2070953)Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1 Show InChI InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Activation of KCNQ4 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay relative to c... |
Bioorg Med Chem Lett 22: 5936-41 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN |
More data for this
Ligand-Target Pair | |
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