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Compile Data Set for Download or QSAR

Found 71 hits of ec50 data for polymerid = 50001413,50001427   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RNase L


(Homo sapiens)
BDBM50085558
PNG
(CHEMBL402676 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(61-29)3-59-67(54,55)65-22-19(49)13(63-31(22)45-8-40-15-24(33)36-6-38-27(15)45)4-60-68(56,57)64-21-18(48)12(2-58-66(51,52)53)62-30(21)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
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n/an/an/an/a 0.130n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085554
PNG
(5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5'...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
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n/an/an/an/a 0.150n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085558
PNG
(CHEMBL402676 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(61-29)3-59-67(54,55)65-22-19(49)13(63-31(22)45-8-40-15-24(33)36-6-38-27(15)45)4-60-68(56,57)64-21-18(48)12(2-58-66(51,52)53)62-30(21)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
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n/an/an/an/a 0.200n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085554
PNG
(5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5'...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
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n/an/an/an/a 0.200n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50421415
PNG
(CHEMBL414948)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
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n/an/an/an/a 0.210n/an/an/an/a



National Institute of Diabetes and Digestive antd Kidney Diseases

Curated by ChEMBL


Assay Description
Binding affinity of compound to human recombinant Ribonuclease L was evaluated


Bioorg Med Chem Lett 10: 1357-60 (2000)


Article DOI: 10.1016/s0960-894x(00)00240-7
BindingDB Entry DOI: 10.7270/Q2TT4Q67
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
RNase L


(Homo sapiens)
BDBM50085553
PNG
(CHEMBL214603 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(65-29)2-62-73(54,55)68-21-18(48)12(66-30(21)44-7-39-14-23(32)35-5-37-26(14)44)3-63-74(56,57)69-22-19(49)13(4-64-75(58,59)71-76(60,61)70-72(51,52)53)67-31(22)45-8-40-15-24(33)36-6-38-27(15)45/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
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n/an/an/an/a 0.240n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085553
PNG
(CHEMBL214603 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(65-29)2-62-73(54,55)68-21-18(48)12(66-30(21)44-7-39-14-23(32)35-5-37-26(14)44)3-63-74(56,57)69-22-19(49)13(4-64-75(58,59)71-76(60,61)70-72(51,52)53)67-31(22)45-8-40-15-24(33)36-6-38-27(15)45/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
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n/an/an/an/a 0.300n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50183267
PNG
(CHEMBL3817920)
Show SMILES C[C@H]1O[C@H]([C@H](OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4c(C)nc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H]1O)n1cc(F)c(=O)[nH]c1=O
Show InChI InChI=1S/C40H49FN17O23P3/c1-12-21(59)26(37(75-12)55-3-14(41)35(64)54-40(55)65)79-82(66,67)73-5-16-23(61)28(39(77-16)57-11-52-19-30(43)46-8-49-33(19)57)81-84(70,71)74-6-17-24(62)27(38(78-17)56-10-51-18-29(42)45-7-48-32(18)56)80-83(68,69)72-4-15-22(60)25(63)36(76-15)58-13(2)53-20-31(44)47-9-50-34(20)58/h3,7-12,15-17,21-28,36-39,59-63H,4-6H2,1-2H3,(H,66,67)(H,68,69)(H,70,71)(H2,42,45,48)(H2,43,46,49)(H2,44,47,50)(H,54,64,65)/t12-,15-,16-,17-,21-,22-,23-,24-,25-,26-,27-,28-,36-,37-,38-,39-/m1/s1
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n/an/an/an/a 0.450n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...


Bioorg Med Chem 24: 3870-4 (2016)


Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50373177
PNG
(CHEMBL404038)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H40N15O25P5/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(64-28)1-61-72(53,54)67-20-17(47)11(65-29(20)44-8-41-14-23(32)35-5-38-26(14)44)2-62-73(55,56)68-21-18(48)12(3-63-74(57,58)70-75(59,60)69-71(50,51)52)66-30(21)45-9-42-15-24(33)36-6-39-27(15)45/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
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n/an/an/an/a 0.5n/an/an/an/a



Lerner Research Institute

Curated by ChEMBL


Assay Description
Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe


Proc Natl Acad Sci USA 104: 9585-90 (2007)


Article DOI: 10.1073/pnas.0700590104
BindingDB Entry DOI: 10.7270/Q2G161PZ
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085556
PNG
(CHEMBL405496 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1
Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(19(49)13(67-31)4-64-75(58,59)71-76(60,61)70-72(51,52)53)69-74(56,57)63-3-12-18(48)21(30(66-12)45-8-40-15-24(33)36-6-38-27(15)45)68-73(54,55)62-2-11-17(47)20(50)29(65-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
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n/an/an/an/a 0.680n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085555
PNG
(CHEMBL384725 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1
Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(18(48)12(62-31)2-58-66(51,52)53)65-68(56,57)60-4-13-19(49)21(30(63-13)45-8-40-15-24(33)36-6-38-27(15)45)64-67(54,55)59-3-11-17(47)20(50)29(61-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
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n/an/an/an/a 0.700n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085556
PNG
(CHEMBL405496 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1
Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(19(49)13(67-31)4-64-75(58,59)71-76(60,61)70-72(51,52)53)69-74(56,57)63-3-12-18(48)21(30(66-12)45-8-40-15-24(33)36-6-38-27(15)45)68-73(54,55)62-2-11-17(47)20(50)29(65-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
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n/an/an/an/a 0.800n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085555
PNG
(CHEMBL384725 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1
Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(18(48)12(62-31)2-58-66(51,52)53)65-68(56,57)60-4-13-19(49)21(30(63-13)45-8-40-15-24(33)36-6-38-27(15)45)64-67(54,55)59-3-11-17(47)20(50)29(61-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
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n/an/an/an/a 0.840n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50189859
PNG
(CHEMBL427600 | {[(2R,3R,4R,5R)-5-(6-amino-9H-purin...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1OP(O)(O)=O
Show InChI InChI=1S/C40H51N20O28P5/c41-29-17-33(49-5-45-29)57(9-53-17)37-25(85-90(68,69)70)21(61)14(82-37)2-78-91(71,72)87-27-23(63)16(84-39(27)59-11-55-19-31(43)47-7-51-35(19)59)4-80-93(75,76)88-28-24(64)15(83-40(28)60-12-56-20-32(44)48-8-52-36(20)60)3-79-92(73,74)86-26-22(62)13(1-77-89(65,66)67)81-38(26)58-10-54-18-30(42)46-6-50-34(18)58/h5-16,21-28,37-40,61-64H,1-4H2,(H,71,72)(H,73,74)(H,75,76)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,65,66,67)(H2,68,69,70)/t13-,14-,15-,16-,21-,22-,23-,24-,25-,26-,27-,28-,37-,38-,39-,40-/m1/s1
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n/an/an/an/a 0.900n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7)


J Med Chem 49: 3955-62 (2006)


Article DOI: 10.1021/jm050401v
BindingDB Entry DOI: 10.7270/Q2X066N8
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50189861
PNG
(CHEMBL424746 | {[(2R,3R,4R,5R)-5-(6-amino-9H-purin...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1OP(O)(O)=O
Show InChI InChI=1S/C40H51N20O28P5/c41-29-17-33(49-5-45-29)57(9-53-17)37-25(85-90(68,69)70)21(61)14(82-37)2-78-91(71,72)87-27-23(63)16(84-39(27)59-11-55-19-31(43)47-7-51-35(19)59)4-80-93(75,76)88-28-24(64)15(83-40(28)60-12-56-20-32(44)48-8-52-36(20)60)3-79-92(73,74)86-26-22(62)13(1-77-89(65,66)67)81-38(26)58-10-54-18-30(42)46-6-50-34(18)58/h5-16,21-28,37-40,61-64H,1-4H2,(H,71,72)(H,73,74)(H,75,76)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,65,66,67)(H2,68,69,70)/t13-,14-,15-,16-,21-,22-,23+,24-,25-,26-,27-,28-,37-,38-,39-,40-/m1/s1
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n/an/an/an/a 1.30n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7)


J Med Chem 49: 3955-62 (2006)


Article DOI: 10.1021/jm050401v
BindingDB Entry DOI: 10.7270/Q2X066N8
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50309129
PNG
(CHEMBL601938 | {[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)...)
Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](CO)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H51N20O22P3/c1-13-57-21-33(45)49-9-53-37(21)61(13)38-26(67)22(63)15(78-38)3-74-84(68,69)82-28-24(65)17(80-40(28)59-11-55-19-31(43)47-7-51-35(19)59)5-76-86(72,73)83-29-25(66)16(79-41(29)60-12-56-20-32(44)48-8-52-36(20)60)4-75-85(70,71)81-27-23(64)14(2-62)77-39(27)58-10-54-18-30(42)46-6-50-34(18)58/h6-12,14-17,22-29,38-41,62-67H,2-5H2,1H3,(H,68,69)(H,70,71)(H,72,73)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a 2.30n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...


Bioorg Med Chem 24: 3870-4 (2016)


Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50183270
PNG
(CHEMBL3818262)
Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](CO)O[C@H]4n4ccc(=O)[nH]c4=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C40H50N17O24P3/c1-13-52-21-32(43)46-10-49-35(21)57(13)36-26(64)22(60)15(76-36)5-72-82(66,67)80-28-24(62)17(78-38(28)55-11-50-19-30(41)44-8-47-33(19)55)7-74-84(70,71)81-29-25(63)16(77-39(29)56-12-51-20-31(42)45-9-48-34(20)56)6-73-83(68,69)79-27-23(61)14(4-58)75-37(27)54-3-2-18(59)53-40(54)65/h2-3,8-12,14-17,22-29,36-39,58,60-64H,4-7H2,1H3,(H,66,67)(H,68,69)(H,70,71)(H2,41,44,47)(H2,42,45,48)(H2,43,46,49)(H,53,59,65)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,36-,37-,38-,39-/m1/s1
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n/an/an/an/a 2.40n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...


Bioorg Med Chem 24: 3870-4 (2016)


Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50309130
PNG
(CHEMBL591446 | {[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)...)
Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c1-13-57-21-33(45)49-9-53-37(21)61(13)38-26(66)22(62)14(80-38)3-77-88(70,71)85-28-24(64)16(82-40(28)59-11-55-19-31(43)47-7-51-35(19)59)5-79-90(74,75)86-29-25(65)17(83-41(29)60-12-56-20-32(44)48-8-52-36(20)60)4-78-89(72,73)84-27-23(63)15(2-76-87(67,68)69)81-39(27)58-10-54-18-30(42)46-6-50-34(18)58/h6-12,14-17,22-29,38-41,62-66H,2-5H2,1H3,(H,70,71)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,67,68,69)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a 2.5n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage


Bioorg Med Chem Lett 20: 1186-8 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.005
BindingDB Entry DOI: 10.7270/Q2G73DVP
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50309129
PNG
(CHEMBL601938 | {[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)...)
Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](CO)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H51N20O22P3/c1-13-57-21-33(45)49-9-53-37(21)61(13)38-26(67)22(63)15(78-38)3-74-84(68,69)82-28-24(65)17(80-40(28)59-11-55-19-31(43)47-7-51-35(19)59)5-76-86(72,73)83-29-25(66)16(79-41(29)60-12-56-20-32(44)48-8-52-36(20)60)4-75-85(70,71)81-27-23(64)14(2-62)77-39(27)58-10-54-18-30(42)46-6-50-34(18)58/h6-12,14-17,22-29,38-41,62-67H,2-5H2,1H3,(H,68,69)(H,70,71)(H,72,73)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a 2.5n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage


Bioorg Med Chem Lett 20: 1186-8 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.005
BindingDB Entry DOI: 10.7270/Q2G73DVP
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50183271
PNG
(CHEMBL3819183)
Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4ccc(=O)[nH]c4=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C40H51N17O27P4/c1-13-52-21-32(43)46-10-49-35(21)57(13)36-26(63)22(59)14(78-36)5-75-86(68,69)83-28-24(61)17(81-38(28)55-11-50-19-30(41)44-8-47-33(19)55)7-77-88(72,73)84-29-25(62)16(80-39(29)56-12-51-20-31(42)45-9-48-34(20)56)6-76-87(70,71)82-27-23(60)15(4-74-85(65,66)67)79-37(27)54-3-2-18(58)53-40(54)64/h2-3,8-12,14-17,22-29,36-39,59-63H,4-7H2,1H3,(H,68,69)(H,70,71)(H,72,73)(H2,41,44,47)(H2,42,45,48)(H2,43,46,49)(H,53,58,64)(H2,65,66,67)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,36-,37-,38-,39-/m1/s1
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n/an/an/an/a 2.70n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...


Bioorg Med Chem 24: 3870-4 (2016)


Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50189862
PNG
(CHEMBL414569 | {[(2R,3R,4R,5R)-5-(6-amino-9H-purin...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1OP(O)(O)=O
Show InChI InChI=1S/C40H51N20O28P5/c41-29-17-33(49-5-45-29)57(9-53-17)37-25(85-90(68,69)70)21(61)14(82-37)2-78-91(71,72)87-27-23(63)16(84-39(27)59-11-55-19-31(43)47-7-51-35(19)59)4-80-93(75,76)88-28-24(64)15(83-40(28)60-12-56-20-32(44)48-8-52-36(20)60)3-79-92(73,74)86-26-22(62)13(1-77-89(65,66)67)81-38(26)58-10-54-18-30(42)46-6-50-34(18)58/h5-16,21-28,37-40,61-64H,1-4H2,(H,71,72)(H,73,74)(H,75,76)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,65,66,67)(H2,68,69,70)/t13-,14-,15-,16-,21-,22-,23-,24-,25-,26-,27+,28-,37-,38-,39-,40-/m1/s1
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n/an/an/an/a 3.60n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7)


J Med Chem 49: 3955-62 (2006)


Article DOI: 10.1021/jm050401v
BindingDB Entry DOI: 10.7270/Q2X066N8
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085559
PNG
(CHEMBL410213 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C33H46N15O25P5/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(67-31)4-64-75(56,57)70-23-20(50)14(68-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47)5-65-76(58,59)71-24-21(51)15(6-66-77(60,61)73-78(62,63)72-74(53,54)55)69-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H,60,61)(H,62,63)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1
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n/an/an/an/a 4n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388146
PNG
(CHEMBL2058766)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COCP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)14(80-38)1-76-13-87(67,68)84-27-23(63)16(82-39(27)59-10-55-19-31(43)47-6-51-35(19)59)3-78-89(72,73)86-29-25(65)17(83-41(29)61-12-57-21-33(45)49-8-53-37(21)61)4-79-90(74,75)85-28-24(64)15(2-77-88(69,70)71)81-40(28)60-11-56-20-32(44)48-7-52-36(20)60/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22+,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a 4.20n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Bioorg Med Chem Lett 22: 181-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.040
BindingDB Entry DOI: 10.7270/Q2H1332W
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085559
PNG
(CHEMBL410213 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C33H46N15O25P5/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(67-31)4-64-75(56,57)70-23-20(50)14(68-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47)5-65-76(58,59)71-24-21(51)15(6-66-77(60,61)73-78(62,63)72-74(53,54)55)69-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H,60,61)(H,62,63)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1
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n/an/an/an/a 4.60n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50438548
PNG
(CHEMBL2414867)
Show SMILES Nc1ncnc2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)O[C@@H]6[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]6n6cnc7ncnc(N)c67)O[C@H]5n5cnc6ncnc(N)c56)O[C@H]4n4cnc5ncnc(N)c45)[C@@H](O)[C@H]3O)c12
Show InChI InChI=1S/C40H52N20O31P6/c41-29-17-33(49-5-45-29)53-9-57(17)37-25(65)21(61)13(83-37)1-79-93(69,70)87-26-22(62)14(84-38(26)58-10-54-34-18(58)30(42)46-6-50-34)2-80-94(71,72)88-27-23(63)15(85-39(27)59-11-55-35-19(59)31(43)47-7-51-35)3-81-95(73,74)89-28-24(64)16(4-82-96(75,76)91-97(77,78)90-92(66,67)68)86-40(28)60-12-56-36-20(60)32(44)48-8-52-36/h5-16,21-28,37-40,61-65H,1-4H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,66,67,68)/t13-,14-,15-,16-,21-,22-,23-,24-,25-,26-,27-,28-,37-,38-,39-,40-/m1/s1
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n/an/an/an/a 6.10n/an/an/an/a



Universit£ Montpellier 2

Curated by ChEMBL


Assay Description
Activation of human recombinant RNase L endonuclease activity using 6-FAM-UUA UCA AAU UCU UAU UUG CCC CAU UUU UUU GGU UUA-BHQ-1 as substrate assessed...


Bioorg Med Chem 21: 5461-9 (2013)


Article DOI: 10.1016/j.bmc.2013.06.008
BindingDB Entry DOI: 10.7270/Q2474C8X
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388147
PNG
(CHEMBL2058765)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COCP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)14(80-38)1-76-13-87(67,68)84-27-23(63)16(82-39(27)59-10-55-19-31(43)47-6-51-35(19)59)3-78-89(72,73)86-29-25(65)17(83-41(29)61-12-57-21-33(45)49-8-53-37(21)61)4-79-90(74,75)85-28-24(64)15(2-77-88(69,70)71)81-40(28)60-11-56-20-32(44)48-7-52-36(20)60/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23-,24-,25-,26+,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a 6.5n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Bioorg Med Chem Lett 22: 181-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.040
BindingDB Entry DOI: 10.7270/Q2H1332W
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50152834
PNG
(2''-5--oligoadenylate derivative | [(2R,3R,4R,5R)-...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP([O-])(=O)O[C@@H]2[C@H](O)[C@@H](COP([O-])(=O)O[C@@H]3[C@H](O)[C@@H](COP([O-])(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)([O-])=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C40H50N20O25P4/c41-29-17-33(49-5-45-29)57(9-53-17)37-25(65)21(61)13(79-37)2-76-87(69,70)84-27-23(63)15(81-39(27)59-11-55-19-31(43)47-7-51-35(19)59)4-78-89(73,74)85-28-24(64)16(82-40(28)60-12-56-20-32(44)48-8-52-36(20)60)3-77-88(71,72)83-26-22(62)14(1-75-86(66,67)68)80-38(26)58-10-54-18-30(42)46-6-50-34(18)58/h5-16,21-28,37-40,61-65H,1-4H2,(H,69,70)(H,71,72)(H,73,74)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,66,67,68)/p-4/t13-,14-,15-,16-,21-,22-,23-,24-,25-,26-,27-,28-,37-,38-,39-,40-/m1/s1
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n/an/an/an/a 9.70n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage


Bioorg Med Chem Lett 20: 1186-8 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.005
BindingDB Entry DOI: 10.7270/Q2G73DVP
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50183322
PNG
(CHEMBL601940)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C40H50N20O25P4/c41-29-17-33(49-5-45-29)57(9-53-17)37-25(65)21(61)13(79-37)2-76-87(69,70)84-27-23(63)15(81-39(27)59-11-55-19-31(43)47-7-51-35(19)59)4-78-89(73,74)85-28-24(64)16(82-40(28)60-12-56-20-32(44)48-8-52-36(20)60)3-77-88(71,72)83-26-22(62)14(1-75-86(66,67)68)80-38(26)58-10-54-18-30(42)46-6-50-34(18)58/h5-16,21-28,37-40,61-65H,1-4H2,(H,69,70)(H,71,72)(H,73,74)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,66,67,68)/t13-,14-,15-,16-,21-,22-,23-,24-,25-,26-,27-,28-,37-,38-,39-,40-/m1/s1
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n/an/an/an/a 13n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...


Bioorg Med Chem 24: 3870-4 (2016)


Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388148
PNG
(CHEMBL2058764)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COCP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)14(80-38)1-76-13-87(67,68)84-27-23(63)16(82-39(27)59-10-55-19-31(43)47-6-51-35(19)59)3-78-89(72,73)86-29-25(65)17(83-41(29)61-12-57-21-33(45)49-8-53-37(21)61)4-79-90(74,75)85-28-24(64)15(2-77-88(69,70)71)81-40(28)60-11-56-20-32(44)48-7-52-36(20)60/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a 15n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Bioorg Med Chem Lett 22: 181-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.040
BindingDB Entry DOI: 10.7270/Q2H1332W
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085557
PNG
(CHEMBL407239 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C33H44N15O19P3/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(63-31)5-61-69(56,57)67-24-21(51)15(65-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48)6-62-70(58,59)66-23-20(50)14(4-60-68(53,54)55)64-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1
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n/an/an/an/a 16n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50152834
PNG
(2''-5--oligoadenylate derivative | [(2R,3R,4R,5R)-...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP([O-])(=O)O[C@@H]2[C@H](O)[C@@H](COP([O-])(=O)O[C@@H]3[C@H](O)[C@@H](COP([O-])(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)([O-])=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C40H50N20O25P4/c41-29-17-33(49-5-45-29)57(9-53-17)37-25(65)21(61)13(79-37)2-76-87(69,70)84-27-23(63)15(81-39(27)59-11-55-19-31(43)47-7-51-35(19)59)4-78-89(73,74)85-28-24(64)16(82-40(28)60-12-56-20-32(44)48-8-52-36(20)60)3-77-88(71,72)83-26-22(62)14(1-75-86(66,67)68)80-38(26)58-10-54-18-30(42)46-6-50-34(18)58/h5-16,21-28,37-40,61-65H,1-4H2,(H,69,70)(H,71,72)(H,73,74)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,66,67,68)/p-4/t13-,14-,15-,16-,21-,22-,23-,24-,25-,26-,27-,28-,37-,38-,39-,40-/m1/s1
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n/an/an/an/a 17n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Bioorg Med Chem Lett 22: 181-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.040
BindingDB Entry DOI: 10.7270/Q2H1332W
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50438547
PNG
(CHEMBL2414866)
Show SMILES CC(C)(C)C(=O)OCO[C@@H]1[C@@H](COP(O)(=O)O[C@@H]2[C@H](OCOC(=O)C(C)(C)C)[C@@H](COP(O)(=O)O[C@@H]3[C@H](OCOC(=O)C(C)(C)C)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]3n3cnc4ncnc(N)c34)O[C@H]2n2cnc3ncnc(N)c23)O[C@H]([C@@H]1O)n1cnc2ncnc(N)c12
Show InChI InChI=1S/C48H70N15O31P5/c1-46(2,3)43(65)82-19-79-29-22(88-40(28(29)64)61-16-58-37-25(61)34(49)52-13-55-37)10-85-96(71,72)91-32-30(80-20-83-44(66)47(4,5)6)23(89-41(32)62-17-59-38-26(62)35(50)53-14-56-38)11-86-97(73,74)92-33-31(81-21-84-45(67)48(7,8)9)24(12-87-98(75,76)94-99(77,78)93-95(68,69)70)90-42(33)63-18-60-39-27(63)36(51)54-15-57-39/h13-18,22-24,28-33,40-42,64H,10-12,19-21H2,1-9H3,(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H2,49,52,55)(H2,50,53,56)(H2,51,54,57)(H2,68,69,70)/t22-,23-,24-,28-,29-,30-,31-,32-,33-,40-,41-,42-/m1/s1
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n/an/an/an/a 19n/an/an/an/a



Universit£ Montpellier 2

Curated by ChEMBL


Assay Description
Activation of human recombinant RNase L endonuclease activity using 6-FAM-UUA UCA AAU UCU UAU UUG CCC CAU UUU UUU GGU UUA-BHQ-1 as substrate assessed...


Bioorg Med Chem 21: 5461-9 (2013)


Article DOI: 10.1016/j.bmc.2013.06.008
BindingDB Entry DOI: 10.7270/Q2474C8X
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50183269
PNG
(CHEMBL3818726)
Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@@H](CO)O[C@H]([C@@H]4O)n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H51N20O22P3/c1-13-57-21-33(45)49-9-53-37(21)61(13)39-25(66)22(63)15(78-39)3-74-85(70,71)82-28-24(65)17(80-40(28)59-11-55-19-31(43)47-7-51-35(19)59)5-76-86(72,73)83-29-23(64)16(79-41(29)60-12-56-20-32(44)48-8-52-36(20)60)4-75-84(68,69)81-27-14(2-62)77-38(26(27)67)58-10-54-18-30(42)46-6-50-34(18)58/h6-12,14-17,22-29,38-41,62-67H,2-5H2,1H3,(H,68,69)(H,70,71)(H,72,73)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a 20n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...


Bioorg Med Chem 24: 3870-4 (2016)


Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50085557
PNG
(CHEMBL407239 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C33H44N15O19P3/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(63-31)5-61-69(56,57)67-24-21(51)15(65-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48)6-62-70(58,59)66-23-20(50)14(4-60-68(53,54)55)64-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1
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n/an/an/an/a 30n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50309127
PNG
(CHEMBL601939 | {[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)...)
Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](CO)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C41H51N20O22P3/c1-13-57-21-33(45)49-9-53-37(21)61(13)41-29(83-86(72,73)74-3-15-22(63)26(67)38(78-15)58-10-54-18-30(42)46-6-50-34(18)58)25(66)17(80-41)5-76-85(70,71)82-28-24(65)16(79-40(28)60-12-56-20-32(44)48-8-52-36(20)60)4-75-84(68,69)81-27-23(64)14(2-62)77-39(27)59-11-55-19-31(43)47-7-51-35(19)59/h6-12,14-17,22-29,38-41,62-67H,2-5H2,1H3,(H,68,69)(H,70,71)(H,72,73)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a>50n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage


Bioorg Med Chem Lett 20: 1186-8 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.005
BindingDB Entry DOI: 10.7270/Q2G73DVP
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50309128
PNG
(CHEMBL591445 | {[(2R,3R,4R,5R)-4-[({[(2R,3S,4R,5R)...)
Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](CO)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C31H39N15O16P2/c1-10-43-16-25(34)37-7-40-28(16)46(10)29-20(51)17(48)12(59-29)3-56-63(52,53)62-22-19(50)13(60-31(22)45-9-42-15-24(33)36-6-39-27(15)45)4-57-64(54,55)61-21-18(49)11(2-47)58-30(21)44-8-41-14-23(32)35-5-38-26(14)44/h5-9,11-13,17-22,29-31,47-51H,2-4H2,1H3,(H,52,53)(H,54,55)(H2,32,35,38)(H2,33,36,39)(H2,34,37,40)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
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n/an/an/an/a>50n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage


Bioorg Med Chem Lett 20: 1186-8 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.005
BindingDB Entry DOI: 10.7270/Q2G73DVP
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388145
PNG
(CHEMBL2057900)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COCP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)15(80-38)2-77-88(70,71)85-28-24(64)17(82-40(28)60-11-56-20-32(44)48-7-52-36(20)60)4-79-90(74,75)86-29-25(65)16(83-41(29)61-12-57-21-33(45)49-8-53-37(21)61)3-78-89(72,73)84-27-23(63)14(1-76-13-87(67,68)69)81-39(27)59-10-55-19-31(43)47-6-51-35(19)59/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,70,71)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,67,68,69)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a 53n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Bioorg Med Chem Lett 22: 181-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.040
BindingDB Entry DOI: 10.7270/Q2H1332W
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50183278
PNG
(CHEMBL3819262)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4ccc(=O)[nH]c4=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C39H49N17O27P4/c40-29-18-32(46-7-43-29)54(10-49-18)35-25(62)21(58)13(77-35)4-74-85(67,68)82-27-23(60)16(80-37(27)55-11-50-19-30(41)44-8-47-33(19)55)6-76-87(71,72)83-28-24(61)15(79-38(28)56-12-51-20-31(42)45-9-48-34(20)56)5-75-86(69,70)81-26-22(59)14(3-73-84(64,65)66)78-36(26)53-2-1-17(57)52-39(53)63/h1-2,7-16,21-28,35-38,58-62H,3-6H2,(H,67,68)(H,69,70)(H,71,72)(H2,40,43,46)(H2,41,44,47)(H2,42,45,48)(H,52,57,63)(H2,64,65,66)/t13-,14-,15-,16-,21-,22-,23-,24-,25-,26-,27-,28-,35-,36-,37-,38-/m1/s1
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n/an/an/an/a 84n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...


Bioorg Med Chem 24: 3870-4 (2016)


Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50183268
PNG
(CHEMBL3818137)
Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@@H](CO)O[C@H]([C@@H]4O)n4ccc(=O)[nH]c4=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C40H50N17O24P3/c1-13-52-21-32(43)46-10-49-35(21)57(13)37-25(63)22(60)15(76-37)5-72-83(68,69)80-28-24(62)17(78-38(28)55-11-50-19-30(41)44-8-47-33(19)55)7-74-84(70,71)81-29-23(61)16(77-39(29)56-12-51-20-31(42)45-9-48-34(20)56)6-73-82(66,67)79-27-14(4-58)75-36(26(27)64)54-3-2-18(59)53-40(54)65/h2-3,8-12,14-17,22-29,36-39,58,60-64H,4-7H2,1H3,(H,66,67)(H,68,69)(H,70,71)(H2,41,44,47)(H2,42,45,48)(H2,43,46,49)(H,53,59,65)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,36-,37-,38-,39-/m1/s1
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n/an/an/an/a 134n/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor...


Bioorg Med Chem 24: 3870-4 (2016)


Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388159
PNG
(CHEMBL2058187)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CO[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)14(81-38)1-77-87(67,68)13-76-27-23(63)16(82-39(27)59-10-55-19-31(43)47-6-51-35(19)59)3-79-89(72,73)86-29-25(65)17(84-41(29)61-12-57-21-33(45)49-8-53-37(21)61)4-80-90(74,75)85-28-24(64)15(2-78-88(69,70)71)83-40(28)60-11-56-20-32(44)48-7-52-36(20)60/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a 200n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Bioorg Med Chem Lett 22: 181-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.040
BindingDB Entry DOI: 10.7270/Q2H1332W
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50438546
PNG
(CHEMBL2414865)
Show SMILES CC(C)(C)C(=O)OCO[C@@H]1[C@@H](COP(O)(=O)O[C@@H]2[C@H](OCOC(=O)C(C)(C)C)[C@@H](COP(O)(=O)O[C@@H]3[C@H](OCOC(=O)C(C)(C)C)[C@@H](COP(O)(=O)O[C@@H]4[C@H](OCOC(=O)C(C)(C)C)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]4n4cnc5ncnc(N)c45)O[C@H]3n3cnc4ncnc(N)c34)O[C@H]2n2cnc3ncnc(N)c23)O[C@H]([C@@H]1O)n1cnc2ncnc(N)c12
Show InChI InChI=1S/C64H92N20O39P6/c1-61(2,3)57(86)107-25-103-38-29(115-53(37(38)85)81-21-77-49-33(81)45(65)69-17-73-49)13-111-125(93,94)119-42-39(104-26-108-58(87)62(4,5)6)30(116-54(42)82-22-78-50-34(82)46(66)70-18-74-50)14-112-126(95,96)120-43-40(105-27-109-59(88)63(7,8)9)31(117-55(43)83-23-79-51-35(83)47(67)71-19-75-51)15-113-127(97,98)121-44-41(106-28-110-60(89)64(10,11)12)32(16-114-128(99,100)123-129(101,102)122-124(90,91)92)118-56(44)84-24-80-52-36(84)48(68)72-20-76-52/h17-24,29-32,37-44,53-56,85H,13-16,25-28H2,1-12H3,(H,93,94)(H,95,96)(H,97,98)(H,99,100)(H,101,102)(H2,65,69,73)(H2,66,70,74)(H2,67,71,75)(H2,68,72,76)(H2,90,91,92)/t29-,30-,31-,32-,37-,38-,39-,40-,41-,42-,43-,44-,53-,54-,55-,56-/m1/s1
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n/an/an/an/a 241n/an/an/an/a



Universit£ Montpellier 2

Curated by ChEMBL


Assay Description
Activation of human recombinant RNase L endonuclease activity using 6-FAM-UUA UCA AAU UCU UAU UUG CCC CAU UUU UUU GGU UUA-BHQ-1 as substrate assessed...


Bioorg Med Chem 21: 5461-9 (2013)


Article DOI: 10.1016/j.bmc.2013.06.008
BindingDB Entry DOI: 10.7270/Q2474C8X
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388151
PNG
(CHEMBL2058191)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COCP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)15(80-38)3-78-89(72,73)85-28-23(63)14(81-40(28)60-11-56-20-32(44)48-7-52-36(20)60)1-76-13-87(67,68)84-27-24(64)17(83-39(27)59-10-55-19-31(43)47-6-51-35(19)59)4-79-90(74,75)86-29-25(65)16(2-77-88(69,70)71)82-41(29)61-12-57-21-33(45)49-8-53-37(21)61/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a 300n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Bioorg Med Chem Lett 22: 181-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.040
BindingDB Entry DOI: 10.7270/Q2H1332W
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388163
PNG
(CHEMBL2058183)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)CO[C@@H]4[C@@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)14(81-38)3-79-89(72,73)86-29-25(65)17(84-41(29)61-12-57-21-33(45)49-8-53-37(21)61)4-80-90(74,75)85-28-24(64)15(83-40(28)60-11-56-20-32(44)48-7-52-36(20)60)1-77-87(67,68)13-76-27-23(63)16(2-78-88(69,70)71)82-39(27)59-10-55-19-31(43)47-6-51-35(19)59/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23+,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a 300n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Bioorg Med Chem Lett 22: 181-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.040
BindingDB Entry DOI: 10.7270/Q2H1332W
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388155
PNG
(CHEMBL2057902)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@@H](O)[C@@H](COCP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)15(80-38)2-77-88(70,71)85-28-24(64)17(82-40(28)60-11-56-20-32(44)48-7-52-36(20)60)4-79-90(74,75)86-29-25(65)16(83-41(29)61-12-57-21-33(45)49-8-53-37(21)61)3-78-89(72,73)84-27-23(63)14(1-76-13-87(67,68)69)81-39(27)59-10-55-19-31(43)47-6-51-35(19)59/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,70,71)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,67,68,69)/t14-,15-,16-,17-,22-,23+,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a 300n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Bioorg Med Chem Lett 22: 181-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.040
BindingDB Entry DOI: 10.7270/Q2H1332W
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50189860
PNG
(CHEMBL261902 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1OP(O)(O)=O
Show InChI InChI=1S/C40H51N20O28P5/c41-29-17-33(49-5-45-29)57(9-53-17)37-25(85-90(68,69)70)21(61)14(82-37)2-78-91(71,72)87-27-23(63)16(84-39(27)59-11-55-19-31(43)47-7-51-35(19)59)4-80-93(75,76)88-28-24(64)15(83-40(28)60-12-56-20-32(44)48-8-52-36(20)60)3-79-92(73,74)86-26-22(62)13(1-77-89(65,66)67)81-38(26)58-10-54-18-30(42)46-6-50-34(18)58/h5-16,21-28,37-40,61-64H,1-4H2,(H,71,72)(H,73,74)(H,75,76)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,65,66,67)(H2,68,69,70)/t13-,14-,15-,16-,21-,22+,23+,24-,25-,26-,27-,28-,37-,38-,39-,40-/m1/s1
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n/an/an/an/a 323n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7)


J Med Chem 49: 3955-62 (2006)


Article DOI: 10.1021/jm050401v
BindingDB Entry DOI: 10.7270/Q2X066N8
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50189858
PNG
(CHEMBL434553 | {[(2R,3R,4R,5R)-5-(6-amino-9H-purin...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1OP(O)(O)=O
Show InChI InChI=1S/C40H51N20O28P5/c41-29-17-33(49-5-45-29)57(9-53-17)37-25(85-90(68,69)70)21(61)14(82-37)2-78-91(71,72)87-27-23(63)16(84-39(27)59-11-55-19-31(43)47-7-51-35(19)59)4-80-93(75,76)88-28-24(64)15(83-40(28)60-12-56-20-32(44)48-8-52-36(20)60)3-79-92(73,74)86-26-22(62)13(1-77-89(65,66)67)81-38(26)58-10-54-18-30(42)46-6-50-34(18)58/h5-16,21-28,37-40,61-64H,1-4H2,(H,71,72)(H,73,74)(H,75,76)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,65,66,67)(H2,68,69,70)/t13-,14-,15-,16-,21-,22-,23+,24+,25-,26-,27-,28-,37-,38-,39-,40-/m1/s1
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n/an/an/an/a 393n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7)


J Med Chem 49: 3955-62 (2006)


Article DOI: 10.1021/jm050401v
BindingDB Entry DOI: 10.7270/Q2X066N8
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50189863
PNG
(CHEMBL439290 | {[(2R,3S,4R,5R)-5-(6-amino-9H-purin...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1OP(O)(O)=O
Show InChI InChI=1S/C40H51N20O28P5/c41-29-17-33(49-5-45-29)57(9-53-17)37-25(85-90(68,69)70)21(61)14(82-37)2-78-91(71,72)87-27-23(63)16(84-39(27)59-11-55-19-31(43)47-7-51-35(19)59)4-80-93(75,76)88-28-24(64)15(83-40(28)60-12-56-20-32(44)48-8-52-36(20)60)3-79-92(73,74)86-26-22(62)13(1-77-89(65,66)67)81-38(26)58-10-54-18-30(42)46-6-50-34(18)58/h5-16,21-28,37-40,61-64H,1-4H2,(H,71,72)(H,73,74)(H,75,76)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,65,66,67)(H2,68,69,70)/t13-,14-,15-,16-,21-,22+,23-,24-,25-,26-,27-,28-,37-,38-,39-,40-/m1/s1
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n/an/an/an/a 396n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of mouse RNase L assessed as ability to cleave 5'-[32P]r(C11U2C7)


J Med Chem 49: 3955-62 (2006)


Article DOI: 10.1021/jm050401v
BindingDB Entry DOI: 10.7270/Q2X066N8
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388149
PNG
(CHEMBL2058763)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@@H](O)[C@@H](COCP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)15(80-38)3-78-89(72,73)85-28-23(63)14(81-40(28)60-11-56-20-32(44)48-7-52-36(20)60)1-76-13-87(67,68)84-27-24(64)17(83-39(27)59-10-55-19-31(43)47-6-51-35(19)59)4-79-90(74,75)86-29-25(65)16(2-77-88(69,70)71)82-41(29)61-12-57-21-33(45)49-8-53-37(21)61/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23+,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Bioorg Med Chem Lett 22: 181-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.040
BindingDB Entry DOI: 10.7270/Q2H1332W
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388150
PNG
(CHEMBL2058192)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@H]2[C@H](O)[C@@H](COCP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)15(80-38)3-78-89(72,73)85-28-23(63)14(81-40(28)60-11-56-20-32(44)48-7-52-36(20)60)1-76-13-87(67,68)84-27-24(64)17(83-39(27)59-10-55-19-31(43)47-6-51-35(19)59)4-79-90(74,75)86-29-25(65)16(2-77-88(69,70)71)82-41(29)61-12-57-21-33(45)49-8-53-37(21)61/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28+,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Bioorg Med Chem Lett 22: 181-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.040
BindingDB Entry DOI: 10.7270/Q2H1332W
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens)
BDBM50388152
PNG
(CHEMBL2058190)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@@H](O)[C@@H](COCP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C41H52N20O25P4/c42-30-18-34(50-5-46-30)58(9-54-18)38-26(66)22(62)15(80-38)3-78-89(72,73)86-29-25(65)17(83-41(29)61-12-57-21-33(45)49-8-53-37(21)61)4-79-90(74,75)85-28-23(63)14(81-40(28)60-11-56-20-32(44)48-7-52-36(20)60)1-76-13-87(67,68)84-27-24(64)16(2-77-88(69,70)71)82-39(27)59-10-55-19-31(43)47-6-51-35(19)59/h5-12,14-17,22-29,38-41,62-66H,1-4,13H2,(H,67,68)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,69,70,71)/t14-,15-,16-,17-,22-,23+,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Activation of human RNase L expressed in Escherichia coli BL21 (DE3) cells assessed as RNA cleavage using Cy5-rC11-UU-C7-BHQ2 as substrate by FRET as...


Bioorg Med Chem Lett 22: 181-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.040
BindingDB Entry DOI: 10.7270/Q2H1332W
More data for this
Ligand-Target Pair
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