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Compile Data Set for Download or QSAR

Found 103 hits of ec50 data for polymerid = 50006345   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205410
PNG
(CHEMBL3970245)
Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H,18H2,(H,28,29,33)
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n/an/an/an/a 0.0800n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205500
PNG
(CHEMBL3933984)
Show SMILES Fc1cnccc1-c1nnn(CC(=O)Nc2ccc(cn2)-c2ccccc2)c1-c1ccccc1
Show InChI InChI=1S/C26H19FN6O/c27-22-16-28-14-13-21(22)25-26(19-9-5-2-6-10-19)33(32-31-25)17-24(34)30-23-12-11-20(15-29-23)18-7-3-1-4-8-18/h1-16H,17H2,(H,29,30,34)
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n/an/an/an/a 0.130n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205473
PNG
(CHEMBL3952126)
Show SMILES Cc1cnccc1-c1nnn(CC(=O)Nc2ccc(cn2)-c2ccccc2)c1-c1ccccc1
Show InChI InChI=1S/C27H22N6O/c1-19-16-28-15-14-23(19)26-27(21-10-6-3-7-11-21)33(32-31-26)18-25(34)30-24-13-12-22(17-29-24)20-8-4-2-5-9-20/h2-17H,18H2,1H3,(H,29,30,34)
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n/an/an/an/a 0.140n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205493
PNG
(CHEMBL3952665)
Show SMILES COc1ccc(cc1)-c1c(nnn1CC(=O)Nc1ccc(cn1)-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C27H22N6O2/c1-35-23-10-7-21(8-11-23)27-26(20-13-15-28-16-14-20)31-32-33(27)18-25(34)30-24-12-9-22(17-29-24)19-5-3-2-4-6-19/h2-17H,18H2,1H3,(H,29,30,34)
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n/an/an/an/a 0.180n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205479
PNG
(CHEMBL3925918)
Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(nc1)-c1ccccc1
Show InChI InChI=1S/C26H20N6O/c33-24(29-22-11-12-23(28-17-22)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H,18H2,(H,29,33)
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n/an/an/an/a 0.200n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205491
PNG
(CHEMBL3899701)
Show SMILES Fc1ccc(cc1)-c1c(nnn1CC(=O)Nc1ccc(cn1)-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C26H19FN6O/c27-22-9-6-20(7-10-22)26-25(19-12-14-28-15-13-19)31-32-33(26)17-24(34)30-23-11-8-21(16-29-23)18-4-2-1-3-5-18/h1-16H,17H2,(H,29,30,34)
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n/an/an/an/a 0.200n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205482
PNG
(CHEMBL3943764)
Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cn1)-c1cccs1
Show InChI InChI=1S/C24H18N6OS/c31-22(27-21-9-8-19(15-26-21)20-7-4-14-32-20)16-30-24(18-5-2-1-3-6-18)23(28-29-30)17-10-12-25-13-11-17/h1-15H,16H2,(H,26,27,31)
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n/an/an/an/a 0.260n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428001
PNG
(CHEMBL2322627)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1cccs1
Show InChI InChI=1S/C23H18N4O2S3/c28-20(26-19-9-8-15(13-24-19)18-7-4-11-30-18)14-32-23-25-17-10-12-31-21(17)22(29)27(23)16-5-2-1-3-6-16/h1-9,11,13H,10,12,14H2,(H,24,26,28)
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n/an/an/an/a 0.300n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205483
PNG
(CHEMBL3935037)
Show SMILES FC(F)(F)c1ccc(cc1)-c1c(nnn1CC(=O)Nc1ccc(cn1)-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C27H19F3N6O/c28-27(29,30)22-9-6-20(7-10-22)26-25(19-12-14-31-15-13-19)34-35-36(26)17-24(37)33-23-11-8-21(16-32-23)18-4-2-1-3-5-18/h1-16H,17H2,(H,32,33,37)
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n/an/an/an/a 0.300n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428009
PNG
(CHEMBL2323230)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(nc1)-c1ccccc1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(27-18-11-12-20(26-15-18)17-7-3-1-4-8-17)16-33-25-28-21-13-14-32-23(21)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,27,30)
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n/an/an/an/a 0.300n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205471
PNG
(CHEMBL3927718)
Show SMILES Cc1cccc(c1)-c1c(nnn1CC(=O)Nc1ccc(cn1)-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C27H22N6O/c1-19-6-5-9-22(16-19)27-26(21-12-14-28-15-13-21)31-32-33(27)18-25(34)30-24-11-10-23(17-29-24)20-7-3-2-4-8-20/h2-17H,18H2,1H3,(H,29,30,34)
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n/an/an/an/a 0.400n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205481
PNG
(CHEMBL3952501)
Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cn1)-c1ccco1
Show InChI InChI=1S/C24H18N6O2/c31-22(27-21-9-8-19(15-26-21)20-7-4-14-32-20)16-30-24(18-5-2-1-3-6-18)23(28-29-30)17-10-12-25-13-11-17/h1-15H,16H2,(H,26,27,31)
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n/an/an/an/a 0.400n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205474
PNG
(CHEMBL3892208)
Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H21N5O/c33-25(29-24-13-11-21(12-14-24)20-7-3-1-4-8-20)19-32-27(23-9-5-2-6-10-23)26(30-31-32)22-15-17-28-18-16-22/h1-18H,19H2,(H,29,33)
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n/an/an/an/a 0.430n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428011
PNG
(CHEMBL2323228)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(27-19-10-8-17(9-11-19)18-5-4-13-26-15-18)16-33-25-28-21-12-14-32-23(21)24(31)29(25)20-6-2-1-3-7-20/h1-11,13,15H,12,14,16H2,(H,27,30)
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n/an/an/an/a 0.450n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205469
PNG
(CHEMBL3897216)
Show SMILES O=C(Cn1nnc(c1-c1ccc(cc1)C#N)-c1ccncc1)Nc1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C27H19N7O/c28-16-19-6-8-22(9-7-19)27-26(21-12-14-29-15-13-21)32-33-34(27)18-25(35)31-24-11-10-23(17-30-24)20-4-2-1-3-5-20/h1-15,17H,18H2,(H,30,31,35)
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n/an/an/an/a 0.480n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428008
PNG
(CHEMBL2323231)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(28-21-12-11-18(15-26-21)17-7-3-1-4-8-17)16-33-25-27-20-13-14-32-23(20)24(31)29(25)19-9-5-2-6-10-19/h1-12,15H,13-14,16H2,(H,26,28,30)
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n/an/an/an/a 0.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205558
PNG
(CHEMBL3953544)
Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cn1)-c1ccoc1
Show InChI InChI=1S/C24H18N6O2/c31-22(27-21-7-6-19(14-26-21)20-10-13-32-16-20)15-30-24(18-4-2-1-3-5-18)23(28-29-30)17-8-11-25-12-9-17/h1-14,16H,15H2,(H,26,27,31)
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n/an/an/an/a 0.600n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205496
PNG
(CHEMBL3980962)
Show SMILES FC(F)(F)c1cc(ccn1)-c1nnn(CC(=O)Nc2ccc(cn2)-c2ccccc2)c1-c1ccccc1
Show InChI InChI=1S/C27H19F3N6O/c28-27(29,30)22-15-20(13-14-31-22)25-26(19-9-5-2-6-10-19)36(35-34-25)17-24(37)33-23-12-11-21(16-32-23)18-7-3-1-4-8-18/h1-16H,17H2,(H,32,33,37)
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n/an/an/an/a 0.600n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205498
PNG
(CHEMBL3981277)
Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cn1)-c1ccsc1
Show InChI InChI=1S/C24H18N6OS/c31-22(27-21-7-6-19(14-26-21)20-10-13-32-16-20)15-30-24(18-4-2-1-3-5-18)23(28-29-30)17-8-11-25-12-9-17/h1-14,16H,15H2,(H,26,27,31)
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n/an/an/an/a 0.650n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205497
PNG
(CHEMBL3907204)
Show SMILES CCOC(=O)c1ccc(cc1)-c1c(nnn1CC(=O)Nc1ccc(cn1)-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C29H24N6O3/c1-2-38-29(37)23-10-8-22(9-11-23)28-27(21-14-16-30-17-15-21)33-34-35(28)19-26(36)32-25-13-12-24(18-31-25)20-6-4-3-5-7-20/h3-18H,2,19H2,1H3,(H,31,32,36)
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n/an/an/an/a 0.700n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428015
PNG
(CHEMBL2322632)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C26H21N3O2S2/c30-23(27-20-13-11-19(12-14-20)18-7-3-1-4-8-18)17-33-26-28-22-15-16-32-24(22)25(31)29(26)21-9-5-2-6-10-21/h1-14H,15-17H2,(H,27,30)
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n/an/an/an/a 0.75n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428006
PNG
(CHEMBL2323233)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1cccnc1
Show InChI InChI=1S/C24H19N5O2S2/c30-21(28-20-9-8-17(14-26-20)16-5-4-11-25-13-16)15-33-24-27-19-10-12-32-22(19)23(31)29(24)18-6-2-1-3-7-18/h1-9,11,13-14H,10,12,15H2,(H,26,28,30)
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n/an/an/an/a 1n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428000
PNG
(CHEMBL2322628)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ncc(cn1)-c1ccoc1
Show InChI InChI=1S/C22H17N5O3S2/c28-18(26-21-23-10-15(11-24-21)14-6-8-30-12-14)13-32-22-25-17-7-9-31-19(17)20(29)27(22)16-4-2-1-3-5-16/h1-6,8,10-12H,7,9,13H2,(H,23,24,26,28)
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n/an/an/an/a 1.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428004
PNG
(CHEMBL2322624)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccoc1
Show InChI InChI=1S/C23H18N4O3S2/c28-20(26-19-7-6-15(12-24-19)16-8-10-30-13-16)14-32-23-25-18-9-11-31-21(18)22(29)27(23)17-4-2-1-3-5-17/h1-8,10,12-13H,9,11,14H2,(H,24,26,28)
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n/an/an/an/a 1.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205489
PNG
(CHEMBL3943114)
Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C26H20N6O/c33-24(29-22-11-9-19(10-12-22)23-8-4-5-15-28-23)18-32-26(21-6-2-1-3-7-21)25(30-31-32)20-13-16-27-17-14-20/h1-17H,18H2,(H,29,33)
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n/an/an/an/a 1.80n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205495
PNG
(CHEMBL3905849)
Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cn1)-c1cncnc1
Show InChI InChI=1S/C24H18N8O/c33-22(29-21-7-6-19(14-28-21)20-12-26-16-27-13-20)15-32-24(18-4-2-1-3-5-18)23(30-31-32)17-8-10-25-11-9-17/h1-14,16H,15H2,(H,28,29,33)
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n/an/an/an/a 1.80n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428002
PNG
(CHEMBL2322626)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccsc1
Show InChI InChI=1S/C23H18N4O2S3/c28-20(26-19-7-6-15(12-24-19)16-8-10-30-13-16)14-32-23-25-18-9-11-31-21(18)22(29)27(23)17-4-2-1-3-5-17/h1-8,10,12-13H,9,11,14H2,(H,24,26,28)
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n/an/an/an/a 2n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205562
PNG
(CHEMBL3893457)
Show SMILES CC(C(=O)Nc1ccc(cn1)-c1ccccc1)n1nnc(c1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C27H22N6O/c1-19(27(34)30-24-13-12-23(18-29-24)20-8-4-2-5-9-20)33-26(22-10-6-3-7-11-22)25(31-32-33)21-14-16-28-17-15-21/h2-19H,1H3,(H,29,30,34)
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n/an/an/an/a 3n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428010
PNG
(CHEMBL2323229)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(27-19-8-6-17(7-9-19)18-10-13-26-14-11-18)16-33-25-28-21-12-15-32-23(21)24(31)29(25)20-4-2-1-3-5-20/h1-11,13-14H,12,15-16H2,(H,27,30)
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n/an/an/an/a 3n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428003
PNG
(CHEMBL2322625)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1ccco1
Show InChI InChI=1S/C23H18N4O3S2/c28-20(26-19-9-8-15(13-24-19)18-7-4-11-30-18)14-32-23-25-17-10-12-31-21(17)22(29)27(23)16-5-2-1-3-6-16/h1-9,11,13H,10,12,14H2,(H,24,26,28)
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n/an/an/an/a 3.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50427999
PNG
(CHEMBL2322629)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ncc(cn1)-c1ccco1
Show InChI InChI=1S/C22H17N5O3S2/c28-18(26-21-23-11-14(12-24-21)17-7-4-9-30-17)13-32-22-25-16-8-10-31-19(16)20(29)27(22)15-5-2-1-3-6-15/h1-7,9,11-12H,8,10,13H2,(H,23,24,26,28)
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n/an/an/an/a 3.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428012
PNG
(CHEMBL2322635)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C25H20N4O2S2/c30-22(27-18-11-9-17(10-12-18)20-8-4-5-14-26-20)16-33-25-28-21-13-15-32-23(21)24(31)29(25)19-6-2-1-3-7-19/h1-12,14H,13,15-16H2,(H,27,30)
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n/an/an/an/a 4n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205487
PNG
(CHEMBL3947115)
Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1cccnc1)Nc1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C26H20N6O/c33-24(29-23-14-13-21(17-28-23)19-8-3-1-4-9-19)18-32-26(20-10-5-2-6-11-20)25(30-31-32)22-12-7-15-27-16-22/h1-17H,18H2,(H,28,29,33)
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n/an/an/an/a 5n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428005
PNG
(CHEMBL2322623)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cn1)-c1cncnc1
Show InChI InChI=1S/C23H18N6O2S2/c30-20(28-19-7-6-15(12-26-19)16-10-24-14-25-11-16)13-33-23-27-18-8-9-32-21(18)22(31)29(23)17-4-2-1-3-5-17/h1-7,10-12,14H,8-9,13H2,(H,26,28,30)
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n/an/an/an/a 5.5n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205470
PNG
(CHEMBL3968025)
Show SMILES O=C(Cn1nnc(c1-c1cccc2ccccc12)-c1ccncc1)Nc1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C30H22N6O/c37-28(33-27-14-13-24(19-32-27)21-7-2-1-3-8-21)20-36-30(29(34-35-36)23-15-17-31-18-16-23)26-12-6-10-22-9-4-5-11-25(22)26/h1-19H,20H2,(H,32,33,37)
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n/an/an/an/a 6.5n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205503
PNG
(CHEMBL3954145)
Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C26H20N6O/c33-24(29-23-8-6-19(7-9-23)20-10-14-27-15-11-20)18-32-26(22-4-2-1-3-5-22)25(30-31-32)21-12-16-28-17-13-21/h1-17H,18H2,(H,29,33)
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n/an/an/an/a 7n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205501
PNG
(CHEMBL3972297)
Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C26H26N6O/c33-24(28-22-9-11-23(12-10-22)31-17-5-2-6-18-31)19-32-26(21-7-3-1-4-8-21)25(29-30-32)20-13-15-27-16-14-20/h1,3-4,7-16H,2,5-6,17-19H2,(H,28,33)
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n/an/an/an/a 8n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205476
PNG
(CHEMBL3982830)
Show SMILES O=C(Cn1nnc(c1-c1ccccc1)-c1ccncc1)Nc1ncc(cn1)-c1ccccc1
Show InChI InChI=1S/C25H19N7O/c33-22(29-25-27-15-21(16-28-25)18-7-3-1-4-8-18)17-32-24(20-9-5-2-6-10-20)23(30-31-32)19-11-13-26-14-12-19/h1-16H,17H2,(H,27,28,29,33)
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n/an/an/an/a 8n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205480
PNG
(CHEMBL3936691)
Show SMILES COc1ccccc1-c1c(nnn1CC(=O)Nc1ccc(cn1)-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C27H22N6O2/c1-35-23-10-6-5-9-22(23)27-26(20-13-15-28-16-14-20)31-32-33(27)18-25(34)30-24-12-11-21(17-29-24)19-7-3-2-4-8-19/h2-17H,18H2,1H3,(H,29,30,34)
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n/an/an/an/a 9n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205485
PNG
(CHEMBL3926685)
Show SMILES O=C(Cn1cc(nn1)-c1ccncc1)Nc1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C20H16N6O/c27-20(14-26-13-18(24-25-26)16-8-10-21-11-9-16)23-19-7-6-17(12-22-19)15-4-2-1-3-5-15/h1-13H,14H2,(H,22,23,27)
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n/an/an/an/a 9n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205445
PNG
(CHEMBL3959152)
Show SMILES CCC(C(=O)Nc1ccc(cn1)-c1ccccc1)n1nnc(c1-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C28H24N6O/c1-2-24(28(35)31-25-14-13-23(19-30-25)20-9-5-3-6-10-20)34-27(22-11-7-4-8-12-22)26(32-33-34)21-15-17-29-18-16-21/h3-19,24H,2H2,1H3,(H,30,31,35)
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n/an/an/an/a 12n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM37088
PNG
(2-[(3,6-dimethyl-4-oxidanylidene-6,7-dihydrothieno...)
Show SMILES CC1Cc2nc(SCC(=O)Nc3nc4ccc(C)cc4s3)n(C)c(=O)c2S1
Show InChI InChI=1S/C18H18N4O2S3/c1-9-4-5-11-13(6-9)27-17(19-11)21-14(23)8-25-18-20-12-7-10(2)26-15(12)16(24)22(18)3/h4-6,10H,7-8H2,1-3H3,(H,19,21,23)
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n/an/an/an/a 15n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428007
PNG
(CHEMBL2323232)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ncc(cn1)-c1ccccc1
Show InChI InChI=1S/C24H19N5O2S2/c30-20(28-23-25-13-17(14-26-23)16-7-3-1-4-8-16)15-33-24-27-19-11-12-32-21(19)22(31)29(24)18-9-5-2-6-10-18/h1-10,13-14H,11-12,15H2,(H,25,26,28,30)
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n/an/an/an/a 15n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428042
PNG
(CHEMBL2324275)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(Cl)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C25H18ClN5O4S/c1-35-16-9-7-15(8-10-16)31-24(34)18-5-3-2-4-17(18)22(30-31)23(33)27-13-21(32)29-25-28-19-11-6-14(26)12-20(19)36-25/h2-12H,13H2,1H3,(H,27,33)(H,28,29,32)
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n/an/an/an/a 15n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Probable protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50205502
PNG
(CHEMBL3908085)
Show SMILES COc1ccc(cc1)-c1nnn(CC(=O)Nc2ccc(cn2)-c2ccccc2)c1-c1ccccc1
Show InChI InChI=1S/C28H23N5O2/c1-35-24-15-12-21(13-16-24)27-28(22-10-6-3-7-11-22)33(32-31-27)19-26(34)30-25-17-14-23(18-29-25)20-8-4-2-5-9-20/h2-18H,19H2,1H3,(H,29,30,34)
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n/an/an/an/a 18n/an/an/an/a



UT Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signaling in mouse L-cells after 24 hrs by springerImage-Topflash reporter assay


Bioorg Med Chem Lett 26: 5891-5895 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.012
BindingDB Entry DOI: 10.7270/Q2959KJR
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428027
PNG
(CHEMBL1257090)
Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(C)cc3s2)nc2CCSc2c1=O
Show InChI InChI=1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)
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n/an/an/an/a 25n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428043
PNG
(CHEMBL2324274)
Show SMILES Fc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(Cl)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C24H15ClFN5O3S/c25-13-5-10-18-19(11-13)35-24(28-18)29-20(32)12-27-22(33)21-16-3-1-2-4-17(16)23(34)31(30-21)15-8-6-14(26)7-9-15/h1-11H,12H2,(H,27,33)(H,28,29,32)
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n/an/an/an/a 25n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428050
PNG
(CHEMBL2322622)
Show SMILES COc1ccc(cc1)-n1nc(C(=O)NCC(=O)Nc2nc3ccc(C)cc3s2)c2ccccc2c1=O
Show InChI InChI=1S/C26H21N5O4S/c1-15-7-12-20-21(13-15)36-26(28-20)29-22(32)14-27-24(33)23-18-5-3-4-6-19(18)25(34)31(30-23)16-8-10-17(35-2)11-9-16/h3-13H,14H2,1-2H3,(H,27,33)(H,28,29,32)
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n/an/an/an/a 25n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428033
PNG
(CHEMBL2325505)
Show SMILES COc1ccccc1-n1c(SCC(=O)Nc2nc3ccc(cc3s2)C(F)(F)F)nc2CCSc2c1=O
Show InChI InChI=1S/C23H17F3N4O3S3/c1-33-16-5-3-2-4-15(16)30-20(32)19-14(8-9-34-19)28-22(30)35-11-18(31)29-21-27-13-7-6-12(23(24,25)26)10-17(13)36-21/h2-7,10H,8-9,11H2,1H3,(H,27,29,31)
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n/an/an/an/a 30n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
Protein-cysteine N-palmitoyltransferase porcupine


(Mus musculus)
BDBM50428016
PNG
(CHEMBL2323243)
Show SMILES O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(cc1)N1CCCCC1
Show InChI InChI=1S/C25H26N4O2S2/c30-22(26-18-9-11-19(12-10-18)28-14-5-2-6-15-28)17-33-25-27-21-13-16-32-23(21)24(31)29(25)20-7-3-1-4-8-20/h1,3-4,7-12H,2,5-6,13-17H2,(H,26,30)
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n/an/an/an/a 30n/an/an/an/a



The University of Texas Southwestern Medical Center

Curated by ChEMBL


Assay Description
Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay


J Med Chem 56: 2700-4 (2013)


Article DOI: 10.1021/jm400159c
BindingDB Entry DOI: 10.7270/Q2TD9ZP5
More data for this
Ligand-Target Pair
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