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Compile Data Set for Download or QSAR

Found 44 hits of ec50 data for polymerid = 50007309   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231814
PNG
(CHEMBL4078870)
Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(=O)NC23CC4CC(CC(C4)C2)C3)C(F)(F)F)cc1OC
Show InChI InChI=1S/C33H37F3N4O6S/c1-45-26-7-5-20(13-27(26)46-2)18-40-19-24(6-8-30(40)42)25-14-28(33(34,35)36)38-31(37-25)47(43,44)9-3-4-29(41)39-32-15-21-10-22(16-32)12-23(11-21)17-32/h5-8,13-14,19,21-23H,3-4,9-12,15-18H2,1-2H3,(H,39,41)
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n/an/an/an/a 0.230n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing tBid assessed as reduction in apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231814
PNG
(CHEMBL4078870)
Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(=O)NC23CC4CC(CC(C4)C2)C3)C(F)(F)F)cc1OC
Show InChI InChI=1S/C33H37F3N4O6S/c1-45-26-7-5-20(13-27(26)46-2)18-40-19-24(6-8-30(40)42)25-14-28(33(34,35)36)38-31(37-25)47(43,44)9-3-4-29(41)39-32-15-21-10-22(16-32)12-23(11-21)17-32/h5-8,13-14,19,21-23H,3-4,9-12,15-18H2,1-2H3,(H,39,41)
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n/an/an/an/a 0.420n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231783
PNG
(CHEMBL4078220)
Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(=O)N2CCCCC2)C(F)(F)F)cc1OC
Show InChI InChI=1S/C28H31F3N4O6S/c1-40-22-10-8-19(15-23(22)41-2)17-35-18-20(9-11-26(35)37)21-16-24(28(29,30)31)33-27(32-21)42(38,39)14-6-7-25(36)34-12-4-3-5-13-34/h8-11,15-16,18H,3-7,12-14,17H2,1-2H3
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n/an/an/an/a 1.40n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231789
PNG
(CHEMBL4091379)
Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)cc1OC
Show InChI InChI=1S/C20H18F3N3O5S/c1-30-15-6-4-12(8-16(15)31-2)10-26-11-13(5-7-18(26)27)14-9-17(20(21,22)23)25-19(24-14)32(3,28)29/h4-9,11H,10H2,1-3H3
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n/an/an/an/a 25n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231785
PNG
(CHEMBL4064603)
Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(=O)N2CCCC2)C(F)(F)F)cc1OC
Show InChI InChI=1S/C27H29F3N4O6S/c1-39-21-9-7-18(14-22(21)40-2)16-34-17-19(8-10-25(34)36)20-15-23(27(28,29)30)32-26(31-20)41(37,38)13-5-6-24(35)33-11-3-4-12-33/h7-10,14-15,17H,3-6,11-13,16H2,1-2H3
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n/an/an/an/a 27n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231795
PNG
(CHEMBL4070501)
Show SMILES COc1cccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)c1
Show InChI InChI=1S/C19H16F3N3O4S/c1-29-14-5-3-4-12(8-14)10-25-11-13(6-7-17(25)26)15-9-16(19(20,21)22)24-18(23-15)30(2,27)28/h3-9,11H,10H2,1-2H3
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n/an/an/an/a 57n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231821
PNG
(CHEMBL4061878)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C18H13ClF3N3O3S/c1-29(27,28)17-23-14(8-15(24-17)18(20,21)22)12-4-7-16(26)25(10-12)9-11-2-5-13(19)6-3-11/h2-8,10H,9H2,1H3
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n/an/an/an/a 66n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231820
PNG
(CHEMBL4092330)
Show SMILES CCCOc1cccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)c1
Show InChI InChI=1S/C21H20F3N3O4S/c1-3-9-31-16-6-4-5-14(10-16)12-27-13-15(7-8-19(27)28)17-11-18(21(22,23)24)26-20(25-17)32(2,29)30/h4-8,10-11,13H,3,9,12H2,1-2H3
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n/an/an/an/a 69n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231793
PNG
(CHEMBL4082074)
Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)cc1
Show InChI InChI=1S/C19H16F3N3O4S/c1-29-14-6-3-12(4-7-14)10-25-11-13(5-8-17(25)26)15-9-16(19(20,21)22)24-18(23-15)30(2,27)28/h3-9,11H,10H2,1-2H3
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n/an/an/an/a 94n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231794
PNG
(CHEMBL4071549)
Show SMILES CCOc1cccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(C)(=O)=O)C(F)(F)F)c1
Show InChI InChI=1S/C20H18F3N3O4S/c1-3-30-15-6-4-5-13(9-15)11-26-12-14(7-8-18(26)27)16-10-17(20(21,22)23)25-19(24-16)31(2,28)29/h4-10,12H,3,11H2,1-2H3
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n/an/an/an/a 110n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231817
PNG
(CHEMBL4086114)
Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(=O)N(C)C)C(F)(F)F)cc1OC
Show InChI InChI=1S/C25H27F3N4O6S/c1-31(2)22(33)6-5-11-39(35,36)24-29-18(13-21(30-24)25(26,27)28)17-8-10-23(34)32(15-17)14-16-7-9-19(37-3)20(12-16)38-4/h7-10,12-13,15H,5-6,11,14H2,1-4H3
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n/an/an/an/a 164n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231787
PNG
(CHEMBL4093871)
Show SMILES COCCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccc(OC)c(OC)c2)c1
Show InChI InChI=1S/C22H22F3N3O6S/c1-32-8-9-35(30,31)21-26-16(11-19(27-21)22(23,24)25)15-5-7-20(29)28(13-15)12-14-4-6-17(33-2)18(10-14)34-3/h4-7,10-11,13H,8-9,12H2,1-3H3
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n/an/an/an/a 216n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231788
PNG
(CHEMBL4083596)
Show SMILES CCCCCCCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccc(OC)c(OC)c2)c1
Show InChI InChI=1S/C26H30F3N3O5S/c1-4-5-6-7-8-13-38(34,35)25-30-20(15-23(31-25)26(27,28)29)19-10-12-24(33)32(17-19)16-18-9-11-21(36-2)22(14-18)37-3/h9-12,14-15,17H,4-8,13,16H2,1-3H3
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n/an/an/an/a 253n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231797
PNG
(CHEMBL4089942)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2cccc(Cl)c2)c1
Show InChI InChI=1S/C18H13ClF3N3O3S/c1-29(27,28)17-23-14(8-15(24-17)18(20,21)22)12-5-6-16(26)25(10-12)9-11-3-2-4-13(19)7-11/h2-8,10H,9H2,1H3
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n/an/an/an/a 257n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231786
PNG
(CHEMBL4073188)
Show SMILES COCCCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccc(OC)c(OC)c2)c1
Show InChI InChI=1S/C23H24F3N3O6S/c1-33-9-4-10-36(31,32)22-27-17(12-20(28-22)23(24,25)26)16-6-8-21(30)29(14-16)13-15-5-7-18(34-2)19(11-15)35-3/h5-8,11-12,14H,4,9-10,13H2,1-3H3
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n/an/an/an/a 282n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231818
PNG
(CHEMBL4101603)
Show SMILES CCCCCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccc(OC)c(OC)c2)c1
Show InChI InChI=1S/C24H26F3N3O5S/c1-4-5-6-11-36(32,33)23-28-18(13-21(29-23)24(25,26)27)17-8-10-22(31)30(15-17)14-16-7-9-19(34-2)20(12-16)35-3/h7-10,12-13,15H,4-6,11,14H2,1-3H3
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n/an/an/an/a 364n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM31068
PNG
(2-(methylsulfonyl)-4-thien-2-yl-6-(trifluoromethyl...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1cccs1
Show InChI InChI=1S/C10H7F3N2O2S2/c1-19(16,17)9-14-6(7-3-2-4-18-7)5-8(15-9)10(11,12)13/h2-5H,1H3
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n/an/an/an/a 749n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231819
PNG
(CHEMBL4101046)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccc(cc2)C#C)c1
Show InChI InChI=1S/C20H14F3N3O3S/c1-3-13-4-6-14(7-5-13)11-26-12-15(8-9-18(26)27)16-10-17(20(21,22)23)25-19(24-16)30(2,28)29/h1,4-10,12H,11H2,2H3
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n/an/an/an/a 817n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231809
PNG
(CHEMBL4070722)
Show SMILES CCOC(=O)CCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1cccs1
Show InChI InChI=1S/C14H13F3N2O4S2/c1-2-23-12(20)5-7-25(21,22)13-18-9(10-4-3-6-24-10)8-11(19-13)14(15,16)17/h3-4,6,8H,2,5,7H2,1H3
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n/an/an/an/a 1.14E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231798
PNG
(CHEMBL4063455)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccccc2Cl)c1
Show InChI InChI=1S/C18H13ClF3N3O3S/c1-29(27,28)17-23-14(8-15(24-17)18(20,21)22)12-6-7-16(26)25(10-12)9-11-4-2-3-5-13(11)19/h2-8,10H,9H2,1H3
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n/an/an/an/a 1.14E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231799
PNG
(CHEMBL4085084)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccccc2)c1
Show InChI InChI=1S/C18H14F3N3O3S/c1-28(26,27)17-22-14(9-15(23-17)18(19,20)21)13-7-8-16(25)24(11-13)10-12-5-3-2-4-6-12/h2-9,11H,10H2,1H3
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n/an/an/an/a 1.16E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231810
PNG
(CHEMBL4097841)
Show SMILES CCS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1cccs1
Show InChI InChI=1S/C11H9F3N2O2S2/c1-2-20(17,18)10-15-7(8-4-3-5-19-8)6-9(16-10)11(12,13)14/h3-6H,2H2,1H3
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n/an/an/an/a 1.43E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231825
PNG
(CHEMBL4090123)
Show SMILES FC(F)(F)c1cc(nc(n1)S(=O)(=O)CCc1ccccc1)-c1cccs1
Show InChI InChI=1S/C17H13F3N2O2S2/c18-17(19,20)15-11-13(14-7-4-9-25-14)21-16(22-15)26(23,24)10-8-12-5-2-1-3-6-12/h1-7,9,11H,8,10H2
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n/an/an/an/a 1.59E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231796
PNG
(CHEMBL4097672)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2cccc(O)c2)c1
Show InChI InChI=1S/C18H14F3N3O4S/c1-29(27,28)17-22-14(8-15(23-17)18(19,20)21)12-5-6-16(26)24(10-12)9-11-3-2-4-13(25)7-11/h2-8,10,25H,9H2,1H3
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n/an/an/an/a 1.82E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM31063
PNG
(2-(methylsulfonyl)-4-phenyl-6-(trifluoromethyl)pyr...)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C12H9F3N2O2S/c1-20(18,19)11-16-9(8-5-3-2-4-6-8)7-10(17-11)12(13,14)15/h2-7H,1H3
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n/an/an/an/a 2.20E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231803
PNG
(CHEMBL4096202)
Show SMILES Cc1cccc(c1)-c1cc(nc(n1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O2S/c1-8-4-3-5-9(6-8)10-7-11(13(14,15)16)18-12(17-10)21(2,19)20/h3-7H,1-2H3
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n/an/an/an/a 3.49E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231790
PNG
(CHEMBL4063532)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2ccc(cc2)C#N)c1
Show InChI InChI=1S/C19H13F3N4O3S/c1-30(28,29)18-24-15(8-16(25-18)19(20,21)22)14-6-7-17(27)26(11-14)10-13-4-2-12(9-23)3-5-13/h2-8,11H,10H2,1H3
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n/an/an/an/a 3.49E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231811
PNG
(CHEMBL4086039)
Show SMILES COC(=O)c1cccc(c1)-c1cc(nc(n1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O4S/c1-23-12(20)9-5-3-4-8(6-9)10-7-11(14(15,16)17)19-13(18-10)24(2,21)22/h3-7H,1-2H3
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n/an/an/an/a 3.52E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231815
PNG
(CHEMBL4103147)
Show SMILES Cc1ccc(O)c(NC(=O)CCCS(=O)(=O)c2nc(cc(n2)C(F)(F)F)-c2cccs2)c1
Show InChI InChI=1S/C20H18F3N3O4S2/c1-12-6-7-15(27)13(10-12)24-18(28)5-3-9-32(29,30)19-25-14(16-4-2-8-31-16)11-17(26-19)20(21,22)23/h2,4,6-8,10-11,27H,3,5,9H2,1H3,(H,24,28)
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n/an/an/an/a 4.00E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231791
PNG
(CHEMBL4074296)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2cccc(c2)C#N)c1
Show InChI InChI=1S/C19H13F3N4O3S/c1-30(28,29)18-24-15(8-16(25-18)19(20,21)22)14-5-6-17(27)26(11-14)10-13-4-2-3-12(7-13)9-23/h2-8,11H,10H2,1H3
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n/an/an/an/a 4.06E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231808
PNG
(CHEMBL4062092)
Show SMILES FC(F)(F)c1cc(nc(n1)S(=O)(=O)Cc1ccc(cc1)-c1ccccc1)-c1cccs1
Show InChI InChI=1S/C22H15F3N2O2S2/c23-22(24,25)20-13-18(19-7-4-12-30-19)26-21(27-20)31(28,29)14-15-8-10-17(11-9-15)16-5-2-1-3-6-16/h1-13H,14H2
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n/an/an/an/a 4.21E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231792
PNG
(CHEMBL4100077)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)n(Cc2cccc(c2)C#C)c1
Show InChI InChI=1S/C20H14F3N3O3S/c1-3-13-5-4-6-14(9-13)11-26-12-15(7-8-18(26)27)16-10-17(20(21,22)23)25-19(24-16)30(2,28)29/h1,4-10,12H,11H2,2H3
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n/an/an/an/a 4.48E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231802
PNG
(CHEMBL4078150)
Show SMILES Cc1ccc(cc1)-c1cc(nc(n1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O2S/c1-8-3-5-9(6-4-8)10-7-11(13(14,15)16)18-12(17-10)21(2,19)20/h3-7H,1-2H3
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n/an/an/an/a 6.36E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231804
PNG
(CHEMBL4104624)
Show SMILES Cc1ccccc1-c1cc(nc(n1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C13H11F3N2O2S/c1-8-5-3-4-6-9(8)10-7-11(13(14,15)16)18-12(17-10)21(2,19)20/h3-7H,1-2H3
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n/an/an/an/a 6.64E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231812
PNG
(CHEMBL4103961)
Show SMILES COC(=O)c1ccccc1-c1cc(nc(n1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O4S/c1-23-12(20)9-6-4-3-5-8(9)10-7-11(14(15,16)17)19-13(18-10)24(2,21)22/h3-7H,1-2H3
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n/an/an/an/a 7.03E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231800
PNG
(CHEMBL4088482)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C18H13F3N2O3S/c1-27(24,25)17-22-15(11-16(23-17)18(19,20)21)12-6-5-9-14(10-12)26-13-7-3-2-4-8-13/h2-11H,1H3
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n/an/an/an/a 8.76E+3n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231824
PNG
(CHEMBL4089190)
Show SMILES CS(=O)(=O)c1nc(cc(n1)-c1cccs1)N=[N+]=[N-]
Show InChI InChI=1S/C9H7N5O2S2/c1-18(15,16)9-11-6(7-3-2-4-17-7)5-8(12-9)13-14-10/h2-5H,1H3
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n/an/an/an/a>2.00E+4n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231823
PNG
(CHEMBL4080611)
Show SMILES COC(=O)c1ccc(cc1)-c1cc(nc(n1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O4S/c1-23-12(20)9-5-3-8(4-6-9)10-7-11(14(15,16)17)19-13(18-10)24(2,21)22/h3-7H,1-2H3
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n/an/an/an/a>2.00E+4n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231822
PNG
(CHEMBL4067221)
Show SMILES CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(=O)[nH]c1
Show InChI InChI=1S/C11H8F3N3O3S/c1-21(19,20)10-16-7(4-8(17-10)11(12,13)14)6-2-3-9(18)15-5-6/h2-5H,1H3,(H,15,18)
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n/an/an/an/a>2.00E+4n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231801
PNG
(CHEMBL4104840)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cc(nc(n1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C15H14F3N3O3S/c1-21(2)13(22)10-6-4-5-9(7-10)11-8-12(15(16,17)18)20-14(19-11)25(3,23)24/h4-8H,1-3H3
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n/an/an/an/a>2.00E+4n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231816
PNG
(CHEMBL4102499)
Show SMILES COc1ccc(Cn2cc(ccc2=O)-c2cc(nc(n2)S(=O)(=O)CCCC(N)=O)C(F)(F)F)cc1OC
Show InChI InChI=1S/C23H23F3N4O6S/c1-35-17-7-5-14(10-18(17)36-2)12-30-13-15(6-8-21(30)32)16-11-19(23(24,25)26)29-22(28-16)37(33,34)9-3-4-20(27)31/h5-8,10-11,13H,3-4,9,12H2,1-2H3,(H2,27,31)
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n/an/an/an/a>2.00E+4n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231805
PNG
(CHEMBL4081324)
Show SMILES CS(=O)(=O)c1nc(cc(n1)-c1cccs1)C1CCC(=O)N1
Show InChI InChI=1S/C13H13N3O3S2/c1-21(18,19)13-15-9(8-4-5-12(17)14-8)7-10(16-13)11-3-2-6-20-11/h2-3,6-8H,4-5H2,1H3,(H,14,17)
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n/an/an/an/a>2.00E+4n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231807
PNG
(CHEMBL4068001)
Show SMILES Cc1cc(nc(n1)S(C)(=O)=O)-c1cccs1
Show InChI InChI=1S/C10H10N2O2S2/c1-7-6-8(9-4-3-5-15-9)12-10(11-7)16(2,13)14/h3-6H,1-2H3
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n/an/an/an/a>2.00E+4n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial


(Homo sapiens)
BDBM50231806
PNG
(CHEMBL4105576)
Show SMILES CS(=O)(=O)c1nc(cc(n1)-c1cccs1)-c1cccs1
Show InChI InChI=1S/C13H10N2O2S3/c1-20(16,17)13-14-9(11-4-2-6-18-11)8-10(15-13)12-5-3-7-19-12/h2-8H,1H3
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n/an/an/an/a>2.00E+4n/an/an/an/a



Peking University

Curated by ChEMBL


Assay Description
Inhibition of SDHB in human U2OS cells over-expressing Bim assessed as inhibition of apoptosis preincubated for 1 hr followed by doxycyclin addition ...


ACS Med Chem Lett 8: 407-412 (2017)

More data for this
Ligand-Target Pair