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Compile Data Set for Download or QSAR

Found 33 hits of ic50 data for polymerid = 2445,50004827   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 0.5n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 0.5n/an/an/an/an/an/a



Laboratoire de Chimie Organique et Bioorganique, FRE3252, ENSCMu, F-68093 Mulhouse Cedex, France.

Curated by ChEMBL


Assay Description
Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysis


Bioorg Med Chem 19: 1434-49 (2011)


Article DOI: 10.1016/j.bmc.2011.01.008
BindingDB Entry DOI: 10.7270/Q2G44QJQ
More data for this
Ligand-Target Pair
Transforming growth factor beta-1


(Homo sapiens (Human))
BDBM50353187
PNG
(CHEMBL1829511)
Show SMILES CN(C)CCCOc1ccc(cn1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C23H24N6O/c1-29(2)12-5-13-30-22-8-7-18(15-26-22)21-14-17(9-11-25-21)19-16-27-28-23(19)20-6-3-4-10-24-20/h3-4,6-11,14-16H,5,12-13H2,1-2H3,(H,27,28)
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n/an/a 11n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Bioorg Med Chem Lett 21: 5642-5 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.120
BindingDB Entry DOI: 10.7270/Q2K937X4
More data for this
Ligand-Target Pair
Transforming growth factor beta-1


(Homo sapiens (Human))
BDBM50184879
PNG
(CHEMBL424676 | dimethyl-{2-[(4-{4-[3-(pyridin-2-yl...)
Show SMILES CN(C)CCOc1ccc(cc1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C23H23N5O/c1-28(2)13-14-29-19-8-6-17(7-9-19)22-15-18(10-12-25-22)20-16-26-27-23(20)21-5-3-4-11-24-21/h3-12,15-16H,13-14H2,1-2H3,(H,26,27)
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n/an/a 19n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Bioorg Med Chem Lett 21: 5642-5 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.120
BindingDB Entry DOI: 10.7270/Q2K937X4
More data for this
Ligand-Target Pair
Transforming growth factor beta-1


(Homo sapiens (Human))
BDBM50353188
PNG
(CHEMBL1829512)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C23H23N7/c1-29-10-12-30(13-11-29)22-6-5-18(15-26-22)21-14-17(7-9-25-21)19-16-27-28-23(19)20-4-2-3-8-24-20/h2-9,14-16H,10-13H2,1H3,(H,27,28)
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n/an/a 32n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Bioorg Med Chem Lett 21: 5642-5 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.120
BindingDB Entry DOI: 10.7270/Q2K937X4
More data for this
Ligand-Target Pair
Transforming growth factor beta-1


(Homo sapiens (Human))
BDBM50353184
PNG
(CHEMBL1828640)
Show SMILES Cn1cc(cn1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C17H14N6/c1-23-11-13(9-21-23)16-8-12(5-7-19-16)14-10-20-22-17(14)15-4-2-3-6-18-15/h2-11H,1H3,(H,20,22)
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n/an/a 68n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Bioorg Med Chem Lett 21: 5642-5 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.120
BindingDB Entry DOI: 10.7270/Q2K937X4
More data for this
Ligand-Target Pair
Transforming growth factor beta-1


(Homo sapiens (Human))
BDBM50353185
PNG
(CHEMBL1829504)
Show SMILES c1cnn(c1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C16H12N6/c1-2-6-17-14(4-1)16-13(11-19-21-16)12-5-8-18-15(10-12)22-9-3-7-20-22/h1-11H,(H,19,21)
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n/an/a 77n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Bioorg Med Chem Lett 21: 5642-5 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.120
BindingDB Entry DOI: 10.7270/Q2K937X4
More data for this
Ligand-Target Pair
Transforming growth factor beta-1


(Homo sapiens (Human))
BDBM50353186
PNG
(CHEMBL1829505)
Show SMILES c1cn(cn1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C16H12N6/c1-2-5-18-14(3-1)16-13(10-20-21-16)12-4-6-19-15(9-12)22-8-7-17-11-22/h1-11H,(H,20,21)
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n/an/a 88n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Bioorg Med Chem Lett 21: 5642-5 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.120
BindingDB Entry DOI: 10.7270/Q2K937X4
More data for this
Ligand-Target Pair
Transforming growth factor beta-1


(Homo sapiens (Human))
BDBM50184872
PNG
(4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-y...)
Show SMILES O=C(NC1CCOCC1)c1ccc(cc1)-c1cc(ccn1)-c1c[nH]nc1-c1ccccn1
Show InChI InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31)
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n/an/a 446n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of TGF-beta1 signaling in human HEK293 cells transfected with luciferase and FAST-2 gene expression vector A3-LUX after 16 hrs by lucifera...


Bioorg Med Chem Lett 21: 5642-5 (2011)


Article DOI: 10.1016/j.bmcl.2010.12.120
BindingDB Entry DOI: 10.7270/Q2K937X4
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23980
PNG
((3Z)-3-{[(5-phenylpentyl)oxy]imino}-1,2,3,4-tetrah...)
Show SMILES NC1Cc2ccccc2C\C1=N\OCCCCCc1ccccc1
Show InChI InChI=1S/C21H26N2O/c22-20-15-18-12-6-7-13-19(18)16-21(20)23-24-14-8-2-5-11-17-9-3-1-4-10-17/h1,3-4,6-7,9-10,12-13,20H,2,5,8,11,14-16,22H2/b23-21-
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n/an/a>1.00E+5n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23977
PNG
((3Z)-3-[(2-phenylethoxy)imino]-1,2,3,4-tetrahydron...)
Show SMILES NC1Cc2ccccc2C\C1=N\OCCc1ccccc1
Show InChI InChI=1S/C18H20N2O/c19-17-12-15-8-4-5-9-16(15)13-18(17)20-21-11-10-14-6-2-1-3-7-14/h1-9,17H,10-13,19H2/b20-18-
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n/an/a>1.00E+5n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM50336496
PNG
(2-aminocycloheptanone hydrochloride | CHEMBL166862...)
Show SMILES NC1CCCCCC1=O
Show InChI InChI=1S/C7H13NO/c8-6-4-2-1-3-5-7(6)9/h6H,1-5,8H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Laboratoire de Chimie Organique et Bioorganique, FRE3252, ENSCMu, F-68093 Mulhouse Cedex, France.

Curated by ChEMBL


Assay Description
Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysis


Bioorg Med Chem 19: 1434-49 (2011)


Article DOI: 10.1016/j.bmc.2011.01.008
BindingDB Entry DOI: 10.7270/Q2G44QJQ
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23979
PNG
((3Z)-3-[(4-phenylbutoxy)imino]-1,2,3,4-tetrahydron...)
Show SMILES NC1Cc2ccccc2C\C1=N\OCCCCc1ccccc1
Show InChI InChI=1S/C20H24N2O/c21-19-14-17-11-4-5-12-18(17)15-20(19)22-23-13-7-6-10-16-8-2-1-3-9-16/h1-5,8-9,11-12,19H,6-7,10,13-15,21H2/b22-20-
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n/an/a>1.00E+5n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23973
PNG
(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Show SMILES NC1Cc2ccccc2CC1=O
Show InChI InChI=1S/C10H11NO/c11-9-5-7-3-1-2-4-8(7)6-10(9)12/h1-4,9H,5-6,11H2
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n/an/a 1.20E+5n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23973
PNG
(3-amino-1,2,3,4-tetrahydronaphthalen-2-one hydroch...)
Show SMILES NC1Cc2ccccc2CC1=O
Show InChI InChI=1S/C10H11NO/c11-9-5-7-3-1-2-4-8(7)6-10(9)12/h1-4,9H,5-6,11H2
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n/an/a 1.20E+5n/an/an/an/an/an/a



Laboratoire de Chimie Organique et Bioorganique, FRE3252, ENSCMu, F-68093 Mulhouse Cedex, France.

Curated by ChEMBL


Assay Description
Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysis


Bioorg Med Chem 19: 1434-49 (2011)


Article DOI: 10.1016/j.bmc.2011.01.008
BindingDB Entry DOI: 10.7270/Q2G44QJQ
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23988
PNG
(2-amino-1,2,3,4-tetrahydroisoquinolin-3-one | N-Su...)
Show SMILES NN1Cc2ccccc2CC1=O
Show InChI InChI=1S/C9H10N2O/c10-11-6-8-4-2-1-3-7(8)5-9(11)12/h1-4H,5-6,10H2
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n/an/a 1.00E+6n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23986
PNG
(3,4-dihydro-1H-2-benzothiopyran-3-one | isothiochr...)
Show SMILES O=C1Cc2ccccc2CS1
Show InChI InChI=1S/C9H8OS/c10-9-5-7-3-1-2-4-8(7)6-11-9/h1-4H,5-6H2
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n/an/a>1.00E+6n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23990
PNG
(3-amino-1,2,3,4-tetrahydroquinolin-2-one hydrochlo...)
Show SMILES NC1Cc2ccccc2NC1=O
Show InChI InChI=1S/C9H10N2O/c10-7-5-6-3-1-2-4-8(6)11-9(7)12/h1-4,7H,5,10H2,(H,11,12)
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n/an/a>1.00E+6n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23985
PNG
(3,4-dihydro-1H-2-benzopyran-3-one | isochromanone,...)
Show SMILES O=C1Cc2ccccc2CO1
Show InChI InChI=1S/C9H8O2/c10-9-5-7-3-1-2-4-8(7)6-11-9/h1-4H,5-6H2
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n/an/a>1.00E+6n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23974
PNG
((3Z)-3-(hydroxyimino)-1,2,3,4-tetrahydronaphthalen...)
Show SMILES ONC1Cc2ccccc2CC1=N
Show InChI InChI=1S/C10H12N2O/c11-9-5-7-3-1-2-4-8(7)6-10(9)12-13/h1-4,10-13H,5-6H2
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n/an/a>1.00E+6n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM50336493
PNG
(1-Aminoindan-2-one, hydrochloride | CHEMBL1668624)
Show SMILES NC1C(=O)Cc2ccccc12
Show InChI InChI=1S/C9H9NO/c10-9-7-4-2-1-3-6(7)5-8(9)11/h1-4,9H,5,10H2
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n/an/a>1.00E+6n/an/an/an/an/an/a



Laboratoire de Chimie Organique et Bioorganique, FRE3252, ENSCMu, F-68093 Mulhouse Cedex, France.

Curated by ChEMBL


Assay Description
Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysis


Bioorg Med Chem 19: 1434-49 (2011)


Article DOI: 10.1016/j.bmc.2011.01.008
BindingDB Entry DOI: 10.7270/Q2G44QJQ
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM50336494
PNG
(6-amino-5,6,8,9-tetrahydrobenzocycloheptene-7-one,...)
Show SMILES NC1Cc2ccccc2CCC1=O
Show InChI InChI=1S/C11H13NO/c12-10-7-9-4-2-1-3-8(9)5-6-11(10)13/h1-4,10H,5-7,12H2
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n/an/a>1.00E+6n/an/an/an/an/an/a



Laboratoire de Chimie Organique et Bioorganique, FRE3252, ENSCMu, F-68093 Mulhouse Cedex, France.

Curated by ChEMBL


Assay Description
Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysis


Bioorg Med Chem 19: 1434-49 (2011)


Article DOI: 10.1016/j.bmc.2011.01.008
BindingDB Entry DOI: 10.7270/Q2G44QJQ
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM50336495
PNG
(7-Amino-5,7,8,9-tetrahydro-benzocyclohepten-6-one,...)
Show SMILES NC1CCc2ccccc2CC1=O
Show InChI InChI=1S/C11H13NO/c12-10-6-5-8-3-1-2-4-9(8)7-11(10)13/h1-4,10H,5-7,12H2
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n/an/a>1.00E+6n/an/an/an/an/an/a



Laboratoire de Chimie Organique et Bioorganique, FRE3252, ENSCMu, F-68093 Mulhouse Cedex, France.

Curated by ChEMBL


Assay Description
Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysis


Bioorg Med Chem 19: 1434-49 (2011)


Article DOI: 10.1016/j.bmc.2011.01.008
BindingDB Entry DOI: 10.7270/Q2G44QJQ
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23984
PNG
(3-amino-1,2,3,4-tetrahydronaphthalene-2-phosphonic...)
Show SMILES OP(O)(O)C1Cc2ccccc2CC1=N
Show InChI InChI=1S/C10H14NO3P/c11-9-5-7-3-1-2-4-8(7)6-10(9)15(12,13)14/h1-4,10-15H,5-6H2
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n/an/a>1.00E+6n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM50336497
PNG
(7-Amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one,6...)
Show SMILES ONC1Cc2ccccc2CCC1=N
Show InChI InChI=1S/C11H14N2O/c12-10-6-5-8-3-1-2-4-9(8)7-11(10)13-14/h1-4,11-14H,5-7H2
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n/an/a>1.00E+6n/an/an/an/an/an/a



Laboratoire de Chimie Organique et Bioorganique, FRE3252, ENSCMu, F-68093 Mulhouse Cedex, France.

Curated by ChEMBL


Assay Description
Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysis


Bioorg Med Chem 19: 1434-49 (2011)


Article DOI: 10.1016/j.bmc.2011.01.008
BindingDB Entry DOI: 10.7270/Q2G44QJQ
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM50336499
PNG
(CHEMBL1668630 | cis-7-amino-6,7,8,9-tetrahydro-5H-...)
Show SMILES N[C@H]1CCc2ccccc2C[C@H]1O
Show InChI InChI=1S/C11H15NO/c12-10-6-5-8-3-1-2-4-9(8)7-11(10)13/h1-4,10-11,13H,5-7,12H2/t10-,11+/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Laboratoire de Chimie Organique et Bioorganique, FRE3252, ENSCMu, F-68093 Mulhouse Cedex, France.

Curated by ChEMBL


Assay Description
Inhibition of bovine lens cytosolic leucine aminopeptidase by Dixon plot analysis


Bioorg Med Chem 19: 1434-49 (2011)


Article DOI: 10.1016/j.bmc.2011.01.008
BindingDB Entry DOI: 10.7270/Q2G44QJQ
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23982
PNG
(1-(3-amino-1,2,3,4-tetrahydronaphthalen-2-yl)ethan...)
Show SMILES CC(=O)C1Cc2ccccc2CC1N
Show InChI InChI=1S/C12H15NO/c1-8(14)11-6-9-4-2-3-5-10(9)7-12(11)13/h2-5,11-12H,6-7,13H2,1H3
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n/an/a>1.00E+6n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23981
PNG
((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Show SMILES NC1CCc2ccccc2C1
Show InChI InChI=1S/C10H13N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-4,10H,5-7,11H2
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n/an/a>1.00E+6n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23978
PNG
((3Z)-3-[(3-phenylpropoxy)imino]-1,2,3,4-tetrahydro...)
Show SMILES NC1Cc2ccccc2C\C1=N\OCCCc1ccccc1
Show InChI InChI=1S/C19H22N2O/c20-18-13-16-10-4-5-11-17(16)14-19(18)21-22-12-6-9-15-7-2-1-3-8-15/h1-5,7-8,10-11,18H,6,9,12-14,20H2/b21-19-
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n/an/a>1.00E+6n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23976
PNG
((3Z)-3-[(benzyloxy)imino]-1,2,3,4-tetrahydronaphth...)
Show SMILES NC1Cc2ccccc2C\C1=N\OCc1ccccc1
Show InChI InChI=1S/C17H18N2O/c18-16-10-14-8-4-5-9-15(14)11-17(16)19-20-12-13-6-2-1-3-7-13/h1-9,16H,10-12,18H2/b19-17-
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n/an/a>1.00E+6n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23975
PNG
((3Z)-3-(methoxyimino)-1,2,3,4-tetrahydronaphthalen...)
Show SMILES CO\N=C1\Cc2ccccc2CC1N
Show InChI InChI=1S/C11H14N2O/c1-14-13-11-7-9-5-3-2-4-8(9)6-10(11)12/h2-5,10H,6-7,12H2,1H3/b13-11-
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n/an/a>1.00E+6n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23987
PNG
(2-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-one | CH...)
Show SMILES ON1Cc2ccccc2CC1=O
Show InChI InChI=1S/C9H9NO2/c11-9-5-7-3-1-2-4-8(7)6-10(9)12/h1-4,12H,5-6H2
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n/an/a>1.00E+6n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair
Cytosol aminopeptidase


(Bos taurus (bovine))
BDBM23989
PNG
(1,2,3,4-tetrahydronaphthalen-2-one | CHEMBL191664 ...)
Show SMILES O=C1CCc2ccccc2C1
Show InChI InChI=1S/C10H10O/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-4H,5-7H2
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n/an/a>1.00E+6n/an/an/an/a8.030



ENSCMu



Assay Description
Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t...


Bioorg Med Chem 14: 7241-57 (2006)


Article DOI: 10.1016/j.bmc.2006.06.050
BindingDB Entry DOI: 10.7270/Q2N29V73
More data for this
Ligand-Target Pair