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Compile Data Set for Download or QSAR

Found 456 hits of ic50 data for polymerid = 439   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345367
PNG
(1-cyclobutyl-4-(1-tetralin-6-ylsulfonyl-4,5-dihydr...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc2CCCCc2c1
Show InChI InChI=1S/C21H30N4O2S/c26-28(27,20-9-8-17-4-1-2-5-18(17)16-20)25-11-10-22-21(25)24-14-12-23(13-15-24)19-6-3-7-19/h8-9,16,19H,1-7,10-15H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0160n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345355
PNG
(1-cyclobutyl-4-[1-[4-(3-thienyl)phenyl]sulfonyl-4,...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccsc1
Show InChI InChI=1S/C21H26N4O2S2/c26-29(27,20-6-4-17(5-7-20)18-8-15-28-16-18)25-10-9-22-21(25)24-13-11-23(12-14-24)19-2-1-3-19/h4-8,15-16,19H,1-3,9-14H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0210n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345352
PNG
(4-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES Oc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H28N4O3S/c28-21-8-4-18(5-9-21)19-6-10-22(11-7-19)31(29,30)27-13-12-24-23(27)26-16-14-25(15-17-26)20-2-1-3-20/h4-11,20,28H,1-3,12-17H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0210n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345354
PNG
(1-cyclobutyl-4-[1-[4-(2-thienyl)phenyl]sulfonyl-4,...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1cccs1
Show InChI InChI=1S/C21H26N4O2S2/c26-29(27,19-8-6-17(7-9-19)20-5-2-16-28-20)25-11-10-22-21(25)24-14-12-23(13-15-24)18-3-1-4-18/h2,5-9,16,18H,1,3-4,10-15H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0270n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345410
PNG
(1-cyclobutyl-4-(1-indan-5-ylsulfonyl-4,5-dihydroim...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc2CCCc2c1
Show InChI InChI=1S/C20H28N4O2S/c25-27(26,19-8-7-16-3-1-4-17(16)15-19)24-10-9-21-20(24)23-13-11-22(12-14-23)18-5-2-6-18/h7-8,15,18H,1-6,9-14H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0310n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345351
PNG
(3-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES Oc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H28N4O3S/c28-21-6-1-3-19(17-21)18-7-9-22(10-8-18)31(29,30)27-12-11-24-23(27)26-15-13-25(14-16-26)20-4-2-5-20/h1,3,6-10,17,20,28H,2,4-5,11-16H2
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0340n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345393
PNG
(1-cyclobutyl-4-[1-[4-(1,1-dimethylpropyl)phenyl]su...)
Show SMILES CCC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C22H34N4O2S/c1-4-22(2,3)18-8-10-20(11-9-18)29(27,28)26-13-12-23-21(26)25-16-14-24(15-17-25)19-6-5-7-19/h8-11,19H,4-7,12-17H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0350n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345350
PNG
(2-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES Oc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H28N4O3S/c28-22-7-2-1-6-21(22)18-8-10-20(11-9-18)31(29,30)27-13-12-24-23(27)26-16-14-25(15-17-26)19-4-3-5-19/h1-2,6-11,19,28H,3-5,12-17H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0370n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345376
PNG
(US10202354, Example 41)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1C[C@H](N=C1N1CCN(CC1)C1CCC1)C1CC1
Show InChI InChI=1S/C23H34N4O2S/c1-17(2)18-8-10-21(11-9-18)30(28,29)27-16-22(19-6-7-19)24-23(27)26-14-12-25(13-15-26)20-4-3-5-20/h8-11,17,19-20,22H,3-7,12-16H2,1-2H3/t22-/m0/s1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0390n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345408
PNG
(1-cyclobutyl-4-[1-[(6-methoxy-2-naphthyl)sulfonyl]...)
Show SMILES COc1ccc2cc(ccc2c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C22H28N4O3S/c1-29-20-7-5-18-16-21(8-6-17(18)15-20)30(27,28)26-10-9-23-22(26)25-13-11-24(12-14-25)19-3-2-4-19/h5-8,15-16,19H,2-4,9-14H2,1H3
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0410n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345409
PNG
(1-[1-[(6-chloro-2-naphthyl)sulfonyl]-4,5-dihydroim...)
Show SMILES Clc1ccc2cc(ccc2c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C21H25ClN4O2S/c22-18-6-4-17-15-20(7-5-16(17)14-18)29(27,28)26-9-8-23-21(26)25-12-10-24(11-13-25)19-2-1-3-19/h4-7,14-15,19H,1-3,8-13H2
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0410n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345366
PNG
(1-cyclobutyl-4-(1-((4-isopropylphenyl)sulfonyl)-4,...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C20H30N4O2S/c1-16(2)17-6-8-19(9-7-17)27(25,26)24-11-10-21-20(24)23-14-12-22(13-15-23)18-4-3-5-18/h6-9,16,18H,3-5,10-15H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0430n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345360
PNG
(1-cyclobutyl-4-[1-[4-(2-fluorophenyl)phe-nyl]sulfo...)
Show SMILES Fc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H27FN4O2S/c24-22-7-2-1-6-21(22)18-8-10-20(11-9-18)31(29,30)28-13-12-25-23(28)27-16-14-26(15-17-27)19-4-3-5-19/h1-2,6-11,19H,3-5,12-17H2
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0460n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345377
PNG
(US10202354, Example 42)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1C[C@@H](N=C1N1CCN(CC1)C1CCC1)C1CC1
Show InChI InChI=1S/C23H34N4O2S/c1-17(2)18-8-10-21(11-9-18)30(28,29)27-16-22(19-6-7-19)24-23(27)26-14-12-25(13-15-26)20-4-3-5-20/h8-11,17,19-20,22H,3-7,12-16H2,1-2H3/t22-/m1/s1
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0470n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345349
PNG
(1-cyclobutyl-4-[1-(4-phenylphenyl)sulfonyl-4,5-dih...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H28N4O2S/c28-30(29,22-11-9-20(10-12-22)19-5-2-1-3-6-19)27-14-13-24-23(27)26-17-15-25(16-18-26)21-7-4-8-21/h1-3,5-6,9-12,21H,4,7-8,13-18H2
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0480n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345363
PNG
(1-cyclobutyl-4-[1-[4-(1-methylpyrazol-3-yl)phenyl]...)
Show SMILES Cn1ccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C21H28N6O2S/c1-24-11-9-20(23-24)17-5-7-19(8-6-17)30(28,29)27-12-10-22-21(27)26-15-13-25(14-16-26)18-3-2-4-18/h5-9,11,18H,2-4,10,12-16H2,1H3
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0490n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345364
PNG
(1-cyclobutyl-4-[1-[4-(2-methylpyrazol-3-yl)phenyl]...)
Show SMILES Cn1nccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C21H28N6O2S/c1-24-20(9-10-23-24)17-5-7-19(8-6-17)30(28,29)27-12-11-22-21(27)26-15-13-25(14-16-26)18-3-2-4-18/h5-10,18H,2-4,11-16H2,1H3
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0490n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345389
PNG
(1-cyclobutyl-4-[1-(3-phenylphenyl)sulfonyl-4,5-dih...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C23H28N4O2S/c28-30(29,22-11-4-8-20(18-22)19-6-2-1-3-7-19)27-13-12-24-23(27)26-16-14-25(15-17-26)21-9-5-10-21/h1-4,6-8,11,18,21H,5,9-10,12-17H2
PDB

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PC sid
UniChem
US Patent
n/an/a 0.0490n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345380
PNG
(2-(4-cyclobutylpiperazin-1-yl)-3-(4-isopropylpheny...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CC2(CCCC2)N=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H36N4O2S/c1-19(2)20-8-10-22(11-9-20)31(29,30)28-18-24(12-3-4-13-24)25-23(28)27-16-14-26(15-17-27)21-6-5-7-21/h8-11,19,21H,3-7,12-18H2,1-2H3
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0490n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345359
PNG
(1-cyclobutyl-4-[1-[4- | US10202354, Example 24)
Show SMILES COc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H30N4O3S/c1-31-23-8-3-2-7-22(23)19-9-11-21(12-10-19)32(29,30)28-14-13-25-24(28)27-17-15-26(16-18-27)20-5-4-6-20/h2-3,7-12,20H,4-6,13-18H2,1H3
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.0500n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345400
PNG
(1-cyclobutyl-4-[1-(4-phenoxyphenyl)sulfonyl-4,5-di...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H28N4O3S/c28-31(29,22-11-9-21(10-12-22)30-20-7-2-1-3-8-20)27-14-13-24-23(27)26-17-15-25(16-18-26)19-5-4-6-19/h1-3,7-12,19H,4-6,13-18H2
PDB

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UniChem
US Patent
n/an/a 0.0500n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345336
PNG
(2-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccccc1C#N
Show InChI InChI=1S/C24H27N5O2S/c25-18-20-4-1-2-7-23(20)19-8-10-22(11-9-19)32(30,31)29-13-12-26-24(29)28-16-14-27(15-17-28)21-5-3-6-21/h1-2,4,7-11,21H,3,5-6,12-17H2
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US Patent
n/an/a 0.0530n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345381
PNG
((R)-1-cyclobutyl-4-[1-(4-isopropylphenyl)sulfonyl-...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1C[C@@H](C)N=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C21H32N4O2S/c1-16(2)18-7-9-20(10-8-18)28(26,27)25-15-17(3)22-21(25)24-13-11-23(12-14-24)19-5-4-6-19/h7-10,16-17,19H,4-6,11-15H2,1-3H3/t17-/m1/s1
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US Patent
n/an/a 0.0540n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345369
PNG
(1-cyclobutyl-4-[1-(4-cyclopropylphenyl)sulfonyl-4,...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)C1CC1
Show InChI InChI=1S/C20H28N4O2S/c25-27(26,19-8-6-17(7-9-19)16-4-5-16)24-11-10-21-20(24)23-14-12-22(13-15-23)18-2-1-3-18/h6-9,16,18H,1-5,10-15H2
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US Patent
n/an/a 0.0580n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345365
PNG
(5-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1cncnc1
Show InChI InChI=1S/C21H26N6O2S/c28-30(29,20-6-4-17(5-7-20)18-14-22-16-23-15-18)27-9-8-24-21(27)26-12-10-25(11-13-26)19-2-1-3-19/h4-7,14-16,19H,1-3,8-13H2
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n/an/a 0.0600n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345414
PNG
(5-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...)
Show SMILES Cn1ccc2cc(ccc12)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C20H27N5O2S/c1-22-9-7-16-15-18(5-6-19(16)22)28(26,27)25-10-8-21-20(25)24-13-11-23(12-14-24)17-3-2-4-17/h5-7,9,15,17H,2-4,8,10-14H2,1H3
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US Patent
n/an/a 0.0620n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345396
PNG
(1-cyclobutyl-4-[1-(2-naphthylsulfonyl)-4,5-dihydro...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C21H26N4O2S/c26-28(27,20-9-8-17-4-1-2-5-18(17)16-20)25-11-10-22-21(25)24-14-12-23(13-15-24)19-6-3-7-19/h1-2,4-5,8-9,16,19H,3,6-7,10-15H2
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n/an/a 0.0620n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345362
PNG
(1-cyclobutyl-4-[1-[4-(4-fluorophenyl)phe-nyl]sulfo...)
Show SMILES Fc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H27FN4O2S/c24-20-8-4-18(5-9-20)19-6-10-22(11-7-19)31(29,30)28-13-12-25-23(28)27-16-14-26(15-17-27)21-2-1-3-21/h4-11,21H,1-3,12-17H2
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n/an/a 0.0710n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345344
PNG
(1-cyclobutyl-4-[1-[4-(m-tolyl)phenyl]sulfonyl-4,5-...)
Show SMILES Cc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H30N4O2S/c1-19-4-2-5-21(18-19)20-8-10-23(11-9-20)31(29,30)28-13-12-25-24(28)27-16-14-26(15-17-27)22-6-3-7-22/h2,4-5,8-11,18,22H,3,6-7,12-17H2,1H3
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n/an/a 0.0740n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345343
PNG
(1-cyclobutyl-4-[1-[4-(o-tolyl)phenyl]sulfonyl-4,5-...)
Show SMILES Cc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H30N4O2S/c1-19-5-2-3-8-23(19)20-9-11-22(12-10-20)31(29,30)28-14-13-25-24(28)27-17-15-26(16-18-27)21-6-4-7-21/h2-3,5,8-12,21H,4,6-7,13-18H2,1H3
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n/an/a 0.0770n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345413
PNG
(1-cyclobutyl-4-[1-[(6-methyl-2-naphthyl)sulfonyl]-...)
Show SMILES Cc1ccc2cc(ccc2c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C22H28N4O2S/c1-17-5-6-19-16-21(8-7-18(19)15-17)29(27,28)26-10-9-23-22(26)25-13-11-24(12-14-25)20-3-2-4-20/h5-8,15-16,20H,2-4,9-14H2,1H3
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n/an/a 0.0770n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345338
PNG
(1-cyclobutyl-4-[1-[4-(4-methoxyphenyl)phe-nyl]sulf...)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H30N4O3S/c1-31-22-9-5-19(6-10-22)20-7-11-23(12-8-20)32(29,30)28-14-13-25-24(28)27-17-15-26(16-18-27)21-3-2-4-21/h5-12,21H,2-4,13-18H2,1H3
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n/an/a 0.0800n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345388
PNG
(1-[4-tert-butylphenyl)sulfonyl-4,5-dihydroimidazol...)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C21H32N4O2S/c1-21(2,3)17-7-9-19(10-8-17)28(26,27)25-12-11-22-20(25)24-15-13-23(14-16-24)18-5-4-6-18/h7-10,18H,4-6,11-16H2,1-3H3
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n/an/a 0.0810n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345356
PNG
(1-[1-[4-(2-chlorophenyl)phe-nyl]sulfonyl-4,5-dihyd...)
Show SMILES Clc1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H27ClN4O2S/c24-22-7-2-1-6-21(22)18-8-10-20(11-9-18)31(29,30)28-13-12-25-23(28)27-16-14-26(15-17-27)19-4-3-5-19/h1-2,6-11,19H,3-5,12-17H2
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n/an/a 0.0840n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345370
PNG
(1-cyclobutyl-4-[1-(3-cyclopropylphenyl)sulfonyl-4,...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1cccc(c1)C1CC1
Show InChI InChI=1S/C20H28N4O2S/c25-27(26,19-6-1-3-17(15-19)16-7-8-16)24-10-9-21-20(24)23-13-11-22(12-14-23)18-4-2-5-18/h1,3,6,15-16,18H,2,4-5,7-14H2
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n/an/a 0.0870n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345391
PNG
(1-cyclobutyl-4-[1-(3,5-dimethylphenyl)sulfonyl-4,5...)
Show SMILES Cc1cc(C)cc(c1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H28N4O2S/c1-15-12-16(2)14-18(13-15)26(24,25)23-7-6-20-19(23)22-10-8-21(9-11-22)17-4-3-5-17/h12-14,17H,3-11H2,1-2H3
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n/an/a 0.0880n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345405
PNG
(N-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H27N5O3S/c1-15(25)21-16-5-7-18(8-6-16)28(26,27)24-10-9-20-19(24)23-13-11-22(12-14-23)17-3-2-4-17/h5-8,17H,2-4,9-14H2,1H3,(H,21,25)
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n/an/a 0.0940n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345353
PNG
(1-cyclobutyl-4-[1-[4-(4-pyridyl)phenyl]sulfonyl-4,...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C22H27N5O2S/c28-30(29,21-6-4-18(5-7-21)19-8-10-23-11-9-19)27-13-12-24-22(27)26-16-14-25(15-17-26)20-2-1-3-20/h4-11,20H,1-3,12-17H2
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n/an/a 0.0950n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345340
PNG
(4-[4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroi...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H27N5O2S/c25-18-19-4-6-20(7-5-19)21-8-10-23(11-9-21)32(30,31)29-13-12-26-24(29)28-16-14-27(15-17-28)22-2-1-3-22/h4-11,22H,1-3,12-17H2
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n/an/a 0.0970n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345337
PNG
(1-cyclobutyl-4-[1-[4-(3-methoxyphenyl)phe-nyl]sulf...)
Show SMILES COc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H30N4O3S/c1-31-22-7-2-4-20(18-22)19-8-10-23(11-9-19)32(29,30)28-13-12-25-24(28)27-16-14-26(15-17-27)21-5-3-6-21/h2,4,7-11,18,21H,3,5-6,12-17H2,1H3
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n/an/a 0.0980n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345341
PNG
(1-cyclobutyl-4-[1-[4-(2-pyridyl)phenyl]sulfonyl-4,...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc(cc1)-c1ccccn1
Show InChI InChI=1S/C22H27N5O2S/c28-30(29,20-9-7-18(8-10-20)21-6-1-2-11-23-21)27-13-12-24-22(27)26-16-14-25(15-17-26)19-4-3-5-19/h1-2,6-11,19H,3-5,12-17H2
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n/an/a 0.102n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345339
PNG
(1-cyclobutyl-4-[1-[4-[2-(trifluoromethyl)phe-nyl]p...)
Show SMILES FC(F)(F)c1ccccc1-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H27F3N4O2S/c25-24(26,27)22-7-2-1-6-21(22)18-8-10-20(11-9-18)34(32,33)31-13-12-28-23(31)30-16-14-29(15-17-30)19-4-3-5-19/h1-2,6-11,19H,3-5,12-17H2
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n/an/a 0.102n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345415
PNG
(6-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...)
Show SMILES Cc1nc2ccc(cc2s1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H25N5O2S2/c1-14-21-17-6-5-16(13-18(17)27-14)28(25,26)24-8-7-20-19(24)23-11-9-22(10-12-23)15-3-2-4-15/h5-6,13,15H,2-4,7-12H2,1H3
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UniChem
US Patent
n/an/a 0.112n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345382
PNG
((S)-1-cyclobutyl-4-[1-(4-isopropylphenyl)sulfonyl-...)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1C[C@H](C)N=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C21H32N4O2S/c1-16(2)18-7-9-20(10-8-18)28(26,27)25-15-17(3)22-21(25)24-13-11-23(12-14-24)19-5-4-6-19/h7-10,16-17,19H,4-6,11-15H2,1-3H3/t17-/m0/s1
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UniChem
US Patent
n/an/a 0.114n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345357
PNG
(1-[1-[4-(3-chlorophenyl)phe-nyl]sulfonyl-4,5-dihyd...)
Show SMILES Clc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H27ClN4O2S/c24-20-4-1-3-19(17-20)18-7-9-22(10-8-18)31(29,30)28-12-11-25-23(28)27-15-13-26(14-16-27)21-5-2-6-21/h1,3-4,7-10,17,21H,2,5-6,11-16H2
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US Patent
n/an/a 0.120n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345416
PNG
(N-[2-chloro-4-[[2-(4-cyclobutylpiperazin-1-yl)-4,5...)
Show SMILES CC(=O)Nc1ccc(cc1Cl)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C19H26ClN5O3S/c1-14(26)22-18-6-5-16(13-17(18)20)29(27,28)25-8-7-21-19(25)24-11-9-23(10-12-24)15-3-2-4-15/h5-6,13,15H,2-4,7-12H2,1H3,(H,22,26)
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US Patent
n/an/a 0.127n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345371
PNG
(6-[[2-(4-cyclobutylpiperazin-1-yl)-4,5-dihydroimid...)
Show SMILES O=S(=O)(N1CCN=C1N1CCN(CC1)C1CCC1)c1ccc2cc(ccc2c1)C#N
Show InChI InChI=1S/C22H25N5O2S/c23-16-17-4-5-19-15-21(7-6-18(19)14-17)30(28,29)27-9-8-24-22(27)26-12-10-25(11-13-26)20-2-1-3-20/h4-7,14-15,20H,1-3,8-13H2
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UniChem
US Patent
n/an/a 0.130n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345346
PNG
(1-cyclobutyl-4-[1-[4-[3-(trifluoromethyl)phe-nyl]p...)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C24H27F3N4O2S/c25-24(26,27)20-4-1-3-19(17-20)18-7-9-22(10-8-18)34(32,33)31-12-11-28-23(31)30-15-13-29(14-16-30)21-5-2-6-21/h1,3-4,7-10,17,21H,2,5-6,11-16H2
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US Patent
n/an/a 0.134n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345402
PNG
(1-cyclobutyl-4-[1-(3,4-dichlorophenyl)sulfonyl-4,5...)
Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C17H22Cl2N4O2S/c18-15-5-4-14(12-16(15)19)26(24,25)23-7-6-20-17(23)22-10-8-21(9-11-22)13-2-1-3-13/h4-5,12-13H,1-3,6-11H2
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UniChem
US Patent
n/an/a 0.136n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
Homo sapiens lysine demethylase 2B (KDM2B)


(Homo sapiens (Human))
BDBM345361
PNG
(1-cyclobutyl-4-[1-[4-(3-fluorophenyl)phe-nyl]sulfo...)
Show SMILES Fc1cccc(c1)-c1ccc(cc1)S(=O)(=O)N1CCN=C1N1CCN(CC1)C1CCC1
Show InChI InChI=1S/C23H27FN4O2S/c24-20-4-1-3-19(17-20)18-7-9-22(10-8-18)31(29,30)28-12-11-25-23(28)27-15-13-26(14-16-27)21-5-2-6-21/h1,3-4,7-10,17,21H,2,5-6,11-16H2
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US Patent
n/an/a 0.138n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...


US Patent US10202354 (2019)

More data for this
Ligand-Target Pair
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