Compile Data Set for Download or QSAR
maximum 50k data
Found 296 of ic50 data for polymerid = 49000716,50003003,50004880,50006057
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383522(CHEMBL2032049)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at mouse MCHR1 assessed inhibition of MCH-mediated intracellular Ca2+ calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Macaca mulatta)
Amgen

Curated by ChEMBL
LigandPNGBDBM50383522(CHEMBL2032049)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at rhesus monkey MCHR1 assessed inhibition of MCH-mediated intracellular Ca2+ calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50383522(CHEMBL2032049)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at rat MCHR1 assessed inhibition of MCH-mediated intracellular Ca2+ calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50383112(CHEMBL2029372)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50388442(CHEMBL2059408)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50162116(2-(4-(benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)e...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory concentration against Melanin-concentrating hormone receptor 1 in diet-induced obese miceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50388443(CHEMBL2059409)
Affinity DataIC50:  1.60nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50383112(CHEMBL2029372)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50167565(1-[1-(2-Isobutylamino-ethyl)-1H-indazol-5-yl]-3-(4...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]-MCHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50219047(CHEMBL245231 | N-(3-(1-(4-(3,4-difluorophenoxy)ben...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of rat MCH1R receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50388452(CHEMBL2059420)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50388444(CHEMBL2059410)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50351312(CHEMBL1818800)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50351322(CHEMBL1818810)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50388460(CHEMBL2059513)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50167552(1-[1-(2-Cyclopentylamino-ethyl)-1H-indazol-5-yl]-3...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]-MCHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50351313(CHEMBL1818801)
Affinity DataIC50:  2.5nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50351308(CHEMBL1818795)
Affinity DataIC50:  2.70nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50388457(CHEMBL2059426)
Affinity DataIC50:  2.70nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM119755(US8685958, 4 | US8685958, 5)
Affinity DataIC50:  3nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50168509(CHEMBL188937 | N-(1-Benzo[1,3]dioxol-5-ylmethyl-pi...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration required for binding affinity against mouse MCHr1 competing human neuronal IMR32 cells receptor in a radiometric binding ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50388458(CHEMBL2059511)
Affinity DataIC50:  3.40nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50351323(CHEMBL1818811)
Affinity DataIC50:  3.70nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Macaca fascicularis)
Amgen

Curated by ChEMBL
LigandPNGBDBM50358743(CHEMBL1922270)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at cynomolgus monkey MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50358743(CHEMBL1922270)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at rat MCHR1 expressed in HEK293 cells by aequorin bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50351324(CHEMBL1818901)
Affinity DataIC50:  4.10nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50388450(CHEMBL2059418)
Affinity DataIC50:  4.20nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50351297(CHEMBL1818783)
Affinity DataIC50:  5.30nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50351314(CHEMBL1818802)
Affinity DataIC50:  5.30nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50388454(CHEMBL2059422)
Affinity DataIC50:  5.60nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50167554(1-(4-Phenoxy-phenyl)-3-[1-(2-pyrrolidin-1-yl-ethyl...)
Affinity DataIC50:  5.90nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]-MCHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50159145(CHEMBL3786685)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50159340(CHEMBL3786169)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50391543(CHEMBL2147477)
Affinity DataIC50:  6.10nMAssay Description:Antagonist activity at rat MCH1 receptor expressed in HEK 293T cells assessed as inhibition of MCH-induced Ca2+ mobilization after 10 mins by FLIPR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50351318(CHEMBL1818806)
Affinity DataIC50:  6.20nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50149456(CHEMBL3769702)
Affinity DataIC50:  6.30nMAssay Description:Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357508(CHEMBL1914637)
Affinity DataIC50:  6.40nMAssay Description:Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50388449(CHEMBL2059417)
Affinity DataIC50:  6.70nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50388445(CHEMBL2059411)
Affinity DataIC50:  6.70nMAssay Description:Displacement of [125I]MCH from rat MCHR1 expressed in CHO cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50159341(CHEMBL3786346)
Affinity DataIC50:  7nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50159339(CHEMBL3786841)
Affinity DataIC50:  7nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM119758(US8685958, 7 | US8685958, 8)
Affinity DataIC50:  7nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50192531(1-(2-chlorophenyl)-3-(2-(3,4-dimethylphenoxy)-5-((...)
Affinity DataIC50:  7nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357504(CHEMBL1914633)
Affinity DataIC50:  7.30nMAssay Description:Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50357503(CHEMBL1914632)
Affinity DataIC50:  7.5nMAssay Description:Displacement of [125I]-MCH(4-19) from rat MCHR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50149462(CHEMBL3771182)
Affinity DataIC50:  7.5nMAssay Description:Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50189576((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)
Affinity DataIC50:  7.70nMAssay Description:Activity at chimeric rat/human MCH1R by accumulation of GTPgammaSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50149457(CHEMBL3771335)
Affinity DataIC50:  7.80nMAssay Description:Displacement of [125I]-MCH (4 to 19 residues) from rat MCHR1 expressed in CHO cell membranes after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50351297(CHEMBL1818783)
Affinity DataIC50:  8nMAssay Description:Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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