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Compile Data Set for Download or QSAR

Found 54 hits of ic50 data for polymerid = 50000311   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279436
PNG
(1-(2,3-dihydro-6-methoxychromen-4-ylideneamino)-3-...)
Show SMILES COc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C21H29N5O4/c1-23-9-11-24(12-10-23)7-3-8-25-20(27)15-26(21(25)28)22-18-6-13-30-19-5-4-16(29-2)14-17(18)19/h4-5,14-15,27H,3,6-13H2,1-2H3
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n/an/a 1.90n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106179
PNG
(CHEMBL125327 | Enantiomer-4-(3-Butyl-[1,2,4]oxadia...)
Show SMILES CCCCc1noc(n1)-c1ccc(cc1)C(=O)NC[C@H]1CCCC1(C)C
Show InChI InChI=1S/C21H29N3O2/c1-4-5-8-18-23-20(26-24-18)16-11-9-15(10-12-16)19(25)22-14-17-7-6-13-21(17,2)3/h9-12,17H,4-8,13-14H2,1-3H3,(H,22,25)/t17-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279740
PNG
(1-(2,3-dihydro-6-propoxychromen-4-ylideneamino)-3-...)
Show SMILES CCCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C24H34N4O4/c1-2-15-31-19-8-9-22-20(17-19)21(10-16-32-22)25-28-18-23(29)27(24(28)30)14-7-6-13-26-11-4-3-5-12-26/h8-9,17-18,29H,2-7,10-16H2,1H3
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n/an/a 3.20n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279471
PNG
(1-(2,3-dihydro-6-chlorochromen-4-ylideneamino)-3-(...)
Show SMILES CN1CCN(CCCn2c(O)cn(N=C3CCOc4ccc(Cl)cc34)c2=O)CC1
Show InChI InChI=1S/C20H26ClN5O3/c1-23-8-10-24(11-9-23)6-2-7-25-19(27)14-26(20(25)28)22-17-5-12-29-18-4-3-15(21)13-16(17)18/h3-4,13-14,27H,2,5-12H2,1H3
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n/an/a 5.80n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106169
PNG
(CHEMBL338973 | Enantiomer-4-(3-Butyl-[1,2,4]oxadia...)
Show SMILES CCCCc1noc(n1)-c1ccc(cc1)C(=O)NC[C@@H]1CCCC1(C)C
Show InChI InChI=1S/C21H29N3O2/c1-4-5-8-18-23-20(26-24-18)16-11-9-15(10-12-16)19(25)22-14-17-7-6-13-21(17,2)3/h9-12,17H,4-8,13-14H2,1-3H3,(H,22,25)/t17-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279454
PNG
(1-(2,3-dihydro-6-propoxychromen-4-ylideneamino)-3-...)
Show SMILES CCCOc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C23H33N5O4/c1-3-14-31-18-5-6-21-19(16-18)20(7-15-32-21)24-28-17-22(29)27(23(28)30)9-4-8-26-12-10-25(2)11-13-26/h5-6,16-17,29H,3-4,7-15H2,1-2H3
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n/an/a 9.5n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106168
PNG
(CHEMBL124448 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Show SMILES CCCc1noc(n1)-c1ccc(cc1)C(=O)NCC1CCCC1(C)C
Show InChI InChI=1S/C20H27N3O2/c1-4-6-17-22-19(25-23-17)15-10-8-14(9-11-15)18(24)21-13-16-7-5-12-20(16,2)3/h8-11,16H,4-7,12-13H2,1-3H3,(H,21,24)
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106167
PNG
(CHEMBL125000 | Enantiomer-4-(3-Cyclopropylmethyl-[...)
Show SMILES CC1(C)CCCC1CNC(=O)c1ccc(cc1)-c1nc(CC2CC2)no1
Show InChI InChI=1S/C21H27N3O2/c1-21(2)11-3-4-17(21)13-22-19(25)15-7-9-16(10-8-15)20-23-18(24-26-20)12-14-5-6-14/h7-10,14,17H,3-6,11-13H2,1-2H3,(H,22,25)
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n/an/a 18n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279703
PNG
(1-(6-butoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCCCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C25H37N5O4/c1-3-4-16-33-20-7-8-23-21(18-20)22(9-17-34-23)26-30-19-24(31)29(25(30)32)11-6-5-10-28-14-12-27(2)13-15-28/h7-8,18-19,31H,3-6,9-17H2,1-2H3
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n/an/a 22n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106178
PNG
(4-(3-Butyl-[1,2,4]oxadiazol-5-yl)-N-(3,3-dimethyl-...)
Show SMILES CCCCc1noc(n1)-c1ccc(cc1)C(=O)NCCC(C)(C)C
Show InChI InChI=1S/C19H27N3O2/c1-5-6-7-16-21-18(24-22-16)15-10-8-14(9-11-15)17(23)20-13-12-19(2,3)4/h8-11H,5-7,12-13H2,1-4H3,(H,20,23)
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n/an/a 23n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106167
PNG
(CHEMBL125000 | Enantiomer-4-(3-Cyclopropylmethyl-[...)
Show SMILES CC1(C)CCCC1CNC(=O)c1ccc(cc1)-c1nc(CC2CC2)no1
Show InChI InChI=1S/C21H27N3O2/c1-21(2)11-3-4-17(21)13-22-19(25)15-7-9-16(10-8-15)20-23-18(24-26-20)12-14-5-6-14/h7-10,14,17H,3-6,11-13H2,1-2H3,(H,22,25)
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n/an/a 23n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptor


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279453
PNG
(1-(6-ethoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCOc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C22H31N5O4/c1-3-30-17-5-6-20-18(15-17)19(7-14-31-20)23-27-16-21(28)26(22(27)29)9-4-8-25-12-10-24(2)11-13-25/h5-6,15-16,28H,3-4,7-14H2,1-2H3
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n/an/a 27n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106176
PNG
(CHEMBL340681 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Show SMILES CC1(C)CCCC1CNC(=O)c1ccc(cc1)-c1noc(CCC(F)(F)F)n1
Show InChI InChI=1S/C20H24F3N3O2/c1-19(2)10-3-4-15(19)12-24-18(27)14-7-5-13(6-8-14)17-25-16(28-26-17)9-11-20(21,22)23/h5-8,15H,3-4,9-12H2,1-2H3,(H,24,27)
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n/an/a 27n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106168
PNG
(CHEMBL124448 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Show SMILES CCCc1noc(n1)-c1ccc(cc1)C(=O)NCC1CCCC1(C)C
Show InChI InChI=1S/C20H27N3O2/c1-4-6-17-22-19(25-23-17)15-10-8-14(9-11-15)18(24)21-13-16-7-5-12-20(16,2)3/h8-11,16H,4-7,12-13H2,1-3H3,(H,21,24)
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n/an/a 27n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptor


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50061218
PNG
((E)-3-(2,4-Dichloro-phenyl)-N-((R)-1-methyl-2-oxo-...)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)\C=C\c2ccc(Cl)cc2Cl)C1=O)c1ccccc1
Show InChI InChI=1S/C25H19Cl2N3O2/c1-30-21-10-6-5-9-19(21)23(17-7-3-2-4-8-17)29-24(25(30)32)28-22(31)14-12-16-11-13-18(26)15-20(16)27/h2-15,24H,1H3,(H,28,31)/b14-12+/t24-/m1/s1
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n/an/a 31n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106176
PNG
(CHEMBL340681 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Show SMILES CC1(C)CCCC1CNC(=O)c1ccc(cc1)-c1noc(CCC(F)(F)F)n1
Show InChI InChI=1S/C20H24F3N3O2/c1-19(2)10-3-4-15(19)12-24-18(27)14-7-5-13(6-8-14)17-25-16(28-26-17)9-11-20(21,22)23/h5-8,15H,3-4,9-12H2,1-2H3,(H,24,27)
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TBA

Curated by ChEMBL


Assay Description
Bindind affinity values obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from a preparation of whole rat brain


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279717
PNG
(1-(2,3-dihydro-6-chlorochromen-4-ylideneamino)-3-(...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=C3CCOc4ccc(Cl)cc34)c2=O)CC1
Show InChI InChI=1S/C21H28ClN5O3/c1-24-9-11-25(12-10-24)7-2-3-8-26-20(28)15-27(21(26)29)23-18-6-13-30-19-5-4-16(22)14-17(18)19/h4-5,14-15,28H,2-3,6-13H2,1H3
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n/an/a 73n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50099582
PNG
((3R,4S)N-[3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluor...)
Show SMILES CN([C@@H]1[C@@H](O)C(C)(C)Oc2ccc(OCCCC(F)(F)F)cc12)S(C)(=O)=O
Show InChI InChI=1S/C17H24F3NO5S/c1-16(2)15(22)14(21(3)27(4,23)24)12-10-11(6-7-13(12)26-16)25-9-5-8-17(18,19)20/h6-7,10,14-15,22H,5,8-9H2,1-4H3/t14-,15+/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Prestwick Chemical Inc.

Curated by ChEMBL


Assay Description
Inhibition of guinea pig Iks potassium channel expressed in Xenopus oocytes


J Med Chem 47: 1303-14 (2004)


Article DOI: 10.1021/jm030480f
BindingDB Entry DOI: 10.7270/Q2FN16X5
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106182
PNG
(CHEMBL123085 | N-(3,3-Dimethyl-butyl)-4-(3-phenyl-...)
Show SMILES CC(C)(C)CCNC(=O)c1ccc(cc1)-c1nc(no1)-c1ccccc1
Show InChI InChI=1S/C21H23N3O2/c1-21(2,3)13-14-22-19(25)16-9-11-17(12-10-16)20-23-18(24-26-20)15-7-5-4-6-8-15/h4-12H,13-14H2,1-3H3,(H,22,25)
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n/an/a 130n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106175
PNG
(CHEMBL121750 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCC1CCCC1(C)C
Show InChI InChI=1S/C21H33NO2/c1-4-5-6-7-15-24-19-12-10-17(11-13-19)20(23)22-16-18-9-8-14-21(18,2)3/h10-13,18H,4-9,14-16H2,1-3H3,(H,22,23)
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TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106164
PNG
(CHEMBL123569 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Show SMILES Cc1noc(n1)-c1ccc(cc1)C(=O)NCC1CCCC1(C)C
Show InChI InChI=1S/C18H23N3O2/c1-12-20-17(23-21-12)14-8-6-13(7-9-14)16(22)19-11-15-5-4-10-18(15,2)3/h6-9,15H,4-5,10-11H2,1-3H3,(H,19,22)
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n/an/a 220n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from a preparation of whole rat brain


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50117913
PNG
((E)-1-((5-(4-chlorophenyl)furan-2-yl)methyleneamin...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=Cc3ccc(o3)-c3ccc(Cl)cc3)c2=O)CC1
Show InChI InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16-17,30H,2-3,10-15H2,1H3
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n/an/a 240n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106166
PNG
(CHEMBL122341 | N-(3,3-Dimethyl-butyl)-4-hexyloxy-b...)
Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCCC(C)(C)C
Show InChI InChI=1S/C19H31NO2/c1-5-6-7-8-15-22-17-11-9-16(10-12-17)18(21)20-14-13-19(2,3)4/h9-12H,5-8,13-15H2,1-4H3,(H,20,21)
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n/an/a 250n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106177
PNG
(CHEMBL431682 | N-(3,3-Dimethyl-butyl)-4-indol-1-yl...)
Show SMILES CC(C)(C)CCNC(=O)c1ccc(cc1)-n1ccc2ccccc12
Show InChI InChI=1S/C21H24N2O/c1-21(2,3)13-14-22-20(24)17-8-10-18(11-9-17)23-15-12-16-6-4-5-7-19(16)23/h4-12,15H,13-14H2,1-3H3,(H,22,24)
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n/an/a 260n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279456
PNG
(1-(2,3-dihydro-6-methylchromen-4-ylideneamino)-3-(...)
Show SMILES CN1CCN(CCCn2c(O)cn(N=C3CCOc4ccc(C)cc34)c2=O)CC1
Show InChI InChI=1S/C21H29N5O3/c1-16-4-5-19-17(14-16)18(6-13-29-19)22-26-15-20(27)25(21(26)28)8-3-7-24-11-9-23(2)10-12-24/h4-5,14-15,27H,3,6-13H2,1-2H3
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n/an/a 304n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279719
PNG
(1-(2,3-dihydro-6-amidecarboxylchromen-4-ylideneami...)
Show SMILES CN1CCN(CCCCn2c(O)cn(N=C3CCOc4ccc(cc34)C(N)=O)c2=O)CC1
Show InChI InChI=1S/C22H30N6O4/c1-25-9-11-26(12-10-25)7-2-3-8-27-20(29)15-28(22(27)31)24-18-6-13-32-19-5-4-16(21(23)30)14-17(18)19/h4-5,14-15,29H,2-3,6-13H2,1H3,(H2,23,30)
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n/an/a 330n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106184
PNG
(CHEMBL121751 | N-(3,3-Dimethyl-cyclopentyl)-4-hexy...)
Show SMILES CCCCCCOc1ccc(cc1)C(=O)NC1CCC(C)(C)C1
Show InChI InChI=1S/C20H31NO2/c1-4-5-6-7-14-23-18-10-8-16(9-11-18)19(22)21-17-12-13-20(2,3)15-17/h8-11,17H,4-7,12-15H2,1-3H3,(H,21,22)
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n/an/a 360n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106180
PNG
(CHEMBL124595 | N-(3,3-Dimethyl-cyclohexylmethyl)-4...)
Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCC1CCCC(C)(C)C1
Show InChI InChI=1S/C22H35NO2/c1-4-5-6-7-15-25-20-12-10-19(11-13-20)21(24)23-17-18-9-8-14-22(2,3)16-18/h10-13,18H,4-9,14-17H2,1-3H3,(H,23,24)
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n/an/a 370n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106181
PNG
(Biphenyl-4-carboxylic acid (3,3-dimethyl-butyl)-am...)
Show SMILES CC(C)(C)CCNC(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H23NO/c1-19(2,3)13-14-20-18(21)17-11-9-16(10-12-17)15-7-5-4-6-8-15/h4-12H,13-14H2,1-3H3,(H,20,21)
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n/an/a 540n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106164
PNG
(CHEMBL123569 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Show SMILES Cc1noc(n1)-c1ccc(cc1)C(=O)NCC1CCCC1(C)C
Show InChI InChI=1S/C18H23N3O2/c1-12-20-17(23-21-12)14-8-6-13(7-9-14)16(22)19-11-15-5-4-10-18(15,2)3/h6-9,15H,4-5,10-11H2,1-3H3,(H,19,22)
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n/an/a 580n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279700
PNG
(1-(2,3-dihydro-6-methoxychromen-4-ylideneamino)-3-...)
Show SMILES COc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C22H31N5O4/c1-24-10-12-25(13-11-24)8-3-4-9-26-21(28)16-27(22(26)29)23-19-7-14-31-20-6-5-17(30-2)15-18(19)20/h5-6,15-16,28H,3-4,7-14H2,1-2H3
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n/an/a 650n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106175
PNG
(CHEMBL121750 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCC1CCCC1(C)C
Show InChI InChI=1S/C21H33NO2/c1-4-5-6-7-15-24-19-12-10-17(11-13-19)20(23)22-16-18-9-8-14-21(18,2)3/h10-13,18H,4-9,14-16H2,1-3H3,(H,22,23)
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n/an/a 710n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptor


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279741
PNG
(1-(6-butoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCCCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C25H36N4O4/c1-2-3-16-32-20-9-10-23-21(18-20)22(11-17-33-23)26-29-19-24(30)28(25(29)31)15-8-7-14-27-12-5-4-6-13-27/h9-10,18-19,30H,2-8,11-17H2,1H3
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n/an/a 1.03E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279739
PNG
(1-(6-ethoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C23H32N4O4/c1-2-30-18-8-9-21-19(16-18)20(10-15-31-21)24-27-17-22(28)26(23(27)29)14-7-6-13-25-11-4-3-5-12-25/h8-9,16-17,28H,2-7,10-15H2,1H3
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n/an/a 1.04E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279455
PNG
(1-(6-butoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCCCOc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C24H35N5O4/c1-3-4-15-32-19-6-7-22-20(17-19)21(8-16-33-22)25-29-18-23(30)28(24(29)31)10-5-9-27-13-11-26(2)12-14-27/h6-7,17-18,30H,3-5,8-16H2,1-2H3
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n/an/a 1.23E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279702
PNG
(1-(2,3-dihydro-6-propoxychromen-4-ylideneamino)-3-...)
Show SMILES CCCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C24H35N5O4/c1-3-15-32-19-6-7-22-20(17-19)21(8-16-33-22)25-29-18-23(30)28(24(29)31)10-5-4-9-27-13-11-26(2)12-14-27/h6-7,17-18,30H,3-5,8-16H2,1-2H3
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n/an/a 1.28E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106174
PNG
(CHEMBL332297 | N-(2,2-Dimethyl-cyclohexylmethyl)-4...)
Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCC1CCCCC1(C)C
Show InChI InChI=1S/C22H35NO2/c1-4-5-6-9-16-25-20-13-11-18(12-14-20)21(24)23-17-19-10-7-8-15-22(19,2)3/h11-14,19H,4-10,15-17H2,1-3H3,(H,23,24)
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n/an/a 1.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106165
PNG
((3-tert-Butyl-pyrrolidin-1-yl)-(4-hexyloxy-phenyl)...)
Show SMILES CCCCCCOc1ccc(cc1)C(=O)N1CCC(C1)C(C)(C)C
Show InChI InChI=1S/C21H33NO2/c1-5-6-7-8-15-24-19-11-9-17(10-12-19)20(23)22-14-13-18(16-22)21(2,3)4/h9-12,18H,5-8,13-16H2,1-4H3
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n/an/a>3.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106174
PNG
(CHEMBL332297 | N-(2,2-Dimethyl-cyclohexylmethyl)-4...)
Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCC1CCCCC1(C)C
Show InChI InChI=1S/C22H35NO2/c1-4-5-6-9-16-25-20-13-11-18(12-14-20)21(24)23-17-19-10-7-8-15-22(19,2)3/h11-14,19H,4-10,15-17H2,1-3H3,(H,23,24)
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n/an/a>3.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from a preparation of whole rat brain


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106170
PNG
(CHEMBL122865 | N-(2-Diethylamino-ethyl)-4-hexyloxy...)
Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCCN(CC)CC
Show InChI InChI=1S/C19H32N2O2/c1-4-7-8-9-16-23-18-12-10-17(11-13-18)19(22)20-14-15-21(5-2)6-3/h10-13H,4-9,14-16H2,1-3H3,(H,20,22)
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n/an/a 3.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106183
PNG
(1-(4-(Hexyloxy)phenyl)-3-(piperidin-1-yl)propan-1-...)
Show SMILES CCCCCCOc1ccc(cc1)C(=O)CCN1CCCCC1
Show InChI InChI=1S/C20H31NO2/c1-2-3-4-8-17-23-19-11-9-18(10-12-19)20(22)13-16-21-14-6-5-7-15-21/h9-12H,2-8,13-17H2,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106171
PNG
(CHEMBL122637 | Diethyl-{2-[4-(1,1,3,3-tetramethyl-...)
Show SMILES CCN(CC)CCOc1ccc(cc1)C(C)(C)CC(C)(C)C
Show InChI InChI=1S/C20H35NO/c1-8-21(9-2)14-15-22-18-12-10-17(11-13-18)20(6,7)16-19(3,4)5/h10-13H,8-9,14-16H2,1-7H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106227
PNG
((3R,4S)-Ethanesulfonic acid (6-cyano-3-hydroxy-2,2...)
Show SMILES CCS(=O)(=O)N(C)[C@@H]1[C@@H](O)C(C)(C)Oc2ccc(cc12)C#N
Show InChI InChI=1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Prestwick Chemical Inc.

Curated by ChEMBL


Assay Description
Inhibition of guinea pig Iks potassium channel expressed in Xenopus oocytes


J Med Chem 47: 1303-14 (2004)


Article DOI: 10.1021/jm030480f
BindingDB Entry DOI: 10.7270/Q2FN16X5
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106173
PNG
(CHEMBL341368 | N,N-Diethyl-2-[4-(1,1,3,3-tetrameth...)
Show SMILES CCN(CC)C(=O)COc1ccc(cc1)C(C)(C)CC(C)(C)C
Show InChI InChI=1S/C20H33NO2/c1-8-21(9-2)18(22)14-23-17-12-10-16(11-13-17)20(6,7)15-19(3,4)5/h10-13H,8-9,14-15H2,1-7H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279433
PNG
(1-(2,3-dihydro-6-hydroxychromen-4-ylideneamino)-3-...)
Show SMILES Oc1cn(N=C2CCOc3ccc(O)cc23)c(=O)n1CCCCN1CCCCC1
Show InChI InChI=1S/C21H28N4O4/c26-16-6-7-19-17(14-16)18(8-13-29-19)22-25-15-20(27)24(21(25)28)12-5-4-11-23-9-2-1-3-10-23/h6-7,14-15,26-27H,1-5,8-13H2
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n/an/a 5.40E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50099567
PNG
((3S,4R)-Ethanesulfonic acid (6-cyano-3-hydroxy-2,2...)
Show SMILES CCS(=O)(=O)N(C)[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C#N
Show InChI InChI=1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m1/s1
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n/an/a 6.20E+3n/an/an/an/an/an/a



Prestwick Chemical Inc.

Curated by ChEMBL


Assay Description
Invitro evaluation against RXR-alpha in CV-1 cells by cotransfection assay was determined


J Med Chem 47: 1303-14 (2004)


Article DOI: 10.1021/jm030480f
BindingDB Entry DOI: 10.7270/Q2FN16X5
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279701
PNG
(1-(6-ethoxy-2,3-dihydrochromen-4-ylideneamino)-3-(...)
Show SMILES CCOc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCN(C)CC4)c3=O)c2c1
Show InChI InChI=1S/C23H33N5O4/c1-3-31-18-6-7-21-19(16-18)20(8-15-32-21)24-28-17-22(29)27(23(28)30)10-5-4-9-26-13-11-25(2)12-14-26/h6-7,16-17,29H,3-5,8-15H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279435
PNG
(1-(2,3-dihydro-6-methylchromen-4-ylideneamino)-3-(...)
Show SMILES Cc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C22H30N4O3/c1-17-7-8-20-18(15-17)19(9-14-29-20)23-26-16-21(27)25(22(26)28)13-6-5-12-24-10-3-2-4-11-24/h7-8,15-16,27H,2-6,9-14H2,1H3
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n/an/a 1.89E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50279738
PNG
(1-(2,3-dihydro-6-methoxychromen-4-ylideneamino)-3-...)
Show SMILES COc1ccc2OCCC(=Nn3cc(O)n(CCCCN4CCCCC4)c3=O)c2c1
Show InChI InChI=1S/C22H30N4O4/c1-29-17-7-8-20-18(15-17)19(9-14-30-20)23-26-16-21(27)25(22(26)28)13-6-5-12-24-10-3-2-4-11-24/h7-8,15-16,27H,2-6,9-14H2,1H3
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n/an/a 2.20E+4n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-cla...


Bioorg Med Chem Lett 19: 1477-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.022
BindingDB Entry DOI: 10.7270/Q22J6BQK
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.1


(Cavia porcellus)
BDBM50106172
PNG
(CHEMBL340222 | N-(2,2-Dimethyl-cyclopentyl)-4-hexy...)
Show SMILES CCCCCCOc1ccc(cc1)C(=O)NC1CCCC1(C)C
Show InChI InChI=1S/C20H31NO2/c1-4-5-6-7-15-23-17-12-10-16(11-13-17)19(22)21-18-9-8-14-20(18,2)3/h10-13,18H,4-9,14-15H2,1-3H3,(H,21,22)
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n/an/a>3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes


J Med Chem 44: 3764-7 (2001)


Article DOI: 10.1021/jm015505u
BindingDB Entry DOI: 10.7270/Q2G1604C
More data for this
Ligand-Target Pair
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