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Compile Data Set for Download or QSAR

Found 52 hits of ic50 data for polymerid = 50001128,50006890,50006965,5123,7323   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Pancreatic alpha-amylase (HPA)


(Homo sapiens (Human))
BDBM50033631
PNG
(2-{2-[2-(2-{2-[2-tert-Butoxycarbonylamino-3-(4-sul...)
Show SMILES CCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(cc1)S(O)(=O)=O)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)OCCc1ccccc1
Show InChI InChI=1S/C50H65N7O14S2/c1-6-7-16-37(45(62)56-41(28-43(59)60)48(65)70-24-22-31-13-9-8-10-14-31)54-47(64)40(27-33-29-51-36-17-12-11-15-35(33)36)53-42(58)30-52-44(61)38(23-25-72-5)55-46(63)39(57-49(66)71-50(2,3)4)26-32-18-20-34(21-19-32)73(67,68)69/h8-15,17-21,29,37-41,51H,6-7,16,22-28,30H2,1-5H3,(H,52,61)(H,53,58)(H,54,64)(H,55,63)(H,56,62)(H,57,66)(H,59,60)(H,67,68,69)/t37-,38-,39-,40+,41-/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



EP CNRS 51

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition of amylase release from rat pancreatic acini


J Med Chem 36: 3021-8 (1993)


Article DOI: 10.1021/jm00072a024
BindingDB Entry DOI: 10.7270/Q2PZ57VG
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase (HPA)


(Homo sapiens (Human))
BDBM50033632
PNG
(3-{2-[2-(2-{2-[2-tert-Butoxycarbonylamino-3-(4-sul...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(cc1)S(O)(=O)=O)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)NC(CCCCc1ccccc1)CC(O)=O
Show InChI InChI=1S/C52H71N7O12S/c1-6-8-22-41(57-49(65)43(59-51(67)71-52(3,4)5)29-35-25-27-38(28-26-35)72(68,69)70)47(63)54-33-45(60)56-44(30-36-32-53-40-24-16-15-21-39(36)40)50(66)58-42(23-9-7-2)48(64)55-37(31-46(61)62)20-14-13-19-34-17-11-10-12-18-34/h10-12,15-18,21,24-28,32,37,41-44,53H,6-9,13-14,19-20,22-23,29-31,33H2,1-5H3,(H,54,63)(H,55,64)(H,56,60)(H,57,65)(H,58,66)(H,59,67)(H,61,62)(H,68,69,70)/t37?,41-,42-,43-,44+/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



EP CNRS 51

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition of amylase release from rat pancreatic acini


J Med Chem 36: 3021-8 (1993)


Article DOI: 10.1021/jm00072a024
BindingDB Entry DOI: 10.7270/Q2PZ57VG
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase (HPA)


(Homo sapiens (Human))
BDBM50033636
PNG
(3-{2-[2-(2-{2-[2-tert-Butoxycarbonylamino-3-(4-sul...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(cc1)S(O)(=O)=O)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)NC(CCCOc1ccccc1)CC(O)=O
Show InChI InChI=1S/C51H69N7O13S/c1-6-8-20-40(56-48(64)42(58-50(66)71-51(3,4)5)28-33-23-25-37(26-24-33)72(67,68)69)46(62)53-32-44(59)55-43(29-34-31-52-39-22-14-13-19-38(34)39)49(65)57-41(21-9-7-2)47(63)54-35(30-45(60)61)16-15-27-70-36-17-11-10-12-18-36/h10-14,17-19,22-26,31,35,40-43,52H,6-9,15-16,20-21,27-30,32H2,1-5H3,(H,53,62)(H,54,63)(H,55,59)(H,56,64)(H,57,65)(H,58,66)(H,60,61)(H,67,68,69)/t35?,40-,41-,42-,43+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



EP CNRS 51

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition of amylase release from rat pancreatic acini


J Med Chem 36: 3021-8 (1993)


Article DOI: 10.1021/jm00072a024
BindingDB Entry DOI: 10.7270/Q2PZ57VG
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Homo sapiens (Human))
BDBM50033636
PNG
(3-{2-[2-(2-{2-[2-tert-Butoxycarbonylamino-3-(4-sul...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(cc1)S(O)(=O)=O)NC(=O)OC(C)(C)C)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCC)C(=O)NC(CCCOc1ccccc1)CC(O)=O
Show InChI InChI=1S/C51H69N7O13S/c1-6-8-20-40(56-48(64)42(58-50(66)71-51(3,4)5)28-33-23-25-37(26-24-33)72(67,68)69)46(62)53-32-44(59)55-43(29-34-31-52-39-22-14-13-19-38(34)39)49(65)57-41(21-9-7-2)47(63)54-35(30-45(60)61)16-15-27-70-36-17-11-10-12-18-36/h10-14,17-19,22-26,31,35,40-43,52H,6-9,15-16,20-21,27-30,32H2,1-5H3,(H,53,62)(H,54,63)(H,55,59)(H,56,64)(H,57,65)(H,58,66)(H,60,61)(H,67,68,69)/t35?,40-,41-,42-,43+/m0/s1
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n/an/a 8n/an/an/an/an/an/a



EP CNRS 51

Curated by ChEMBL


Assay Description
Inhibition of [125I]-BH-CCK- binding to cholecystokinin type B receptor from jurkat Tcells


J Med Chem 36: 3021-8 (1993)


Article DOI: 10.1021/jm00072a024
BindingDB Entry DOI: 10.7270/Q2PZ57VG
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM223316
PNG
(YPYSCWVRH | piHA-Dm)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)N1SCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CO)C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C59H76N16O13S2/c1-31(2)49(56(86)68-40(9-5-19-64-59(61)62)51(81)69-41(50(60)80)24-35-26-63-30-66-35)73-53(83)43(23-34-25-65-39-8-4-3-7-38(34)39)71-55(85)47(28-89)75-58(88)45(27-76)72-52(82)42(21-32-11-15-36(77)16-12-32)70-54(84)46-10-6-20-74(46)57(87)44(67-48(79)29-90-75)22-33-13-17-37(78)18-14-33/h3-4,7-8,11-18,25-26,30-31,40-47,49,65,76-78,89H,5-6,9-10,19-24,27-29H2,1-2H3,(H2,60,80)(H,63,66)(H,67,79)(H,68,86)(H,69,81)(H,70,84)(H,71,85)(H,72,82)(H,73,83)(H4,61,62,64)/t40-,41-,42-,43-,44-,45-,46-,47-,49-/m0/s1
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n/an/a 8.5n/an/an/an/a7.0n/a



The University of Tokyo



Assay Description
After kinetic analysis with HPA, piHA-Dm was tested as an inhibitor of ten additional enzymes. The conditions are listed as follows: Agrobacterium fa...


Cell Chem Biol 24: 381-390 (2017)


Article DOI: 10.1016/j.chembiol.2017.02.001
BindingDB Entry DOI: 10.7270/Q27D2T0M
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005681
PNG
(2-Cyclohexyl-2-phenyl-propionic acid 3-dimethylami...)
Show SMILES CN(C)CCCOC(=O)C(C)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C20H31NO2/c1-20(17-11-6-4-7-12-17,18-13-8-5-9-14-18)19(22)23-16-10-15-21(2)3/h4,6-7,11-12,18H,5,8-10,13-16H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)


Article DOI: 10.1021/jm00085a017
BindingDB Entry DOI: 10.7270/Q28914T0
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005684
PNG
(2-Cyclohexyl-2-phenyl-propionic acid 3-diethylamin...)
Show SMILES CCN(CC)CCCOC(=O)C(C)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C22H35NO2/c1-4-23(5-2)17-12-18-25-21(24)22(3,19-13-8-6-9-14-19)20-15-10-7-11-16-20/h6,8-9,13-14,20H,4-5,7,10-12,15-18H2,1-3H3
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n/an/a 21n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)


Article DOI: 10.1021/jm00085a017
BindingDB Entry DOI: 10.7270/Q28914T0
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005685
PNG
(2,2-Diphenyl-propionic acid 2-diethylamino-ethyl e...)
Show SMILES CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H27NO2/c1-4-22(5-2)16-17-24-20(23)21(3,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15H,4-5,16-17H2,1-3H3
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n/an/a 46n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)


Article DOI: 10.1021/jm00085a017
BindingDB Entry DOI: 10.7270/Q28914T0
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005686
PNG
(2-Cyclohexyl-2-phenyl-propionic acid 2-diethylamin...)
Show SMILES CCN(CC)CCOC(=O)C(C)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C21H33NO2/c1-4-22(5-2)16-17-24-20(23)21(3,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6,8-9,12-13,19H,4-5,7,10-11,14-17H2,1-3H3
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n/an/a 52n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)


Article DOI: 10.1021/jm00085a017
BindingDB Entry DOI: 10.7270/Q28914T0
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005682
PNG
(2-Cyclohexyl-2-phenyl-propionic acid 4-dimethylami...)
Show SMILES CN(C)CCCCOC(=O)C(C)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C21H33NO2/c1-21(18-12-6-4-7-13-18,19-14-8-5-9-15-19)20(23)24-17-11-10-16-22(2)3/h4,6-7,12-13,19H,5,8-11,14-17H2,1-3H3
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n/an/a 190n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)


Article DOI: 10.1021/jm00085a017
BindingDB Entry DOI: 10.7270/Q28914T0
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005683
PNG
(2-Cyclohexyl-2-phenyl-propionic acid 4-diethylamin...)
Show SMILES CCN(CC)CCCCOC(=O)C(C)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C23H37NO2/c1-4-24(5-2)18-12-13-19-26-22(25)23(3,20-14-8-6-9-15-20)21-16-10-7-11-17-21/h6,8-9,14-15,21H,4-5,7,10-13,16-19H2,1-3H3
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n/an/a 380n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)


Article DOI: 10.1021/jm00085a017
BindingDB Entry DOI: 10.7270/Q28914T0
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase (HPA)


(Homo sapiens (Human))
BDBM50120847
PNG
(CHEMBL3618487)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1NC1=C[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C31H53NO23/c1-7-13(16(39)22(45)29(49-7)54-26-11(5-35)50-28(48)21(44)19(26)42)32-9-2-8(3-33)25(18(41)14(9)37)53-31-24(47)20(43)27(12(6-36)52-31)55-30-23(46)17(40)15(38)10(4-34)51-30/h2,7-8,10-48H,3-6H2,1H3/t7-,8-,10-,11-,12-,13-,14+,15-,16+,17+,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28+,29-,30-,31-/m1/s1
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n/an/a 2.59E+3n/an/an/an/an/an/a



Freie Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibition of human pancreatic alpha-amylase expressed in Pichia pastoris using amylase as substrate preincubated with substrate for 10 mins followed...


Bioorg Med Chem 23: 6725-32 (2015)


Article DOI: 10.1016/j.bmc.2015.09.007
BindingDB Entry DOI: 10.7270/Q21G0P2X
More data for this
Ligand-Target Pair
Alpha-amylase


(Tenebrio molitor)
BDBM50090176
PNG
(CHEMBL3581562)
Show SMILES CC[C@H](C)[C@@H]1NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc4cnc[nH]4)C(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC3=O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC1=O)[C@@H](C)CC
Show InChI InChI=1S/C18H19N3/c1-14(15-9-5-3-6-10-15)20-18-19-13-17(21(18)2)16-11-7-4-8-12-16/h3-14H,1-2H3,(H,19,20)/t14-/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Nanyang Technological University

Curated by ChEMBL


Assay Description
Inhibition of Tenebrio molitor alpha-amylase pre-incubated for 20 mins at 37 degC by bernfeld method


J Nat Prod 78: 695-704 (2015)


Article DOI: 10.1021/np500866c
BindingDB Entry DOI: 10.7270/Q2Q241Z9
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005680
PNG
(2-Cyclohexyl-2-phenyl-propionic acid 5-diethylamin...)
Show SMILES CCN(CC)CCCCCOC(=O)C(C)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C24H39NO2/c1-4-25(5-2)19-13-8-14-20-27-23(26)24(3,21-15-9-6-10-16-21)22-17-11-7-12-18-22/h6,9-10,15-16,22H,4-5,7-8,11-14,17-20H2,1-3H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)


Article DOI: 10.1021/jm00085a017
BindingDB Entry DOI: 10.7270/Q28914T0
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50401976
PNG
(CHEMBL2203334)
Show SMILES Brc1ccc(cc1)C1=C\C(=C/C#N)N2C(Sc3ccccc23)=N1
Show InChI InChI=1S/C18H10BrN3S/c19-13-7-5-12(6-8-13)15-11-14(9-10-20)22-16-3-1-2-4-17(16)23-18(22)21-15/h1-9,11H/b14-9+
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n/an/a 1.53E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50425183
PNG
(CHEMBL2313583)
Show SMILES CCOc1ccc2nc(N=C(CC(=O)c3ccc(Br)cc3)SC)sc2c1
Show InChI InChI=1S/C19H17BrN2O2S2/c1-3-24-14-8-9-15-17(10-14)26-19(21-15)22-18(25-2)11-16(23)12-4-6-13(20)7-5-12/h4-10H,3,11H2,1-2H3
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n/an/a 1.59E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of pig pancreatic alpha-amylase by Bernfeld method


Eur J Med Chem 59: 304-9 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.020
BindingDB Entry DOI: 10.7270/Q2028SV2
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50425181
PNG
(CHEMBL2313585)
Show SMILES CCOc1ccc2nc(N=C(CC(=O)c3ccccc3)SC)sc2c1
Show InChI InChI=1S/C19H18N2O2S2/c1-3-23-14-9-10-15-17(11-14)25-19(20-15)21-18(24-2)12-16(22)13-7-5-4-6-8-13/h4-11H,3,12H2,1-2H3
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n/an/a 1.63E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of pig pancreatic alpha-amylase by Bernfeld method


Eur J Med Chem 59: 304-9 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.020
BindingDB Entry DOI: 10.7270/Q2028SV2
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50425180
PNG
(CHEMBL2313586)
Show SMILES CSC(CC(=O)c1ccc(Br)cc1)=Nc1nc2cc(C)c(C)cc2s1
Show InChI InChI=1S/C19H17BrN2OS2/c1-11-8-15-17(9-12(11)2)25-19(21-15)22-18(24-3)10-16(23)13-4-6-14(20)7-5-13/h4-9H,10H2,1-3H3
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n/an/a 1.69E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of pig pancreatic alpha-amylase by Bernfeld method


Eur J Med Chem 59: 304-9 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.020
BindingDB Entry DOI: 10.7270/Q2028SV2
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50401967
PNG
(CHEMBL2207959)
Show SMILES COc1ccc2N3C(Sc2c1)=NC(=C\C3=C/C#N)c1ccc(Br)cc1
Show InChI InChI=1S/C19H12BrN3OS/c1-24-15-6-7-17-18(11-15)25-19-22-16(10-14(8-9-21)23(17)19)12-2-4-13(20)5-3-12/h2-8,10-11H,1H3/b14-8+
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n/an/a 1.74E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50425182
PNG
(CHEMBL2313584)
Show SMILES CSC(CC(=O)c1ccc(Br)cc1)=Nc1nc2ccccc2s1
Show InChI InChI=1S/C17H13BrN2OS2/c1-22-16(10-14(21)11-6-8-12(18)9-7-11)20-17-19-13-4-2-3-5-15(13)23-17/h2-9H,10H2,1H3
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n/an/a 1.78E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of pig pancreatic alpha-amylase by Bernfeld method


Eur J Med Chem 59: 304-9 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.020
BindingDB Entry DOI: 10.7270/Q2028SV2
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50425178
PNG
(CHEMBL2313588)
Show SMILES CCOc1ccc2nc(N=C(CC(=O)c3ccc(Cl)cc3)SC)sc2c1
Show InChI InChI=1S/C19H17ClN2O2S2/c1-3-24-14-8-9-15-17(10-14)26-19(21-15)22-18(25-2)11-16(23)12-4-6-13(20)7-5-12/h4-10H,3,11H2,1-2H3
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n/an/a 1.79E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of pig pancreatic alpha-amylase by Bernfeld method


Eur J Med Chem 59: 304-9 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.020
BindingDB Entry DOI: 10.7270/Q2028SV2
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50425176
PNG
(CHEMBL2313590)
Show SMILES CCOc1ccc2nc(N=C(CC(=O)c3ccc(F)cc3)SC)sc2c1
Show InChI InChI=1S/C19H17FN2O2S2/c1-3-24-14-8-9-15-17(10-14)26-19(21-15)22-18(25-2)11-16(23)12-4-6-13(20)7-5-12/h4-10H,3,11H2,1-2H3
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n/an/a 1.84E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of pig pancreatic alpha-amylase by Bernfeld method


Eur J Med Chem 59: 304-9 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.020
BindingDB Entry DOI: 10.7270/Q2028SV2
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50425175
PNG
(CHEMBL2313591)
Show SMILES CCOc1ccc2nc(N=C(CC(=O)c3ccc(OC)cc3)SC)sc2c1
Show InChI InChI=1S/C20H20N2O3S2/c1-4-25-15-9-10-16-18(11-15)27-20(21-16)22-19(26-3)12-17(23)13-5-7-14(24-2)8-6-13/h5-11H,4,12H2,1-3H3
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n/an/a 1.86E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of pig pancreatic alpha-amylase by Bernfeld method


Eur J Med Chem 59: 304-9 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.020
BindingDB Entry DOI: 10.7270/Q2028SV2
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50401973
PNG
(CHEMBL2207953)
Show SMILES COc1ccc2N3C(Sc2c1)=NC(=C\C3=C/C#N)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H15N3OS/c1-27-19-8-9-21-22(14-19)28-23-25-20(13-18(10-11-24)26(21)23)17-7-6-15-4-2-3-5-16(15)12-17/h2-10,12-14H,1H3/b18-10+
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n/an/a 1.87E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50425184
PNG
(CHEMBL2313582)
Show SMILES CCOc1ccc2nc(N=C(CC(=O)c3ccc(C)cc3)SC)sc2c1
Show InChI InChI=1S/C20H20N2O2S2/c1-4-24-15-9-10-16-18(11-15)26-20(21-16)22-19(25-3)12-17(23)14-7-5-13(2)6-8-14/h5-11H,4,12H2,1-3H3
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n/an/a 1.89E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of pig pancreatic alpha-amylase by Bernfeld method


Eur J Med Chem 59: 304-9 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.020
BindingDB Entry DOI: 10.7270/Q2028SV2
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50401970
PNG
(CHEMBL2207956)
Show SMILES COc1ccc2N3C(Sc2c1)=NC(=C\C3=C/C#N)c1ccc(C)cc1
Show InChI InChI=1S/C20H15N3OS/c1-13-3-5-14(6-4-13)17-11-15(9-10-21)23-18-8-7-16(24-2)12-19(18)25-20(23)22-17/h3-9,11-12H,1-2H3/b15-9+
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n/an/a 1.95E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50425177
PNG
(CHEMBL2313589)
Show SMILES CSC(CC(=O)c1ccc(F)cc1)=Nc1nc2ccccc2s1
Show InChI InChI=1S/C17H13FN2OS2/c1-22-16(10-14(21)11-6-8-12(18)9-7-11)20-17-19-13-4-2-3-5-15(13)23-17/h2-9H,10H2,1H3
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n/an/a 1.99E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of pig pancreatic alpha-amylase by Bernfeld method


Eur J Med Chem 59: 304-9 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.020
BindingDB Entry DOI: 10.7270/Q2028SV2
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50401974
PNG
(CHEMBL2207952)
Show SMILES N#C\C=C1/C=C(N=C2Sc3ccccc3N12)c1ccc2ccccc2c1
Show InChI InChI=1S/C22H13N3S/c23-12-11-18-14-19(17-10-9-15-5-1-2-6-16(15)13-17)24-22-25(18)20-7-3-4-8-21(20)26-22/h1-11,13-14H/b18-11+
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n/an/a 1.99E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50401972
PNG
(CHEMBL2207954)
Show SMILES COc1ccc2N3C(Sc2c1)=NC(=C\C3=C/C#N)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H12ClN3OS/c1-24-15-6-7-17-18(11-15)25-19-22-16(10-14(8-9-21)23(17)19)12-2-4-13(20)5-3-12/h2-8,10-11H,1H3/b14-8+
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n/an/a 2.02E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50425179
PNG
(CHEMBL2313587)
Show SMILES CSC(CC(=O)c1ccc(Cl)cc1)=Nc1nc2ccccc2s1
Show InChI InChI=1S/C17H13ClN2OS2/c1-22-16(10-14(21)11-6-8-12(18)9-7-11)20-17-19-13-4-2-3-5-15(13)23-17/h2-9H,10H2,1H3
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n/an/a 2.03E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of pig pancreatic alpha-amylase by Bernfeld method


Eur J Med Chem 59: 304-9 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.020
BindingDB Entry DOI: 10.7270/Q2028SV2
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50425174
PNG
(CHEMBL2313592)
Show SMILES CSC(CC(=O)c1ccc(C)cc1)=Nc1nc2ccccc2s1
Show InChI InChI=1S/C18H16N2OS2/c1-12-7-9-13(10-8-12)15(21)11-17(22-2)20-18-19-14-5-3-4-6-16(14)23-18/h3-10H,11H2,1-2H3
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n/an/a 2.06E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of pig pancreatic alpha-amylase by Bernfeld method


Eur J Med Chem 59: 304-9 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.020
BindingDB Entry DOI: 10.7270/Q2028SV2
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50401975
PNG
(CHEMBL2207951)
Show SMILES COc1ccc2N3C(Sc2c1)=NC(=C\C3=C/C#N)c1ccc(F)cc1
Show InChI InChI=1S/C19H12FN3OS/c1-24-15-6-7-17-18(11-15)25-19-22-16(10-14(8-9-21)23(17)19)12-2-4-13(20)5-3-12/h2-8,10-11H,1H3/b14-8+
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n/an/a 2.06E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50401968
PNG
(CHEMBL2207958)
Show SMILES CCOc1ccc2N3C(Sc2c1)=NC(=C\C3=C/C#N)c1ccccc1
Show InChI InChI=1S/C20H15N3OS/c1-2-24-16-8-9-18-19(13-16)25-20-22-17(14-6-4-3-5-7-14)12-15(10-11-21)23(18)20/h3-10,12-13H,2H2,1H3/b15-10+
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n/an/a 2.18E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50401978
PNG
(CHEMBL2207949)
Show SMILES Clc1ccc(cc1)C1=C\C(=C/C#N)N2C(Sc3ccccc23)=N1
Show InChI InChI=1S/C18H10ClN3S/c19-13-7-5-12(6-8-13)15-11-14(9-10-20)22-16-3-1-2-4-17(16)23-18(22)21-15/h1-9,11H/b14-9+
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n/an/a 2.19E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50401969
PNG
(CHEMBL2207957)
Show SMILES COc1ccc2N3C(Sc2c1)=NC(=C\C3=C/C#N)c1ccccc1
Show InChI InChI=1S/C19H13N3OS/c1-23-15-7-8-17-18(12-15)24-19-21-16(13-5-3-2-4-6-13)11-14(9-10-20)22(17)19/h2-9,11-12H,1H3/b14-9+
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n/an/a 2.23E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50401979
PNG
(CHEMBL2207948)
Show SMILES N#C\C=C1/C=C(N=C2Sc3ccccc3N12)c1ccccc1
Show InChI InChI=1S/C18H11N3S/c19-11-10-14-12-15(13-6-2-1-3-7-13)20-18-21(14)16-8-4-5-9-17(16)22-18/h1-10,12H/b14-10+
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n/an/a 2.30E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50401971
PNG
(CHEMBL2207955)
Show SMILES Cc1ccc(cc1)C1=C\C(=C/C#N)N2C(Sc3ccccc23)=N1
Show InChI InChI=1S/C19H13N3S/c1-13-6-8-14(9-7-13)16-12-15(10-11-20)22-17-4-2-3-5-18(17)23-19(22)21-16/h2-10,12H,1H3/b15-10+
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n/an/a 2.32E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50401977
PNG
(CHEMBL2207950)
Show SMILES Fc1ccc(cc1)C1=C\C(=C/C#N)N2C(Sc3ccccc23)=N1
Show InChI InChI=1S/C18H10FN3S/c19-13-7-5-12(6-8-13)15-11-14(9-10-20)22-16-3-1-2-4-17(16)23-18(22)21-15/h1-9,11H/b14-9+
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n/an/a 2.44E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM23406
PNG
((3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4S,5...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)OC(O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23?,24-,25-/m1/s1
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n/an/a 2.63E+4n/an/an/an/an/an/a



Universit£ degli Studi della Basilicata

Curated by ChEMBL


Assay Description
Inhibition of hog pancreas alpha-amylase using starch as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by ...


J Nat Prod 79: 2104-12 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00484
BindingDB Entry DOI: 10.7270/Q2QN68R4
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50351096
PNG
(ASCORBIC ACID)
Show SMILES OC[C@H](O)[C@H]1OC(=O)C(=O)C1O
Show InChI InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-3,5,7-9H,1H2/t2-,3?,5+/m0/s1
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n/an/a 2.65E+4n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
The compound was tested for inhibition of malt Alpha-amylase by Megazyme assay


Bioorg Med Chem Lett 10: 1575-6 (2000)


Article DOI: 10.1016/s0960-894x(00)00288-2
BindingDB Entry DOI: 10.7270/Q2R49R9C
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50090254
PNG
((R)-5-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3,4-di...)
Show SMILES CC1(C)OC[C@H](O1)c1oc(O)c(O)c1O
Show InChI InChI=1S/C9H12O6/c1-9(2)13-3-4(15-9)7-5(10)6(11)8(12)14-7/h4,10-12H,3H2,1-2H3/t4-/m0/s1
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n/an/a 2.80E+4n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
The compound was tested for inhibition of malt Alpha-amylase by Megazyme assay


Bioorg Med Chem Lett 10: 1575-6 (2000)


Article DOI: 10.1016/s0960-894x(00)00288-2
BindingDB Entry DOI: 10.7270/Q2R49R9C
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50333465
PNG
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1
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n/an/a 3.55E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of porcine pancreatic alpha amylase using starch as substrate by Bernfeld method


Bioorg Med Chem Lett 22: 7011-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.025
BindingDB Entry DOI: 10.7270/Q2FN17CD
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50333465
PNG
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1
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n/an/a 3.55E+4n/an/an/an/an/an/a



North Maharashtra University

Curated by ChEMBL


Assay Description
Inhibition of pig pancreatic alpha-amylase by Bernfeld method


Eur J Med Chem 59: 304-9 (2013)


Article DOI: 10.1016/j.ejmech.2012.11.020
BindingDB Entry DOI: 10.7270/Q2028SV2
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM92367
PNG
(GPESB15)
Show SMILES O[C@@H]1O[C@H](Cn2cc(nn2)C2=CCCCC2)[C@H](O)C1O
Show InChI InChI=1S/C13H19N3O4/c17-11-10(20-13(19)12(11)18)7-16-6-9(14-15-16)8-4-2-1-3-5-8/h4,6,10-13,17-19H,1-3,5,7H2/t10-,11+,12?,13-/m1/s1
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3.36E+4 -26.6 3.58E+4n/an/an/an/a7.037



Yonsei University



Assay Description
To test whether GCTs share a common binding pocket on PPA with acarbose, we performed an experiment according to the method of Yonetani and Theorell.


Chembiochem 13: 1584-93 (2012)


Article DOI: 10.1002/cbic.201200272
BindingDB Entry DOI: 10.7270/Q2ST7NFC
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50451094
PNG
(ASCORBYL PALMITATE | Ascorbyl Palmitate | Ascorbyl...)
Show SMILES CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O
Show InChI InChI=1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21+/m0/s1
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n/an/a 6.25E+4n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
The compound was tested for inhibition of malt Alpha-amylase by Megazyme assay


Bioorg Med Chem Lett 10: 1575-6 (2000)


Article DOI: 10.1016/s0960-894x(00)00288-2
BindingDB Entry DOI: 10.7270/Q2R49R9C
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM50202632
PNG
(CHEMBL460030)
Show SMILES CC(=O)OCC1=C[C@H](O)[C@H]2[C@@H]1[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)OC=C2C(O)=O
Show InChI InChI=1S/C18H24O12/c1-6(20)27-4-7-2-9(21)12-8(16(25)26)5-28-17(11(7)12)30-18-15(24)14(23)13(22)10(3-19)29-18/h2,5,9-15,17-19,21-24H,3-4H2,1H3,(H,25,26)/t9-,10+,11+,12-,13+,14-,15+,17-,18-/m0/s1
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n/an/a 6.94E+4n/an/an/an/an/an/a



Universit£ degli Studi della Basilicata

Curated by ChEMBL


Assay Description
Inhibition of hog pancreas alpha-amylase using starch as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by ...


J Nat Prod 79: 2104-12 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00484
BindingDB Entry DOI: 10.7270/Q2QN68R4
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM23410
PNG
(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Show SMILES COc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C16H12O7/c1-22-8-5-11(19)13-12(6-8)23-16(15(21)14(13)20)7-2-3-9(17)10(18)4-7/h2-6,17-19,21H,1H3
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n/an/a 7.39E+4n/an/an/an/an/an/a



Universit£ degli Studi della Basilicata

Curated by ChEMBL


Assay Description
Inhibition of hog pancreas alpha-amylase using starch as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by ...


J Nat Prod 79: 2104-12 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00484
BindingDB Entry DOI: 10.7270/Q2QN68R4
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM92366
PNG
(GPESB14)
Show SMILES O[C@@H]1O[C@H](Cn2cc(nn2)-c2ccccc2)[C@H](O)C1O
Show InChI InChI=1S/C13H15N3O4/c17-11-10(20-13(19)12(11)18)7-16-6-9(14-15-16)8-4-2-1-3-5-8/h1-6,10-13,17-19H,7H2/t10-,11+,12?,13-/m1/s1
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2.04E+5 -21.9 8.89E+4n/an/an/an/a7.037



Yonsei University



Assay Description
To test whether GCTs share a common binding pocket on PPA with acarbose, we performed an experiment according to the method of Yonetani and Theorell.


Chembiochem 13: 1584-93 (2012)


Article DOI: 10.1002/cbic.201200272
BindingDB Entry DOI: 10.7270/Q2ST7NFC
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM92365
PNG
(GPESB11)
Show SMILES CO[C@@H]1O[C@H](Cn2cc(COC(C)=O)nn2)[C@@H]2OC(C)(C)OC12
Show InChI InChI=1S/C14H21N3O6/c1-8(18)20-7-9-5-17(16-15-9)6-10-11-12(13(19-4)21-10)23-14(2,3)22-11/h5,10-13H,6-7H2,1-4H3/t10-,11+,12?,13-/m1/s1
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2.34E+5 -21.6 1.25E+5n/an/an/an/a7.037



Yonsei University



Assay Description
To test whether GCTs share a common binding pocket on PPA with acarbose, we performed an experiment according to the method of Yonetani and Theorell.


Chembiochem 13: 1584-93 (2012)


Article DOI: 10.1002/cbic.201200272
BindingDB Entry DOI: 10.7270/Q2ST7NFC
More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Sus scrofa (Pig))
BDBM92363
PNG
(GPESB02)
Show SMILES CO[C@@H]1O[C@H](Cn2cc(nn2)C2=CCCCC2)[C@@H]2OC(C)(C)OC12
Show InChI InChI=1S/C17H25N3O4/c1-17(2)23-14-13(22-16(21-3)15(14)24-17)10-20-9-12(18-19-20)11-7-5-4-6-8-11/h7,9,13-16H,4-6,8,10H2,1-3H3/t13-,14+,15?,16-/m1/s1
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3.42E+5 -20.6 1.50E+5n/an/an/an/a7.037



Yonsei University



Assay Description
To test whether GCTs share a common binding pocket on PPA with acarbose, we performed an experiment according to the method of Yonetani and Theorell.


Chembiochem 13: 1584-93 (2012)


Article DOI: 10.1002/cbic.201200272
BindingDB Entry DOI: 10.7270/Q2ST7NFC
More data for this
Ligand-Target Pair
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