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Compile Data Set for Download or QSAR

Found 626 hits of ic50 data for polymerid = 50001330,50001957   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271230
PNG
(US10059720, Example 45)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1/C28H32N2O6S/c1-37(34,35)25-13-11-20(12-14-25)19-7-9-21(10-8-19)26(29)28(33,27(31)32)18-22-17-24(15-16-30-22)36-23-5-3-2-4-6-23/h7-17,23,26,33H,2-6,18,29H2,1H3,(H,31,32)/t26-,28+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284944
PNG
(US10023583, Example 16)
Show SMILES N[C@@H](CCC1CC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1/C21H28N2O4/c22-19(8-6-14-3-4-14)21(26,20(24)25)12-17-16-11-15(7-5-13-1-2-13)27-18(16)9-10-23-17/h9-11,13-14,19,26H,1-8,12,22H2,(H,24,25)/t19-,21+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)


Article DOI: 10.1038/nm1003
BindingDB Entry DOI: 10.7270/Q29Z96X2
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401319
PNG
(US10005762, Example 3)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)CCC2CC2)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C21H32N2O3/c1-14-13-23-18(11-17(14)4-2-3-15-5-6-15)12-21(26,20(24)25)19(22)10-9-16-7-8-16/h11,13,15-16,19,26H,2-10,12,22H2,1H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271290
PNG
(US10059720, Example 105)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O
Show InChI InChI=1/C19H30N2O4S/c1-3-26-12-17(20)19(24,18(22)23)11-14-10-16(8-9-21-14)25-15-6-4-13(2)5-7-15/h8-10,13,15,17,24H,3-7,11-12,20H2,1-2H3,(H,22,23)/t13-,15-,17-,19+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401367
PNG
(US10005762, Example 47)
Show SMILES CC(C)CC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-14(2)7-10-19(22)21(26,20(24)25)12-18-11-17(15(3)13-23-18)6-4-5-16-8-9-16/h11,13-14,16,19,26H,4-10,12,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271257
PNG
(US10059720, Example 72)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC(C)(C)C)c(C)cn1)C(O)=O
Show InChI InChI=1/C20H34N2O4/c1-13(2)9-17(21)20(25,18(23)24)11-15-10-16(14(3)12-22-15)26-8-7-19(4,5)6/h10,12-13,17,25H,7-9,11,21H2,1-6H3,(H,23,24)/t17-,20+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271330
PNG
(US10059720, Example 145)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O
Show InChI InChI=1/C20H32N2O4S/c1-3-10-27-13-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(2)5-7-16/h8-9,11,14,16,18,25H,3-7,10,12-13,21H2,1-2H3,(H,23,24)/t14-,16-,18-,20+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284942
PNG
(US10023583, Example 14)
Show SMILES N[C@@H](CCC1CCC1)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1/C22H30N2O4/c23-20(9-7-14-2-1-3-14)22(27,21(25)26)13-18-17-12-16(8-6-15-4-5-15)28-19(17)10-11-24-18/h10-12,14-15,20,27H,1-9,13,23H2,(H,25,26)/t20-,22+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)


Article DOI: 10.1038/nm1003
BindingDB Entry DOI: 10.7270/Q29Z96X2
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271230
PNG
(US10059720, Example 45)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1/C28H32N2O6S/c1-37(34,35)25-13-11-20(12-14-25)19-7-9-21(10-8-19)26(29)28(33,27(31)32)18-22-17-24(15-16-30-22)36-23-5-3-2-4-6-23/h7-17,23,26,33H,2-6,18,29H2,1H3,(H,31,32)/t26-,28+/s2
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Astellas Pharma Inc

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271310
PNG
(US10059720, Example 125)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)(C)F)C(O)=O)c1
Show InChI InChI=1/C20H31FN2O4/c1-13-4-6-15(7-5-13)27-16-8-9-23-14(10-16)11-20(26,18(24)25)17(22)12-19(2,3)21/h8-10,13,15,17,26H,4-7,11-12,22H2,1-3H3,(H,24,25)/t13-,15-,17-,20+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271316
PNG
(US10059720, Example 131)
Show SMILES CC(C)CC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1/C21H30N2O4/c1-13(2)3-8-19(22)21(26,20(24)25)12-17-16-11-15(7-6-14-4-5-14)27-18(16)9-10-23-17/h9-11,13-14,19,26H,3-8,12,22H2,1-2H3,(H,24,25)/t19-,21+/s2
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US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271309
PNG
(US10059720, Example 124)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)(C)C)C(O)=O)c1
Show InChI InChI=1/C21H34N2O4/c1-14-5-7-16(8-6-14)27-17-9-10-23-15(11-17)12-21(26,19(24)25)18(22)13-20(2,3)4/h9-11,14,16,18,26H,5-8,12-13,22H2,1-4H3,(H,24,25)/t14-,16-,18-,21+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271257
PNG
(US10059720, Example 72)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC(C)(C)C)c(C)cn1)C(O)=O
Show InChI InChI=1/C20H34N2O4/c1-13(2)9-17(21)20(25,18(23)24)11-15-10-16(14(3)12-22-15)26-8-7-19(4,5)6/h10,12-13,17,25H,7-9,11,21H2,1-6H3,(H,23,24)/t17-,20+/s2
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Astellas Pharma Inc

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401355
PNG
(US10005762, Example 35)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(CCCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3S/c1-13-11-21-16(9-15(13)6-4-3-5-14-7-8-14)10-19(24,18(22)23)17(20)12-25-2/h9,11,14,17,24H,3-8,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271275
PNG
(US10059720, Example 90)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCC(C)(C)CC1)C(O)=O
Show InChI InChI=1/C20H33N3O3/c1-14(2)11-17(21)20(26,18(24)25)13-15-12-16(5-8-22-15)23-9-6-19(3,4)7-10-23/h5,8,12,14,17,26H,6-7,9-11,13,21H2,1-4H3,(H,24,25)/t17-,20+/s2
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Astellas Pharma Inc

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271318
PNG
(US10059720, Example 133)
Show SMILES N[C@@H](CCC(F)(F)F)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1/C19H23F3N2O4/c20-19(21,22)7-5-16(23)18(27,17(25)26)10-14-13-9-12(4-3-11-1-2-11)28-15(13)6-8-24-14/h6,8-9,11,16,27H,1-5,7,10,23H2,(H,25,26)/t16-,18+/s2
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US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271198
PNG
(US10059720, Example 13)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCCCC1)C(O)=O
Show InChI InChI=1/C18H29N3O3/c1-13(2)10-16(19)18(24,17(22)23)12-14-11-15(6-7-20-14)21-8-4-3-5-9-21/h6-7,11,13,16,24H,3-5,8-10,12,19H2,1-2H3,(H,22,23)/t16-,18+/s2
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US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271275
PNG
(US10059720, Example 90)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCC(C)(C)CC1)C(O)=O
Show InChI InChI=1/C20H33N3O3/c1-14(2)11-17(21)20(26,18(24)25)13-15-12-16(5-8-22-15)23-9-6-19(3,4)7-10-23/h5,8,12,14,17,26H,6-7,9-11,13,21H2,1-4H3,(H,24,25)/t17-,20+/s2
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US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271288
PNG
(US10059720, Example 103)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O
Show InChI InChI=1/C18H28N2O4S/c1-12-3-5-14(6-4-12)24-15-7-8-20-13(9-15)10-18(23,17(21)22)16(19)11-25-2/h7-9,12,14,16,23H,3-6,10-11,19H2,1-2H3,(H,21,22)/t12-,14-,16-,18+/s2
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US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284929
PNG
(US10023583, Example 2)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1/C18H24N2O4S/c1-25-10-16(19)18(23,17(21)22)9-14-13-8-12(5-4-11-2-3-11)24-15(13)6-7-20-14/h6-8,11,16,23H,2-5,9-10,19H2,1H3,(H,21,22)/t16-,18+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)


Article DOI: 10.1038/nm1003
BindingDB Entry DOI: 10.7270/Q29Z96X2
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271258
PNG
(US10059720, Example 73)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)c(C)cn1)C(O)=O
Show InChI InChI=1/C21H34N2O4/c1-13(2)9-19(22)21(26,20(24)25)11-16-10-18(15(4)12-23-16)27-17-7-5-14(3)6-8-17/h10,12-14,17,19,26H,5-9,11,22H2,1-4H3,(H,24,25)/t14-,17-,19-,21+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271277
PNG
(US10059720, Example 92)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H](C)Cc2ccccc2)ccn1)C(O)=O
Show InChI InChI=1/C22H30N2O4/c1-15(2)11-20(23)22(27,21(25)26)14-18-13-19(9-10-24-18)28-16(3)12-17-7-5-4-6-8-17/h4-10,13,15-16,20,27H,11-12,14,23H2,1-3H3,(H,25,26)/t16-,20+,22-/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271190
PNG
(US10059720, Example 6)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O
Show InChI InChI=1/C20H32N2O4/c1-13(2)10-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(3)5-7-16/h8-9,11,13-14,16,18,25H,4-7,10,12,21H2,1-3H3,(H,23,24)/t14-,16-,18-,20+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401322
PNG
(US10005762, Example 4(3))
Show SMILES CCC(O)CCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C20H34N2O4/c1-5-17(23)8-6-7-15-10-16(22-12-14(15)4)11-20(26,19(24)25)18(21)9-13(2)3/h10,12-13,17-18,23,26H,5-9,11,21H2,1-4H3,(H,24,25)/t17?,18-,20+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271260
PNG
(US10059720, Example 75)
Show SMILES COCCCCC[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1/C21H34N2O5/c1-27-13-7-3-6-10-19(22)21(26,20(24)25)15-16-14-18(11-12-23-16)28-17-8-4-2-5-9-17/h11-12,14,17,19,26H,2-10,13,15,22H2,1H3,(H,24,25)/t19-,21+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271277
PNG
(US10059720, Example 92)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H](C)Cc2ccccc2)ccn1)C(O)=O
Show InChI InChI=1/C22H30N2O4/c1-15(2)11-20(23)22(27,21(25)26)14-18-13-19(9-10-24-18)28-16(3)12-17-7-5-4-6-8-17/h4-10,13,15-16,20,27H,11-12,14,23H2,1-3H3,(H,25,26)/t16-,20+,22-/s2
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Astellas Pharma Inc

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271213
PNG
(US10059720, Example 28)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC2(C)CC2)ccn1)C(O)=O
Show InChI InChI=1/C19H30N2O4/c1-13(2)10-16(20)19(24,17(22)23)12-14-11-15(4-8-21-14)25-9-7-18(3)5-6-18/h4,8,11,13,16,24H,5-7,9-10,12,20H2,1-3H3,(H,22,23)/t16-,19+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271272
PNG
(US10059720, Example 87)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CCN(CC2)C(=O)OCc2ccccc2)ccn1)C(O)=O
Show InChI InChI=1/C26H35N3O6/c1-18(2)14-23(27)26(33,24(30)31)16-20-15-22(8-11-28-20)35-21-9-12-29(13-10-21)25(32)34-17-19-6-4-3-5-7-19/h3-8,11,15,18,21,23,33H,9-10,12-14,16-17,27H2,1-2H3,(H,30,31)/t23-,26+/s2
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Astellas Pharma Inc

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271243
PNG
(US10059720, Example 58)
Show SMILES CC(C)C[C@@H](C)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1/C19H32N2O4/c1-12(2)8-14(5)25-16-6-7-21-15(10-16)11-19(24,18(22)23)17(20)9-13(3)4/h6-7,10,12-14,17,24H,8-9,11,20H2,1-5H3,(H,22,23)/t14-,17+,19-/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271330
PNG
(US10059720, Example 145)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O
Show InChI InChI=1/C20H32N2O4S/c1-3-10-27-13-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(2)5-7-16/h8-9,11,14,16,18,25H,3-7,10,12-13,21H2,1-2H3,(H,23,24)/t14-,16-,18-,20+/s2
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Astellas Pharma Inc

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271198
PNG
(US10059720, Example 13)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCCCC1)C(O)=O
Show InChI InChI=1/C18H29N3O3/c1-13(2)10-16(19)18(24,17(22)23)12-14-11-15(6-7-20-14)21-8-4-3-5-9-21/h6-7,11,13,16,24H,3-5,8-10,12,19H2,1-2H3,(H,22,23)/t16-,18+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271190
PNG
(US10059720, Example 6)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O
Show InChI InChI=1/C20H32N2O4/c1-13(2)10-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(3)5-7-16/h8-9,11,13-14,16,18,25H,4-7,10,12,21H2,1-3H3,(H,23,24)/t14-,16-,18-,20+/s2
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Astellas Pharma Inc

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401350
PNG
(US10005762, Example 30)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)CC(C)(C)F)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C20H31FN2O3/c1-13-12-23-16(9-15(13)6-4-5-14-7-8-14)10-20(26,18(24)25)17(22)11-19(2,3)21/h9,12,14,17,26H,4-8,10-11,22H2,1-3H3,(H,24,25)/t17-,20+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271288
PNG
(US10059720, Example 103)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O
Show InChI InChI=1/C18H28N2O4S/c1-12-3-5-14(6-4-12)24-15-7-8-20-13(9-15)10-18(23,17(21)22)16(19)11-25-2/h7-9,12,14,16,23H,3-6,10-11,19H2,1-2H3,(H,21,22)/t12-,14-,16-,18+/s2
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Astellas Pharma Inc

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271272
PNG
(US10059720, Example 87)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CCN(CC2)C(=O)OCc2ccccc2)ccn1)C(O)=O
Show InChI InChI=1/C26H35N3O6/c1-18(2)14-23(27)26(33,24(30)31)16-20-15-22(8-11-28-20)35-21-9-12-29(13-10-21)25(32)34-17-19-6-4-3-5-7-19/h3-8,11,15,18,21,23,33H,9-10,12-14,16-17,27H2,1-2H3,(H,30,31)/t23-,26+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271199
PNG
(US10059720, Example 14)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCc2cccc3ccccc23)ccn1)C(O)=O
Show InChI InChI=1/C24H28N2O4/c1-16(2)12-22(25)24(29,23(27)28)14-19-13-20(10-11-26-19)30-15-18-8-5-7-17-6-3-4-9-21(17)18/h3-11,13,16,22,29H,12,14-15,25H2,1-2H3,(H,27,28)/t22-,24+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401393
PNG
(US10005762, Example 73)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-14(2)10-19(22)21(26,20(24)25)12-18-11-17(15(3)13-23-18)7-5-4-6-16-8-9-16/h11,13-14,16,19,26H,4-10,12,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401369
PNG
(US10005762, Example 49)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCC2(C)CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-14(2)10-18(22)21(26,19(24)25)12-17-11-16(15(3)13-23-17)6-5-7-20(4)8-9-20/h11,13-14,18,26H,5-10,12,22H2,1-4H3,(H,24,25)/t18-,21+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271311
PNG
(US10059720, Example 126)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1cc(OC2CCC3(CC3)CC2)ccn1)C(O)=O
Show InChI InChI=1/C20H30N2O4S/c1-2-27-13-17(21)20(25,18(23)24)12-14-11-16(5-10-22-14)26-15-3-6-19(7-4-15)8-9-19/h5,10-11,15,17,25H,2-4,6-9,12-13,21H2,1H3,(H,23,24)/t17-,20+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271280
PNG
(US10059720, Example 95)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCc2ccsc2)ccn1)C(O)=O
Show InChI InChI=1/C19H26N2O4S/c1-13(2)9-17(20)19(24,18(22)23)11-15-10-16(3-6-21-15)25-7-4-14-5-8-26-12-14/h3,5-6,8,10,12-13,17,24H,4,7,9,11,20H2,1-2H3,(H,22,23)/t17-,19+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271280
PNG
(US10059720, Example 95)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCc2ccsc2)ccn1)C(O)=O
Show InChI InChI=1/C19H26N2O4S/c1-13(2)9-17(20)19(24,18(22)23)11-15-10-16(3-6-21-15)25-7-4-14-5-8-26-12-14/h3,5-6,8,10,12-13,17,24H,4,7,9,11,20H2,1-2H3,(H,22,23)/t17-,19+/s2
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Astellas Pharma Inc

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271218
PNG
(US10059720, Example 33)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc2n(CCC3CCCCC3)cnc2cn1)C(O)=O
Show InChI InChI=1/C22H34N4O3/c1-15(2)10-20(23)22(29,21(27)28)12-17-11-19-18(13-24-17)25-14-26(19)9-8-16-6-4-3-5-7-16/h11,13-16,20,29H,3-10,12,23H2,1-2H3,(H,27,28)/t20-,22+/s2
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Astellas Pharma Inc

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271232
PNG
(US10059720, Example 47)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CC3CCC2C3)ccn1)C(O)=O
Show InChI InChI=1/C20H30N2O4/c1-12(2)7-18(21)20(25,19(23)24)11-15-10-16(5-6-22-15)26-17-9-13-3-4-14(17)8-13/h5-6,10,12-14,17-18,25H,3-4,7-9,11,21H2,1-2H3,(H,23,24)/t13?,14?,17?,18-,20+/s2
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Astellas Pharma Inc

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271184
PNG
(US10059720, Example 1)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1/C18H28N2O4/c1-12(2)9-16(19)18(23,17(21)22)11-14-10-15(5-7-20-14)24-8-6-13-3-4-13/h5,7,10,12-13,16,23H,3-4,6,8-9,11,19H2,1-2H3,(H,21,22)/t16-,18+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))
BDBM271245
PNG
(US10059720, Example 60)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CC(C)(C)OC(C)(C)C2)ccn1)C(O)=O
Show InChI InChI=1/C22H36N2O5/c1-14(2)9-18(23)22(27,19(25)26)11-15-10-16(7-8-24-15)28-17-12-20(3,4)29-21(5,6)13-17/h7-8,10,14,17-18,27H,9,11-13,23H2,1-6H3,(H,25,26)/t18-,22+/s2
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Astellas Pharma Inc

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271306
PNG
(US10059720, Example 121)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(SC2CCCCCC2)ccn1)C(O)=O
Show InChI InChI=1/C20H32N2O3S/c1-14(2)11-18(21)20(25,19(23)24)13-15-12-17(9-10-22-15)26-16-7-5-3-4-6-8-16/h9-10,12,14,16,18,25H,3-8,11,13,21H2,1-2H3,(H,23,24)/t18-,20+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM271187
PNG
(US10059720, Example 3)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O
Show InChI InChI=1/C19H30N2O4/c1-13(2)10-17(20)19(24,18(22)23)12-14-11-16(8-9-21-14)25-15-6-4-3-5-7-15/h8-9,11,13,15,17,24H,3-7,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10059720 (2018)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401355
PNG
(US10005762, Example 35)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(CCCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3S/c1-13-11-21-16(9-15(13)6-4-3-5-14-7-8-14)10-19(24,18(22)23)17(20)12-25-2/h9,11,14,17,24H,3-8,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)
BDBM284941
PNG
(US10023583, Example 13)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O
Show InChI InChI=1/C20H28N2O4S/c1-2-9-27-12-18(21)20(25,19(23)24)11-16-15-10-14(6-5-13-3-4-13)26-17(15)7-8-22-16/h7-8,10,13,18,25H,2-6,9,11-12,21H2,1H3,(H,23,24)/t18-,20+/s2
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Astellas Pharma Inc

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000g for 30 minutes to obtain microsomes containing IRAP. The m...


US Patent US10023583 (2018)


Article DOI: 10.1038/nm1003
BindingDB Entry DOI: 10.7270/Q29Z96X2
More data for this
Ligand-Target Pair
Cystinyl aminopeptidase


(Rattus norvegicus)
BDBM401360
PNG
(US10005762, Example 40)
Show SMILES N[C@@H](CCC1CC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c21-18(9-8-15-6-7-15)20(25,19(23)24)13-17-12-16(10-11-22-17)3-1-2-14-4-5-14/h10-12,14-15,18,25H,1-9,13,21H2,(H,23,24)/t18-,20+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
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