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Compile Data Set for Download or QSAR

Found 44 hits of ic50 data for polymerid = 50001413,50001427   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RNase L


(Homo sapiens (Human))
BDBM50085553
PNG
(CHEMBL214603 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(65-29)2-62-73(54,55)68-21-18(48)12(66-30(21)44-7-39-14-23(32)35-5-37-26(14)44)3-63-74(56,57)69-22-19(49)13(4-64-75(58,59)71-76(60,61)70-72(51,52)53)67-31(22)45-8-40-15-24(33)36-6-38-27(15)45/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
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n/an/a 0.720n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50421415
PNG
(CHEMBL414948)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/s2
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n/an/a 0.950n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in mouse L cells


J Med Chem 28: 1376-80 (1985)


Article DOI: 10.1021/jm00147a048
BindingDB Entry DOI: 10.7270/Q26W9BNH
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens (Human))
BDBM50421415
PNG
(CHEMBL414948)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/s2
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n/an/a 1.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cells


J Med Chem 28: 1376-80 (1985)


Article DOI: 10.1021/jm00147a048
BindingDB Entry DOI: 10.7270/Q26W9BNH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
RNase L


(Mus musculus)
BDBM50370219
PNG
(CHEMBL610868)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OC6[C@H](O)[C@@H](COP(O)(O)=O)OC6n6c(N=[N+]=[N-])nc7c(N)ncnc67)OC5n5c(N=[N+]=[N-])nc6c(N)ncnc56)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12
Show InChI InChI=1/C40H46N32O25P4/c41-25-13-29(53-5-49-25)69(37(57-13)61-65-45)33-21(77)17(73)9(91-33)2-88-99(81,82)96-23-19(75)11(93-35(23)71-31-15(27(43)51-7-55-31)59-39(71)63-67-47)4-90-101(85,86)97-24-20(76)12(94-36(24)72-32-16(28(44)52-8-56-32)60-40(72)64-68-48)3-89-100(83,84)95-22-18(74)10(1-87-98(78,79)80)92-34(22)70-30-14(26(42)50-6-54-30)58-38(70)62-66-46/h5-12,17-24,33-36,73-77H,1-4H2,(H,81,82)(H,83,84)(H,85,86)(H2,41,49,53)(H2,42,50,54)(H2,43,51,55)(H2,44,52,56)(H2,78,79,80)/t9-,10-,11-,12-,17-,18-,19-,20-,21-,22?,23-,24-,33?,34?,35?,36?/s2
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n/an/a 2n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50370220
PNG
(CHEMBL1163094)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)OC4C(O)C(COP(O)(=O)OC5C(O)C(COP(O)(O)=O)OC5n5c(N=[N+]=[N-])nc6c(N)ncnc56)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12
Show InChI InChI=1/C30H35N24O19P3/c31-19-10-22(40-4-37-19)52(28(43-10)46-49-34)25-16(58)13(55)7(69-25)2-67-75(62,63)73-18-15(57)9(71-27(18)54-24-12(21(33)39-6-42-24)45-30(54)48-51-36)3-68-76(64,65)72-17-14(56)8(1-66-74(59,60)61)70-26(17)53-23-11(20(32)38-5-41-23)44-29(53)47-50-35/h4-9,13-18,25-27,55-58H,1-3H2,(H,62,63)(H,64,65)(H2,31,37,40)(H2,32,38,41)(H2,33,39,42)(H2,59,60,61)/t7-,8?,9?,13-,14?,15?,16-,17?,18?,25?,26?,27?/s2
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n/an/a 2n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50025002
PNG
(CHEMBL404038 | ppp'A2'p5'A2'p5'A | ppp5'A2'p5'A2'p...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H40N15O25P5/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(64-28)1-61-72(53,54)67-20-17(47)11(65-29(20)44-8-41-14-23(32)35-5-38-26(14)44)2-62-73(55,56)68-21-18(48)12(3-63-74(57,58)70-75(59,60)69-71(50,51)52)66-30(21)45-9-42-15-24(33)36-6-39-27(15)45/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
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n/an/a 2.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts


J Med Chem 29: 1015-22 (1986)


Article DOI: 10.1021/jm00156a020
BindingDB Entry DOI: 10.7270/Q2SX6C6K
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens (Human))
BDBM50085558
PNG
(CHEMBL402676 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)ncnc56)O[C@H]4n4cnc5c(N)ncnc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)29-20(50)17(47)11(61-29)3-59-67(54,55)65-22-19(49)13(63-31(22)45-8-40-15-24(33)36-6-38-27(15)45)4-60-68(56,57)64-21-18(48)12(2-58-66(51,52)53)62-30(21)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
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n/an/a 2.60n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50373177
PNG
(CHEMBL404038)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H40N15O25P5/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(64-28)1-61-72(53,54)67-20-17(47)11(65-29(20)44-8-41-14-23(32)35-5-38-26(14)44)2-62-73(55,56)68-21-18(48)12(3-63-74(57,58)70-75(59,60)69-71(50,51)52)66-30(21)45-9-42-15-24(33)36-6-39-27(15)45/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50421415
PNG
(CHEMBL414948)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/s2
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n/an/a 4n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens (Human))
BDBM50085554
PNG
(5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5'...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1
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n/an/a 7.30n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens (Human))
BDBM50421415
PNG
(CHEMBL414948)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/s2
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n/an/a 13n/an/an/an/an/an/a



National Institute of Diabetes and Digestive antd Kidney Diseases

Curated by ChEMBL


Assay Description
Displacement of the probe bound to Ribonuclease L by compound in radiobinding assay was evaluated


Bioorg Med Chem Lett 10: 1357-60 (2000)


Article DOI: 10.1016/s0960-894x(00)00240-7
BindingDB Entry DOI: 10.7270/Q2TT4Q67
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
RNase L


(Homo sapiens (Human))
BDBM50421415
PNG
(CHEMBL414948)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[C@@H]2[C@H](O)[C@@H](CO[P@](O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/s2
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n/an/a 20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytes


J Med Chem 28: 1376-80 (1985)


Article DOI: 10.1021/jm00147a048
BindingDB Entry DOI: 10.7270/Q26W9BNH
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
RNase L


(Homo sapiens (Human))
BDBM50085556
PNG
(CHEMBL405496 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1
Show InChI InChI=1S/C31H42N15O25P5/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(19(49)13(67-31)4-64-75(58,59)71-76(60,61)70-72(51,52)53)69-74(56,57)63-3-12-18(48)21(30(66-12)45-8-40-15-24(33)36-6-38-27(15)45)68-73(54,55)62-2-11-17(47)20(50)29(65-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50025005
PNG
(CHEMBL3143469 | CHEMBL385731 | pp5'(br8A)2'p5'(br8...)
Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12
Show InChI InChI=1/C30H36Br3N15O22P4/c31-28-43-10-19(34)37-4-40-22(10)46(28)25-16(52)13(49)7(65-25)1-62-72(56,57)68-17-14(50)8(66-26(17)47-23-11(44-29(47)32)20(35)38-5-41-23)2-63-73(58,59)69-18-15(51)9(3-64-74(60,61)70-71(53,54)55)67-27(18)48-24-12(45-30(48)33)21(36)39-6-42-24/h4-9,13-18,25-27,49-52H,1-3H2,(H,56,57)(H,58,59)(H,60,61)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,53,54,55)/t7-,8-,9-,13-,14-,15-,16-,17-,18-,25-,26-,27-/s2
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n/an/a 48n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts


J Med Chem 29: 1015-22 (1986)


Article DOI: 10.1021/jm00156a020
BindingDB Entry DOI: 10.7270/Q2SX6C6K
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50370222
PNG
(CHEMBL610866)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)OC4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)O[C@@H]6[C@H](O)[C@@H](CO)OC6n6c(N=[N+]=[N-])nc7c(N)ncnc67)OC5n5c(N=[N+]=[N-])nc6c(N)ncnc56)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12
Show InChI InChI=1/C40H45N32O22P3/c41-25-13-29(53-5-49-25)69(37(57-13)61-65-45)33-21(78)17(74)10(89-33)2-85-95(79,80)93-23-19(76)12(91-35(23)71-31-15(27(43)51-7-55-31)59-39(71)63-67-47)4-87-97(83,84)94-24-20(77)11(90-36(24)72-32-16(28(44)52-8-56-32)60-40(72)64-68-48)3-86-96(81,82)92-22-18(75)9(1-73)88-34(22)70-30-14(26(42)50-6-54-30)58-38(70)62-66-46/h5-12,17-24,33-36,73-78H,1-4H2,(H,79,80)(H,81,82)(H,83,84)(H2,41,49,53)(H2,42,50,54)(H2,43,51,55)(H2,44,52,56)/t9-,10-,11-,12-,17-,18-,19-,20-,21-,22-,23?,24-,33?,34?,35?,36?/s2
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n/an/a 50n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50366437
PNG
(CHEMBL608874)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](OP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-16(47)14(45)9(58-26)1-56-65(52,53)61-18-15(46)10(59-27(18)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)29(63-64(49,50)51)60-28(19)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17+,18-,19-,26?,27-,28-,29-/s2
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n/an/a 50n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from mouse L cell extract


Bioorg Med Chem Lett 6: 1785-1790 (1996)

Checked by Author
Article DOI: 10.1016/0960-894X(96)00314-9
BindingDB Entry DOI: 10.7270/Q2XS5VWT
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens (Human))
BDBM50085555
PNG
(CHEMBL384725 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4cnc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)c2n1
Show InChI InChI=1S/C31H40N15O19P3/c1-10-42-25(34)16-28(43-10)46(9-41-16)31-22(18(48)12(62-31)2-58-66(51,52)53)65-68(56,57)60-4-13-19(49)21(30(63-13)45-8-40-15-24(33)36-6-38-27(15)45)64-67(54,55)59-3-11-17(47)20(50)29(61-11)44-7-39-14-23(32)35-5-37-26(14)44/h5-9,11-13,17-22,29-31,47-50H,2-4H2,1H3,(H,54,55)(H,56,57)(H2,32,35,37)(H2,33,36,38)(H2,34,42,43)(H2,51,52,53)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1
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n/an/a 57n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50370227
PNG
(CHEMBL610609)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)C(COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](CO)OC5n5c(N=[N+]=[N-])nc6c(N)ncnc56)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12
Show InChI InChI=1/C30H34N24O16P2/c31-19-10-22(40-4-37-19)52(28(43-10)46-49-34)25-16(59)13(56)8(67-25)2-64-71(60,61)70-18-15(58)9(68-27(18)54-24-12(21(33)39-6-42-24)45-30(54)48-51-36)3-65-72(62,63)69-17-14(57)7(1-55)66-26(17)53-23-11(20(32)38-5-41-23)44-29(53)47-50-35/h4-9,13-18,25-27,55-59H,1-3H2,(H,60,61)(H,62,63)(H2,31,37,40)(H2,32,38,41)(H2,33,39,42)/t7-,8-,9?,13-,14-,15-,16-,17-,18-,25?,26?,27?/s2
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n/an/a 70n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens (Human))
BDBM50085559
PNG
(CHEMBL410213 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C33H46N15O25P5/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(67-31)4-64-75(56,57)70-23-20(50)14(68-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47)5-65-76(58,59)71-24-21(51)15(6-66-77(60,61)73-78(62,63)72-74(53,54)55)69-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H,60,61)(H,62,63)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1
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n/an/a 105n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50025001
PNG
(CHEMBL3143411 | CHEMBL415173 | pp5'(br8A)2'p5'(br8...)
Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12
Show InChI InChI=1/C30H37Br3N15O25P5/c31-28-43-10-19(34)37-4-40-22(10)46(28)25-16(52)13(49)7(67-25)1-64-75(56,57)70-17-14(50)8(68-26(17)47-23-11(44-29(47)32)20(35)38-5-41-23)2-65-76(58,59)71-18-15(51)9(3-66-77(60,61)73-78(62,63)72-74(53,54)55)69-27(18)48-24-12(45-30(48)33)21(36)39-6-42-24/h4-9,13-18,25-27,49-52H,1-3H2,(H,56,57)(H,58,59)(H,60,61)(H,62,63)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,53,54,55)/t7-,8-,9-,13-,14-,15-,16-,17-,18-,25-,26-,27-/s2
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n/an/a 150n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts


J Med Chem 29: 1015-22 (1986)


Article DOI: 10.1021/jm00156a020
BindingDB Entry DOI: 10.7270/Q2SX6C6K
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens (Human))
BDBM50021104
PNG
((2'-5'(pAris)3)
Show SMILES Nc1ncnc2n(cnc12)C1CC(COP([O-])(=O)OC2C(O)C(COP([O-])(=O)OC3C(O)C(COP([O-])([O-])=O)CC3n3cnc4c(N)ncnc34)CC2n2cnc3c(N)ncnc23)C(O)C1O
Show InChI InChI=1/C33H44N15O16P3/c34-28-19-31(40-7-37-28)46(10-43-19)16-1-13(22(49)25(16)52)5-61-66(56,57)64-27-18(48-12-45-21-30(36)39-9-42-33(21)48)3-15(24(27)51)6-62-67(58,59)63-26-17(2-14(23(26)50)4-60-65(53,54)55)47-11-44-20-29(35)38-8-41-32(20)47/h7-18,22-27,49-52H,1-6H2,(H,56,57)(H,58,59)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,53,54,55)/p-4
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n/an/a 210n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cells


J Med Chem 28: 1376-80 (1985)


Article DOI: 10.1021/jm00147a048
BindingDB Entry DOI: 10.7270/Q26W9BNH
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50025000
PNG
(CHEMBL3143409 | CHEMBL413945 | ppp5'(br8A)2'p5'(br...)
Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)O[C@@H]6[C@H](O)[C@@H](COP(O)(=O)O[C@@H]7[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]7n7c(Br)nc8c(N)ncnc78)O[C@H]6n6c(Br)nc7c(N)ncnc67)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12
Show InChI InChI=1/C50H59Br5N25O37P7/c51-46-71-16-31(56)61-6-66-36(16)76(46)41-26(86)21(81)11(107-41)1-102-119(90,91)112-27-22(82)12(108-42(27)77-37-17(72-47(77)52)32(57)62-7-67-37)2-103-120(92,93)113-28-23(83)13(109-43(28)78-38-18(73-48(78)53)33(58)63-8-68-38)3-104-121(94,95)114-29-24(84)14(110-44(29)79-39-19(74-49(79)54)34(59)64-9-69-39)4-105-122(96,97)115-30-25(85)15(5-106-123(98,99)117-124(100,101)116-118(87,88)89)111-45(30)80-40-20(75-50(80)55)35(60)65-10-70-40/h6-15,21-30,41-45,81-86H,1-5H2,(H,90,91)(H,92,93)(H,94,95)(H,96,97)(H,98,99)(H,100,101)(H2,56,61,66)(H2,57,62,67)(H2,58,63,68)(H2,59,64,69)(H2,60,65,70)(H2,87,88,89)/t11-,12-,13-,14-,15-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,41-,42-,43-,44-,45-/s2
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n/an/a 250n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts


J Med Chem 29: 1015-22 (1986)


Article DOI: 10.1021/jm00156a020
BindingDB Entry DOI: 10.7270/Q2SX6C6K
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50021104
PNG
((2'-5'(pAris)3)
Show SMILES Nc1ncnc2n(cnc12)C1CC(COP([O-])(=O)OC2C(O)C(COP([O-])(=O)OC3C(O)C(COP([O-])([O-])=O)CC3n3cnc4c(N)ncnc34)CC2n2cnc3c(N)ncnc23)C(O)C1O
Show InChI InChI=1/C33H44N15O16P3/c34-28-19-31(40-7-37-28)46(10-43-19)16-1-13(22(49)25(16)52)5-61-66(56,57)64-27-18(48-12-45-21-30(36)39-9-42-33(21)48)3-15(24(27)51)6-62-67(58,59)63-26-17(2-14(23(26)50)4-60-65(53,54)55)47-11-44-20-29(35)38-8-41-32(20)47/h7-18,22-27,49-52H,1-6H2,(H,56,57)(H,58,59)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,53,54,55)/p-4
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n/an/a 320n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in mouse L cells


J Med Chem 28: 1376-80 (1985)


Article DOI: 10.1021/jm00147a048
BindingDB Entry DOI: 10.7270/Q26W9BNH
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50370221
PNG
(CHEMBL610855)
Show SMILES Nc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)OC4n4c(N)nc5c(N)ncnc45)OC3n3c(N)nc4c(N)ncnc34)OC2n2c(N)nc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C40H54N24O25P4/c41-25-13-29(53-5-49-25)61(37(45)57-13)33-21(69)17(65)9(83-33)2-80-91(73,74)88-23-19(67)11(85-35(23)63-31-15(59-39(63)47)27(43)51-7-55-31)4-82-93(77,78)89-24-20(68)12(86-36(24)64-32-16(60-40(64)48)28(44)52-8-56-32)3-81-92(75,76)87-22-18(66)10(1-79-90(70,71)72)84-34(22)62-30-14(58-38(62)46)26(42)50-6-54-30/h5-12,17-24,33-36,65-69H,1-4H2,(H2,45,57)(H2,46,58)(H2,47,59)(H2,48,60)(H,73,74)(H,75,76)(H,77,78)(H2,41,49,53)(H2,42,50,54)(H2,43,51,55)(H2,44,52,56)(H2,70,71,72)/t9-,10-,11-,12-,17-,18-,19-,20-,21-,22-,23-,24-,33?,34?,35?,36?/s2
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n/an/a 500n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50024997
PNG
(CHEMBL3143462 | CHEMBL7277 | p5'(br8A)2'p5'(br8A)2...)
Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)O[C@@H]6[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]6n6c(Br)nc7c(N)ncnc67)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12
Show InChI InChI=1/C40H46Br4N20O25P4/c41-37-57-13-25(45)49-5-53-29(13)61(37)33-21(69)17(65)9(83-33)2-80-91(73,74)88-23-19(67)11(85-35(23)63-31-15(59-39(63)43)27(47)51-7-55-31)4-82-93(77,78)89-24-20(68)12(86-36(24)64-32-16(60-40(64)44)28(48)52-8-56-32)3-81-92(75,76)87-22-18(66)10(1-79-90(70,71)72)84-34(22)62-30-14(58-38(62)42)26(46)50-6-54-30/h5-12,17-24,33-36,65-69H,1-4H2,(H,73,74)(H,75,76)(H,77,78)(H2,45,49,53)(H2,46,50,54)(H2,47,51,55)(H2,48,52,56)(H2,70,71,72)/t9-,10-,11-,12-,17-,18-,19-,20-,21-,22-,23-,24-,33-,34-,35-,36-/s2
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n/an/a 700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts


J Med Chem 29: 1015-22 (1986)


Article DOI: 10.1021/jm00156a020
BindingDB Entry DOI: 10.7270/Q2SX6C6K
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50025003
PNG
((br8A)2'p5'(br8A)2'p5'(br8A) | CHEMBL3143413 | CHE...)
Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12
Show InChI InChI=1/C30H35Br3N15O19P3/c31-28-43-10-19(34)37-4-40-22(10)46(28)25-16(52)13(49)7(63-25)2-61-69(56,57)67-18-15(51)9(65-27(18)48-24-12(45-30(48)33)21(36)39-6-42-24)3-62-70(58,59)66-17-14(50)8(1-60-68(53,54)55)64-26(17)47-23-11(44-29(47)32)20(35)38-5-41-23/h4-9,13-18,25-27,49-52H,1-3H2,(H,56,57)(H,58,59)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,53,54,55)/t7-,8-,9-,13-,14-,15-,16-,17-,18-,25-,26-,27-/s2
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts


J Med Chem 29: 1015-22 (1986)


Article DOI: 10.1021/jm00156a020
BindingDB Entry DOI: 10.7270/Q2SX6C6K
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50370224
PNG
(CHEMBL610867)
Show SMILES Nc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OC2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](CO)OC4n4c(N)nc5c(N)ncnc45)OC3n3c(N)nc4c(N)ncnc34)OC2n2c(N)nc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C40H53N24O22P3/c41-25-13-29(53-5-49-25)61(37(45)57-13)33-21(70)17(66)10(81-33)2-77-87(71,72)85-23-19(68)12(83-35(23)63-31-15(59-39(63)47)27(43)51-7-55-31)4-79-89(75,76)86-24-20(69)11(82-36(24)64-32-16(60-40(64)48)28(44)52-8-56-32)3-78-88(73,74)84-22-18(67)9(1-65)80-34(22)62-30-14(58-38(62)46)26(42)50-6-54-30/h5-12,17-24,33-36,65-70H,1-4H2,(H2,45,57)(H2,46,58)(H2,47,59)(H2,48,60)(H,71,72)(H,73,74)(H,75,76)(H2,41,49,53)(H2,42,50,54)(H2,43,51,55)(H2,44,52,56)/t9-,10-,11-,12-,17-,18-,19-,20-,21-,22-,23?,24-,33?,34?,35?,36?/s2
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n/an/a 1.00E+3n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens (Human))
BDBM50366437
PNG
(CHEMBL608874)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](OP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-16(47)14(45)9(58-26)1-56-65(52,53)61-18-15(46)10(59-27(18)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)29(63-64(49,50)51)60-28(19)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17+,18-,19-,26?,27-,28-,29-/s2
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysate


Bioorg Med Chem Lett 6: 1785-1790 (1996)

Checked by Author
Article DOI: 10.1016/0960-894X(96)00314-9
BindingDB Entry DOI: 10.7270/Q2XS5VWT
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens (Human))
BDBM50085557
PNG
(CHEMBL407239 | Oligoadenylate analogue)
Show SMILES Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]5n5cnc6c(N)nc(C)nc56)O[C@H]4n4cnc5c(N)nc(C)nc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C33H44N15O19P3/c1-10-40-25(34)16-28(43-10)46(7-37-16)31-22(52)19(49)13(63-31)5-61-69(56,57)67-24-21(51)15(65-33(24)48-9-39-18-27(36)42-12(3)45-30(18)48)6-62-70(58,59)66-23-20(50)14(4-60-68(53,54)55)64-32(23)47-8-38-17-26(35)41-11(2)44-29(17)47/h7-9,13-15,19-24,31-33,49-52H,4-6H2,1-3H3,(H,56,57)(H,58,59)(H2,34,40,43)(H2,35,41,44)(H2,36,42,45)(H2,53,54,55)/t13-,14-,15-,19-,20-,21-,22-,23-,24-,31-,32-,33-/m1/s1
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n/an/a 1.06E+3n/an/an/an/an/an/a



Gifu University

Curated by ChEMBL


Assay Description
Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L


Bioorg Med Chem Lett 10: 329-31 (2000)


Article DOI: 10.1016/s0960-894x(99)00703-9
BindingDB Entry DOI: 10.7270/Q2TM79B4
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens (Human))
BDBM50021104
PNG
((2'-5'(pAris)3)
Show SMILES Nc1ncnc2n(cnc12)C1CC(COP([O-])(=O)OC2C(O)C(COP([O-])(=O)OC3C(O)C(COP([O-])([O-])=O)CC3n3cnc4c(N)ncnc34)CC2n2cnc3c(N)ncnc23)C(O)C1O
Show InChI InChI=1/C33H44N15O16P3/c34-28-19-31(40-7-37-28)46(10-43-19)16-1-13(22(49)25(16)52)5-61-66(56,57)64-27-18(48-12-45-21-30(36)39-9-42-33(21)48)3-15(24(27)51)6-62-67(58,59)63-26-17(2-14(23(26)50)4-60-65(53,54)55)47-11-44-20-29(35)38-8-41-32(20)47/h7-18,22-27,49-52H,1-6H2,(H,56,57)(H,58,59)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,53,54,55)/p-4
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n/an/a 2.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytes


J Med Chem 28: 1376-80 (1985)


Article DOI: 10.1021/jm00147a048
BindingDB Entry DOI: 10.7270/Q26W9BNH
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50370229
PNG
(CHEMBL607600)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12
Show InChI InChI=1/C20H24N16O13P2/c21-13-7-15(27-3-25-13)35(19(29-7)31-33-23)17-11(39)9(37)5(47-17)2-46-51(43,44)49-12-10(38)6(1-45-50(40,41)42)48-18(12)36-16-8(14(22)26-4-28-16)30-20(36)32-34-24/h3-6,9-12,17-18,37-39H,1-2H2,(H,43,44)(H2,21,25,27)(H2,22,26,28)(H2,40,41,42)/t5-,6-,9-,10-,11-,12-,17?,18?/s2
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n/an/a 5.00E+3n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50366438
PNG
(CHEMBL608875)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](OP(O)(O)=O)O[C@@H]3n3cnc4c(N)ncnc34)O[C@@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-16(47)14(45)9(58-26)1-56-65(52,53)61-18-15(46)10(59-27(18)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)29(63-64(49,50)51)60-28(19)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17+,18-,19-,26?,27+,28+,29-/s2
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n/an/a 4.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from mouse L cell extract


Bioorg Med Chem Lett 6: 1785-1790 (1996)

Checked by Author
Article DOI: 10.1016/0960-894X(96)00314-9
BindingDB Entry DOI: 10.7270/Q2XS5VWT
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50025006
PNG
((br8A)2'p5'(br8A)2'p5'(br8A)2'p5'(br8A) | CHEMBL31...)
Show SMILES Nc1ncnc2n([C@H]3O[C@@H](COP(O)(=O)O[C@H]4[C@@H](O)[C@H](COP(O)(=O)O[C@H]5[C@@H](O)[C@H](COP(O)(=O)O[C@H]6[C@@H](O)[C@H](COP(O)(=O)O[C@H]7[C@@H](O)[C@H](COP(O)(O)=O)O[C@@H]7n7c(Br)nc8c(N)ncnc78)O[C@@H]6n6c(Br)nc7c(N)ncnc67)O[C@@H]5n5c(Br)nc6c(N)ncnc56)O[C@@H]4n4c(Br)nc5c(N)ncnc45)[C@H](O)[C@@H]3O)c(Br)nc12
Show InChI InChI=1/C50H57Br5N25O31P5/c51-46-71-16-31(56)61-6-66-36(16)76(46)41-26(86)21(81)11(103-41)2-99-113(90,91)109-28-23(83)13(105-43(28)78-38-18(73-48(78)53)33(58)63-8-68-38)4-101-115(94,95)111-30-25(85)15(107-45(30)80-40-20(75-50(80)55)35(60)65-10-70-40)5-102-116(96,97)110-29-24(84)14(106-44(29)79-39-19(74-49(79)54)34(59)64-9-69-39)3-100-114(92,93)108-27-22(82)12(1-98-112(87,88)89)104-42(27)77-37-17(72-47(77)52)32(57)62-7-67-37/h6-15,21-30,41-45,81-86H,1-5H2,(H,90,91)(H,92,93)(H,94,95)(H,96,97)(H2,56,61,66)(H2,57,62,67)(H2,58,63,68)(H2,59,64,69)(H2,60,65,70)(H2,87,88,89)/t11-,12-,13-,14-,15-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,41-,42-,43-,44-,45-/s2
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n/an/a>4.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts


J Med Chem 29: 1015-22 (1986)


Article DOI: 10.1021/jm00156a020
BindingDB Entry DOI: 10.7270/Q2SX6C6K
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens (Human))
BDBM50366436
PNG
(CHEMBL605454)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@@H](COP(O)(=O)O[C@@H]3[C@@H](OP(O)(O)=O)O[C@@H]([C@@H]3O)n3cnc4c(N)ncnc34)O[C@@H]([C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-15(46)14(45)9(58-26)1-56-65(52,53)61-18-10(59-27(16(18)47)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)28(60-29(19)63-64(49,50)51)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17-,18-,19+,26?,27+,28+,29-/s2
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n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysate


Bioorg Med Chem Lett 6: 1785-1790 (1996)

Checked by Author
Article DOI: 10.1016/0960-894X(96)00314-9
BindingDB Entry DOI: 10.7270/Q2XS5VWT
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50366436
PNG
(CHEMBL605454)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@@H](COP(O)(=O)O[C@@H]3[C@@H](OP(O)(O)=O)O[C@@H]([C@@H]3O)n3cnc4c(N)ncnc34)O[C@@H]([C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-15(46)14(45)9(58-26)1-56-65(52,53)61-18-10(59-27(16(18)47)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)28(60-29(19)63-64(49,50)51)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17-,18-,19+,26?,27+,28+,29-/s2
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n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from mouse L cell extract


Bioorg Med Chem Lett 6: 1785-1790 (1996)

Checked by Author
Article DOI: 10.1016/0960-894X(96)00314-9
BindingDB Entry DOI: 10.7270/Q2XS5VWT
More data for this
Ligand-Target Pair
RNase L


(Homo sapiens (Human))
BDBM50366438
PNG
(CHEMBL608875)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](OP(O)(O)=O)O[C@@H]3n3cnc4c(N)ncnc34)O[C@@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C29H36N15O19P3/c30-20-11-23(36-3-33-20)42(6-39-11)26-16(47)14(45)9(58-26)1-56-65(52,53)61-18-15(46)10(59-27(18)43-7-40-12-21(31)34-4-37-24(12)43)2-57-66(54,55)62-19-17(48)29(63-64(49,50)51)60-28(19)44-8-41-13-22(32)35-5-38-25(13)44/h3-10,14-19,26-29,45-48H,1-2H2,(H,52,53)(H,54,55)(H2,30,33,36)(H2,31,34,37)(H2,32,35,38)(H2,49,50,51)/t9-,10-,14-,15-,16-,17+,18-,19-,26?,27+,28+,29-/s2
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n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysate


Bioorg Med Chem Lett 6: 1785-1790 (1996)

Checked by Author
Article DOI: 10.1016/0960-894X(96)00314-9
BindingDB Entry DOI: 10.7270/Q2XS5VWT
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50025004
PNG
(CHEMBL3143467 | CHEMBL412481 | p5'(br8A)2'p5'(br8A...)
Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](CO)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12
Show InChI InChI=1/C30H34Br3N15O16P2/c31-28-43-10-19(34)37-4-40-22(10)46(28)25-16(53)13(50)8(61-25)2-58-65(54,55)64-18-15(52)9(62-27(18)48-24-12(45-30(48)33)21(36)39-6-42-24)3-59-66(56,57)63-17-14(51)7(1-49)60-26(17)47-23-11(44-29(47)32)20(35)38-5-41-23/h4-9,13-18,25-27,49-53H,1-3H2,(H,54,55)(H,56,57)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)/t7-,8-,9-,13-,14-,15-,16-,17-,18-,25-,26-,27-/s2
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n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts


J Med Chem 29: 1015-22 (1986)


Article DOI: 10.1021/jm00156a020
BindingDB Entry DOI: 10.7270/Q2SX6C6K
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50370230
PNG
(CHEMBL610610)
Show SMILES Nc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OC2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)OC3n3c(N)nc4c(N)ncnc34)OC2n2c(N)nc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C30H41N18O19P3/c31-19-10-22(40-4-37-19)46(28(34)43-10)25-16(52)13(49)7(63-25)2-61-69(56,57)67-18-15(51)9(65-27(18)48-24-12(45-30(48)36)21(33)39-6-42-24)3-62-70(58,59)66-17-14(50)8(1-60-68(53,54)55)64-26(17)47-23-11(44-29(47)35)20(32)38-5-41-23/h4-9,13-18,25-27,49-52H,1-3H2,(H2,34,43)(H2,35,44)(H2,36,45)(H,56,57)(H,58,59)(H2,31,37,40)(H2,32,38,41)(H2,33,39,42)(H2,53,54,55)/t7-,8-,9-,13-,14-,15-,16-,17-,18?,25?,26?,27?/s2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50370228
PNG
(CHEMBL607882)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](CO)OC4n4c(N=[N+]=[N-])nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12
Show InChI InChI=1/C20H23N16O10P/c21-13-7-15(27-3-25-13)35(19(29-7)31-33-23)17-11(40)9(38)6(45-17)2-43-47(41,42)46-12-10(39)5(1-37)44-18(12)36-16-8(14(22)26-4-28-16)30-20(36)32-34-24/h3-6,9-12,17-18,37-40H,1-2H2,(H,41,42)(H2,21,25,27)(H2,22,26,28)/t5-,6-,9-,10-,11-,12-,17?,18?/s2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50370223
PNG
(CHEMBL607888)
Show SMILES Nc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](CO)OC2n2c(N)nc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C20H27N12O10P/c21-13-7-15(27-3-25-13)31(19(23)29-7)17-11(36)9(34)6(41-17)2-39-43(37,38)42-12-10(35)5(1-33)40-18(12)32-16-8(30-20(32)24)14(22)26-4-28-16/h3-6,9-12,17-18,33-36H,1-2H2,(H2,23,29)(H2,24,30)(H,37,38)(H2,21,25,27)(H2,22,26,28)/t5-,6-,9-,10-,11-,12-,17?,18?/s2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50370225
PNG
(CHEMBL608161)
Show SMILES Nc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(O)=O)OC2n2c(N)nc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C20H28N12O13P2/c21-13-7-15(27-3-25-13)31(19(23)29-7)17-11(35)9(33)5(43-17)2-42-47(39,40)45-12-10(34)6(1-41-46(36,37)38)44-18(12)32-16-8(30-20(32)24)14(22)26-4-28-16/h3-6,9-12,17-18,33-35H,1-2H2,(H2,23,29)(H2,24,30)(H,39,40)(H2,21,25,27)(H2,22,26,28)(H2,36,37,38)/t5-,6-,9-,10-,11-,12-,17?,18?/s2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50370226
PNG
(CHEMBL607595)
Show SMILES Nc1nc2c(N)ncnc2n1C1O[C@H](COP(P)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](CO)OC3n3c(N)nc4c(N)ncnc34)OC2n2c(N)nc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C30H41N18O15P3/c31-19-10-22(40-4-37-19)46(28(34)43-10)25-16(53)13(50)8(60-25)3-58-66(56,64)63-18-15(52)9(61-27(18)48-24-12(45-30(48)36)21(33)39-6-42-24)2-57-65(54,55)62-17-14(51)7(1-49)59-26(17)47-23-11(44-29(47)35)20(32)38-5-41-23/h4-9,13-18,25-27,49-53H,1-3,64H2,(H2,34,43)(H2,35,44)(H2,36,45)(H,54,55)(H2,31,37,40)(H2,32,38,41)(H2,33,39,42)/t7-,8-,9-,13-,14-,15-,16-,17-,18-,25?,26?,27?,66?/s2
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n/an/a 1.00E+5n/an/an/an/an/an/a



Gunma University

Curated by ChEMBL


Assay Description
Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver


J Med Chem 46: 4926-32 (2003)


Article DOI: 10.1021/jm030035k
BindingDB Entry DOI: 10.7270/Q2QR4XVM
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50024999
PNG
(CHEMBL414948 | Sulfuric acid mono-{5-(6-amino-puri...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1/C30H38N15O19P3/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(60-28)2-58-66(53,54)64-21-18(48)12(62-30(21)45-9-42-15-24(33)36-6-39-27(15)45)3-59-67(55,56)63-20-17(47)11(1-57-65(50,51)52)61-29(20)44-8-41-14-23(32)35-5-38-26(14)44/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/s2
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n/an/a 2.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts


J Med Chem 29: 1015-22 (1986)


Article DOI: 10.1021/jm00156a020
BindingDB Entry DOI: 10.7270/Q2SX6C6K
More data for this
Ligand-Target Pair
RNase L


(Mus musculus)
BDBM50024998
PNG
(CHEMBL3143412 | CHEMBL436701 | p5'(br8A)2'p5'(br8A...)
Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)O[C@@H]6[C@H](O)[C@@H](CO)O[C@H]6n6c(Br)nc7c(N)ncnc67)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12
Show InChI InChI=1/C40H45Br4N20O22P3/c41-37-57-13-25(45)49-5-53-29(13)61(37)33-21(70)17(66)10(81-33)2-77-87(71,72)85-23-19(68)12(83-35(23)63-31-15(59-39(63)43)27(47)51-7-55-31)4-79-89(75,76)86-24-20(69)11(82-36(24)64-32-16(60-40(64)44)28(48)52-8-56-32)3-78-88(73,74)84-22-18(67)9(1-65)80-34(22)62-30-14(58-38(62)42)26(46)50-6-54-30/h5-12,17-24,33-36,65-70H,1-4H2,(H,71,72)(H,73,74)(H,75,76)(H2,45,49,53)(H2,46,50,54)(H2,47,51,55)(H2,48,52,56)/t9-,10-,11-,12-,17-,18-,19-,20-,21-,22-,23-,24-,33-,34-,35-,36-/s2
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n/an/a>2.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts


J Med Chem 29: 1015-22 (1986)


Article DOI: 10.1021/jm00156a020
BindingDB Entry DOI: 10.7270/Q2SX6C6K
More data for this
Ligand-Target Pair