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Compile Data Set for Download or QSAR

Found 34 hits of ic50 data for polymerid = 50006687   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072265
PNG
(CHEMBL3408320)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C16H18N4O3/c1-4-19-12-7-6-10(8-13(12)20(5-2)16(19)23)14(21)11-9-17-18(3)15(11)22/h6-9,22H,4-5H2,1-3H3
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PubMed
n/an/a 21n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072237
PNG
(CHEMBL3408314)
Show SMILES CCn1c2cc(ccc2n(C)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C15H16N4O3/c1-4-19-12-7-9(5-6-11(12)17(2)15(19)22)13(20)10-8-16-18(3)14(10)21/h5-8,21H,4H2,1-3H3
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PubMed
n/an/a 22n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072264
PNG
(CHEMBL3408319)
Show SMILES CCCn1c2cc(ccc2n(CC)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-4-8-21-14-9-11(6-7-13(14)20(5-2)17(21)24)15(22)12-10-18-19(3)16(12)23/h6-7,9-10,23H,4-5,8H2,1-3H3
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n/an/a 22n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072269
PNG
(CHEMBL3408324)
Show SMILES CCCn1c2ccc(cc2n(CC)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-4-8-21-13-7-6-11(9-14(13)20(5-2)17(21)24)15(22)12-10-18-19(3)16(12)23/h6-7,9-10,23H,4-5,8H2,1-3H3
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n/an/a 39n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072270
PNG
(CHEMBL3408325)
Show SMILES CCCn1c2ccc(cc2n(CCC)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C18H22N4O3/c1-4-8-21-14-7-6-12(10-15(14)22(9-5-2)18(21)25)16(23)13-11-19-20(3)17(13)24/h6-7,10-11,24H,4-5,8-9H2,1-3H3
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n/an/a 40n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072230
PNG
(CHEMBL3408157)
Show SMILES CCCn1c2cc(ccc2n(C)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C16H18N4O3/c1-4-7-20-13-8-10(5-6-12(13)18(2)16(20)23)14(21)11-9-17-19(3)15(11)22/h5-6,8-9,22H,4,7H2,1-3H3
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PubMed
n/an/a 59n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072236
PNG
(CHEMBL3408313)
Show SMILES CC(C)n1c2cc(ccc2n(C)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C16H18N4O3/c1-9(2)20-13-7-10(5-6-12(13)18(3)16(20)23)14(21)11-8-17-19(4)15(11)22/h5-9,22H,1-4H3
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PubMed
n/an/a 61n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072266
PNG
(CHEMBL3408321)
Show SMILES CCn1c2ccc(cc2n(C(C)C)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-5-20-13-7-6-11(8-14(13)21(10(2)3)17(20)24)15(22)12-9-18-19(4)16(12)23/h6-10,23H,5H2,1-4H3
PDB

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PubMed
n/an/a 64n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072223
PNG
(CHEMBL3408156)
Show SMILES CCC(=O)C(C(C)=O)C(=O)c1ccc(cc1[N+]([O-])=O)C(F)(F)F
Show InChI InChI=1S/C14H12F3NO5/c1-3-11(20)12(7(2)19)13(21)9-5-4-8(14(15,16)17)6-10(9)18(22)23/h4-6,12H,3H2,1-2H3
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PubMed
n/an/a 68n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072271
PNG
(CHEMBL3408326)
Show SMILES CCCn1c2ccc(cc2n(c1=O)C(C)(C)C)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C19H24N4O3/c1-6-9-22-14-8-7-12(16(24)13-11-20-21(5)17(13)25)10-15(14)23(18(22)26)19(2,3)4/h7-8,10-11,25H,6,9H2,1-5H3
PDB

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PubMed
n/an/a 77n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072263
PNG
(CHEMBL3408318)
Show SMILES Cn1ncc(C(=O)c2ccc3n(C)c(=O)n(C4CC4)c3c2)c1O
Show InChI InChI=1S/C16H16N4O3/c1-18-12-6-3-9(14(21)11-8-17-19(2)15(11)22)7-13(12)20(16(18)23)10-4-5-10/h3,6-8,10,22H,4-5H2,1-2H3
PDB

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PubMed
n/an/a 100n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072238
PNG
(CHEMBL3408315)
Show SMILES Cn1ncc(C(=O)c2ccc3n(C)c(=O)n(c3c2)C(C)(C)C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-17(2,3)21-13-8-10(6-7-12(13)19(4)16(21)24)14(22)11-9-18-20(5)15(11)23/h6-9,23H,1-5H3
PDB

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PubMed
n/an/a 100n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072235
PNG
(CHEMBL3408312)
Show SMILES Cn1ncc(C(=O)c2ccc3n(C)c(=O)n(C4CCCC4)c3c2)c1O
Show InChI InChI=1S/C18H20N4O3/c1-20-14-8-7-11(16(23)13-10-19-21(2)17(13)24)9-15(14)22(18(20)25)12-5-3-4-6-12/h7-10,12,24H,3-6H2,1-2H3
PDB

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PubMed
n/an/a 130n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072240
PNG
(CHEMBL3408317)
Show SMILES Cn1ncc(C(=O)c2ccc3n(C)c(=O)n(Cc4ccccc4)c3c2)c1O
Show InChI InChI=1S/C20H18N4O3/c1-22-16-9-8-14(18(25)15-11-21-23(2)19(15)26)10-17(16)24(20(22)27)12-13-6-4-3-5-7-13/h3-11,26H,12H2,1-2H3
PDB

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PubMed
n/an/a 130n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072232
PNG
(CHEMBL3408311)
Show SMILES CC(C)Cn1c2cc(ccc2n(C)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-10(2)9-21-14-7-11(5-6-13(14)19(3)17(21)24)15(22)12-8-18-20(4)16(12)23/h5-8,10,23H,9H2,1-4H3
PDB

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PubMed
n/an/a 140n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072267
PNG
(CHEMBL3408322)
Show SMILES CCn1c2ccc(cc2n(c1=O)C(C)(C)C)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C18H22N4O3/c1-6-21-13-8-7-11(15(23)12-10-19-20(5)16(12)24)9-14(13)22(17(21)25)18(2,3)4/h7-10,24H,6H2,1-5H3
PDB

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n/an/a 150n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072231
PNG
(CHEMBL3408310)
Show SMILES CCCCn1c2cc(ccc2n(C)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-4-5-8-21-14-9-11(6-7-13(14)19(2)17(21)24)15(22)12-10-18-20(3)16(12)23/h6-7,9-10,23H,4-5,8H2,1-3H3
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n/an/a 170n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072268
PNG
(CHEMBL3408323)
Show SMILES CCn1c2ccc(cc2n(C2CC2)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C17H18N4O3/c1-3-20-13-7-4-10(15(22)12-9-18-19(2)16(12)23)8-14(13)21(17(20)24)11-5-6-11/h4,7-9,11,23H,3,5-6H2,1-2H3
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PubMed
n/an/a 220n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072239
PNG
(CHEMBL3408316)
Show SMILES Cc1ccc(cc1)-n1c2cc(ccc2n(C)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C20H18N4O3/c1-12-4-7-14(8-5-12)24-17-10-13(6-9-16(17)22(2)20(24)27)18(25)15-11-21-23(3)19(15)26/h4-11,26H,1-3H3
PDB

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n/an/a 250n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072273
PNG
(CHEMBL3408328)
Show SMILES CCCCn1c2cc(ccc2n(C)c1=O)C(=O)c1c(C)nn(C)c1O
Show InChI InChI=1S/C18H22N4O3/c1-5-6-9-22-14-10-12(7-8-13(14)20(3)18(22)25)16(23)15-11(2)19-21(4)17(15)24/h7-8,10,24H,5-6,9H2,1-4H3
PDB

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PubMed
n/an/a 640n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072218
PNG
(CHEMBL3408335)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2n(C)c(=O)n(Cc3ccccc3)c2c1
Show InChI InChI=1S/C21H20N4O3/c1-13-18(20(27)24(3)22-13)19(26)15-9-10-16-17(11-15)25(21(28)23(16)2)12-14-7-5-4-6-8-14/h4-11,27H,12H2,1-3H3
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n/an/a 670n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072276
PNG
(CHEMBL3408340)
Show SMILES CCCn1c2ccc(cc2n(CCC)c1=O)C(=O)c1c(C)nn(C)c1O
Show InChI InChI=1S/C19H24N4O3/c1-5-9-22-14-8-7-13(11-15(14)23(10-6-2)19(22)26)17(24)16-12(3)20-21(4)18(16)25/h7-8,11,25H,5-6,9-10H2,1-4H3
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n/an/a 720n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072275
PNG
(CHEMBL3408339)
Show SMILES CCCn1c2ccc(cc2n(CC)c1=O)C(=O)c1c(C)nn(C)c1O
Show InChI InChI=1S/C18H22N4O3/c1-5-9-22-13-8-7-12(10-14(13)21(6-2)18(22)25)16(23)15-11(3)19-20(4)17(15)24/h7-8,10,24H,5-6,9H2,1-4H3
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n/an/a 740n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072219
PNG
(CHEMBL3408336)
Show SMILES CCCn1c2cc(ccc2n(CC)c1=O)C(=O)c1c(C)nn(C)c1O
Show InChI InChI=1S/C18H22N4O3/c1-5-9-22-14-10-12(7-8-13(14)21(6-2)18(22)25)16(23)15-11(3)19-20(4)17(15)24/h7-8,10,24H,5-6,9H2,1-4H3
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n/an/a 880n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072180
PNG
(CHEMBL3408330)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2n(C)c(=O)n(C3CCCC3)c2c1
Show InChI InChI=1S/C19H22N4O3/c1-11-16(18(25)22(3)20-11)17(24)12-8-9-14-15(10-12)23(19(26)21(14)2)13-6-4-5-7-13/h8-10,13,25H,4-7H2,1-3H3
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n/an/a 930n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072221
PNG
(CHEMBL3408337)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)C(=O)c1c(C)nn(C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-5-20-12-8-7-11(9-13(12)21(6-2)17(20)24)15(22)14-10(3)18-19(4)16(14)23/h7-9,23H,5-6H2,1-4H3
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n/an/a 940n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072181
PNG
(CHEMBL3408331)
Show SMILES CC(C)n1c2cc(ccc2n(C)c1=O)C(=O)c1c(C)nn(C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-9(2)21-13-8-11(6-7-12(13)19(4)17(21)24)15(22)14-10(3)18-20(5)16(14)23/h6-9,23H,1-5H3
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n/an/a 940n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072222
PNG
(CHEMBL3408338)
Show SMILES CCn1c2ccc(cc2n(C(C)C)c1=O)C(=O)c1c(C)nn(C)c1O
Show InChI InChI=1S/C18H22N4O3/c1-6-21-13-8-7-12(9-14(13)22(10(2)3)18(21)25)16(23)15-11(4)19-20(5)17(15)24/h7-10,24H,6H2,1-5H3
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n/an/a 970n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072213
PNG
(CHEMBL3408332)
Show SMILES CCn1c2cc(ccc2n(C)c1=O)C(=O)c1c(C)nn(C)c1O
Show InChI InChI=1S/C16H18N4O3/c1-5-20-12-8-10(6-7-11(12)18(3)16(20)23)14(21)13-9(2)17-19(4)15(13)22/h6-8,22H,5H2,1-4H3
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n/an/a 970n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072216
PNG
(CHEMBL3408333)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2n(C)c(=O)n(c2c1)C(C)(C)C
Show InChI InChI=1S/C18H22N4O3/c1-10-14(16(24)21(6)19-10)15(23)11-7-8-12-13(9-11)22(18(2,3)4)17(25)20(12)5/h7-9,24H,1-6H3
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n/an/a 990n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072217
PNG
(CHEMBL3408334)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2n(C)c(=O)n(-c3ccc(C)cc3)c2c1
Show InChI InChI=1S/C21H20N4O3/c1-12-5-8-15(9-6-12)25-17-11-14(7-10-16(17)23(3)21(25)28)19(26)18-13(2)22-24(4)20(18)27/h5-11,27H,1-4H3
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n/an/a 990n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072272
PNG
(CHEMBL3408327)
Show SMILES CCCn1c2cc(ccc2n(C)c1=O)C(=O)c1c(C)nn(C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-5-8-21-13-9-11(6-7-12(13)19(3)17(21)24)15(22)14-10(2)18-20(4)16(14)23/h6-7,9,23H,5,8H2,1-4H3
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n/an/a 1.03E+3n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072277
PNG
(CHEMBL3408341)
Show SMILES CCCn1c2ccc(cc2n(C(C)C)c1=O)C(=O)c1c(C)nn(C)c1O
Show InChI InChI=1S/C19H24N4O3/c1-6-9-22-14-8-7-13(10-15(14)23(11(2)3)19(22)26)17(24)16-12(4)20-21(5)18(16)25/h7-8,10-11,25H,6,9H2,1-5H3
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n/an/a 1.19E+3n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens (Human))
BDBM50072274
PNG
(CHEMBL3408329)
Show SMILES CC(C)Cn1c2cc(ccc2n(C)c1=O)C(=O)c1c(C)nn(C)c1O
Show InChI InChI=1S/C18H22N4O3/c1-10(2)9-22-14-8-12(6-7-13(14)20(4)18(22)25)16(23)15-11(3)19-21(5)17(15)24/h6-8,10,24H,9H2,1-5H3
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n/an/a 2.71E+3n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Eur J Med Chem 92: 427-38 (2015)


Article DOI: 10.1016/j.ejmech.2015.01.018
BindingDB Entry DOI: 10.7270/Q20C4XFX
More data for this
Ligand-Target Pair