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Compile Data Set for Download or QSAR

Found 162 hits of ic50 data for polymerid = 50007324,50007325,50007326,50007327   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266796
PNG
(CHEMBL4068580)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)NCc2cc3ccccc3s2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C23H18F3N3O2S.ClH/c24-23(25,26)20-8-14(12-27)9-21(29-20)31-17-6-3-5-16(10-17)22(30)28-13-18-11-15-4-1-2-7-19(15)32-18;/h1-11H,12-13,27H2,(H,28,30);1H
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n/an/a 34n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266838
PNG
(CHEMBL4084982)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)NCCS(N)(=O)=O)nc(c1)C(F)(F)F
Show InChI InChI=1S/C16H17F3N4O4S.ClH/c17-16(18,19)13-6-10(9-20)7-14(23-13)27-12-3-1-2-11(8-12)15(24)22-4-5-28(21,25)26;/h1-3,6-8H,4-5,9,20H2,(H,22,24)(H2,21,25,26);1H
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n/an/a 35n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266811
PNG
(CHEMBL4059919)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)Nc2ccccc2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C20H16F3N3O2.ClH/c21-20(22,23)17-9-13(12-24)10-18(26-17)28-16-8-4-5-14(11-16)19(27)25-15-6-2-1-3-7-15;/h1-11H,12,24H2,(H,25,27);1H
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n/an/a 42n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266824
PNG
(CHEMBL4082808)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)NCCn2cnnn2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C17H16F3N7O2.ClH/c18-17(19,20)14-6-11(9-21)7-15(24-14)29-13-3-1-2-12(8-13)16(28)22-4-5-27-10-23-25-26-27;/h1-3,6-8,10H,4-5,9,21H2,(H,22,28);1H
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n/an/a 43n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266783
PNG
(CHEMBL4086010)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)Nc2ccc(F)cc2)c1
Show InChI InChI=1S/C19H16FN3O2.ClH/c20-15-4-6-16(7-5-15)23-19(24)14-2-1-3-17(11-14)25-18-10-13(12-21)8-9-22-18;/h1-11H,12,21H2,(H,23,24);1H
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n/an/a 50n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266784
PNG
(CHEMBL4103928)
Show SMILES Cl.COc1ccc(NC(=O)c2cccc(Oc3cc(CN)ccn3)c2)cc1
Show InChI InChI=1S/C20H19N3O3.ClH/c1-25-17-7-5-16(6-8-17)23-20(24)15-3-2-4-18(12-15)26-19-11-14(13-21)9-10-22-19;/h2-12H,13,21H2,1H3,(H,23,24);1H
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n/an/a 53n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266789
PNG
(CHEMBL4088453)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C19H17N3O2.ClH/c20-13-14-9-10-21-18(11-14)24-17-8-4-5-15(12-17)19(23)22-16-6-2-1-3-7-16;/h1-12H,13,20H2,(H,22,23);1H
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n/an/a 56n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266823
PNG
(CHEMBL4097435)
Show SMILES Cl.Cl.NCc1cc(Oc2cccc(c2)C(=O)N2CC[C@@H](N)C2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N4O2.2ClH/c19-18(20,21)15-6-11(9-22)7-16(24-15)27-14-3-1-2-12(8-14)17(26)25-5-4-13(23)10-25;;/h1-3,6-8,13H,4-5,9-10,22-23H2;2*1H/t13-;;/m1../s1
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n/an/a 58n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266788
PNG
(CHEMBL4067192)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C20H19N3O2.ClH/c21-13-16-9-10-22-19(11-16)25-18-8-4-7-17(12-18)20(24)23-14-15-5-2-1-3-6-15;/h1-12H,13-14,21H2,(H,23,24);1H
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n/an/a 62n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266811
PNG
(CHEMBL4059919)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)Nc2ccccc2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C20H16F3N3O2.ClH/c21-20(22,23)17-9-13(12-24)10-18(26-17)28-16-8-4-5-14(11-16)19(27)25-15-6-2-1-3-7-15;/h1-11H,12,24H2,(H,25,27);1H
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n/an/a 62n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266838
PNG
(CHEMBL4084982)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)NCCS(N)(=O)=O)nc(c1)C(F)(F)F
Show InChI InChI=1S/C16H17F3N4O4S.ClH/c17-16(18,19)13-6-10(9-20)7-14(23-13)27-12-3-1-2-11(8-12)15(24)22-4-5-28(21,25)26;/h1-3,6-8H,4-5,9,20H2,(H,22,24)(H2,21,25,26);1H
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n/an/a 62n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50232678
PNG
(CHEBI:27413 | CHEMBL1618272)
Show InChI InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2
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n/an/a 66n/an/an/an/an/an/a



PharmAkea Inc

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated...


ACS Med Chem Lett 8: 423-427 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00014
BindingDB Entry DOI: 10.7270/Q2542QV6
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50232678
PNG
(CHEBI:27413 | CHEMBL1618272)
Show InChI InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2
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n/an/a 66n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266840
PNG
(CHEMBL4089707)
Show SMILES NCc1cc(Oc2cccc(Oc3ccccc3)c2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C19H15F3N2O2/c20-19(21,22)17-9-13(12-23)10-18(24-17)26-16-8-4-7-15(11-16)25-14-5-2-1-3-6-14/h1-11H,12,23H2
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n/an/a 67n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50232678
PNG
(CHEBI:27413 | CHEMBL1618272)
Show InChI InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2
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n/an/a 73n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant LOXL2 (unknown origin) expressed in NS0 cells using diaminopentane as substrate preincubated for 30 mins followed by substr...


Bioorg Med Chem Lett 28: 3113-3118 (2018)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266786
PNG
(CHEMBL4063337)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)c1
Show InChI InChI=1S/C17H18FN3O3.ClH/c18-14-9-21(10-15(14)22)17(23)12-2-1-3-13(7-12)24-16-6-11(8-19)4-5-20-16;/h1-7,14-15,22H,8-10,19H2;1H/t14-,15-;/m1./s1
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n/an/a 74n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266837
PNG
(CHEMBL4100783)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)NC[C@@H](O)CO)nc(c1)C(F)(F)F
Show InChI InChI=1S/C17H18F3N3O4.ClH/c18-17(19,20)14-4-10(7-21)5-15(23-14)27-13-3-1-2-11(6-13)16(26)22-8-12(25)9-24;/h1-6,12,24-25H,7-9,21H2,(H,22,26);1H/t12-;/m1./s1
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n/an/a 77n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266822
PNG
(CHEMBL4079398)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C18H17F4N3O3.ClH/c19-13-8-25(9-14(13)26)17(27)11-2-1-3-12(6-11)28-16-5-10(7-23)4-15(24-16)18(20,21)22;/h1-6,13-14,26H,7-9,23H2;1H/t13-,14-;/m1./s1
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n/an/a 78n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266794
PNG
(CHEMBL4093765)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)NCc2cc3ccccc3s2)c1
Show InChI InChI=1S/C22H19N3O2S.ClH/c23-13-15-8-9-24-21(10-15)27-18-6-3-5-17(11-18)22(26)25-14-19-12-16-4-1-2-7-20(16)28-19;/h1-12H,13-14,23H2,(H,25,26);1H
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n/an/a 79n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266824
PNG
(CHEMBL4082808)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)NCCn2cnnn2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C17H16F3N7O2.ClH/c18-17(19,20)14-6-11(9-21)7-15(24-14)29-13-3-1-2-12(8-13)16(28)22-4-5-27-10-23-25-26-27;/h1-3,6-8,10H,4-5,9,21H2,(H,22,28);1H
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n/an/a 80n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266795
PNG
(CHEMBL4063420)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)Nc2ccc(cc2)C(O)=O)c1
Show InChI InChI=1S/C20H17N3O4.ClH/c21-12-13-8-9-22-18(10-13)27-17-3-1-2-15(11-17)19(24)23-16-6-4-14(5-7-16)20(25)26;/h1-11H,12,21H2,(H,23,24)(H,25,26);1H
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n/an/a 81n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266787
PNG
(CHEMBL4092740)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)N2C[C@H](O)[C@@H](F)C2)c1
Show InChI InChI=1S/C17H18FN3O3.ClH/c18-14-9-21(10-15(14)22)17(23)12-2-1-3-13(7-12)24-16-6-11(8-19)4-5-20-16;/h1-7,14-15,22H,8-10,19H2;1H/t14-,15-;/m0./s1
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n/an/a 82n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50232678
PNG
(CHEBI:27413 | CHEMBL1618272)
Show InChI InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2
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n/an/a 83n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50232678
PNG
(CHEBI:27413 | CHEMBL1618272)
Show InChI InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2
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Article
PubMed
n/an/a 83n/an/an/an/an/an/a



PharmAkea Inc

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated...


ACS Med Chem Lett 8: 423-427 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00014
BindingDB Entry DOI: 10.7270/Q2542QV6
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266837
PNG
(CHEMBL4100783)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)NC[C@@H](O)CO)nc(c1)C(F)(F)F
Show InChI InChI=1S/C17H18F3N3O4.ClH/c18-17(19,20)14-4-10(7-21)5-15(23-14)27-13-3-1-2-11(6-13)16(26)22-8-12(25)9-24;/h1-6,12,24-25H,7-9,21H2,(H,22,26);1H/t12-;/m1./s1
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n/an/a 88n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))
BDBM50058655
PNG
(1,1',1'',1'''-[disulfanediylbis(carbonothioylnitri...)
Show SMILES CCN(CC)C(=S)SSC(=S)N(CC)CC
Show InChI InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
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n/an/a 93n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...


Bioorg Med Chem Lett 28: 3113-3118 (2018)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266826
PNG
(CHEMBL4105137)
Show SMILES Cl.CONC(=O)c1cccc(Oc2cc(CN)cc(n2)C(F)(F)F)c1
Show InChI InChI=1S/C15H14F3N3O3.ClH/c1-23-21-14(22)10-3-2-4-11(7-10)24-13-6-9(8-19)5-12(20-13)15(16,17)18;/h2-7H,8,19H2,1H3,(H,21,22);1H
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n/an/a 96n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266796
PNG
(CHEMBL4068580)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)NCc2cc3ccccc3s2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C23H18F3N3O2S.ClH/c24-23(25,26)20-8-14(12-27)9-21(29-20)31-17-6-3-5-16(10-17)22(30)28-13-18-11-15-4-1-2-7-19(15)32-18;/h1-11H,12-13,27H2,(H,28,30);1H
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n/an/a 100n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266822
PNG
(CHEMBL4079398)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C18H17F4N3O3.ClH/c19-13-8-25(9-14(13)26)17(27)11-2-1-3-12(6-11)28-16-5-10(7-23)4-15(24-16)18(20,21)22;/h1-6,13-14,26H,7-9,23H2;1H/t13-,14-;/m1./s1
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n/an/a 100n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Mus musculus)
BDBM50266786
PNG
(CHEMBL4063337)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)c1
Show InChI InChI=1S/C17H18FN3O3.ClH/c18-14-9-21(10-15(14)22)17(23)12-2-1-3-13(7-12)24-16-6-11(8-19)4-5-20-16;/h1-7,14-15,22H,8-10,19H2;1H/t14-,15-;/m1./s1
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PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse LOXL2 expressed in mouse whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266823
PNG
(CHEMBL4097435)
Show SMILES Cl.Cl.NCc1cc(Oc2cccc(c2)C(=O)N2CC[C@@H](N)C2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N4O2.2ClH/c19-18(20,21)15-6-11(9-22)7-16(24-15)27-14-3-1-2-12(8-14)17(26)25-5-4-13(23)10-25;;/h1-3,6-8,13H,4-5,9-10,22-23H2;2*1H/t13-;;/m1../s1
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PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266794
PNG
(CHEMBL4093765)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)NCc2cc3ccccc3s2)c1
Show InChI InChI=1S/C22H19N3O2S.ClH/c23-13-15-8-9-24-21(10-15)27-18-6-3-5-17(11-18)22(26)25-14-19-12-16-4-1-2-7-20(16)28-19;/h1-12H,13-14,23H2,(H,25,26);1H
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PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266788
PNG
(CHEMBL4067192)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)NCc2ccccc2)c1
Show InChI InChI=1S/C20H19N3O2.ClH/c21-13-16-9-10-22-19(11-16)25-18-8-4-7-17(12-18)20(24)23-14-15-5-2-1-3-6-15;/h1-12H,13-14,21H2,(H,23,24);1H
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PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266839
PNG
(CHEMBL4071963)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)N2CC[C@@H](O)C2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C18H18F3N3O3.ClH/c19-18(20,21)15-6-11(9-22)7-16(23-15)27-14-3-1-2-12(8-14)17(26)24-5-4-13(25)10-24;/h1-3,6-8,13,25H,4-5,9-10,22H2;1H/t13-;/m1./s1
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n/an/a 110n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266786
PNG
(CHEMBL4063337)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)c1
Show InChI InChI=1S/C17H18FN3O3.ClH/c18-14-9-21(10-15(14)22)17(23)12-2-1-3-13(7-12)24-16-6-11(8-19)4-5-20-16;/h1-7,14-15,22H,8-10,19H2;1H/t14-,15-;/m1./s1
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n/an/a 110n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 3


(Homo sapiens (Human))
BDBM43362
PNG
(MLS000069752 | N,N-dimethylcarbamodithioic acid (d...)
Show SMILES CN(C)C(=S)SSC(=S)N(C)C
Show InChI InChI=1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3
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Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL3 expressed in CHO cells using diaminopentane as substrate preincubated for 30 mins followed by substrate additio...


Bioorg Med Chem Lett 28: 3113-3118 (2018)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266787
PNG
(CHEMBL4092740)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)N2C[C@H](O)[C@@H](F)C2)c1
Show InChI InChI=1S/C17H18FN3O3.ClH/c18-14-9-21(10-15(14)22)17(23)12-2-1-3-13(7-12)24-16-6-11(8-19)4-5-20-16;/h1-7,14-15,22H,8-10,19H2;1H/t14-,15-;/m0./s1
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n/an/a 120n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Rattus norvegicus)
BDBM50266786
PNG
(CHEMBL4063337)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)c1
Show InChI InChI=1S/C17H18FN3O3.ClH/c18-14-9-21(10-15(14)22)17(23)12-2-1-3-13(7-12)24-16-6-11(8-19)4-5-20-16;/h1-7,14-15,22H,8-10,19H2;1H/t14-,15-;/m1./s1
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n/an/a 120n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of rat LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266785
PNG
(CHEMBL4066192)
Show SMILES NCc1ccnc(Oc2cccc(c2)C(=O)N2CCc3ccccc3C2)c1
Show InChI InChI=1S/C22H21N3O2/c23-14-16-8-10-24-21(12-16)27-20-7-3-6-18(13-20)22(26)25-11-9-17-4-1-2-5-19(17)15-25/h1-8,10,12-13H,9,11,14-15,23H2
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PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50232679
PNG
(CHEMBL4068784)
Show SMILES NCc1ccnc(Cl)c1
Show InChI InChI=1S/C6H7ClN2/c7-6-3-5(4-8)1-2-9-6/h1-3H,4,8H2
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n/an/a 126n/an/an/an/an/an/a



PharmAkea Inc

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated...


ACS Med Chem Lett 8: 423-427 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00014
BindingDB Entry DOI: 10.7270/Q2542QV6
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Rattus norvegicus)
BDBM50232678
PNG
(CHEBI:27413 | CHEMBL1618272)
Show InChI InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2
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n/an/a 127n/an/an/an/an/an/a



PharmAkea Inc

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant rat LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated f...


ACS Med Chem Lett 8: 423-427 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00014
BindingDB Entry DOI: 10.7270/Q2542QV6
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Mus musculus)
BDBM50232678
PNG
(CHEBI:27413 | CHEMBL1618272)
Show InChI InChI=1S/C3H6N2/c4-2-1-3-5/h1-2,4H2
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n/an/a 128n/an/an/an/an/an/a



PharmAkea Inc

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant mouse LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated...


ACS Med Chem Lett 8: 423-427 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00014
BindingDB Entry DOI: 10.7270/Q2542QV6
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266783
PNG
(CHEMBL4086010)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)Nc2ccc(F)cc2)c1
Show InChI InChI=1S/C19H16FN3O2.ClH/c20-15-4-6-16(7-5-15)23-19(24)14-2-1-3-17(11-14)25-18-10-13(12-21)8-9-22-18;/h1-11H,12,21H2,(H,23,24);1H
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PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266821
PNG
(CHEMBL4087273)
Show SMILES NCc1cc(O[C@H]2CCCN(C2)C(=O)Nc2ccccc2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C19H21F3N4O2/c20-19(21,22)16-9-13(11-23)10-17(25-16)28-15-7-4-8-26(12-15)18(27)24-14-5-2-1-3-6-14/h1-3,5-6,9-10,15H,4,7-8,11-12,23H2,(H,24,27)/t15-/m0/s1
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PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266789
PNG
(CHEMBL4088453)
Show SMILES Cl.NCc1ccnc(Oc2cccc(c2)C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C19H17N3O2.ClH/c20-13-14-9-10-21-18(11-14)24-17-8-4-5-15(12-17)19(23)22-16-6-2-1-3-7-16;/h1-12H,13,20H2,(H,22,23);1H
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PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Rattus norvegicus)
BDBM50232679
PNG
(CHEMBL4068784)
Show SMILES NCc1ccnc(Cl)c1
Show InChI InChI=1S/C6H7ClN2/c7-6-3-5(4-8)1-2-9-6/h1-3H,4,8H2
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n/an/a 136n/an/an/an/an/an/a



PharmAkea Inc

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant rat LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated f...


ACS Med Chem Lett 8: 423-427 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00014
BindingDB Entry DOI: 10.7270/Q2542QV6
More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266826
PNG
(CHEMBL4105137)
Show SMILES Cl.CONC(=O)c1cccc(Oc2cc(CN)cc(n2)C(F)(F)F)c1
Show InChI InChI=1S/C15H14F3N3O3.ClH/c1-23-21-14(22)10-3-2-4-11(7-10)24-13-6-9(8-19)5-12(20-13)15(16,17)18;/h2-7H,8,19H2,1H3,(H,21,22);1H
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PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50058655
PNG
(1,1',1'',1'''-[disulfanediylbis(carbonothioylnitri...)
Show SMILES CCN(CC)C(=S)SSC(=S)N(CC)CC
Show InChI InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
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n/an/a 150n/an/an/an/an/an/a



Hungarian Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant LOXL2 (unknown origin) expressed in NS0 cells using diaminopentane as substrate preincubated for 30 mins followed by substr...


Bioorg Med Chem Lett 28: 3113-3118 (2018)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266839
PNG
(CHEMBL4071963)
Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)N2CC[C@@H](O)C2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C18H18F3N3O3.ClH/c19-18(20,21)15-6-11(9-22)7-16(23-15)27-14-3-1-2-12(8-14)17(26)24-5-4-13(25)10-24;/h1-3,6-8,13,25H,4-5,9-10,22H2;1H/t13-;/m1./s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 150n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
Lysyl oxidase homolog 2


(Homo sapiens (Human))
BDBM50266821
PNG
(CHEMBL4087273)
Show SMILES NCc1cc(O[C@H]2CCCN(C2)C(=O)Nc2ccccc2)nc(c1)C(F)(F)F
Show InChI InChI=1S/C19H21F3N4O2/c20-19(21,22)16-9-13(11-23)10-17(25-16)28-15-7-4-8-26(12-15)18(27)24-14-5-2-1-3-6-14/h1-3,5-6,9-10,15H,4,7-8,11-12,23H2,(H,24,27)/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 160n/an/an/an/an/an/a



PharmAkea Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...


J Med Chem 60: 4403-4423 (2017)

More data for this
Ligand-Target Pair
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