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Compile Data Set for Download or QSAR

Found 2 hits of ic50 data for polymerid = 50007361   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA-directed RNA polymerase, mitochondrial


(Homo sapiens (Human))
BDBM50236025
PNG
(CHEMBL2016761)
Show SMILES Nc1ncnn2c(ccc12)[C@@]1(O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C#N
Show InChI InChI=1/C12H16N5O13P3/c13-4-12(8-2-1-6-11(14)15-5-16-17(6)8)10(19)9(18)7(28-12)3-27-32(23,24)30-33(25,26)29-31(20,21)22/h1-2,5,7,9-10,18-19H,3H2,(H,23,24)(H,25,26)(H2,14,15,16)(H2,20,21,22)/t7-,9-,10-,12+/s2
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.00E+5n/an/an/an/an/an/a



Gilead Sciences Inc

Curated by ChEMBL


Assay Description
Inhibition of human mitochondrial RNA polymerase after 30 mins in presence of [33P]GTP


J Med Chem 60: 1648-1661 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01594
BindingDB Entry DOI: 10.7270/Q2QZ2D7N
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase, mitochondrial


(Homo sapiens (Human))
BDBM50261285
PNG
(CHEMBL4069349)
Show SMILES C[C@@]1(Cl)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O
Show InChI InChI=1/C10H16ClN2O14P3/c1-10(11)7(15)5(25-8(10)13-3-2-6(14)12-9(13)16)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2-3,5,7-8,15H,4H2,1H3,(H,20,21)(H,22,23)(H,12,14,16)(H2,17,18,19)/t5-,7-,8-,10-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



IDENIX an MSD Company

Curated by ChEMBL


Assay Description
Inhibition of human mitochondrial RNA polymerase


Bioorg Med Chem Lett 27: 4323-4330 (2017)

More data for this
Ligand-Target Pair