BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 487 hits of ic50 data for polymerid = 5790   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109578
PNG
(CHEMBL3604156)
Show SMILES Fc1ccc(NC(=O)c2n[nH]c(Cl)c2Br)c(Cl)c1
Show InChI InChI=1S/C10H5BrCl2FN3O/c11-7-8(16-17-9(7)13)10(18)15-6-2-1-4(14)3-5(6)12/h1-3H,(H,15,18)(H,16,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109729
PNG
(CHEMBL3604185)
Show SMILES Clc1[nH]nc(c1Cl)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C10H4Cl3N3O/c11-4-1-2-5-6(3-4)17-10(14-5)8-7(12)9(13)16-15-8/h1-3H,(H,15,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109751
PNG
(CHEMBL3604184)
Show SMILES Clc1cc(n[nH]1)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C10H5Cl2N3O/c11-5-1-2-6-8(3-5)16-10(13-6)7-4-9(12)15-14-7/h1-4H,(H,14,15)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50329321
PNG
(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Show SMILES O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1ccsc1
Show InChI InChI=1S/C21H14N2O3S2/c24-20(16-10-13-27-14-16)25-11-3-4-12-28-21-23-22-19(26-21)18-9-5-7-15-6-1-2-8-17(15)18/h1-2,5-10,13-14H,11-12H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<10n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysis


J Med Chem 53: 7392-404 (2010)


Article DOI: 10.1021/jm1008852
BindingDB Entry DOI: 10.7270/Q2SJ1KVW
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50329329
PNG
(4-(5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-ylthio)but...)
Show SMILES Fc1ccc(cc1)C(=O)OCC#CCSc1nnc(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H12ClFN2O3S/c20-15-7-3-13(4-8-15)17-22-23-19(26-17)27-12-2-1-11-25-18(24)14-5-9-16(21)10-6-14/h3-10H,11-12H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<10n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysis


J Med Chem 53: 7392-404 (2010)


Article DOI: 10.1021/jm1008852
BindingDB Entry DOI: 10.7270/Q2SJ1KVW
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50329326
PNG
(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)OCC#CCSc1nnc(o1)-c1cccc2ccccc12
Show InChI InChI=1S/C24H15F3N2O4S/c25-24(26,27)33-18-12-10-17(11-13-18)22(30)31-14-3-4-15-34-23-29-28-21(32-23)20-9-5-7-16-6-1-2-8-19(16)20/h1-2,5-13H,14-15H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<10n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysis


J Med Chem 53: 7392-404 (2010)


Article DOI: 10.1021/jm1008852
BindingDB Entry DOI: 10.7270/Q2SJ1KVW
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109578
PNG
(CHEMBL3604156)
Show SMILES Fc1ccc(NC(=O)c2n[nH]c(Cl)c2Br)c(Cl)c1
Show InChI InChI=1S/C10H5BrCl2FN3O/c11-7-8(16-17-9(7)13)10(18)15-6-2-1-4(14)3-5(6)12/h1-3H,(H,15,18)(H,16,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50329325
PNG
(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Show SMILES Fc1ccc(cc1F)C(=O)OCC#CCSc1nnc(o1)-c1cccc2ccccc12
Show InChI InChI=1S/C23H14F2N2O3S/c24-19-11-10-16(14-20(19)25)22(28)29-12-3-4-13-31-23-27-26-21(30-23)18-9-5-7-15-6-1-2-8-17(15)18/h1-2,5-11,14H,12-13H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<10n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysis


J Med Chem 53: 7392-404 (2010)


Article DOI: 10.1021/jm1008852
BindingDB Entry DOI: 10.7270/Q2SJ1KVW
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50329327
PNG
(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)OCC#CCSc1nnc(o1)-c1cccc2ccccc12
Show InChI InChI=1S/C24H15F3N2O3S/c25-24(26,27)18-12-10-17(11-13-18)22(30)31-14-3-4-15-33-23-29-28-21(32-23)20-9-5-7-16-6-1-2-8-19(16)20/h1-2,5-13H,14-15H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<10n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysis


J Med Chem 53: 7392-404 (2010)


Article DOI: 10.1021/jm1008852
BindingDB Entry DOI: 10.7270/Q2SJ1KVW
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50329324
PNG
(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Show SMILES Fc1cccc(c1)C(=O)OCC#CCSc1nnc(o1)-c1cccc2ccccc12
Show InChI InChI=1S/C23H15FN2O3S/c24-18-10-5-9-17(15-18)22(27)28-13-3-4-14-30-23-26-25-21(29-23)20-12-6-8-16-7-1-2-11-19(16)20/h1-2,5-12,15H,13-14H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<10n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysis


J Med Chem 53: 7392-404 (2010)


Article DOI: 10.1021/jm1008852
BindingDB Entry DOI: 10.7270/Q2SJ1KVW
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50329328
PNG
(4-(5-(naphthalen-2-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Show SMILES Fc1ccc(cc1)C(=O)OCC#CCSc1nnc(o1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H15FN2O3S/c24-20-11-9-17(10-12-20)22(27)28-13-3-4-14-30-23-26-25-21(29-23)19-8-7-16-5-1-2-6-18(16)15-19/h1-2,5-12,15H,13-14H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<10n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysis


J Med Chem 53: 7392-404 (2010)


Article DOI: 10.1021/jm1008852
BindingDB Entry DOI: 10.7270/Q2SJ1KVW
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50020589
PNG
(CHEMBL3290441)
Show SMILES COc1cc(\C=C\c2cc(\C=C\c3cc(CC=C(C)C)c(O)c(OC)c3)[nH]n2)cc(CC=C(C)C)c1O
Show InChI InChI=1S/C31H36N2O4/c1-20(2)7-11-24-15-22(17-28(36-5)30(24)34)9-13-26-19-27(33-32-26)14-10-23-16-25(12-8-21(3)4)31(35)29(18-23)37-6/h7-10,13-19,34-35H,11-12H2,1-6H3,(H,32,33)/b13-9+,14-10+
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13n/an/an/an/an/an/a



University Jena

Curated by ChEMBL


Assay Description
Inhibition of 15-LO-mediated 15-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition ...


J Med Chem 57: 5638-48 (2014)


Article DOI: 10.1021/jm500308c
BindingDB Entry DOI: 10.7270/Q2HT2QWN
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109746
PNG
(CHEMBL3604180)
Show SMILES Clc1ccc2nc(oc2c1)-c1cc[nH]n1
Show InChI InChI=1S/C10H6ClN3O/c11-6-1-2-7-9(5-6)15-10(13-7)8-3-4-12-14-8/h1-5H,(H,12,14)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109814
PNG
(CHEMBL3604153)
Show SMILES Fc1ccc(NC(=O)c2n[nH]c(Cl)c2Cl)c(Cl)c1
Show InChI InChI=1S/C10H5Cl3FN3O/c11-5-3-4(14)1-2-6(5)15-10(18)8-7(12)9(13)17-16-8/h1-3H,(H,15,18)(H,16,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50105870
PNG
(CHEMBL3597768)
Show SMILES Fc1ccc(NC(=O)c2ccn(n2)C(=S)Nc2ccc3OCOc3c2)c(Cl)c1
Show InChI InChI=1S/C18H12ClFN4O3S/c19-12-7-10(20)1-3-13(12)22-17(25)14-5-6-24(23-14)18(28)21-11-2-4-15-16(8-11)27-9-26-15/h1-8H,9H2,(H,21,28)(H,22,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 using arachidonic acid as substrate by cell based assay


Bioorg Med Chem Lett 25: 3017-23 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.007
BindingDB Entry DOI: 10.7270/Q2F191G3
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50329320
PNG
(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Show SMILES O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1cccs1
Show InChI InChI=1S/C21H14N2O3S2/c24-20(18-11-6-14-27-18)25-12-3-4-13-28-21-23-22-19(26-21)17-10-5-8-15-7-1-2-9-16(15)17/h1-2,5-11,14H,12-13H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 catalytic site assessed as 15-HPETE formation by Michaelis-Menten equation ...


J Med Chem 53: 7392-404 (2010)


Article DOI: 10.1021/jm1008852
BindingDB Entry DOI: 10.7270/Q2SJ1KVW
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50329320
PNG
(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Show SMILES O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1cccs1
Show InChI InChI=1S/C21H14N2O3S2/c24-20(18-11-6-14-27-18)25-12-3-4-13-28-21-23-22-19(26-21)17-10-5-8-15-7-1-2-9-16(15)17/h1-2,5-11,14H,12-13H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 19n/an/an/an/an/an/a



National Human Genome Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal His6-tagged reticulocyte 15-lipoxygenase-1 after 15 mins by UV-vis spectrophotometer analysis


J Med Chem 53: 7392-404 (2010)


Article DOI: 10.1021/jm1008852
BindingDB Entry DOI: 10.7270/Q2SJ1KVW
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109746
PNG
(CHEMBL3604180)
Show SMILES Clc1ccc2nc(oc2c1)-c1cc[nH]n1
Show InChI InChI=1S/C10H6ClN3O/c11-6-1-2-7-9(5-6)15-10(13-7)8-3-4-12-14-8/h1-5H,(H,12,14)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 20n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109813
PNG
(CHEMBL3604152)
Show SMILES Fc1ccc(NC(=O)c2cc(Cl)[nH]n2)c(Cl)c1
Show InChI InChI=1S/C10H6Cl2FN3O/c11-6-3-5(13)1-2-7(6)14-10(17)8-4-9(12)16-15-8/h1-4H,(H,14,17)(H,15,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109568
PNG
(CHEMBL3604132)
Show SMILES Fc1ccc(NC(=O)c2cc[nH]n2)c(Cl)c1
Show InChI InChI=1S/C10H7ClFN3O/c11-7-5-6(12)1-2-8(7)14-10(16)9-3-4-13-15-9/h1-5H,(H,13,15)(H,14,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109539
PNG
(CHEMBL3604138)
Show SMILES Clc1ccc(NC(=O)c2cc[nH]n2)nc1
Show InChI InChI=1S/C9H7ClN4O/c10-6-1-2-8(11-5-6)13-9(15)7-3-4-12-14-7/h1-5H,(H,12,14)(H,11,13,15)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 26n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109643
PNG
(CHEMBL3604158)
Show SMILES Fc1ccc(NC(=O)c2cc(I)[nH]n2)c(Cl)c1
Show InChI InChI=1S/C10H6ClFIN3O/c11-6-3-5(12)1-2-7(6)14-10(17)8-4-9(13)16-15-8/h1-4H,(H,14,17)(H,15,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109814
PNG
(CHEMBL3604153)
Show SMILES Fc1ccc(NC(=O)c2n[nH]c(Cl)c2Cl)c(Cl)c1
Show InChI InChI=1S/C10H5Cl3FN3O/c11-5-3-4(14)1-2-6(5)15-10(18)8-7(12)9(13)17-16-8/h1-3H,(H,15,18)(H,16,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 32n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109730
PNG
(CHEMBL3604151)
Show SMILES Fc1ccc(NC(=O)c2n[nH]cc2Cl)c(Cl)c1
Show InChI InChI=1S/C10H6Cl2FN3O/c11-6-3-5(13)1-2-8(6)15-10(17)9-7(12)4-14-16-9/h1-4H,(H,14,16)(H,15,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109729
PNG
(CHEMBL3604185)
Show SMILES Clc1[nH]nc(c1Cl)-c1nc2ccc(Cl)cc2o1
Show InChI InChI=1S/C10H4Cl3N3O/c11-4-1-2-5-6(3-4)17-10(14-5)8-7(12)9(13)16-15-8/h1-3H,(H,15,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109649
PNG
(CHEMBL3604162)
Show SMILES Fc1ccc(NC(=O)c2n[nH]c(c2Cl)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C11H5Cl2F4N3O/c12-5-3-4(14)1-2-6(5)18-10(21)8-7(13)9(20-19-8)11(15,16)17/h1-3H,(H,18,21)(H,19,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 37n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109752
PNG
(CHEMBL3604164)
Show SMILES FC(F)c1[nH]nc(C(=O)Nc2ccc(F)cc2Cl)c1Cl
Show InChI InChI=1S/C11H6Cl2F3N3O/c12-5-3-4(14)1-2-6(5)17-11(20)9-7(13)8(10(15)16)18-19-9/h1-3,10H,(H,17,20)(H,18,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 39n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109577
PNG
(CHEMBL3604155)
Show SMILES Fc1ccc(NC(=O)c2n[nH]cc2Br)c(Cl)c1
Show InChI InChI=1S/C10H6BrClFN3O/c11-6-4-14-16-9(6)10(17)15-8-2-1-5(13)3-7(8)12/h1-4H,(H,14,16)(H,15,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 39n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109576
PNG
(CHEMBL3604154)
Show SMILES Fc1c[nH]nc1C(=O)Nc1ccc(F)cc1Cl
Show InChI InChI=1S/C10H6ClF2N3O/c11-6-3-5(12)1-2-8(6)15-10(17)9-7(13)4-14-16-9/h1-4H,(H,14,16)(H,15,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109736
PNG
(CHEMBL3604149)
Show SMILES CC(C)(C)c1cc(n[nH]1)C(=O)Nc1ccc(F)cc1Cl
Show InChI InChI=1S/C14H15ClFN3O/c1-14(2,3)12-7-11(18-19-12)13(20)17-10-5-4-8(16)6-9(10)15/h4-7H,1-3H3,(H,17,20)(H,18,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109539
PNG
(CHEMBL3604138)
Show SMILES Clc1ccc(NC(=O)c2cc[nH]n2)nc1
Show InChI InChI=1S/C9H7ClN4O/c10-6-1-2-8(11-5-6)13-9(15)7-3-4-12-14-7/h1-5H,(H,12,14)(H,11,13,15)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 43n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50105866
PNG
(CHEMBL3597764)
Show SMILES Fc1ccc(NC(=O)c2ccn(n2)C(=O)Nc2ccc3OCOc3c2)c(Cl)c1
Show InChI InChI=1S/C18H12ClFN4O4/c19-12-7-10(20)1-3-13(12)22-17(25)14-5-6-24(23-14)18(26)21-11-2-4-15-16(8-11)28-9-27-15/h1-8H,9H2,(H,21,26)(H,22,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 47n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 using arachidonic acid as substrate by cell based assay


Bioorg Med Chem Lett 25: 3017-23 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.007
BindingDB Entry DOI: 10.7270/Q2F191G3
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109707
PNG
(CHEMBL445420)
Show SMILES O=C(Nc1ccccc1)c1cc[nH]n1
Show InChI InChI=1S/C10H9N3O/c14-10(9-6-7-11-13-9)12-8-4-2-1-3-5-8/h1-7H,(H,11,13)(H,12,14)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 47n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50347329
PNG
(CHEMBL1796851)
Show SMILES CCN([C@@H]1CCN(C1)C(C)c1ccc(F)cc1)S(=O)(=O)NCCc1c(n[nH]c1-c1cccs1)-c1cnccn1
Show InChI InChI=1S/C27H32FN7O2S2/c1-3-35(22-11-15-34(18-22)19(2)20-6-8-21(28)9-7-20)39(36,37)31-12-10-23-26(24-17-29-13-14-30-24)32-33-27(23)25-5-4-16-38-25/h4-9,13-14,16-17,19,22,31H,3,10-12,15,18H2,1-2H3,(H,32,33)/t19?,22-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 51n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human 15-LO expressed in CHO cells by cell-based assay


Bioorg Med Chem Lett 21: 4141-5 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.107
BindingDB Entry DOI: 10.7270/Q2028RW3
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109702
PNG
(CHEMBL3604174)
Show SMILES Clc1ccc(NC(=O)c2cn[nH]n2)c(Cl)c1
Show InChI InChI=1S/C9H6Cl2N4O/c10-5-1-2-7(6(11)3-5)13-9(16)8-4-12-15-14-8/h1-4H,(H,13,16)(H,12,14,15)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50114093
PNG
(4-chloro-5-[(2R,3S)-4-(2-chloro-4,5-dihydroxypheny...)
Show SMILES C[C@@H](Cc1cc(O)c(O)cc1Cl)[C@H](C)Cc1cc(O)c(O)cc1Cl
Show InChI InChI=1S/C18H20Cl2O4/c1-9(3-11-5-15(21)17(23)7-13(11)19)10(2)4-12-6-16(22)18(24)8-14(12)20/h5-10,21-24H,3-4H2,1-2H3/t9-,10+
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 65n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory activity against human reticulocyte 15-lipoxygenase (15-HLO)


J Med Chem 45: 2659-61 (2002)


Article DOI: 10.1021/jm0201262
BindingDB Entry DOI: 10.7270/Q2GT5NWN
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109740
PNG
(CHEMBL3604173)
Show SMILES Fc1ccc(NC(=O)c2cn[nH]n2)c(Cl)c1
Show InChI InChI=1S/C9H6ClFN4O/c10-6-3-5(11)1-2-7(6)13-9(16)8-4-12-15-14-8/h1-4H,(H,13,16)(H,12,14,15)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 68n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109731
PNG
(CHEMBL3604166)
Show SMILES Nc1c[nH]nc1C(=O)Nc1ccc(F)cc1Cl
Show InChI InChI=1S/C10H8ClFN4O/c11-6-3-5(12)1-2-8(6)15-10(17)9-7(13)4-14-16-9/h1-4H,13H2,(H,14,16)(H,15,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 69n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109813
PNG
(CHEMBL3604152)
Show SMILES Fc1ccc(NC(=O)c2cc(Cl)[nH]n2)c(Cl)c1
Show InChI InChI=1S/C10H6Cl2FN3O/c11-6-3-5(13)1-2-7(6)14-10(17)8-4-9(12)16-15-8/h1-4H,(H,14,17)(H,15,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 71n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109741
PNG
(CHEMBL3604175)
Show SMILES Clc1ccc(Cl)c(NC(=O)c2cn[nH]n2)c1
Show InChI InChI=1S/C9H6Cl2N4O/c10-5-1-2-6(11)7(3-5)13-9(16)8-4-12-15-14-8/h1-4H,(H,13,16)(H,12,14,15)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 79n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109568
PNG
(CHEMBL3604132)
Show SMILES Fc1ccc(NC(=O)c2cc[nH]n2)c(Cl)c1
Show InChI InChI=1S/C10H7ClFN3O/c11-7-5-6(12)1-2-8(7)14-10(16)9-3-4-13-15-9/h1-5H,(H,13,15)(H,14,16)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 81n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50114094
PNG
(4-bromo-5-[(2R,3S)-4-(2-bromo-4,5-dihydroxyphenyl)...)
Show SMILES C[C@@H](Cc1cc(O)c(O)cc1Br)[C@H](C)Cc1cc(O)c(O)cc1Br
Show InChI InChI=1S/C18H20Br2O4/c1-9(3-11-5-15(21)17(23)7-13(11)19)10(2)4-12-6-16(22)18(24)8-14(12)20/h5-10,21-24H,3-4H2,1-2H3/t9-,10+
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 83n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory activity against human reticulocyte 15-lipoxygenase (15-HLO)


J Med Chem 45: 2659-61 (2002)


Article DOI: 10.1021/jm0201262
BindingDB Entry DOI: 10.7270/Q2GT5NWN
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50114097
PNG
(4-[4-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)-2,3-di...)
Show SMILES C[C@@H](Cc1ccc2OC(C)(C)Oc2c1)[C@H](C)Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C21H26O4/c1-13(9-15-5-7-17(22)18(23)11-15)14(2)10-16-6-8-19-20(12-16)25-21(3,4)24-19/h5-8,11-14,22-23H,9-10H2,1-4H3/t13-,14+/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 85n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibitory activity against human reticulocyte 15-lipoxygenase (15-HLO)


J Med Chem 45: 2659-61 (2002)


Article DOI: 10.1021/jm0201262
BindingDB Entry DOI: 10.7270/Q2GT5NWN
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109730
PNG
(CHEMBL3604151)
Show SMILES Fc1ccc(NC(=O)c2n[nH]cc2Cl)c(Cl)c1
Show InChI InChI=1S/C10H6Cl2FN3O/c11-6-3-5(13)1-2-8(6)15-10(17)9-7(12)4-14-16-9/h1-4H,(H,14,16)(H,15,17)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 85n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50105864
PNG
(CHEMBL3597775)
Show SMILES CCCCCCNC(=O)n1nc(cc1C)C(=O)Nc1ccc(F)cc1Cl
Show InChI InChI=1S/C18H22ClFN4O2/c1-3-4-5-6-9-21-18(26)24-12(2)10-16(23-24)17(25)22-15-8-7-13(20)11-14(15)19/h7-8,10-11H,3-6,9H2,1-2H3,(H,21,26)(H,22,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 85n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 using arachidonic acid as substrate by cell based assay


Bioorg Med Chem Lett 25: 3017-23 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.007
BindingDB Entry DOI: 10.7270/Q2F191G3
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50123669
PNG
(CHEMBL3622735)
Show SMILES CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(=O)C[C@@H](C)CCCC(C)C
Show InChI InChI=1S/C21H28ClNO3/c1-5-26-21(25)20-19(16-10-9-15(22)12-17(16)23-20)18(24)11-14(4)8-6-7-13(2)3/h9-10,12-14,23H,5-8,11H2,1-4H3/t14-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 90n/an/an/an/an/an/a



University of Groningen

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX1 assessed as conversion of linoleic acid to 13(S)-HpODE after 10 mins by UV analysis


J Med Chem 58: 7850-62 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01121
BindingDB Entry DOI: 10.7270/Q28P62BK
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109562
PNG
(CHEMBL3604141)
Show SMILES O=C(Nc1cnc2ccccc2c1)c1cc[nH]n1
Show InChI InChI=1S/C13H10N4O/c18-13(12-5-6-15-17-12)16-10-7-9-3-1-2-4-11(9)14-8-10/h1-8H,(H,15,17)(H,16,18)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 92n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109570
PNG
(CHEMBL3604134)
Show SMILES Fc1ccc(NC(=O)c2cc[nH]n2)c(c1)C(F)(F)F
Show InChI InChI=1S/C11H7F4N3O/c12-6-1-2-8(7(5-6)11(13,14)15)17-10(19)9-3-4-16-18-9/h1-5H,(H,16,18)(H,17,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
MMDB
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 94n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109737
PNG
(CHEMBL3604170)
Show SMILES O=C(Nc1ccccc1)c1cn[nH]n1
Show InChI InChI=1S/C9H8N4O/c14-9(8-6-10-13-12-8)11-7-4-2-1-3-5-7/h1-6H,(H,11,14)(H,10,12,13)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 97n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of 15-LOX-1 in human L1236 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arachidonic...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50109702
PNG
(CHEMBL3604174)
Show SMILES Clc1ccc(NC(=O)c2cn[nH]n2)c(Cl)c1
Show InChI InChI=1S/C9H6Cl2N4O/c10-5-1-2-7(6(11)3-5)13-9(16)8-4-12-15-14-8/h1-4H,(H,13,16)(H,12,14,15)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 99n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of human 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before ara...


Bioorg Med Chem Lett 25: 3024-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.05.004
BindingDB Entry DOI: 10.7270/Q2R21350
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 487 total )  |  Next  |  Last  >>
Jump to: