BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1404 hits of ic50 data for polymerid = 6285,8418   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endothelial lipase


(Homo sapiens (Human))
BDBM151267
PNG
(US8987314, B63)
Show SMILES COCc1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C20H23N3O6S3/c1-29-12-13-3-5-14(6-4-13)15-7-8-16-17(11-15)30-20(23-16)18(31(2,25)26)19(24)22-9-10-32(21,27)28/h3-8,11,18H,9-10,12H2,1-2H3,(H,22,24)(H2,21,27,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.5n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151268
PNG
(US8987314, B64)
Show SMILES COCCOC(=O)Nc1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C22H26N4O8S3/c1-33-10-11-34-22(28)25-16-6-3-14(4-7-16)15-5-8-17-18(13-15)35-21(26-17)19(36(2,29)30)20(27)24-9-12-37(23,31)32/h3-8,13,19H,9-12H2,1-2H3,(H,24,27)(H,25,28)(H2,23,31,32)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.5n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151568
PNG
(US8987314, B379)
Show SMILES CC(=O)Nc1cccc(c1)-c1ccc2sc(nc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C20H22N4O6S3/c1-12(25)23-15-5-3-4-13(10-15)14-6-7-17-16(11-14)24-20(31-17)18(32(2,27)28)19(26)22-8-9-33(21,29)30/h3-7,10-11,18H,8-9H2,1-2H3,(H,22,26)(H,23,25)(H2,21,29,30)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.5n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151498
PNG
(US8987314, B309)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2cc(ccc2s1)-c1ccc(F)nc1)S(=O)(=O)Cc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C24H20F4N4O6S3/c25-20-8-4-16(12-31-20)15-3-7-19-18(11-15)32-23(39-19)21(22(33)30-9-10-41(29,36)37)40(34,35)13-14-1-5-17(6-2-14)38-24(26,27)28/h1-8,11-12,21H,9-10,13H2,(H,30,33)(H2,29,36,37)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.5n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151416
PNG
(US8987314, B227)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)Cc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C26H23F3N4O7S3/c27-26(28,29)40-19-8-1-15(2-9-19)14-42(36,37)22(24(35)32-11-12-43(31,38)39)25-33-20-10-7-18(13-21(20)41-25)16-3-5-17(6-4-16)23(30)34/h1-10,13,22H,11-12,14H2,(H2,30,34)(H,32,35)(H2,31,38,39)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.5n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151415
PNG
(US8987314, B226)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)NC1CC1)S(=O)(=O)Cc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C29H27F3N4O7S3/c30-29(31,32)43-22-10-1-17(2-11-22)16-45(39,40)25(27(38)34-13-14-46(33,41)42)28-36-23-12-7-20(15-24(23)44-28)18-3-5-19(6-4-18)26(37)35-21-8-9-21/h1-7,10-12,15,21,25H,8-9,13-14,16H2,(H,34,38)(H,35,37)(H2,33,41,42)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.5n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151387
PNG
(US8987314, B193)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccnc(O)c1F
Show InChI InChI=1S/C17H17FN4O6S3/c1-30(25,26)14(16(24)21-6-7-31(19,27)28)17-22-11-3-2-9(8-12(11)29-17)10-4-5-20-15(23)13(10)18/h2-5,8,14H,6-7H2,1H3,(H,20,23)(H,21,24)(H2,19,27,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.5n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151297
PNG
(US8987314, B93)
Show SMILES COCCNC(=O)c1ccc(cc1)-c1ccc2sc(nc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C22H26N4O7S3/c1-33-11-9-24-20(27)15-5-3-14(4-6-15)16-7-8-18-17(13-16)26-22(34-18)19(35(2,29)30)21(28)25-10-12-36(23,31)32/h3-8,13,19H,9-12H2,1-2H3,(H,24,27)(H,25,28)(H2,23,31,32)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.5n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151292
PNG
(US8987314, B88)
Show SMILES COc1cc(ccn1)-c1ccc2sc(nc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C18H20N4O6S3/c1-28-15-10-12(5-6-20-15)11-3-4-14-13(9-11)22-18(29-14)16(30(2,24)25)17(23)21-7-8-31(19,26)27/h3-6,9-10,16H,7-8H2,1-2H3,(H,21,23)(H2,19,26,27)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.5n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151291
PNG
(US8987314, B87)
Show SMILES COc1ccc(cn1)-c1ccc2sc(nc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C18H20N4O6S3/c1-28-15-6-4-12(10-21-15)11-3-5-14-13(9-11)22-18(29-14)16(30(2,24)25)17(23)20-7-8-31(19,26)27/h3-6,9-10,16H,7-8H2,1-2H3,(H,20,23)(H2,19,26,27)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.5n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151399
PNG
(US8987314, B210)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C24H23N3O6S3/c1-35(29,30)22(23(28)26-12-13-36(25,31)32)24-27-20-11-10-17(15-21(20)34-24)16-6-5-9-19(14-16)33-18-7-3-2-4-8-18/h2-11,14-15,22H,12-13H2,1H3,(H,26,28)(H2,25,31,32)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.600n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151510
PNG
(US8987314, B321)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2cc(ccc2s1)-c1ccc(cc1)C(=O)N1CC(F)(F)C1
Show InChI InChI=1S/C22H22F2N4O6S3/c1-36(31,32)18(19(29)26-8-9-37(25,33)34)20-27-16-10-15(6-7-17(16)35-20)13-2-4-14(5-3-13)21(30)28-11-22(23,24)12-28/h2-7,10,18H,8-9,11-12H2,1H3,(H,26,29)(H2,25,33,34)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.600n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151400
PNG
(US8987314, B211)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)NCCCO
Show InChI InChI=1S/C22H26N4O7S3/c1-35(30,31)19(21(29)25-10-12-36(23,32)33)22-26-17-8-7-16(13-18(17)34-22)14-3-5-15(6-4-14)20(28)24-9-2-11-27/h3-8,13,19,27H,2,9-12H2,1H3,(H,24,28)(H,25,29)(H2,23,32,33)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.700n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151493
PNG
(US8987314, B304)
Show SMILES CO[C@H]1CCN(C1)C(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1S/C26H29F3N4O7S3/c1-40-19-8-11-33(15-19)25(35)17-4-2-16(3-5-17)18-6-7-20-21(14-18)41-24(32-20)22(23(34)31-10-13-43(30,38)39)42(36,37)12-9-26(27,28)29/h2-7,14,19,22H,8-13,15H2,1H3,(H,31,34)(H2,30,38,39)/t19-,22?/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.700n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151572
PNG
(US8987314, B383)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2cc(ccc2s1)-c1cccnc1F
Show InChI InChI=1S/C17H17FN4O5S3/c1-29(24,25)14(16(23)21-7-8-30(19,26)27)17-22-12-9-10(4-5-13(12)28-17)11-3-2-6-20-15(11)18/h2-6,9,14H,7-8H2,1H3,(H,21,23)(H2,19,26,27)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.700n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151567
PNG
(US8987314, B378)
Show SMILES COCc1ccc(cc1)-c1ccc2sc(nc2c1)C(C(=O)NCCS(N)(=O)=O)S(C)(=O)=O
Show InChI InChI=1S/C20H23N3O6S3/c1-29-12-13-3-5-14(6-4-13)15-7-8-17-16(11-15)23-20(30-17)18(31(2,25)26)19(24)22-9-10-32(21,27)28/h3-8,11,18H,9-10,12H2,1-2H3,(H,22,24)(H2,21,27,28)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.700n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151315
PNG
(BDBM151471 | US8987314, B113)
Show SMILES COCCNC(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)Cc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C29H29F3N4O8S3/c1-43-14-12-34-26(37)20-6-4-19(5-7-20)21-8-11-23-24(16-21)45-28(36-23)25(27(38)35-13-15-47(33,41)42)46(39,40)17-18-2-9-22(10-3-18)44-29(30,31)32/h2-11,16,25H,12-15,17H2,1H3,(H,34,37)(H,35,38)(H2,33,41,42)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.700n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151519
PNG
(US8987314, B330)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(cc1)C(=O)N1CC(F)C1
Show InChI InChI=1S/C22H23FN4O6S3/c1-35(30,31)19(20(28)25-8-9-36(24,32)33)21-26-17-7-6-15(10-18(17)34-21)13-2-4-14(5-3-13)22(29)27-11-16(23)12-27/h2-7,10,16,19H,8-9,11-12H2,1H3,(H,25,28)(H2,24,32,33)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.700n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151480
PNG
(US8987314, B291)
Show SMILES COCCN(C)C(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)CC1CC1
Show InChI InChI=1S/C26H32N4O7S3/c1-30(12-13-37-2)26(32)19-7-5-18(6-8-19)20-9-10-21-22(15-20)38-25(29-21)23(39(33,34)16-17-3-4-17)24(31)28-11-14-40(27,35)36/h5-10,15,17,23H,3-4,11-14,16H2,1-2H3,(H,28,31)(H2,27,35,36)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.700n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151541
PNG
(US8987314, B352)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2cc(ccc2s1)-c1ccccc1F
Show InChI InChI=1S/C18H18FN3O5S3/c1-29(24,25)16(17(23)21-8-9-30(20,26)27)18-22-14-10-11(6-7-15(14)28-18)12-4-2-3-5-13(12)19/h2-7,10,16H,8-9H2,1H3,(H,21,23)(H2,20,26,27)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.800n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151397
PNG
(US8987314, B208)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H18ClN3O5S3/c1-29(24,25)16(17(23)21-7-8-30(20,26)27)18-22-14-6-5-12(10-15(14)28-18)11-3-2-4-13(19)9-11/h2-6,9-10,16H,7-8H2,1H3,(H,21,23)(H2,20,26,27)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.800n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151563
PNG
(US8987314, B374)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2cc(ccc2s1)-c1ncccn1
Show InChI InChI=1S/C16H17N5O5S3/c1-28(23,24)13(15(22)20-7-8-29(17,25)26)16-21-11-9-10(3-4-12(11)27-16)14-18-5-2-6-19-14/h2-6,9,13H,7-8H2,1H3,(H,20,22)(H2,17,25,26)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.800n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151316
PNG
(US8987314, B114)
Show SMILES COCCNC(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)CC1CC1
Show InChI InChI=1S/C25H30N4O7S3/c1-36-12-10-27-23(30)18-6-4-17(5-7-18)19-8-9-20-21(14-19)37-25(29-20)22(38(32,33)15-16-2-3-16)24(31)28-11-13-39(26,34)35/h4-9,14,16,22H,2-3,10-13,15H2,1H3,(H,27,30)(H,28,31)(H2,26,34,35)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.800n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151477
PNG
(US8987314, B288)
Show SMILES COCCN(C)C(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C30H31F3N4O7S3/c1-37(14-15-44-2)29(39)21-7-5-20(6-8-21)22-9-12-24-25(17-22)45-28(36-24)26(27(38)35-13-16-47(34,42)43)46(40,41)18-19-3-10-23(11-4-19)30(31,32)33/h3-12,17,26H,13-16,18H2,1-2H3,(H,35,38)(H2,34,42,43)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.800n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151259
PNG
(BDBM151425 | US8987314, B55)
Show SMILES CC(=O)Nc1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1S/C22H23F3N4O6S3/c1-13(30)28-16-5-2-14(3-6-16)15-4-7-17-18(12-15)36-21(29-17)19(20(31)27-9-11-38(26,34)35)37(32,33)10-8-22(23,24)25/h2-7,12,19H,8-11H2,1H3,(H,27,31)(H,28,30)(H2,26,34,35)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.800n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151433
PNG
(US8987314, B244)
Show SMILES COC(C)(C)CNC(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)CC1CC1
Show InChI InChI=1S/C27H34N4O7S3/c1-27(2,38-3)16-30-24(32)19-8-6-18(7-9-19)20-10-11-21-22(14-20)39-26(31-21)23(40(34,35)15-17-4-5-17)25(33)29-12-13-41(28,36)37/h6-11,14,17,23H,4-5,12-13,15-16H2,1-3H3,(H,29,33)(H,30,32)(H2,28,36,37)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.900n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319524
PNG
(2-{6-[4-(5-amino- 4-cyano-1H- pyrazol-1-yl) phenyl...)
Show SMILES COCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(cc1)-n1ncc([N+]#[C-])c1N
Show InChI InChI=1S/C27H26FN7O5S2/c1-30-21-13-32-35(25(21)29)17-7-3-15(4-8-17)18-11-22-20(12-19(18)28)34-27(41-22)24(42(38,39)10-9-40-2)26(37)31-14-23(36)33-16-5-6-16/h3-4,7-8,11-13,16,24H,5-6,9-10,14,29H2,2H3,(H,31,37)(H,33,36)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319525
PNG
(5-amino-1-{4-[2- ({[(cyclopropyl- carbamoyl)methyl...)
Show SMILES COCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(cc1)-n1ncc(C(N)=O)c1N
Show InChI InChI=1S/C27H28FN7O6S2/c1-41-8-9-43(39,40)23(26(38)31-13-22(36)33-15-4-5-15)27-34-20-11-19(28)17(10-21(20)42-27)14-2-6-16(7-3-14)35-24(29)18(12-32-35)25(30)37/h2-3,6-7,10-12,15,23H,4-5,8-9,13,29H2,1H3,(H2,30,37)(H,31,38)(H,33,36)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151389
PNG
(US8987314, B195)
Show SMILES CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2cc(ccc2s1)-c1ccc(O)nc1
Show InChI InChI=1S/C17H18N4O6S3/c1-29(24,25)15(16(23)19-6-7-30(18,26)27)17-21-12-8-10(2-4-13(12)28-17)11-3-5-14(22)20-9-11/h2-5,8-9,15H,6-7H2,1H3,(H,19,23)(H,20,22)(H2,18,26,27)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151537
PNG
(US8987314, B348)
Show SMILES Cc1cc2nc(sc2cc1-c1ccc(cc1)C(=O)N1CCCCC1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C31H34N4O6S3/c1-21-18-26-27(19-25(21)23-10-12-24(13-11-23)31(37)35-15-6-3-7-16-35)42-30(34-26)28(29(36)33-14-17-44(32,40)41)43(38,39)20-22-8-4-2-5-9-22/h2,4-5,8-13,18-19,28H,3,6-7,14-17,20H2,1H3,(H,33,36)(H2,32,40,41)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151534
PNG
(US8987314, B345)
Show SMILES CC(C)(O)CNC(=O)c1cccc(c1)-c1ccc2nc(sc2c1)C(C(=O)NCCS(N)(=O)=O)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1S/C25H29F3N4O7S3/c1-24(2,35)14-31-21(33)17-5-3-4-15(12-17)16-6-7-18-19(13-16)40-23(32-18)20(22(34)30-9-11-42(29,38)39)41(36,37)10-8-25(26,27)28/h3-7,12-13,20,35H,8-11,14H2,1-2H3,(H,30,34)(H,31,33)(H2,29,38,39)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151499
PNG
(US8987314, B310)
Show SMILES NS(=O)(=O)CCNC(=O)C(c1nc2cc(ccc2s1)-c1ccc(F)nc1)S(=O)(=O)Cc1ccc(F)cc1
Show InChI InChI=1S/C23H20F2N4O5S3/c24-17-5-1-14(2-6-17)13-36(31,32)21(22(30)27-9-10-37(26,33)34)23-29-18-11-15(3-7-19(18)35-23)16-4-8-20(25)28-12-16/h1-8,11-12,21H,9-10,13H2,(H,27,30)(H2,26,33,34)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319013
PNG
(US10173991, Example 54 | benzyl N-(4-{2- [cyclohex...)
Show SMILES Fc1cc2nc(sc2cc1-c1ccc(NC(=O)OCc2ccccc2)cc1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CC1CCCCC1
Show InChI InChI=1S/C35H37FN4O6S2/c36-28-18-29-30(17-27(28)24-11-13-26(14-12-24)39-35(43)46-20-22-7-3-1-4-8-22)47-34(40-29)32(33(42)37-19-31(41)38-25-15-16-25)48(44,45)21-23-9-5-2-6-10-23/h1,3-4,7-8,11-14,17-18,23,25,32H,2,5-6,9-10,15-16,19-21H2,(H,37,42)(H,38,41)(H,39,43)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319011
PNG
(US10173991, Example 52 | benzyl N-{4-[2- ({[(cyclo...)
Show SMILES CCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(NC(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C31H31FN4O6S2/c1-2-14-44(40,41)28(29(38)33-17-27(37)34-21-12-13-21)30-36-25-16-24(32)23(15-26(25)43-30)20-8-10-22(11-9-20)35-31(39)42-18-19-6-4-3-5-7-19/h3-11,15-16,21,28H,2,12-14,17-18H2,1H3,(H,33,38)(H,34,37)(H,35,39)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319007
PNG
(US10173991, Example 48 | benzyl N-{4-[2- ({[(cyclo...)
Show SMILES CCCCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(NC(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C33H35FN4O6S2/c1-2-3-7-16-46(42,43)30(31(40)35-19-29(39)36-23-14-15-23)32-38-27-18-26(34)25(17-28(27)45-32)22-10-12-24(13-11-22)37-33(41)44-20-21-8-5-4-6-9-21/h4-6,8-13,17-18,23,30H,2-3,7,14-16,19-20H2,1H3,(H,35,40)(H,36,39)(H,37,41)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM318970
PNG
(US10173991, Example 11 | benzyl N-(4-{2- [(cyclopr...)
Show SMILES Fc1cc2sc(nc2cc1-c1ccc(NC(=O)OCc2ccccc2)cc1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C31H29FN4O6S2/c32-24-15-26-25(14-23(24)19-6-8-21(9-7-19)35-31(39)42-17-18-4-2-1-3-5-18)36-30(43-26)28(44(40,41)22-12-13-22)29(38)33-16-27(37)34-20-10-11-20/h1-9,14-15,20,22,28H,10-13,16-17H2,(H,33,38)(H,34,37)(H,35,39)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM318969
PNG
(US10173991, Example 10 | benzyl N-{4-[2- ({[(cyclo...)
Show SMILES OCCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(c(F)cc2s1)-c1ccc(NC(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C31H31FN4O7S2/c32-24-16-26-25(15-23(24)20-7-9-22(10-8-20)35-31(40)43-18-19-5-2-1-3-6-19)36-30(44-26)28(45(41,42)14-4-13-37)29(39)33-17-27(38)34-21-11-12-21/h1-3,5-10,15-16,21,28,37H,4,11-14,17-18H2,(H,33,39)(H,34,38)(H,35,40)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM318968
PNG
(US10173991, Example 9 | benzyl N-{4-[2- ({[(cyclop...)
Show SMILES Fc1cc2sc(nc2cc1-c1ccc(NC(=O)OCc2ccccc2)cc1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1S/C31H28F4N4O6S2/c32-23-15-25-24(14-22(23)19-6-8-21(9-7-19)38-30(42)45-17-18-4-2-1-3-5-18)39-29(46-25)27(47(43,44)13-12-31(33,34)35)28(41)36-16-26(40)37-20-10-11-20/h1-9,14-15,20,27H,10-13,16-17H2,(H,36,41)(H,37,40)(H,38,42)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM318967
PNG
(US10173991, Example 8 | benzyl N-{4-[2- ({[(cyclop...)
Show SMILES CS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(c(F)cc2s1)-c1ccc(NC(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C29H27FN4O6S2/c1-42(38,39)26(27(36)31-15-25(35)32-19-11-12-19)28-34-23-13-21(22(30)14-24(23)41-28)18-7-9-20(10-8-18)33-29(37)40-16-17-5-3-2-4-6-17/h2-10,13-14,19,26H,11-12,15-16H2,1H3,(H,31,36)(H,32,35)(H,33,37)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319101
PNG
(N-[(cyclopropyl- carbamoyl) methyl]-2-{5- fluoro-6...)
Show SMILES Fc1cc2nc(sc2cc1-c1ccc(cc1)-c1ccn[nH]1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1S/C26H23F4N5O4S2/c27-18-12-20-21(11-17(18)14-1-3-15(4-2-14)19-7-9-32-35-19)40-25(34-20)23(41(38,39)10-8-26(28,29)30)24(37)31-13-22(36)33-16-5-6-16/h1-4,7,9,11-12,16,23H,5-6,8,10,13H2,(H,31,37)(H,32,35)(H,33,36)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319094
PNG
(N-[(cyclopropyl- carbamoyl) methyl]-2-{5- fluoro-6...)
Show SMILES Fc1cc2nc(sc2cc1-c1cccc(c1)-n1cccn1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1S/C26H23F4N5O4S2/c27-19-13-20-21(12-18(19)15-3-1-4-17(11-15)35-9-2-8-32-35)40-25(34-20)23(41(38,39)10-7-26(28,29)30)24(37)31-14-22(36)33-16-5-6-16/h1-4,8-9,11-13,16,23H,5-7,10,14H2,(H,31,37)(H,33,36)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319050
PNG
(N-[(cyclopropyl- carbamoyl) methyl]-2-(2- methoxye...)
Show SMILES OCCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2ccc(cc2s1)-c1ccc(cc1)-c1ncco1
Show InChI InChI=1S/C26H26N4O6S2/c31-11-1-13-38(34,35)23(24(33)28-15-22(32)29-19-7-8-19)26-30-20-9-6-18(14-21(20)37-26)16-2-4-17(5-3-16)25-27-10-12-36-25/h2-6,9-10,12,14,19,23,31H,1,7-8,11,13,15H2,(H,28,33)(H,29,32)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319153
PNG
(N-[(cyclopropyl- carbamoyl) methyl]-2-[5- fluoro-6...)
Show SMILES Cn1ncc2ccc(cc12)-c1cc2sc(nc2cc1F)C(C(=O)NCC(=O)NC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H22FN5O4S2/c1-29-18-7-12(3-4-13(18)10-26-29)15-8-19-17(9-16(15)24)28-23(34-19)21(35(2,32)33)22(31)25-11-20(30)27-14-5-6-14/h3-4,7-10,14,21H,5-6,11H2,1-2H3,(H,25,31)(H,27,30)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319205
PNG
(N-[(cyclopropyl- carbamoyl) methyl]-2-[5- fluoro-6...)
Show SMILES Cc1nc2cc(ccc2s1)-c1cc2sc(nc2cc1F)C(C(=O)NCC(=O)NC1CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H21FN4O4S3/c1-11-26-16-7-12(3-6-18(16)33-11)14-8-19-17(9-15(14)24)28-23(34-19)21(35(2,31)32)22(30)25-10-20(29)27-13-4-5-13/h3,6-9,13,21H,4-5,10H2,1-2H3,(H,25,30)(H,27,29)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319335
PNG
(2-[6-(6- fluoropyridin- 3-yl)-1,3- benzothiazol- 2...)
Show SMILES COCCS(=O)(=O)C(C(=O)NCC(=O)NCCOc1ccccc1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C27H27FN4O6S2/c1-37-13-14-40(35,36)25(26(34)31-17-24(33)29-11-12-38-20-5-3-2-4-6-20)27-32-21-9-7-18(15-22(21)39-27)19-8-10-23(28)30-16-19/h2-10,15-16,25H,11-14,17H2,1H3,(H,29,33)(H,31,34)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319332
PNG
(N-({[2- (benzyloxy)ethyl] carbamoyl} methyl)-2-[6-...)
Show SMILES COCCS(=O)(=O)C(C(=O)NCC(=O)NCCOCc1ccccc1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C28H29FN4O6S2/c1-38-13-14-41(36,37)26(27(35)32-17-25(34)30-11-12-39-18-19-5-3-2-4-6-19)28-33-22-9-7-20(15-23(22)40-28)21-8-10-24(29)31-16-21/h2-10,15-16,26H,11-14,17-18H2,1H3,(H,30,34)(H,32,35)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319442
PNG
(N-[(cyclopropyl- carbamoyl) methyl]-2- (dimethyl- ...)
Show SMILES CN(C)S(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2c(F)cc(cc2s1)-c1ccc2c(ccn(C)c2=O)c1
Show InChI InChI=1S/C26H26FN5O5S2/c1-31(2)39(36,37)23(24(34)28-13-21(33)29-17-5-6-17)25-30-22-19(27)11-16(12-20(22)38-25)14-4-7-18-15(10-14)8-9-32(3)26(18)35/h4,7-12,17,23H,5-6,13H2,1-3H3,(H,28,34)(H,29,33)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319375
PNG
(US10173991, Example 423 | benzyl N-{4-[2- ({[(cycl...)
Show SMILES Fc1cc2nc(sc2cc1-c1ccc(NC(=O)OCc2ccccc2)cc1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCN1CCOCC1
Show InChI InChI=1S/C34H36FN5O7S2/c35-27-19-28-29(18-26(27)23-6-8-25(9-7-23)38-34(43)47-21-22-4-2-1-3-5-22)48-33(39-28)31(32(42)36-20-30(41)37-24-10-11-24)49(44,45)17-14-40-12-15-46-16-13-40/h1-9,18-19,24,31H,10-17,20-21H2,(H,36,42)(H,37,41)(H,38,43)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319517
PNG
(N-{4-[2- ({[(cyclopropyl- carbamoyl)methyl] carbam...)
Show SMILES COCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(NC(=O)CCc2ccccc2)cc1
Show InChI InChI=1S/C32H33FN4O6S2/c1-43-15-16-45(41,42)30(31(40)34-19-29(39)36-23-12-13-23)32-37-26-18-25(33)24(17-27(26)44-32)21-8-10-22(11-9-21)35-28(38)14-7-20-5-3-2-4-6-20/h2-6,8-11,17-18,23,30H,7,12-16,19H2,1H3,(H,34,40)(H,35,38)(H,36,39)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM319458
PNG
(2-(6-{4-[(benzyl- carbamoyl) amino]phenyl}- 5-fluo...)
Show SMILES Fc1cc2nc(sc2cc1-c1ccc(NC(=O)NCc2ccccc2)cc1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCC(F)(F)F
Show InChI InChI=1S/C31H29F4N5O5S2/c32-23-15-24-25(14-22(23)19-6-8-21(9-7-19)39-30(43)37-16-18-4-2-1-3-5-18)46-29(40-24)27(47(44,45)13-12-31(33,34)35)28(42)36-17-26(41)38-20-10-11-20/h1-9,14-15,20,27H,10-13,16-17H2,(H,36,42)(H,38,41)(H2,37,39,43)
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US10173991 (2019)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 1404 total )  |  Next  |  Last  >>
Jump to: