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Compile Data Set for Download or QSAR

Found 30 hits of ic50 data for polymerid = 6548   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50323040
PNG
(1-(3-Thiophen-2-yl-phenyl)-ethanone, O-(phenylamin...)
Show SMILES CC(=NOC(=O)Nc1ccccc1)c1cccc(c1)-c1cccs1
Show InChI InChI=1S/C19H16N2O2S/c1-14(21-23-19(22)20-17-9-3-2-4-10-17)15-7-5-8-16(13-15)18-11-6-12-24-18/h2-13H,1H3,(H,20,22)
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n/an/a 1n/an/an/an/an/an/a



Università degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human recombinant 5HT5A receptor expressed in CHO cells


Bioorg Med Chem Lett 20: 4406-11 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.050
BindingDB Entry DOI: 10.7270/Q24Q7V5B
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/a 1.80n/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human recombinant 5-HT5A receptor expressed in HEK293 cells


Bioorg Med Chem 24: 1793-810 (2016)


Article DOI: 10.1016/j.bmc.2016.03.006
BindingDB Entry DOI: 10.7270/Q2J67JS7
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/a 1.80n/an/an/an/an/an/a



Jagiellonian University Medical College

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human recombinant 5HT5A receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method


Bioorg Med Chem 25: 471-482 (2017)


Article DOI: 10.1016/j.bmc.2016.11.014
BindingDB Entry DOI: 10.7270/Q2CF9S3S
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422022
PNG
(CHEMBL101138)
Show SMILES CN(C)CCc1c[nH]c2ccc(cc12)N1CCN(Cc2ccccc2)S1(=O)=O
Show InChI InChI=1S/C21H26N4O2S/c1-23(2)11-10-18-15-22-21-9-8-19(14-20(18)21)25-13-12-24(28(25,26)27)16-17-6-4-3-5-7-17/h3-9,14-15,22H,10-13,16H2,1-2H3
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n/an/a 79n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422016
PNG
(CHEMBL323334)
Show SMILES CN(C)CCc1c[nH]c2ccc(CN3CCCN(C)S3(=O)=O)cc12
Show InChI InChI=1S/C17H26N4O2S/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-21-9-4-8-20(3)24(21,22)23/h5-6,11-12,18H,4,7-10,13H2,1-3H3
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n/an/a 126n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422021
PNG
(CHEMBL103549)
Show SMILES CN(C)CCc1c[nH]c2ccc(CCN3CCNS3(=O)=O)cc12
Show InChI InChI=1S/C16H24N4O2S/c1-19(2)8-6-14-12-17-16-4-3-13(11-15(14)16)5-9-20-10-7-18-23(20,21)22/h3-4,11-12,17-18H,5-10H2,1-2H3
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n/an/a 126n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422019
PNG
(CHEMBL321963)
Show SMILES CCN1CCN(CCc2ccc3[nH]cc(CCN(C)C)c3c2)S1(=O)=O
Show InChI InChI=1S/C18H28N4O2S/c1-4-21-11-12-22(25(21,23)24)10-7-15-5-6-18-17(13-15)16(14-19-18)8-9-20(2)3/h5-6,13-14,19H,4,7-12H2,1-3H3
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n/an/a 126n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422029
PNG
(CHEMBL103388)
Show SMILES CN(C)CCc1c[nH]c2ccc(CN3CCN(Cc4ccc(NC(C)=O)cc4)S3(=O)=O)cc12
Show InChI InChI=1S/C24H31N5O3S/c1-18(30)26-22-7-4-19(5-8-22)16-28-12-13-29(33(28,31)32)17-20-6-9-24-23(14-20)21(15-25-24)10-11-27(2)3/h4-9,14-15,25H,10-13,16-17H2,1-3H3,(H,26,30)
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n/an/a 200n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422025
PNG
(CHEMBL103371)
Show SMILES CN(C)CCc1c[nH]c2ccc(CCN3CCN(C)S3(=O)=O)cc12
Show InChI InChI=1S/C17H26N4O2S/c1-19(2)8-7-15-13-18-17-5-4-14(12-16(15)17)6-9-21-11-10-20(3)24(21,22)23/h4-5,12-13,18H,6-11H2,1-3H3
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n/an/a 200n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422026
PNG
(CHEMBL320412)
Show SMILES CN(C)CCc1c[nH]c2ccc(CN3CC(C)(C)NS3(=O)=O)cc12
Show InChI InChI=1S/C17H26N4O2S/c1-17(2)12-21(24(22,23)19-17)11-13-5-6-16-15(9-13)14(10-18-16)7-8-20(3)4/h5-6,9-10,18-19H,7-8,11-12H2,1-4H3
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n/an/a 251n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/a 260n/an/an/an/an/an/a



The University of Newcastle

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human recombinant 5-HT5a receptor in HEK293 cells after 120 mins by scintillation counting


J Med Chem 60: 349-361 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01422
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50005835
PNG
((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Show SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3
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n/an/a 501n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422023
PNG
(CHEMBL318571)
Show SMILES CC(C)N1CCN(Cc2ccc3[nH]cc(CCN(C)C)c3c2)S1(=O)=O
Show InChI InChI=1S/C18H28N4O2S/c1-14(2)22-10-9-21(25(22,23)24)13-15-5-6-18-17(11-15)16(12-19-18)7-8-20(3)4/h5-6,11-12,14,19H,7-10,13H2,1-4H3
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n/an/a 501n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422024
PNG
(CHEMBL319223)
Show SMILES CN(C)CCc1c[nH]c2ccc(cc12)N1CCN(C)S1(=O)=O
Show InChI InChI=1S/C15H22N4O2S/c1-17(2)7-6-12-11-16-15-5-4-13(10-14(12)15)19-9-8-18(3)22(19,20)21/h4-5,10-11,16H,6-9H2,1-3H3
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n/an/a 631n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422017
PNG
(CHEMBL103854)
Show SMILES CN1CCN(Cc2ccc3[nH]cc(CCN)c3c2)S1(=O)=O
Show InChI InChI=1S/C14H20N4O2S/c1-17-6-7-18(21(17,19)20)10-11-2-3-14-13(8-11)12(4-5-15)9-16-14/h2-3,8-9,16H,4-7,10,15H2,1H3
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n/an/a 631n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422028
PNG
(CHEMBL102548)
Show SMILES CN(C)CCc1c[nH]c2ccc(CN3CCNS3(=O)=O)cc12
Show InChI InChI=1S/C15H22N4O2S/c1-18(2)7-5-13-10-16-15-4-3-12(9-14(13)15)11-19-8-6-17-22(19,20)21/h3-4,9-10,16-17H,5-8,11H2,1-2H3
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n/an/a 794n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422020
PNG
(CHEMBL103205)
Show SMILES CN(C)CCc1c[nH]c2ccc(CN3CCN(C)S3(=O)=O)cc12
Show InChI InChI=1S/C16H24N4O2S/c1-18(2)7-6-14-11-17-16-5-4-13(10-15(14)16)12-20-9-8-19(3)23(20,21)22/h4-5,10-11,17H,6-9,12H2,1-3H3
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n/an/a 794n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422030
PNG
(CHEMBL102586)
Show SMILES CNCCc1c[nH]c2ccc(CN3CCN(C)S3(=O)=O)cc12
Show InChI InChI=1S/C15H22N4O2S/c1-16-6-5-13-10-17-15-4-3-12(9-14(13)15)11-19-8-7-18(2)22(19,20)21/h3-4,9-10,16-17H,5-8,11H2,1-2H3
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n/an/a 794n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422018
PNG
(CHEMBL102645)
Show SMILES CN(C)CCc1c[nH]c2ccc(CN3C(C)(C)CNS3(=O)=O)cc12
Show InChI InChI=1S/C17H26N4O2S/c1-17(2)12-19-24(22,23)21(17)11-13-5-6-16-15(9-13)14(10-18-16)7-8-20(3)4/h5-6,9-10,18-19H,7-8,11-12H2,1-4H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50330813
PNG
(3-[(1S,3R)-3-Dimethylaminocyclopentyl]-1H-indole-5...)
Show SMILES CN(C)[C@@H]1CC[C@@H](C1)c1c[nH]c2ccc(cc12)C#N
Show InChI InChI=1S/C16H19N3/c1-19(2)13-5-4-12(8-13)15-10-18-16-6-3-11(9-17)7-14(15)16/h3,6-7,10,12-13,18H,4-5,8H2,1-2H3/t12-,13+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Bristol Myers Squibb

Curated by ChEMBL


Assay Description
Binding affinity to 5HT5A receptor


J Med Chem 53: 7564-72 (2010)


Article DOI: 10.1021/jm100515z
BindingDB Entry DOI: 10.7270/Q25B02QV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50330441
PNG
(3-amino-2-(4-(4-(quinolin-2-yl)piperazin-1-yl)buty...)
Show SMILES Nn1c(CCCCN2CCN(CC2)c2ccc3ccccc3n2)nc2CCCCc2c1=O
Show InChI InChI=1S/C25H32N6O/c26-31-24(28-22-10-4-2-8-20(22)25(31)32)11-5-6-14-29-15-17-30(18-16-29)23-13-12-19-7-1-3-9-21(19)27-23/h1,3,7,9,12-13H,2,4-6,8,10-11,14-18,26H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



ASKA Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human recombinant 5HT5A receptor


J Med Chem 53: 7549-63 (2010)


Article DOI: 10.1021/jm1002292
BindingDB Entry DOI: 10.7270/Q27082D1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50422027
PNG
(CHEMBL2111620)
Show SMILES CN1CCN(Cc2ccc3scc(CCN)c3c2)S1(=O)=O
Show InChI InChI=1S/C14H19N3O2S2/c1-16-6-7-17(21(16,18)19)9-11-2-3-14-13(8-11)12(4-5-15)10-20-14/h2-3,8,10H,4-7,9,15H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortex


J Med Chem 37: 3023-32 (1994)


Article DOI: 10.1021/jm00045a006
BindingDB Entry DOI: 10.7270/Q2V69KWJ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50105109
PNG
(4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazine-1-c...)
Show SMILES Fc1ccc(cc1)C(CCCN1CCN(CC1)C(=O)OCCc1ccc(cc1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C30H31F2N3O2/c31-27-11-7-25(8-12-27)29(26-9-13-28(32)14-10-26)2-1-16-34-17-19-35(20-18-34)30(36)37-21-15-23-3-5-24(22-33)6-4-23/h3-14,29H,1-2,15-21H2
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n/an/a 3.38E+3n/an/an/an/an/an/a



F-59000 Lille

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 5A receptor


J Med Chem 44: 3391-401 (2001)


Article DOI: 10.1021/jm010878g
BindingDB Entry DOI: 10.7270/Q2057GN9
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50105107
PNG
(1-{4-[4,4-Bis-(4-fluoro-phenyl)-butyl]-piperazin-1...)
Show SMILES Fc1ccc(cc1)C(CCCN1CCN(CC1)C(=O)CCCc1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C30H34F2N2O/c31-27-15-11-25(12-16-27)29(26-13-17-28(32)18-14-26)9-5-19-33-20-22-34(23-21-33)30(35)10-4-8-24-6-2-1-3-7-24/h1-3,6-7,11-18,29H,4-5,8-10,19-23H2
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n/an/a 5.52E+3n/an/an/an/an/an/a



F-59000 Lille

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 5A receptor


J Med Chem 44: 3391-401 (2001)


Article DOI: 10.1021/jm010878g
BindingDB Entry DOI: 10.7270/Q2057GN9
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50304075
PNG
(3-(5-(4-tert-butylphenyl)-3-((dimethylamino)methyl...)
Show SMILES CN(C)Cc1nc(-c2ccc(cc2)C(C)(C)C)n(n1)-c1cccc(O)c1
Show InChI InChI=1S/C21H26N4O/c1-21(2,3)16-11-9-15(10-12-16)20-22-19(14-24(4)5)23-25(20)17-7-6-8-18(26)13-17/h6-13,26H,14H2,1-5H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and the Informatics Institute of UMDNJ

Curated by ChEMBL


Assay Description
Inhibition of 5HT5A receptor


Bioorg Med Chem 17: 6442-50 (2009)


Article DOI: 10.1016/j.bmc.2009.07.007
BindingDB Entry DOI: 10.7270/Q2QZ2B14
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50212239
PNG
(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)
Show SMILES COc1cc(NC(=O)c2ccc(o2)-c2ccc(Cl)cc2)cc(OC)c1
Show InChI InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from 5HT5A receptor


Proc Natl Acad Sci USA 104: 8520-5 (2007)


Article DOI: 10.1073/pnas.0611364104
BindingDB Entry DOI: 10.7270/Q2J10411
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50060429
PNG
((R)-2-(4-Fluoro-phenyl)-2-{1-[3-(5-[1,2,4]triazol-...)
Show SMILES OC[C@H](NC1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C26H31FN6O/c27-21-5-3-19(4-6-21)26(16-34)31-22-9-12-32(13-10-22)11-1-2-20-15-28-25-8-7-23(14-24(20)25)33-17-29-30-18-33/h3-8,14-15,17-18,22,26,28,31,34H,1-2,9-13,16H2/t26-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Compound was tested for the displacement of [3H]-5-HT binding to cloned human 5-hydroxytryptamine 5A receptor receptor stably expressed in CHO cells


J Med Chem 42: 4981-5001 (2000)


Article DOI: 10.1021/jm9910021
BindingDB Entry DOI: 10.7270/Q20P0Z77
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM10838
PNG
(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12
Show InChI InChI=1S/C12H10N4O/c13-12-14-5-4-8(16-12)7-6-15-9-2-1-3-10(17)11(7)9/h1-6,15,17H,(H2,13,14,16)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from 5-HT5A receptor after 1.5 hrs by scintillation counting


Bioorg Med Chem 19: 5756-62 (2011)


Article DOI: 10.1016/j.bmc.2011.08.033
BindingDB Entry DOI: 10.7270/Q25X29BF
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50353903
PNG
(CHEMBL1829961)
Show SMILES Nc1nc(Cl)ncc1-c1c[nH]c2cccc(O)c12
Show InChI InChI=1S/C12H9ClN4O/c13-12-16-5-7(11(14)17-12)6-4-15-8-2-1-3-9(18)10(6)8/h1-5,15,18H,(H2,14,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from 5-HT5A receptor after 1.5 hrs by scintillation counting


Bioorg Med Chem 19: 5756-62 (2011)


Article DOI: 10.1016/j.bmc.2011.08.033
BindingDB Entry DOI: 10.7270/Q25X29BF
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50353901
PNG
(CHEMBL1829958)
Show SMILES Nc1nc(Br)ncc1-c1c[nH]c2cccc(O)c12
Show InChI InChI=1S/C12H9BrN4O/c13-12-16-5-7(11(14)17-12)6-4-15-8-2-1-3-9(18)10(6)8/h1-5,15,18H,(H2,14,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of South Florida

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from 5-HT5A receptor after 1.5 hrs by scintillation counting


Bioorg Med Chem 19: 5756-62 (2011)


Article DOI: 10.1016/j.bmc.2011.08.033
BindingDB Entry DOI: 10.7270/Q25X29BF
More data for this
Ligand-Target Pair